Basal body-orientation factor 1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AX10_LEIMU

TriTrypDb:

LmxM.24.1650

Length:

532

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AX10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	293	297	PF00656	0.563
CLV_C14_Caspase3-7	361	365	PF00656	0.543
CLV_C14_Caspase3-7	90	94	PF00656	0.378
CLV_MEL_PAP_1	337	343	PF00089	0.519
CLV_NRD_NRD_1	14	16	PF00675	0.757
CLV_NRD_NRD_1	232	234	PF00675	0.441
CLV_NRD_NRD_1	272	274	PF00675	0.531
CLV_NRD_NRD_1	303	305	PF00675	0.473
CLV_NRD_NRD_1	324	326	PF00675	0.535
CLV_NRD_NRD_1	434	436	PF00675	0.460
CLV_NRD_NRD_1	64	66	PF00675	0.726
CLV_PCSK_FUR_1	270	274	PF00082	0.527
CLV_PCSK_KEX2_1	272	274	PF00082	0.531
CLV_PCSK_KEX2_1	303	305	PF00082	0.467
CLV_PCSK_KEX2_1	323	325	PF00082	0.297
CLV_PCSK_PC7_1	299	305	PF00082	0.572
CLV_PCSK_SKI1_1	110	114	PF00082	0.616
CLV_PCSK_SKI1_1	16	20	PF00082	0.694
CLV_PCSK_SKI1_1	233	237	PF00082	0.526
CLV_PCSK_SKI1_1	255	259	PF00082	0.497
CLV_PCSK_SKI1_1	318	322	PF00082	0.397
CLV_PCSK_SKI1_1	388	392	PF00082	0.635
CLV_PCSK_SKI1_1	393	397	PF00082	0.623
CLV_PCSK_SKI1_1	497	501	PF00082	0.479
CLV_Separin_Metazoa	165	169	PF03568	0.593
DEG_APCC_DBOX_1	380	388	PF00400	0.525
DEG_ODPH_VHL_1	35	46	PF01847	0.683
DEG_SPOP_SBC_1	471	475	PF00917	0.746
DOC_MAPK_gen_1	233	240	PF00069	0.444
DOC_MAPK_gen_1	323	334	PF00069	0.602
DOC_MAPK_gen_1	435	441	PF00069	0.468
DOC_MAPK_gen_1	495	504	PF00069	0.490
DOC_PP1_RVXF_1	498	505	PF00149	0.475
DOC_PP2B_LxvP_1	35	38	PF13499	0.686
DOC_USP7_MATH_1	38	42	PF00917	0.734
DOC_USP7_MATH_1	470	474	PF00917	0.706
DOC_USP7_UBL2_3	329	333	PF12436	0.528
DOC_USP7_UBL2_3	493	497	PF12436	0.601
DOC_WW_Pin1_4	466	471	PF00397	0.654
DOC_WW_Pin1_4	472	477	PF00397	0.646
DOC_WW_Pin1_4	511	516	PF00397	0.661
DOC_WW_Pin1_4	521	526	PF00397	0.666
LIG_14-3-3_CanoR_1	15	24	PF00244	0.742
LIG_14-3-3_CanoR_1	176	181	PF00244	0.591
LIG_14-3-3_CanoR_1	374	378	PF00244	0.557
LIG_14-3-3_CanoR_1	388	395	PF00244	0.532
LIG_14-3-3_CanoR_1	457	465	PF00244	0.768
LIG_14-3-3_CanoR_1	68	77	PF00244	0.703
LIG_BIR_II_1	1	5	PF00653	0.756
LIG_BRCT_BRCA1_1	482	486	PF00533	0.727
LIG_BRCT_BRCA1_1	500	504	PF00533	0.441
LIG_Clathr_ClatBox_1	237	241	PF01394	0.446
LIG_EH1_1	282	290	PF00400	0.584
LIG_FHA_1	144	150	PF00498	0.553
LIG_FHA_1	179	185	PF00498	0.555
LIG_FHA_1	200	206	PF00498	0.565
LIG_FHA_1	269	275	PF00498	0.527
LIG_FHA_1	280	286	PF00498	0.408
LIG_FHA_1	290	296	PF00498	0.439
LIG_FHA_1	389	395	PF00498	0.600
LIG_FHA_1	5	11	PF00498	0.761
LIG_FHA_2	100	106	PF00498	0.466
LIG_FHA_2	291	297	PF00498	0.593
LIG_FHA_2	457	463	PF00498	0.746
LIG_FHA_2	88	94	PF00498	0.651
LIG_GBD_Chelix_1	123	131	PF00786	0.484
LIG_LIR_Gen_1	247	256	PF02991	0.566
LIG_LIR_LC3C_4	213	217	PF02991	0.588
LIG_LIR_Nem_3	247	251	PF02991	0.567
LIG_LIR_Nem_3	261	267	PF02991	0.516
LIG_PCNA_TLS_4	398	405	PF02747	0.496
LIG_PCNA_yPIPBox_3	209	221	PF02747	0.589
LIG_PTB_Apo_2	504	511	PF02174	0.589
LIG_PTB_Phospho_1	504	510	PF10480	0.620
LIG_SH2_CRK	177	181	PF00017	0.476
LIG_SH2_NCK_1	177	181	PF00017	0.562
LIG_SH2_STAT3	194	197	PF00017	0.579
LIG_SH2_STAT3	95	98	PF00017	0.669
LIG_SH2_STAT5	194	197	PF00017	0.566
LIG_SH2_STAT5	95	98	PF00017	0.469
