Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AX04_LEIMU

TriTrypDb:

LmxM.24.1590

Length:

556

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AX04

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX04

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.585
CLV_C14_Caspase3-7	410	414	PF00656	0.685
CLV_NRD_NRD_1	183	185	PF00675	0.570
CLV_NRD_NRD_1	289	291	PF00675	0.709
CLV_NRD_NRD_1	380	382	PF00675	0.688
CLV_PCSK_FUR_1	378	382	PF00082	0.753
CLV_PCSK_KEX2_1	183	185	PF00082	0.570
CLV_PCSK_KEX2_1	377	379	PF00082	0.689
CLV_PCSK_KEX2_1	380	382	PF00082	0.682
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.730
CLV_PCSK_PC7_1	373	379	PF00082	0.746
CLV_PCSK_SKI1_1	132	136	PF00082	0.516
CLV_PCSK_SKI1_1	145	149	PF00082	0.390
CLV_PCSK_SKI1_1	24	28	PF00082	0.612
CLV_PCSK_SKI1_1	279	283	PF00082	0.560
CLV_PCSK_SKI1_1	373	377	PF00082	0.583
CLV_PCSK_SKI1_1	444	448	PF00082	0.667
CLV_Separin_Metazoa	162	166	PF03568	0.450
DEG_APCC_DBOX_1	525	533	PF00400	0.612
DEG_APCC_DBOX_1	8	16	PF00400	0.575
DEG_Nend_UBRbox_2	1	3	PF02207	0.607
DEG_SCF_TRCP1_1	248	253	PF00400	0.321
DOC_CYCLIN_yClb5_NLxxxL_5	518	527	PF00134	0.603
DOC_MAPK_MEF2A_6	145	152	PF00069	0.426
DOC_MAPK_NFAT4_5	145	153	PF00069	0.431
DOC_PP2B_LxvP_1	241	244	PF13499	0.523
DOC_PP2B_LxvP_1	34	37	PF13499	0.775
DOC_PP2B_LxvP_1	436	439	PF13499	0.517
DOC_USP7_MATH_1	187	191	PF00917	0.686
DOC_USP7_MATH_1	44	48	PF00917	0.586
DOC_USP7_MATH_1	445	449	PF00917	0.697
DOC_USP7_MATH_1	514	518	PF00917	0.602
DOC_WW_Pin1_4	29	34	PF00397	0.658
DOC_WW_Pin1_4	297	302	PF00397	0.661
DOC_WW_Pin1_4	305	310	PF00397	0.753
DOC_WW_Pin1_4	483	488	PF00397	0.758
DOC_WW_Pin1_4	492	497	PF00397	0.639
DOC_WW_Pin1_4	500	505	PF00397	0.681
LIG_14-3-3_CanoR_1	122	131	PF00244	0.459
LIG_14-3-3_CanoR_1	149	153	PF00244	0.524
LIG_14-3-3_CanoR_1	254	263	PF00244	0.392
LIG_14-3-3_CanoR_1	283	292	PF00244	0.482
LIG_14-3-3_CanoR_1	330	340	PF00244	0.647
LIG_14-3-3_CanoR_1	343	349	PF00244	0.740
LIG_14-3-3_CanoR_1	362	368	PF00244	0.512
LIG_Actin_WH2_2	360	375	PF00022	0.751
LIG_Actin_WH2_2	8	26	PF00022	0.598
LIG_deltaCOP1_diTrp_1	166	175	PF00928	0.420
LIG_FHA_1	386	392	PF00498	0.592
LIG_FHA_1	413	419	PF00498	0.713
LIG_FHA_1	423	429	PF00498	0.700
LIG_FHA_1	60	66	PF00498	0.539
LIG_FHA_2	256	262	PF00498	0.524
LIG_FHA_2	405	411	PF00498	0.626
LIG_FHA_2	463	469	PF00498	0.768
LIG_FHA_2	534	540	PF00498	0.683
LIG_FHA_2	97	103	PF00498	0.647
LIG_GBD_Chelix_1	50	58	PF00786	0.552
LIG_LIR_Gen_1	166	177	PF02991	0.321
LIG_LIR_Gen_1	204	215	PF02991	0.430
LIG_LIR_Nem_3	166	172	PF02991	0.418
LIG_LIR_Nem_3	204	210	PF02991	0.433
LIG_LIR_Nem_3	502	508	PF02991	0.524
LIG_LYPXL_yS_3	19	22	PF13949	0.550
LIG_MYND_1	309	313	PF01753	0.641
LIG_NRBOX	11	17	PF00104	0.583
LIG_SH2_NCK_1	257	261	PF00017	0.608
LIG_SH2_STAT3	256	259	PF00017	0.494
LIG_SH2_STAT5	129	132	PF00017	0.467
LIG_SH2_STAT5	257	260	PF00017	0.455
LIG_SH3_2	37	42	PF14604	0.506
LIG_SH3_2	439	444	PF14604	0.528
LIG_SH3_3	214	220	PF00018	0.467
LIG_SH3_3	266	272	PF00018	0.636
LIG_SH3_3	34	40	PF00018	0.646
LIG_SH3_3	395	401	PF00018	0.534
LIG_SH3_3	436	442	PF00018	0.720
LIG_SUMO_SIM_anti_2	193	198	PF11976	0.533
LIG_SUMO_SIM_anti_2	78	84	PF11976	0.448
