UBA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AX03_LEIMU

TriTrypDb:

LmxM.24.1580

Length:

396

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AX03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX03

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	306	310	PF00656	0.594
CLV_NRD_NRD_1	191	193	PF00675	0.728
CLV_NRD_NRD_1	321	323	PF00675	0.468
CLV_NRD_NRD_1	347	349	PF00675	0.545
CLV_NRD_NRD_1	85	87	PF00675	0.363
CLV_PCSK_FUR_1	319	323	PF00082	0.511
CLV_PCSK_KEX2_1	191	193	PF00082	0.728
CLV_PCSK_KEX2_1	321	323	PF00082	0.470
CLV_PCSK_KEX2_1	346	348	PF00082	0.563
CLV_PCSK_KEX2_1	51	53	PF00082	0.642
CLV_PCSK_KEX2_1	85	87	PF00082	0.360
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.672
CLV_PCSK_PC7_1	317	323	PF00082	0.532
CLV_PCSK_PC7_1	81	87	PF00082	0.341
CLV_PCSK_SKI1_1	167	171	PF00082	0.373
CLV_PCSK_SKI1_1	176	180	PF00082	0.363
CLV_PCSK_SKI1_1	237	241	PF00082	0.368
CLV_PCSK_SKI1_1	244	248	PF00082	0.352
CLV_PCSK_SKI1_1	51	55	PF00082	0.704
DEG_APCC_DBOX_1	236	244	PF00400	0.567
DEG_APCC_DBOX_1	51	59	PF00400	0.453
DEG_Nend_Nbox_1	1	3	PF02207	0.462
DOC_CYCLIN_RxL_1	48	57	PF00134	0.590
DOC_MAPK_DCC_7	167	177	PF00069	0.307
DOC_MAPK_gen_1	191	199	PF00069	0.383
DOC_MAPK_gen_1	241	251	PF00069	0.629
DOC_MAPK_MEF2A_6	191	199	PF00069	0.376
DOC_MAPK_MEF2A_6	233	242	PF00069	0.560
DOC_PP1_RVXF_1	202	208	PF00149	0.184
DOC_PP1_RVXF_1	220	227	PF00149	0.562
DOC_PP2B_LxvP_1	40	43	PF13499	0.469
DOC_PP4_FxxP_1	242	245	PF00568	0.585
DOC_USP7_MATH_1	148	152	PF00917	0.665
DOC_USP7_MATH_1	215	219	PF00917	0.465
DOC_WW_Pin1_4	177	182	PF00397	0.540
DOC_WW_Pin1_4	346	351	PF00397	0.765
LIG_14-3-3_CanoR_1	125	134	PF00244	0.319
LIG_14-3-3_CanoR_1	150	154	PF00244	0.719
LIG_14-3-3_CanoR_1	225	235	PF00244	0.608
LIG_14-3-3_CanoR_1	244	253	PF00244	0.622
LIG_14-3-3_CanoR_1	29	34	PF00244	0.555
LIG_Actin_WH2_2	132	147	PF00022	0.449
LIG_BRCT_BRCA1_1	31	35	PF00533	0.423
LIG_Clathr_ClatBox_1	254	258	PF01394	0.527
LIG_eIF4E_1	234	240	PF01652	0.626
LIG_FHA_1	10	16	PF00498	0.354
LIG_FHA_1	139	145	PF00498	0.344
LIG_FHA_1	230	236	PF00498	0.644
LIG_FHA_1	245	251	PF00498	0.563
LIG_FHA_1	96	102	PF00498	0.359
LIG_FHA_2	161	167	PF00498	0.510
LIG_FHA_2	304	310	PF00498	0.725
LIG_IRF3_LxIS_1	11	16	PF10401	0.449
LIG_IRF3_LxIS_1	59	66	PF10401	0.449
LIG_LIR_Gen_1	89	100	PF02991	0.375
LIG_LIR_Nem_3	203	209	PF02991	0.397
LIG_LIR_Nem_3	229	234	PF02991	0.651
LIG_LIR_Nem_3	248	254	PF02991	0.445
LIG_LIR_Nem_3	89	95	PF02991	0.373
LIG_Pex14_1	227	231	PF04695	0.556