LIG_SH3_1	512	518	PF00018	0.420
LIG_SH3_3	464	470	PF00018	0.621
LIG_SH3_3	512	518	PF00018	0.470
LIG_SUMO_SIM_anti_2	7	13	PF11976	0.674
LIG_SUMO_SIM_par_1	236	241	PF11976	0.447
LIG_TRAF2_1	155	158	PF00917	0.608
LIG_TRAF2_1	259	262	PF00917	0.556
LIG_TRAF2_1	459	462	PF00917	0.782
LIG_UBA3_1	237	242	PF00899	0.579
MOD_CDK_SPK_2	521	526	PF00069	0.670
MOD_CK1_1	179	185	PF00069	0.531
MOD_CK1_1	372	378	PF00069	0.564
MOD_CK1_1	430	436	PF00069	0.708
MOD_CK1_1	456	462	PF00069	0.724
MOD_CK1_1	87	93	PF00069	0.549
MOD_CK2_1	396	402	PF00069	0.499
MOD_CK2_1	456	462	PF00069	0.735
MOD_CK2_1	521	527	PF00069	0.623
MOD_CK2_1	99	105	PF00069	0.441
MOD_GlcNHglycan	1	4	PF01048	0.712
MOD_GlcNHglycan	20	23	PF01048	0.707
MOD_GlcNHglycan	418	422	PF01048	0.724
MOD_GlcNHglycan	429	432	PF01048	0.740
MOD_GlcNHglycan	445	448	PF01048	0.699
MOD_GlcNHglycan	482	485	PF01048	0.701
MOD_GlcNHglycan	57	60	PF01048	0.707
MOD_GSK3_1	10	17	PF00069	0.742
MOD_GSK3_1	133	140	PF00069	0.526
MOD_GSK3_1	369	376	PF00069	0.579
MOD_GSK3_1	419	426	PF00069	0.652
MOD_GSK3_1	466	473	PF00069	0.664
MOD_GSK3_1	476	483	PF00069	0.749
MOD_GSK3_1	51	58	PF00069	0.774
MOD_GSK3_1	60	67	PF00069	0.699
MOD_GSK3_1	76	83	PF00069	0.644
MOD_NEK2_1	126	131	PF00069	0.599
MOD_NEK2_1	14	19	PF00069	0.751
MOD_NEK2_1	240	245	PF00069	0.487
MOD_NEK2_1	268	273	PF00069	0.598
MOD_NEK2_1	370	375	PF00069	0.495
MOD_NEK2_1	404	409	PF00069	0.616
MOD_NEK2_1	419	424	PF00069	0.681
MOD_NEK2_1	480	485	PF00069	0.758
MOD_NEK2_1	64	69	PF00069	0.760
MOD_NEK2_1	76	81	PF00069	0.627
MOD_NEK2_1	85	90	PF00069	0.501
MOD_NEK2_2	476	481	PF00069	0.673
MOD_PIKK_1	143	149	PF00454	0.582
MOD_PIKK_1	419	425	PF00454	0.606
MOD_PIKK_1	94	100	PF00454	0.623
MOD_PK_1	176	182	PF00069	0.590
MOD_PKA_2	14	20	PF00069	0.771
MOD_PKA_2	373	379	PF00069	0.578
MOD_PKA_2	456	462	PF00069	0.716
MOD_PKA_2	64	70	PF00069	0.753
MOD_PKB_1	386	394	PF00069	0.622
MOD_Plk_1	199	205	PF00069	0.549
MOD_Plk_1	240	246	PF00069	0.512
MOD_Plk_1	342	348	PF00069	0.449
MOD_Plk_4	498	504	PF00069	0.598
MOD_Plk_4	76	82	PF00069	0.703
MOD_ProDKin_1	466	472	PF00069	0.646
MOD_ProDKin_1	511	517	PF00069	0.665
MOD_ProDKin_1	521	527	PF00069	0.665
MOD_SUMO_rev_2	275	280	PF00179	0.628
MOD_SUMO_rev_2	328	334	PF00179	0.488
MOD_SUMO_rev_2	364	373	PF00179	0.592
TRG_DiLeu_BaEn_1	247	252	PF01217	0.508
TRG_ENDOCYTIC_2	163	166	PF00928	0.482
TRG_ENDOCYTIC_2	177	180	PF00928	0.476
TRG_ER_diArg_1	270	273	PF00400	0.555
TRG_ER_diArg_1	302	304	PF00400	0.481
TRG_ER_diArg_1	323	325	PF00400	0.454
TRG_NES_CRM1_1	206	220	PF08389	0.592
TRG_NES_CRM1_1	336	349	PF08389	0.363
TRG_Pf-PMV_PEXEL_1	132	137	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	258	262	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	272	276	PF00026	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEM1	Leptomonas seymouri	54%	100%
A0A0S4JCG1	Bodo saltans	26%	85%
A0A1X0NPU9	Trypanosomatidae	36%	87%
A0A3Q8ICZ4	Leishmania donovani	93%	99%
A0A422NQP6	Trypanosoma rangeli	38%	95%
A4HDM5	Leishmania braziliensis	78%	100%
D0A6S8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	94%
E9AH72	Leishmania infantum	93%	99%
Q4QAG6	Leishmania major	92%	100%
V5BJY8	Trypanosoma cruzi	30%	94%