LeishMANIAdb
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Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Gene product:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Species:
Leishmania mexicana
UniProt:
E9AX08_LEIMU
TriTrypDb:
LmxM.24.1630
Length:
607

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 8
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005743 mitochondrial inner membrane 5 11
GO:0016020 membrane 2 11
GO:0019866 organelle inner membrane 4 11
GO:0031090 organelle membrane 3 11
GO:0031966 mitochondrial membrane 4 11
GO:0110165 cellular anatomical entity 1 12
GO:0000331 contractile vacuole 6 1
GO:0005737 cytoplasm 2 1
GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) 4 1
GO:0005773 vacuole 5 1
GO:0031410 cytoplasmic vesicle 6 1
GO:0031982 vesicle 4 1
GO:0032991 protein-containing complex 1 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0045257 succinate dehydrogenase complex (ubiquinone) 5 1
GO:0045281 succinate dehydrogenase complex 4 1
GO:0045283 fumarate reductase complex 3 1
GO:0097708 intracellular vesicle 5 1
GO:0098796 membrane protein complex 2 1
GO:0098798 mitochondrial protein-containing complex 2 1
GO:0098800 inner mitochondrial membrane protein complex 3 1
GO:0098803 respiratory chain complex 3 1
GO:1902494 catalytic complex 2 1
GO:1990204 oxidoreductase complex 3 1