LIG_Pex14_2	251	255	PF04695	0.694
LIG_SH2_STAT5	143	146	PF00017	0.467
LIG_SH2_STAT5	234	237	PF00017	0.617
LIG_SH2_STAT5	27	30	PF00017	0.665
LIG_SH2_STAT5	300	303	PF00017	0.664
LIG_SH3_3	175	181	PF00018	0.392
LIG_SH3_3	56	62	PF00018	0.362
LIG_SUMO_SIM_anti_2	66	72	PF11976	0.276
LIG_SUMO_SIM_anti_2	9	17	PF11976	0.439
LIG_SUMO_SIM_par_1	11	17	PF11976	0.418
LIG_TRAF2_1	310	313	PF00917	0.716
LIG_TRAF2_1	349	352	PF00917	0.732
LIG_UBA3_1	171	176	PF00899	0.393
MOD_CK1_1	149	155	PF00069	0.713
MOD_CK1_1	16	22	PF00069	0.367
MOD_CK1_1	180	186	PF00069	0.483
MOD_CK1_1	218	224	PF00069	0.581
MOD_CK2_1	160	166	PF00069	0.473
MOD_CK2_1	346	352	PF00069	0.763
MOD_CK2_1	368	374	PF00069	0.669
MOD_GlcNHglycan	113	116	PF01048	0.610
MOD_GlcNHglycan	127	130	PF01048	0.258
MOD_GlcNHglycan	136	139	PF01048	0.301
MOD_GlcNHglycan	98	101	PF01048	0.348
MOD_GSK3_1	109	116	PF00069	0.402
MOD_GSK3_1	125	132	PF00069	0.202
MOD_GSK3_1	134	141	PF00069	0.281
MOD_GSK3_1	25	32	PF00069	0.558
MOD_GSK3_1	9	16	PF00069	0.353
MOD_N-GLC_1	160	165	PF02516	0.343
MOD_N-GLC_1	271	276	PF02516	0.576
MOD_NEK2_1	13	18	PF00069	0.385
MOD_NEK2_1	379	384	PF00069	0.662
MOD_NEK2_1	54	59	PF00069	0.451
MOD_NEK2_1	63	68	PF00069	0.349
MOD_NEK2_1	95	100	PF00069	0.331
MOD_NEK2_2	138	143	PF00069	0.475
MOD_PIKK_1	180	186	PF00454	0.450
MOD_PK_1	117	123	PF00069	0.497
MOD_PKA_2	149	155	PF00069	0.711
MOD_Plk_1	160	166	PF00069	0.497
MOD_Plk_4	129	135	PF00069	0.309
MOD_Plk_4	167	173	PF00069	0.419
MOD_Plk_4	18	24	PF00069	0.344
MOD_Plk_4	88	94	PF00069	0.510
MOD_Plk_4	9	15	PF00069	0.392
MOD_ProDKin_1	177	183	PF00069	0.548
MOD_ProDKin_1	346	352	PF00069	0.762
TRG_DiLeu_BaLyEn_6	170	175	PF01217	0.291
TRG_DiLeu_BaLyEn_6	235	240	PF01217	0.579
TRG_DiLeu_BaLyEn_6	49	54	PF01217	0.690
TRG_ENDOCYTIC_2	30	33	PF00928	0.704
TRG_ENDOCYTIC_2	92	95	PF00928	0.455
TRG_ER_diArg_1	190	192	PF00400	0.522
TRG_ER_diArg_1	314	317	PF00400	0.703
TRG_ER_diArg_1	318	321	PF00400	0.699
TRG_ER_diArg_1	346	348	PF00400	0.755
TRG_ER_diArg_1	85	87	PF00400	0.560
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	52	56	PF00026	0.678

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM84	Leptomonas seymouri	62%	100%
A0A0S4JKW6	Bodo saltans	24%	98%
A0A1X0NVU5	Trypanosomatidae	35%	100%
A0A3S7WYG8	Leishmania donovani	93%	100%
A0A422N8E9	Trypanosoma rangeli	32%	100%
A4HDL8	Leishmania braziliensis	82%	100%
C9ZWE6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AH65	Leishmania infantum	93%	100%
Q4QAH3	Leishmania major	93%	100%
V5AVK1	Trypanosoma cruzi	35%	100%