Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AX12_LEIMU

TriTrypDb:

LmxM.24.1670

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AX12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	137	139	PF00675	0.519
CLV_NRD_NRD_1	151	153	PF00675	0.439
CLV_NRD_NRD_1	174	176	PF00675	0.539
CLV_NRD_NRD_1	198	200	PF00675	0.542
CLV_NRD_NRD_1	201	203	PF00675	0.543
CLV_NRD_NRD_1	206	208	PF00675	0.538
CLV_PCSK_FUR_1	178	182	PF00082	0.595
CLV_PCSK_FUR_1	199	203	PF00082	0.545
CLV_PCSK_KEX2_1	137	139	PF00082	0.495
CLV_PCSK_KEX2_1	180	182	PF00082	0.598
CLV_PCSK_KEX2_1	200	202	PF00082	0.358
CLV_PCSK_KEX2_1	205	207	PF00082	0.531
CLV_PCSK_KEX2_1	48	50	PF00082	0.488
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.598
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.358
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.502
CLV_PCSK_PC7_1	201	207	PF00082	0.591
CLV_PCSK_SKI1_1	129	133	PF00082	0.617
CLV_PCSK_SKI1_1	238	242	PF00082	0.569
CLV_PCSK_SKI1_1	9	13	PF00082	0.616
DEG_Nend_Nbox_1	1	3	PF02207	0.626
DEG_SPOP_SBC_1	33	37	PF00917	0.593
DOC_MAPK_gen_1	180	189	PF00069	0.556
DOC_PP4_FxxP_1	87	90	PF00568	0.428
DOC_USP7_MATH_1	216	220	PF00917	0.624
DOC_USP7_MATH_1	34	38	PF00917	0.432
DOC_USP7_UBL2_3	176	180	PF12436	0.546
DOC_WW_Pin1_4	16	21	PF00397	0.578
LIG_14-3-3_CanoR_1	152	158	PF00244	0.557
LIG_14-3-3_CanoR_1	265	271	PF00244	0.675
LIG_14-3-3_CanoR_1	9	18	PF00244	0.586
LIG_Actin_WH2_2	225	240	PF00022	0.602
LIG_Actin_WH2_2	95	111	PF00022	0.463
LIG_deltaCOP1_diTrp_1	222	228	PF00928	0.573
LIG_deltaCOP1_diTrp_1	79	87	PF00928	0.459
LIG_FHA_1	13	19	PF00498	0.595
LIG_FHA_1	227	233	PF00498	0.584
LIG_FHA_1	39	45	PF00498	0.649
LIG_LIR_Apic_2	84	90	PF02991	0.433
LIG_LIR_Gen_1	140	147	PF02991	0.521
LIG_LIR_Gen_1	222	233	PF02991	0.559
LIG_LIR_Gen_1	47	57	PF02991	0.477
LIG_LIR_Gen_1	79	90	PF02991	0.410
LIG_LIR_Nem_3	140	146	PF02991	0.518
LIG_LIR_Nem_3	222	228	PF02991	0.554
LIG_LIR_Nem_3	47	53	PF02991	0.469
LIG_LIR_Nem_3	56	62	PF02991	0.460
LIG_LIR_Nem_3	79	85	PF02991	0.425
LIG_Pex14_1	77	81	PF04695	0.378
LIG_SH2_CRK	31	35	PF00017	0.346
LIG_SH2_GRB2like	101	104	PF00017	0.426
LIG_SH2_STAT5	171	174	PF00017	0.576
LIG_SH2_STAT5	59	62	PF00017	0.505
LIG_SH2_STAT5	82	85	PF00017	0.416
LIG_SUMO_SIM_par_1	12	19	PF11976	0.478
LIG_TRAF2_1	212	215	PF00917	0.593
LIG_TRFH_1	87	91	PF08558	0.414
MOD_CK1_1	21	27	PF00069	0.494
MOD_CK1_1	266	272	PF00069	0.671
MOD_CK2_1	205	211	PF00069	0.522
MOD_CK2_1	216	222	PF00069	0.564
MOD_CK2_1	34	40	PF00069	0.504
MOD_CMANNOS	77	80	PF00535	0.371
MOD_GlcNHglycan	12	15	PF01048	0.646
MOD_GlcNHglycan	218	221	PF01048	0.573
MOD_GlcNHglycan	55	58	PF01048	0.521
MOD_GSK3_1	113	120	PF00069	0.545
MOD_GSK3_1	18	25	PF00069	0.399
MOD_GSK3_1	216	223	PF00069	0.567
MOD_GSK3_1	251	258	PF00069	0.612
MOD_GSK3_1	34	41	PF00069	0.642
MOD_GSK3_1	5	12	PF00069	0.629
MOD_GSK3_1	85	92	PF00069	0.442
MOD_N-GLC_1	113	118	PF02516	0.540
MOD_N-GLC_1	226	231	PF02516	0.573
MOD_N-GLC_1	53	58	PF02516	0.540
MOD_N-GLC_1	85	90	PF02516	0.486
MOD_NEK2_1	10	15	PF00069	0.615
MOD_NEK2_1	158	163	PF00069	0.494
MOD_NEK2_1	44	49	PF00069	0.476
MOD_NEK2_1	53	58	PF00069	0.513
MOD_NEK2_1	85	90	PF00069	0.459
MOD_NEK2_2	263	268	PF00069	0.761
MOD_PKA_1	205	211	PF00069	0.442
MOD_PKA_2	151	157	PF00069	0.560
MOD_PKA_2	174	180	PF00069	0.543
MOD_PKA_2	2	8	PF00069	0.681
MOD_PKA_2	205	211	PF00069	0.438
MOD_PKA_2	242	248	PF00069	0.573
MOD_PKA_2	251	257	PF00069	0.574
MOD_PKA_2	44	50	PF00069	0.470
MOD_Plk_1	185	191	PF00069	0.547
MOD_Plk_1	85	91	PF00069	0.487
MOD_Plk_4	158	164	PF00069	0.500
MOD_ProDKin_1	16	22	PF00069	0.570
MOD_SUMO_rev_2	70	75	PF00179	0.528
TRG_ENDOCYTIC_2	59	62	PF00928	0.394
TRG_ENDOCYTIC_2	82	85	PF00928	0.418
TRG_ER_diArg_1	199	202	PF00400	0.545
TRG_ER_diArg_1	205	207	PF00400	0.548
TRG_NLS_MonoExtN_4	199	204	PF00514	0.566
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.569
TRG_Pf-PMV_PEXEL_1	156	160	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7U3	Leptomonas seymouri	85%	100%
A0A0S4JQ00	Bodo saltans	52%	100%
A0A1X0NW91	Trypanosomatidae	78%	100%
A0A3S7WYJ0	Leishmania donovani	96%	100%
A4HDM7	Leishmania braziliensis	93%	100%
C9ZWD8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	100%
E9AH74	Leishmania infantum	96%	100%
Q4QAG4	Leishmania major	96%	100%
V5BK26	Trypanosoma cruzi	75%	99%