RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

RNA binding protein

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)/RNA recognition motif (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania mexicana

UniProt:

E9AX02_LEIMU

TriTrypDb:

LmxM.24.1570

Length:

696

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AX02

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX02

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.738
CLV_NRD_NRD_1	424	426	PF00675	0.588
CLV_NRD_NRD_1	431	433	PF00675	0.602
CLV_PCSK_KEX2_1	424	426	PF00082	0.597
CLV_PCSK_KEX2_1	431	433	PF00082	0.670
CLV_PCSK_SKI1_1	247	251	PF00082	0.346
CLV_PCSK_SKI1_1	263	267	PF00082	0.346
DEG_COP1_1	486	496	PF00400	0.510
DEG_Nend_UBRbox_3	1	3	PF02207	0.780
DEG_SCF_FBW7_1	166	171	PF00400	0.801
DEG_SCF_FBW7_1	3	10	PF00400	0.543
DEG_SCF_FBW7_1	653	659	PF00400	0.597
DEG_SPOP_SBC_1	445	449	PF00917	0.753
DOC_CDC14_PxL_1	490	498	PF14671	0.519
DOC_CDC14_PxL_1	622	630	PF14671	0.751
DOC_CKS1_1	114	119	PF01111	0.712
DOC_CKS1_1	183	188	PF01111	0.796
DOC_CKS1_1	598	603	PF01111	0.809
DOC_CKS1_1	653	658	PF01111	0.597
DOC_MAPK_FxFP_2	154	157	PF00069	0.786
DOC_MAPK_FxFP_2	28	31	PF00069	0.690
DOC_MAPK_gen_1	245	252	PF00069	0.620
DOC_MAPK_gen_1	272	281	PF00069	0.576
DOC_PP1_RVXF_1	272	279	PF00149	0.619
DOC_PP2B_LxvP_1	166	169	PF13499	0.630
DOC_PP2B_LxvP_1	502	505	PF13499	0.791
DOC_PP4_FxxP_1	154	157	PF00568	0.786
DOC_PP4_FxxP_1	28	31	PF00568	0.690
DOC_PP4_FxxP_1	460	463	PF00568	0.715
DOC_PP4_FxxP_1	623	626	PF00568	0.828
DOC_USP7_MATH_1	126	130	PF00917	0.699
DOC_USP7_MATH_1	190	194	PF00917	0.816
DOC_USP7_MATH_1	214	218	PF00917	0.751
DOC_USP7_MATH_1	220	224	PF00917	0.637
DOC_USP7_MATH_1	29	33	PF00917	0.774
DOC_USP7_MATH_1	455	459	PF00917	0.727
DOC_USP7_MATH_1	461	465	PF00917	0.636
DOC_USP7_MATH_1	613	617	PF00917	0.541
DOC_USP7_MATH_1	633	637	PF00917	0.722
DOC_USP7_MATH_1	656	660	PF00917	0.623
DOC_USP7_MATH_1	671	675	PF00917	0.715
DOC_USP7_MATH_1	80	84	PF00917	0.781
DOC_USP7_MATH_1	95	99	PF00917	0.622
DOC_USP7_UBL2_3	403	407	PF12436	0.570
DOC_WW_Pin1_4	101	106	PF00397	0.720
DOC_WW_Pin1_4	113	118	PF00397	0.583
DOC_WW_Pin1_4	164	169	PF00397	0.801
DOC_WW_Pin1_4	182	187	PF00397	0.795
DOC_WW_Pin1_4	3	8	PF00397	0.772
DOC_WW_Pin1_4	401	406	PF00397	0.562
DOC_WW_Pin1_4	473	478	PF00397	0.525
DOC_WW_Pin1_4	483	488	PF00397	0.560
DOC_WW_Pin1_4	597	602	PF00397	0.810
DOC_WW_Pin1_4	652	657	PF00397	0.601
LIG_14-3-3_CanoR_1	128	132	PF00244	0.690
LIG_14-3-3_CanoR_1	335	339	PF00244	0.546
LIG_14-3-3_CanoR_1	88	92	PF00244	0.757
LIG_Actin_WH2_2	505	523	PF00022	0.730
LIG_BIR_III_4	522	526	PF00653	0.680
LIG_BRCT_BRCA1_1	23	27	PF00533	0.651
LIG_BRCT_BRCA1_1	232	236	PF00533	0.508
LIG_BRCT_BRCA1_1	554	558	PF00533	0.781
LIG_FHA_1	150	156	PF00498	0.781
LIG_FHA_1	303	309	PF00498	0.694
LIG_FHA_1	440	446	PF00498	0.758
LIG_FHA_1	49	55	PF00498	0.727