LIG_SUMO_SIM_par_1	386	396	PF11976	0.531
LIG_SUMO_SIM_par_1	78	84	PF11976	0.448
LIG_TRAF2_1	300	303	PF00917	0.515
MOD_CDK_SPxxK_3	492	499	PF00069	0.635
MOD_CK1_1	100	106	PF00069	0.528
MOD_CK1_1	190	196	PF00069	0.542
MOD_CK1_1	347	353	PF00069	0.739
MOD_CK1_1	363	369	PF00069	0.655
MOD_CK1_1	384	390	PF00069	0.823
MOD_CK2_1	255	261	PF00069	0.525
MOD_CK2_1	297	303	PF00069	0.800
MOD_CK2_1	414	420	PF00069	0.821
MOD_CK2_1	445	451	PF00069	0.546
MOD_CK2_1	462	468	PF00069	0.748
MOD_CK2_1	533	539	PF00069	0.685
MOD_CK2_1	75	81	PF00069	0.447
MOD_CK2_1	96	102	PF00069	0.632
MOD_CMANNOS	528	531	PF00535	0.683
MOD_DYRK1A_RPxSP_1	297	301	PF00069	0.502
MOD_GlcNHglycan	132	135	PF01048	0.507
MOD_GlcNHglycan	189	192	PF01048	0.600
MOD_GlcNHglycan	247	251	PF01048	0.602
MOD_GlcNHglycan	272	275	PF01048	0.483
MOD_GlcNHglycan	287	290	PF01048	0.550
MOD_GlcNHglycan	331	334	PF01048	0.597
MOD_GlcNHglycan	46	50	PF01048	0.616
MOD_GlcNHglycan	511	514	PF01048	0.814
MOD_GSK3_1	197	204	PF00069	0.495
MOD_GSK3_1	246	253	PF00069	0.502
MOD_GSK3_1	305	312	PF00069	0.731
MOD_GSK3_1	344	351	PF00069	0.819
MOD_GSK3_1	353	360	PF00069	0.718
MOD_GSK3_1	381	388	PF00069	0.643
MOD_GSK3_1	400	407	PF00069	0.843
MOD_GSK3_1	408	415	PF00069	0.833
MOD_GSK3_1	423	430	PF00069	0.509
MOD_GSK3_1	462	469	PF00069	0.791
MOD_GSK3_1	500	507	PF00069	0.673
MOD_GSK3_1	514	521	PF00069	0.643
MOD_GSK3_1	533	540	PF00069	0.573
MOD_GSK3_1	59	66	PF00069	0.434
MOD_GSK3_1	94	101	PF00069	0.619
MOD_N-GLC_1	344	349	PF02516	0.716
MOD_N-GLC_2	414	416	PF02516	0.612
MOD_NEK2_1	130	135	PF00069	0.500
MOD_NEK2_1	148	153	PF00069	0.352
MOD_NEK2_1	197	202	PF00069	0.332
MOD_NEK2_1	246	251	PF00069	0.541
MOD_NEK2_1	385	390	PF00069	0.534
MOD_NEK2_1	423	428	PF00069	0.631
MOD_NEK2_1	508	513	PF00069	0.618
MOD_NEK2_1	518	523	PF00069	0.502
MOD_PIKK_1	122	128	PF00454	0.458
MOD_PIKK_1	255	261	PF00454	0.501
MOD_PIKK_1	357	363	PF00454	0.731
MOD_PK_1	63	69	PF00069	0.456
MOD_PKA_2	148	154	PF00069	0.527
MOD_PKA_2	270	276	PF00069	0.523
MOD_PKA_2	329	335	PF00069	0.632
MOD_PKB_1	120	128	PF00069	0.463
MOD_PKB_1	379	387	PF00069	0.821
MOD_Plk_1	292	298	PF00069	0.608
MOD_Plk_1	344	350	PF00069	0.819
MOD_Plk_1	45	51	PF00069	0.568
MOD_Plk_1	59	65	PF00069	0.357
MOD_Plk_4	206	212	PF00069	0.482
MOD_Plk_4	387	393	PF00069	0.562
MOD_Plk_4	424	430	PF00069	0.794
MOD_ProDKin_1	29	35	PF00069	0.662
MOD_ProDKin_1	297	303	PF00069	0.664
MOD_ProDKin_1	305	311	PF00069	0.754
MOD_ProDKin_1	483	489	PF00069	0.760
MOD_ProDKin_1	492	498	PF00069	0.639
MOD_ProDKin_1	500	506	PF00069	0.682
TRG_ENDOCYTIC_2	19	22	PF00928	0.554
TRG_ENDOCYTIC_2	257	260	PF00928	0.497
TRG_ENDOCYTIC_2	505	508	PF00928	0.528
TRG_ER_diArg_1	378	381	PF00400	0.690
TRG_ER_diArg_1	523	526	PF00400	0.530
TRG_ER_diArg_1	543	546	PF00400	0.545
TRG_NES_CRM1_1	317	329	PF08389	0.695
TRG_NLS_MonoCore_2	375	380	PF00514	0.726
TRG_NLS_MonoExtC_3	375	380	PF00514	0.828
TRG_NLS_MonoExtN_4	373	380	PF00514	0.728

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7U6	Leptomonas seymouri	44%	80%
A0A3S7WYG0	Leishmania donovani	83%	100%
A4HDL9	Leishmania braziliensis	67%	100%
E9AH66	Leishmania infantum	84%	100%
Q4QAH2	Leishmania major	82%	100%