Thioredoxin-like_fold domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AX07_LEIMU

TriTrypDb:

LmxM.24.1620

Length:

382

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	1
GO:0005741	mitochondrial outer membrane	5	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

E9AX07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX07

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006626	protein targeting to mitochondrion	5	1
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070585	protein localization to mitochondrion	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072655	establishment of protein localization to mitochondrion	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	188	190	PF00675	0.449
CLV_NRD_NRD_1	24	26	PF00675	0.394
CLV_NRD_NRD_1	51	53	PF00675	0.426
CLV_NRD_NRD_1	80	82	PF00675	0.519
CLV_PCSK_KEX2_1	150	152	PF00082	0.468
CLV_PCSK_KEX2_1	188	190	PF00082	0.436
CLV_PCSK_KEX2_1	239	241	PF00082	0.561
CLV_PCSK_KEX2_1	272	274	PF00082	0.542
CLV_PCSK_KEX2_1	380	382	PF00082	0.540
CLV_PCSK_KEX2_1	51	53	PF00082	0.418
CLV_PCSK_KEX2_1	79	81	PF00082	0.526
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.468
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.518
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.542
CLV_PCSK_SKI1_1	201	205	PF00082	0.489
CLV_PCSK_SKI1_1	26	30	PF00082	0.461
CLV_PCSK_SKI1_1	273	277	PF00082	0.438
CLV_PCSK_SKI1_1	72	76	PF00082	0.595
DEG_APCC_DBOX_1	13	21	PF00400	0.583
DEG_APCC_DBOX_1	79	87	PF00400	0.295
DEG_Nend_UBRbox_1	1	4	PF02207	0.676
DOC_ANK_TNKS_1	50	57	PF00023	0.429
DOC_CYCLIN_RxL_1	270	279	PF00134	0.268
DOC_CYCLIN_yCln2_LP_2	291	297	PF00134	0.328
DOC_MAPK_gen_1	236	243	PF00069	0.328
DOC_MAPK_gen_1	79	85	PF00069	0.330
DOC_MAPK_MEF2A_6	92	100	PF00069	0.370
DOC_MAPK_RevD_3	226	239	PF00069	0.419
DOC_PP1_RVXF_1	199	205	PF00149	0.268
DOC_PP2B_LxvP_1	137	140	PF13499	0.229
DOC_PP2B_LxvP_1	291	294	PF13499	0.292
DOC_PP4_FxxP_1	99	102	PF00568	0.271
DOC_USP7_MATH_1	13	17	PF00917	0.715
DOC_USP7_MATH_1	171	175	PF00917	0.237
DOC_USP7_MATH_1	245	249	PF00917	0.405
DOC_USP7_MATH_1	30	34	PF00917	0.563
DOC_USP7_MATH_1	339	343	PF00917	0.348
DOC_USP7_UBL2_3	365	369	PF12436	0.345
DOC_WW_Pin1_4	101	106	PF00397	0.329
DOC_WW_Pin1_4	44	49	PF00397	0.592
LIG_14-3-3_CanoR_1	14	18	PF00244	0.678
LIG_14-3-3_CanoR_1	188	192	PF00244	0.311
LIG_14-3-3_CanoR_1	240	250	PF00244	0.382
LIG_14-3-3_CanoR_1	273	281	PF00244	0.313
LIG_14-3-3_CanoR_1	323	329	PF00244	0.292
LIG_14-3-3_CanoR_1	340	344	PF00244	0.463
LIG_14-3-3_CanoR_1	72	77	PF00244	0.436
LIG_APCC_ABBAyCdc20_2	272	278	PF00400	0.268
LIG_BRCT_BRCA1_1	332	336	PF00533	0.264
LIG_BRCT_BRCA1_1	70	74	PF00533	0.419
LIG_EH1_1	192	200	PF00400	0.237
LIG_eIF4E_1	193	199	PF01652	0.237
LIG_FHA_1	214	220	PF00498	0.384
LIG_FHA_1	365	371	PF00498	0.346
LIG_FHA_2	113	119	PF00498	0.332
LIG_FHA_2	280	286	PF00498	0.231
LIG_FHA_2	353	359	PF00498	0.560
LIG_FHA_2	73	79	PF00498	0.397
LIG_IRF3_LxIS_1	215	222	PF10401	0.399
LIG_LIR_Gen_1	305	316	PF02991	0.324
LIG_LIR_Gen_1	326	336	PF02991	0.308
LIG_LIR_Gen_1	71	78	PF02991	0.380
LIG_LIR_Gen_1	94	105	PF02991	0.296
LIG_LIR_Nem_3	143	149	PF02991	0.342
LIG_LIR_Nem_3	244	249	PF02991	0.351
LIG_LIR_Nem_3	305	311	PF02991	0.291
LIG_LIR_Nem_3	326	332	PF02991	0.235
LIG_LIR_Nem_3	71	77	PF02991	0.377
LIG_LIR_Nem_3	94	100	PF02991	0.389
LIG_MYND_1	108	112	PF01753	0.311