LIG_FHA_1	593	599	PF00498	0.700
LIG_FHA_2	335	341	PF00498	0.546
LIG_FHA_2	369	375	PF00498	0.710
LIG_FHA_2	74	80	PF00498	0.733
LIG_IBAR_NPY_1	682	684	PF08397	0.723
LIG_IRF3_LxIS_1	593	599	PF10401	0.629
LIG_LIR_Apic_2	151	157	PF02991	0.781
LIG_LIR_Apic_2	458	463	PF02991	0.718
LIG_LIR_Gen_1	336	345	PF02991	0.555
LIG_LIR_Gen_1	489	496	PF02991	0.689
LIG_LIR_Nem_3	153	159	PF02991	0.786
LIG_LIR_Nem_3	24	30	PF02991	0.787
LIG_LIR_Nem_3	336	342	PF02991	0.555
LIG_LIR_Nem_3	489	493	PF02991	0.731
LIG_LYPXL_S_1	155	159	PF13949	0.712
LIG_MLH1_MIPbox_1	554	558	PF16413	0.781
LIG_MYND_1	109	113	PF01753	0.625
LIG_MYND_1	626	630	PF01753	0.817
LIG_PTB_Apo_2	523	530	PF02174	0.703
LIG_PTB_Apo_2	679	686	PF02174	0.729
LIG_PTB_Phospho_1	523	529	PF10480	0.697
LIG_SH2_CRK	545	549	PF00017	0.804
LIG_SH2_NCK_1	529	533	PF00017	0.719
LIG_SH2_NCK_1	545	549	PF00017	0.702
LIG_SH2_SRC	315	318	PF00017	0.566
LIG_SH2_SRC	529	532	PF00017	0.647
LIG_SH2_STAT3	341	344	PF00017	0.546
LIG_SH2_STAT5	315	318	PF00017	0.603
LIG_SH2_STAT5	341	344	PF00017	0.546
LIG_SH2_STAT5	597	600	PF00017	0.735
LIG_SH2_STAT5	684	687	PF00017	0.817
LIG_SH3_3	180	186	PF00018	0.699
LIG_SH3_3	314	320	PF00018	0.615
LIG_SH3_3	474	480	PF00018	0.660
LIG_SH3_3	488	494	PF00018	0.739
LIG_SH3_3	528	534	PF00018	0.805
LIG_SH3_3	559	565	PF00018	0.746
LIG_SH3_3	569	575	PF00018	0.582
LIG_SH3_3	602	608	PF00018	0.683
LIG_SH3_3	624	630	PF00018	0.691
LIG_SUMO_SIM_par_1	240	246	PF11976	0.518
LIG_SUMO_SIM_par_1	248	254	PF11976	0.486
LIG_SUMO_SIM_par_1	264	270	PF11976	0.443
LIG_SUMO_SIM_par_1	329	334	PF11976	0.546
LIG_UBA3_1	249	255	PF00899	0.375
LIG_WRC_WIRS_1	156	161	PF05994	0.498
MOD_CDK_SPxK_1	401	407	PF00069	0.570
MOD_CK1_1	124	130	PF00069	0.567
MOD_CK1_1	133	139	PF00069	0.683
MOD_CK1_1	149	155	PF00069	0.777
MOD_CK1_1	164	170	PF00069	0.556
MOD_CK1_1	194	200	PF00069	0.801
MOD_CK1_1	334	340	PF00069	0.411
MOD_CK1_1	352	358	PF00069	0.411
MOD_CK1_1	365	371	PF00069	0.586
MOD_CK1_1	38	44	PF00069	0.536
MOD_CK1_1	446	452	PF00069	0.728
MOD_CK1_1	486	492	PF00069	0.682
MOD_CK1_1	500	506	PF00069	0.667
MOD_CK1_1	73	79	PF00069	0.724
MOD_CK2_1	334	340	PF00069	0.389
MOD_CK2_1	367	373	PF00069	0.637
MOD_CK2_1	385	391	PF00069	0.448
MOD_CK2_1	55	61	PF00069	0.689
MOD_GlcNHglycan	129	132	PF01048	0.747
MOD_GlcNHglycan	135	138	PF01048	0.656
MOD_GlcNHglycan	148	151	PF01048	0.678
MOD_GlcNHglycan	216	219	PF01048	0.730
MOD_GlcNHglycan	222	225	PF01048	0.756
MOD_GlcNHglycan	260	263	PF01048	0.369
MOD_GlcNHglycan	31	34	PF01048	0.704
MOD_GlcNHglycan	364	367	PF01048	0.711
MOD_GlcNHglycan	37	40	PF01048	0.816
MOD_GlcNHglycan	522	526	PF01048	0.605
MOD_GlcNHglycan	558	561	PF01048	0.753
MOD_GlcNHglycan	605	608	PF01048	0.627
MOD_GlcNHglycan	623	626	PF01048	0.565
MOD_GlcNHglycan	656	659	PF01048	0.593
MOD_GlcNHglycan	72	75	PF01048	0.807
MOD_GlcNHglycan	97	100	PF01048	0.786
MOD_GSK3_1	1	8	PF00069	0.810