Expansion

Sequence features

E9AX08
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX08

Function

Biological processes
Term Name Level Count
GO:0006091 generation of precursor metabolites and energy 3 12
GO:0006099 tricarboxylic acid cycle 3 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0022900 electron transport chain 4 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0006121 mitochondrial electron transport, succinate to ubiquinone 7 1
GO:0009060 aerobic respiration 6 1
GO:0015980 energy derivation by oxidation of organic compounds 4 1
GO:0019646 aerobic electron transport chain 6 1
GO:0022904 respiratory electron transport chain 5 1
GO:0045333 cellular respiration 5 1
Molecular functions
Term Name Level Count
GO:0000104 succinate dehydrogenase activity 4 12
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0005488 binding 1 12
GO:0008177 succinate dehydrogenase (ubiquinone) activity 5 12
GO:0016491 oxidoreductase activity 2 12
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 3 12
GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0050660 flavin adenine dinucleotide binding 4 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12
GO:0009055 electron transfer activity 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 146 148 PF00675 0.253
CLV_NRD_NRD_1 3 5 PF00675 0.532
CLV_NRD_NRD_1 439 441 PF00675 0.473
CLV_NRD_NRD_1 545 547 PF00675 0.255
CLV_PCSK_KEX2_1 146 148 PF00082 0.253
CLV_PCSK_KEX2_1 3 5 PF00082 0.532
CLV_PCSK_KEX2_1 497 499 PF00082 0.317
CLV_PCSK_KEX2_1 604 606 PF00082 0.368
CLV_PCSK_PC1ET2_1 497 499 PF00082 0.317
CLV_PCSK_PC1ET2_1 604 606 PF00082 0.292
CLV_PCSK_SKI1_1 304 308 PF00082 0.253
CLV_PCSK_SKI1_1 4 8 PF00082 0.583
CLV_PCSK_SKI1_1 530 534 PF00082 0.253
DEG_Nend_Nbox_1 1 3 PF02207 0.518
DOC_CDC14_PxL_1 369 377 PF14671 0.253
DOC_CYCLIN_yClb5_NLxxxL_5 518 527 PF00134 0.253
DOC_MAPK_gen_1 3 11 PF00069 0.589
DOC_MAPK_gen_1 319 327 PF00069 0.253
DOC_MAPK_gen_1 473 482 PF00069 0.253
DOC_MAPK_MEF2A_6 319 327 PF00069 0.253
DOC_PP1_RVXF_1 218 224 PF00149 0.396
DOC_USP7_MATH_1 29 33 PF00917 0.268
DOC_USP7_MATH_1 402 406 PF00917 0.253
DOC_USP7_MATH_1 55 59 PF00917 0.299
DOC_USP7_UBL2_3 437 441 PF12436 0.476
DOC_WW_Pin1_4 379 384 PF00397 0.290
DOC_WW_Pin1_4 513 518 PF00397 0.253
LIG_14-3-3_CanoR_1 207 213 PF00244 0.147
LIG_14-3-3_CanoR_1 3 7 PF00244 0.520
LIG_14-3-3_CanoR_1 304 309 PF00244 0.278
LIG_BIR_III_4 576 580 PF00653 0.396
LIG_deltaCOP1_diTrp_1 75 81 PF00928 0.257
LIG_eIF4E_1 178 184 PF01652 0.268
LIG_eIF4E_1 260 266 PF01652 0.253
LIG_FHA_1 234 240 PF00498 0.253
LIG_FHA_1 305 311 PF00498 0.253
LIG_FHA_1 375 381 PF00498 0.253
LIG_FHA_1 477 483 PF00498 0.268
LIG_FHA_1 592 598 PF00498 0.253
LIG_HCF-1_HBM_1 19 22 PF13415 0.449
LIG_LIR_Gen_1 19 29 PF02991 0.257
LIG_LIR_Gen_1 208 218 PF02991 0.232
LIG_LIR_Gen_1 248 259 PF02991 0.253
LIG_LIR_Gen_1 5 14 PF02991 0.490
LIG_LIR_Nem_3 12 18 PF02991 0.412
LIG_LIR_Nem_3 177 181 PF02991 0.271
LIG_LIR_Nem_3 19 25 PF02991 0.331
LIG_LIR_Nem_3 208 213 PF02991 0.246
LIG_LIR_Nem_3 215 221 PF02991 0.262
LIG_LIR_Nem_3 248 254 PF02991 0.253
LIG_LIR_Nem_3 5 9 PF02991 0.509