LIG_NRP_CendR_1	380	382	PF00754	0.540
LIG_Pex14_2	6	10	PF04695	0.603
LIG_SH2_CRK	200	204	PF00017	0.268
LIG_SH2_CRK	246	250	PF00017	0.315
LIG_SH2_CRK	289	293	PF00017	0.257
LIG_SH2_CRK	308	312	PF00017	0.257
LIG_SH2_GRB2like	320	323	PF00017	0.331
LIG_SH2_NCK_1	308	312	PF00017	0.337
LIG_SH2_STAP1	233	237	PF00017	0.332
LIG_SH2_STAP1	284	288	PF00017	0.222
LIG_SH2_STAP1	289	293	PF00017	0.222
LIG_SH2_STAP1	308	312	PF00017	0.289
LIG_SH2_STAT3	149	152	PF00017	0.268
LIG_SH2_STAT5	274	277	PF00017	0.311
LIG_SH2_STAT5	320	323	PF00017	0.263
LIG_SH2_STAT5	5	8	PF00017	0.571
LIG_SH3_3	99	105	PF00018	0.348
LIG_TYR_ITIM	126	131	PF00017	0.425
LIG_TYR_ITIM	198	203	PF00017	0.277
LIG_WRC_WIRS_1	117	122	PF05994	0.250
MOD_CDK_SPxxK_3	44	51	PF00069	0.494
MOD_CK1_1	174	180	PF00069	0.340
MOD_CK1_1	248	254	PF00069	0.473
MOD_CK1_1	300	306	PF00069	0.212
MOD_CK1_1	330	336	PF00069	0.376
MOD_CK1_1	375	381	PF00069	0.719
MOD_CK1_1	44	50	PF00069	0.605
MOD_CK2_1	112	118	PF00069	0.425
MOD_CK2_1	29	35	PF00069	0.643
MOD_CK2_1	352	358	PF00069	0.727
MOD_CK2_1	72	78	PF00069	0.469
MOD_GlcNHglycan	304	307	PF01048	0.419
MOD_GlcNHglycan	308	311	PF01048	0.387
MOD_GlcNHglycan	313	316	PF01048	0.334
MOD_GlcNHglycan	333	336	PF01048	0.467
MOD_GlcNHglycan	374	377	PF01048	0.737
MOD_GSK3_1	112	119	PF00069	0.375
MOD_GSK3_1	183	190	PF00069	0.406
MOD_GSK3_1	241	248	PF00069	0.455
MOD_GSK3_1	276	283	PF00069	0.285
MOD_GSK3_1	302	309	PF00069	0.406
MOD_GSK3_1	327	334	PF00069	0.486
MOD_GSK3_1	339	346	PF00069	0.515
MOD_GSK3_1	62	69	PF00069	0.416
MOD_N-GLC_1	279	284	PF02516	0.266
MOD_NEK2_1	172	177	PF00069	0.350
MOD_NEK2_1	219	224	PF00069	0.552
MOD_NEK2_1	241	246	PF00069	0.497
MOD_NEK2_1	276	281	PF00069	0.307
MOD_NEK2_1	338	343	PF00069	0.597
MOD_PKA_2	13	19	PF00069	0.644
MOD_PKA_2	187	193	PF00069	0.393
MOD_PKA_2	322	328	PF00069	0.328
MOD_PKA_2	339	345	PF00069	0.473
MOD_PKA_2	91	97	PF00069	0.441
MOD_Plk_1	172	178	PF00069	0.470
MOD_Plk_1	191	197	PF00069	0.213
MOD_Plk_1	279	285	PF00069	0.308
MOD_Plk_1	352	358	PF00069	0.702
MOD_Plk_2-3	353	359	PF00069	0.443
MOD_Plk_4	116	122	PF00069	0.234
MOD_Plk_4	245	251	PF00069	0.508
MOD_ProDKin_1	101	107	PF00069	0.404
MOD_ProDKin_1	44	50	PF00069	0.489
TRG_DiLeu_BaEn_1	143	148	PF01217	0.321
TRG_DiLeu_BaEn_2	92	98	PF01217	0.378
TRG_DiLeu_BaLyEn_6	194	199	PF01217	0.277
TRG_ENDOCYTIC_2	128	131	PF00928	0.402
TRG_ENDOCYTIC_2	200	203	PF00928	0.443
TRG_ENDOCYTIC_2	246	249	PF00928	0.371
TRG_ENDOCYTIC_2	289	292	PF00928	0.256
TRG_ENDOCYTIC_2	308	311	PF00928	0.256
TRG_ER_diArg_1	151	154	PF00400	0.321
TRG_ER_diArg_1	187	189	PF00400	0.297
TRG_ER_diArg_1	224	227	PF00400	0.420
TRG_ER_diArg_1	379	382	PF00400	0.422
TRG_ER_diArg_1	51	53	PF00400	0.563
TRG_ER_diArg_1	79	81	PF00400	0.415
TRG_NLS_MonoExtC_3	149	155	PF00514	0.321
TRG_NLS_MonoExtN_4	236	242	PF00514	0.346
TRG_Pf-PMV_PEXEL_1	273	278	PF00026	0.321

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM13	Leptomonas seymouri	63%	87%
A0A0N1PD54	Leptomonas seymouri	30%	100%
A0A0S4JQS8	Bodo saltans	30%	100%
A0A1X0NVQ5	Trypanosomatidae	26%	100%
A0A1X0NVT0	Trypanosomatidae	27%	82%
A0A3S5H7D4	Leishmania donovani	91%	100%
A0A422N8G9	Trypanosoma rangeli	29%	100%
A0A422N8I7	Trypanosoma rangeli	32%	95%
A4HDM2	Leishmania braziliensis	76%	100%
E9AH69	Leishmania infantum	91%	100%
Q4QAG9	Leishmania major	86%	100%
V5BK31	Trypanosoma cruzi	29%	100%
V5DBK9	Trypanosoma cruzi	32%	93%