MOD_GSK3_1	126	133	PF00069	0.698
MOD_GSK3_1	142	149	PF00069	0.569
MOD_GSK3_1	164	171	PF00069	0.798
MOD_GSK3_1	190	197	PF00069	0.790
MOD_GSK3_1	205	212	PF00069	0.644
MOD_GSK3_1	329	336	PF00069	0.492
MOD_GSK3_1	362	369	PF00069	0.677
MOD_GSK3_1	397	404	PF00069	0.557
MOD_GSK3_1	439	446	PF00069	0.725
MOD_GSK3_1	449	456	PF00069	0.716
MOD_GSK3_1	479	486	PF00069	0.551
MOD_GSK3_1	55	62	PF00069	0.687
MOD_GSK3_1	552	559	PF00069	0.775
MOD_GSK3_1	592	599	PF00069	0.748
MOD_GSK3_1	652	659	PF00069	0.619
MOD_GSK3_1	671	678	PF00069	0.710
MOD_N-GLC_1	124	129	PF02516	0.791
MOD_N-GLC_1	191	196	PF02516	0.752
MOD_N-GLC_1	205	210	PF02516	0.659
MOD_N-GLC_1	294	299	PF02516	0.411
MOD_N-GLC_1	321	326	PF02516	0.511
MOD_N-GLC_1	362	367	PF02516	0.583
MOD_N-GLC_1	497	502	PF02516	0.524
MOD_N-GLC_1	549	554	PF02516	0.617
MOD_NEK2_1	191	196	PF00069	0.742
MOD_NEK2_1	294	299	PF00069	0.387
MOD_NEK2_1	331	336	PF00069	0.411
MOD_NEK2_1	596	601	PF00069	0.691
MOD_NEK2_1	89	94	PF00069	0.755
MOD_NEK2_2	419	424	PF00069	0.692
MOD_PIKK_1	142	148	PF00454	0.493
MOD_PIKK_1	209	215	PF00454	0.777
MOD_PIKK_1	5	11	PF00454	0.793
MOD_PIKK_1	549	555	PF00454	0.553
MOD_PIKK_1	55	61	PF00454	0.790
MOD_PIKK_1	613	619	PF00454	0.628
MOD_PIKK_1	633	639	PF00454	0.799
MOD_PIKK_1	675	681	PF00454	0.728
MOD_PKA_2	127	133	PF00069	0.704
MOD_PKA_2	334	340	PF00069	0.411
MOD_PKA_2	366	372	PF00069	0.511
MOD_PKA_2	427	433	PF00069	0.651
MOD_PKA_2	87	93	PF00069	0.702
MOD_Plk_1	150	156	PF00069	0.684
MOD_Plk_1	161	167	PF00069	0.685
MOD_Plk_1	191	197	PF00069	0.811
MOD_Plk_1	321	327	PF00069	0.513
MOD_Plk_1	349	355	PF00069	0.411
MOD_Plk_1	419	425	PF00069	0.696
MOD_Plk_1	55	61	PF00069	0.499
MOD_Plk_4	150	156	PF00069	0.760
MOD_Plk_4	175	181	PF00069	0.655
MOD_Plk_4	321	327	PF00069	0.513
MOD_Plk_4	334	340	PF00069	0.411
MOD_Plk_4	486	492	PF00069	0.806
MOD_Plk_4	503	509	PF00069	0.607
MOD_Plk_4	552	558	PF00069	0.774
MOD_Plk_4	59	65	PF00069	0.691
MOD_Plk_4	592	598	PF00069	0.709
MOD_Plk_4	656	662	PF00069	0.621
MOD_Plk_4	671	677	PF00069	0.709
MOD_ProDKin_1	101	107	PF00069	0.717
MOD_ProDKin_1	113	119	PF00069	0.584
MOD_ProDKin_1	164	170	PF00069	0.804
MOD_ProDKin_1	182	188	PF00069	0.797
MOD_ProDKin_1	3	9	PF00069	0.776
MOD_ProDKin_1	401	407	PF00069	0.570
MOD_ProDKin_1	473	479	PF00069	0.524
MOD_ProDKin_1	483	489	PF00069	0.562
MOD_ProDKin_1	597	603	PF00069	0.810
MOD_ProDKin_1	652	658	PF00069	0.598
MOD_SUMO_rev_2	373	380	PF00179	0.618
TRG_DiLeu_BaLyEn_6	410	415	PF01217	0.493
TRG_DiLeu_BaLyEn_6	624	629	PF01217	0.705
TRG_ENDOCYTIC_2	156	159	PF00928	0.711
TRG_ENDOCYTIC_2	684	687	PF00928	0.715
TRG_ER_diArg_1	423	425	PF00400	0.658
TRG_ER_diArg_1	431	434	PF00400	0.641
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1V6	Leptomonas seymouri	44%	92%
A0A3S7WYI1	Leishmania donovani	91%	100%
A4HDU7	Leishmania braziliensis	69%	98%
E9AH64	Leishmania infantum	92%	100%
Q4QAH4	Leishmania major	87%	98%