LIG_LIR_Nem_3 501 507 PF02991 0.253
LIG_LIR_Nem_3 78 84 PF02991 0.257
LIG_LYPXL_yS_3 15 18 PF13949 0.340
LIG_NRBOX 528 534 PF00104 0.253
LIG_PTB_Apo_2 173 180 PF02174 0.253
LIG_PTB_Phospho_1 173 179 PF10480 0.253
LIG_SH2_CRK 210 214 PF00017 0.268
LIG_SH2_CRK 218 222 PF00017 0.268
LIG_SH2_CRK 22 26 PF00017 0.404
LIG_SH2_CRK 483 487 PF00017 0.253
LIG_SH2_CRK 585 589 PF00017 0.253
LIG_SH2_CRK 84 88 PF00017 0.253
LIG_SH2_NCK_1 483 487 PF00017 0.253
LIG_SH2_STAP1 22 26 PF00017 0.396
LIG_SH2_STAP1 483 487 PF00017 0.253
LIG_SH2_STAT3 101 104 PF00017 0.253
LIG_SH2_STAT5 179 182 PF00017 0.308
LIG_SH2_STAT5 210 213 PF00017 0.253
LIG_SH2_STAT5 222 225 PF00017 0.253
LIG_SH2_STAT5 276 279 PF00017 0.253
LIG_SH2_STAT5 573 576 PF00017 0.265
LIG_SH3_3 357 363 PF00018 0.285
LIG_SH3_3 377 383 PF00018 0.123
LIG_SUMO_SIM_anti_2 416 422 PF11976 0.275
LIG_TYR_ITIM 583 588 PF00017 0.253
LIG_UBA3_1 417 425 PF00899 0.270
LIG_UBA3_1 432 437 PF00899 0.343
MOD_CDK_SPK_2 379 384 PF00069 0.287
MOD_CK1_1 152 158 PF00069 0.255
MOD_CK1_1 208 214 PF00069 0.247
MOD_CK1_1 227 233 PF00069 0.401
MOD_CK1_1 492 498 PF00069 0.342
MOD_CK2_1 108 114 PF00069 0.253
MOD_CK2_1 277 283 PF00069 0.260
MOD_Cter_Amidation 438 441 PF01082 0.471
MOD_Cter_Amidation 495 498 PF01082 0.396
MOD_GlcNHglycan 226 229 PF01048 0.253
MOD_GlcNHglycan 31 34 PF01048 0.261
MOD_GlcNHglycan 344 347 PF01048 0.253
MOD_GlcNHglycan 42 45 PF01048 0.235
MOD_GlcNHglycan 540 543 PF01048 0.344
MOD_GSK3_1 108 115 PF00069 0.268
MOD_GSK3_1 145 152 PF00069 0.253
MOD_GSK3_1 208 215 PF00069 0.298
MOD_GSK3_1 223 230 PF00069 0.232
MOD_GSK3_1 300 307 PF00069 0.253
MOD_GSK3_1 361 368 PF00069 0.324
MOD_GSK3_1 423 430 PF00069 0.274
MOD_GSK3_1 53 60 PF00069 0.260
MOD_GSK3_1 83 90 PF00069 0.253
MOD_N-GLC_1 433 438 PF02516 0.353
MOD_NEK2_1 159 164 PF00069 0.253
MOD_NEK2_1 2 7 PF00069 0.507
MOD_NEK2_1 223 228 PF00069 0.253
MOD_NEK2_1 423 428 PF00069 0.263
MOD_NEK2_1 476 481 PF00069 0.255
MOD_NEK2_1 538 543 PF00069 0.287
MOD_NEK2_1 567 572 PF00069 0.267
MOD_NEK2_1 9 14 PF00069 0.443
MOD_NEK2_2 134 139 PF00069 0.253
MOD_NEK2_2 402 407 PF00069 0.253
MOD_PKA_1 546 552 PF00069 0.253
MOD_PKA_2 145 151 PF00069 0.253
MOD_PKA_2 2 8 PF00069 0.504
MOD_Plk_1 18 24 PF00069 0.332
MOD_Plk_1 450 456 PF00069 0.403
MOD_Plk_1 489 495 PF00069 0.208
MOD_Plk_4 159 165 PF00069 0.253
MOD_Plk_4 208 214 PF00069 0.298
MOD_Plk_4 371 377 PF00069 0.270
MOD_Plk_4 413 419 PF00069 0.253
MOD_Plk_4 427 433 PF00069 0.297
MOD_ProDKin_1 379 385 PF00069 0.290
MOD_ProDKin_1 513 519 PF00069 0.253
TRG_DiLeu_BaEn_1 273 278 PF01217 0.253
TRG_DiLeu_BaEn_1 528 533 PF01217 0.253
TRG_DiLeu_BaEn_2 246 252 PF01217 0.253
TRG_DiLeu_BaEn_2 280 286 PF01217 0.253
TRG_ENDOCYTIC_2 15 18 PF00928 0.354
TRG_ENDOCYTIC_2 178 181 PF00928 0.268
TRG_ENDOCYTIC_2 210 213 PF00928 0.253
TRG_ENDOCYTIC_2 218 221 PF00928 0.253
TRG_ENDOCYTIC_2 22 25 PF00928 0.268
TRG_ENDOCYTIC_2 483 486 PF00928 0.253
TRG_ENDOCYTIC_2 504 507 PF00928 0.261
TRG_ENDOCYTIC_2 585 588 PF00928 0.253
TRG_ENDOCYTIC_2 84 87 PF00928 0.253
TRG_ER_diArg_1 2 4 PF00400 0.540
TRG_Pf-PMV_PEXEL_1 498 502 PF00026 0.317

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PFQ2 Leptomonas seymouri 96% 100%
A0A0S4IHN0 Bodo saltans 26% 100%
A0A0S4KLA2 Bodo saltans 89% 99%
A0A0S4KND3 Bodo saltans 27% 100%
A0A1S3YEG8 Nicotiana tabacum 33% 94%
A0A1S4BJT3 Nicotiana tabacum 34% 94%
A0A1X0NVS8 Trypanosomatidae 91% 100%
A0A3Q8ID36 Leishmania donovani 99% 100%
A0A3R7K4Y6 Trypanosoma rangeli 91% 100%
A4HDM3 Leishmania braziliensis 97% 100%
C8WLE3 Eggerthella lenta (strain ATCC 25559 / DSM 2243 / CCUG 17323 / JCM 9979 / KCTC 3265 / NCTC 11813 / VPI 0255 / 1899 B) 26% 100%
C9ZWE3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 90% 100%
D9PU00 Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) 37% 100%
E9AH70 Leishmania infantum 99% 100%
G4V4G6 Serratia sp. (strain ATCC 39006) 50% 100%
O06913 Helicobacter pylori (strain ATCC 700392 / 26695) 36% 85%
O57765 Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) 31% 100%
O66973 Aquifex aeolicus (strain VF5) 30% 100%
O82663 Arabidopsis thaliana 64% 96%
P00363 Escherichia coli (strain K12) 41% 100%
P08065 Bacillus subtilis (strain 168) 33% 100%
P0AC41 Escherichia coli (strain K12) 50% 100%
P0AC42 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 50% 100%
P0AC43 Escherichia coli O157:H7 50% 100%
P0C278 Shewanella frigidimarina 24% 100%
P10902 Escherichia coli (strain K12) 32% 100%
P17412 Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) 36% 93%
P20922 Proteus vulgaris 40% 100%
P21375 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 21% 100%
P31038 Rickettsia prowazekii (strain Madrid E) 60% 100%
P31039 Bos taurus 59% 91%
P31040 Homo sapiens 60% 91%
P32614 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 100%
P38032 Bacillus subtilis (strain 168) 31% 100%
P44894 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 38% 100%
P47052 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 60% 96%
P51054 Coxiella burnetii (strain RSA 493 / Nine Mile phase I) 52% 100%
P64175 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 37% 100%
P65500 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 31% 100%
P74562 Synechocystis sp. (strain PCC 6803 / Kazusa) 31% 100%
P83223 Shewanella oneidensis (strain MR-1) 27% 100%
P9WJJ8 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 31% 100%
P9WJJ9 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 31% 100%
P9WN90 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 37% 100%
P9WN91 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 37% 100%
Q00711 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 60% 95%
Q07WU7 Shewanella frigidimarina (strain NCIMB 400) 24% 100%
Q09508 Caenorhabditis elegans 61% 94%
Q0QF01 Sus scrofa 60% 91%
Q0QF17 Mesocricetus auratus 62% 100%
Q1RHB9 Rickettsia bellii (strain RML369-C) 60% 100%
Q28ED0 Xenopus tropicalis 59% 91%
Q49617 Mycobacterium leprae (strain TN) 31% 100%
Q4QAG8 Leishmania major 99% 100%
Q4UJM1 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) 60% 100%
Q51363 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 32% 100%
Q59661 Paracoccus denitrificans 58% 100%
Q5R616 Pongo abelii 60% 91%
Q60356 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 35% 100%
Q68XN9 Rickettsia typhi (strain ATCC VR-144 / Wilmington) 60% 100%
Q6PA58 Xenopus laevis 59% 91%
Q6Z836 Oryza sativa subsp. japonica 32% 94%
Q6ZDY8 Oryza sativa subsp. japonica 64% 96%
Q7M827 Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) 38% 99%
Q7ZVF3 Danio rerio 60% 92%
Q801S2 Xenopus laevis 59% 91%
Q87D19 Xylella fastidiosa (strain Temecula1 / ATCC 700964) 29% 100%
Q8CVD0 Shewanella oneidensis (strain MR-1) 25% 100%
Q8HXW3 Macaca fascicularis 59% 91%
Q8K2B3 Mus musculus 60% 91%
Q8TZL4 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) 28% 100%
Q8U8J4 Agrobacterium fabrum (strain C58 / ATCC 33970) 30% 100%
Q8XA23 Escherichia coli O157:H7 32% 100%
Q8XNE2 Clostridium perfringens (strain 13 / Type A) 28% 100%
Q8XQG4 Ralstonia solanacearum (strain GMI1000) 31% 100%
Q8XWM7 Ralstonia solanacearum (strain GMI1000) 33% 100%
Q8Y5N4 Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) 29% 100%
Q8YXJ6 Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576) 32% 100%
Q8Z4K0 Salmonella typhi 31% 100%
Q8ZD80 Yersinia pestis 31% 100%
Q8ZMX9 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 31% 100%
Q8ZQU3 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 49% 100%
Q920L2 Rattus norvegicus 60% 93%
Q929Z2 Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262) 32% 100%
Q92J97 Rickettsia conorii (strain ATCC VR-613 / Malish 7) 60% 100%
Q92R32 Rhizobium meliloti (strain 1021) 31% 100%
Q94523 Drosophila melanogaster 61% 92%
Q94AY1 Arabidopsis thaliana 35% 93%
Q972D2 Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) 30% 100%
Q97K95 Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) 31% 100%
Q97ZC5 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 31% 100%
Q98AV8 Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) 30% 100%
Q9A4C3 Caulobacter vibrioides (strain ATCC 19089 / CB15) 32% 100%
Q9HNZ0 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 30% 100%
Q9JSX4 Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491) 30% 100%
Q9K107 Neisseria meningitidis serogroup B (strain MC58) 30% 100%
Q9KDJ5 Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) 29% 100%
Q9KPA4 Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) 32% 100%
Q9PC57 Xylella fastidiosa (strain 9a5c) 29% 100%
Q9U3X4 Dictyostelium discoideum 62% 97%
Q9UTJ7 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 62% 95%
Q9V2R0 Pyrococcus abyssi (strain GE5 / Orsay) 29% 100%
Q9X8N8 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) 31% 100%
Q9YHT1 Gallus gallus 60% 91%
Q9Z4P0 Shewanella frigidimarina (strain NCIMB 400) 26% 100%
Q9ZMP0 Helicobacter pylori (strain J99 / ATCC 700824) 36% 85%
Q9ZPX5 Arabidopsis thaliana 64% 96%
V3TQ67 Serratia sp. (strain ATCC 39006) 40% 100%
V5BFJ9 Trypanosoma cruzi 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS