Leucine-rich repeat domain, L domain-like

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AX01_LEIMU

TriTrypDb:

LmxM.24.1560

Length:

600

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12

Expansion

Sequence features

E9AX01

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX01

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.395
CLV_C14_Caspase3-7	311	315	PF00656	0.557
CLV_C14_Caspase3-7	396	400	PF00656	0.598
CLV_NRD_NRD_1	219	221	PF00675	0.512
CLV_NRD_NRD_1	468	470	PF00675	0.409
CLV_NRD_NRD_1	486	488	PF00675	0.664
CLV_NRD_NRD_1	80	82	PF00675	0.415
CLV_PCSK_FUR_1	484	488	PF00082	0.613
CLV_PCSK_KEX2_1	221	223	PF00082	0.491
CLV_PCSK_KEX2_1	486	488	PF00082	0.655
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.496
CLV_PCSK_SKI1_1	178	182	PF00082	0.433
CLV_PCSK_SKI1_1	266	270	PF00082	0.385
CLV_PCSK_SKI1_1	375	379	PF00082	0.518
CLV_PCSK_SKI1_1	575	579	PF00082	0.458
DEG_COP1_1	396	406	PF00400	0.696
DOC_CKS1_1	288	293	PF01111	0.517
DOC_CKS1_1	307	312	PF01111	0.461
DOC_CYCLIN_RxL_1	173	185	PF00134	0.523
DOC_CYCLIN_yClb5_NLxxxL_5	158	167	PF00134	0.575
DOC_CYCLIN_yCln2_LP_2	199	205	PF00134	0.474
DOC_CYCLIN_yCln2_LP_2	366	372	PF00134	0.505
DOC_MAPK_gen_1	220	229	PF00069	0.454
DOC_MAPK_gen_1	375	383	PF00069	0.614
DOC_PP2B_LxvP_1	366	369	PF13499	0.472
DOC_PP2B_PxIxI_1	71	77	PF00149	0.500
DOC_PP4_FxxP_1	450	453	PF00568	0.549
DOC_PP4_FxxP_1	590	593	PF00568	0.551
DOC_USP7_MATH_1	19	23	PF00917	0.475
DOC_USP7_MATH_1	376	380	PF00917	0.458
DOC_USP7_MATH_1	388	392	PF00917	0.595
DOC_USP7_UBL2_3	217	221	PF12436	0.551
DOC_USP7_UBL2_3	466	470	PF12436	0.504
DOC_USP7_UBL2_3	489	493	PF12436	0.698
DOC_WW_Pin1_4	15	20	PF00397	0.443
DOC_WW_Pin1_4	287	292	PF00397	0.530
DOC_WW_Pin1_4	306	311	PF00397	0.531
DOC_WW_Pin1_4	479	484	PF00397	0.566
LIG_14-3-3_CanoR_1	220	229	PF00244	0.510
LIG_14-3-3_CanoR_1	375	381	PF00244	0.453
LIG_14-3-3_CanoR_1	412	417	PF00244	0.676
LIG_14-3-3_CanoR_1	554	559	PF00244	0.479
LIG_14-3-3_CanoR_1	81	86	PF00244	0.451
LIG_Actin_WH2_2	359	377	PF00022	0.383
LIG_APCC_ABBA_1	591	596	PF00400	0.574
LIG_BIR_III_4	185	189	PF00653	0.560
LIG_BRCT_BRCA1_1	390	394	PF00533	0.663
LIG_BRCT_BRCA1_1	410	414	PF00533	0.364
LIG_BRCT_BRCA1_1	419	423	PF00533	0.626
LIG_BRCT_BRCA1_1	502	506	PF00533	0.467
LIG_BRCT_BRCA1_1	90	94	PF00533	0.493
LIG_CtBP_PxDLS_1	453	457	PF00389	0.249
LIG_FHA_1	187	193	PF00498	0.533
LIG_FHA_1	224	230	PF00498	0.458
LIG_FHA_1	251	257	PF00498	0.353
LIG_FHA_1	369	375	PF00498	0.531
LIG_FHA_1	447	453	PF00498	0.578
LIG_FHA_1	52	58	PF00498	0.565
LIG_FHA_1	531	537	PF00498	0.472
LIG_FHA_2	240	246	PF00498	0.449
LIG_FHA_2	307	313	PF00498	0.533
LIG_FHA_2	394	400	PF00498	0.708
LIG_FHA_2	483	489	PF00498	0.597
LIG_FHA_2	533	539	PF00498	0.428
LIG_LIR_Apic_2	120	125	PF02991	0.511
LIG_LIR_Apic_2	449	453	PF02991	0.440
LIG_LIR_Apic_2	587	593	PF02991	0.547
LIG_LIR_Gen_1	189	199	PF02991	0.448
LIG_LIR_Gen_1	231	240	PF02991	0.409
LIG_LIR_Gen_1	255	263	PF02991	0.399
LIG_LIR_Gen_1	37	47	PF02991	0.544
LIG_LIR_Gen_1	592	600	PF02991	0.680
LIG_LIR_Nem_3	189	194	PF02991	0.454
LIG_LIR_Nem_3	21	26	PF02991	0.504
LIG_LIR_Nem_3	231	235	PF02991	0.410
LIG_LIR_Nem_3	37	42	PF02991	0.439
LIG_LIR_Nem_3	391	395	PF02991	0.633
LIG_LIR_Nem_3	592	597	PF02991	0.669
LIG_LYPXL_yS_3	203	206	PF13949	0.525
LIG_PCNA_yPIPBox_3	160	173	PF02747	0.532
LIG_PCNA_yPIPBox_3	549	562	PF02747	0.405
LIG_Pex14_1	49	53	PF04695	0.583
LIG_Pex14_2	590	594	PF04695	0.553
LIG_REV1ctd_RIR_1	461	470	PF16727	0.452
LIG_SH2_CRK	122	126	PF00017	0.510
LIG_SH2_CRK	23	27	PF00017	0.447
LIG_SH2_CRK	39	43	PF00017	0.458
LIG_SH2_GRB2like	237	240	PF00017	0.407
LIG_SH2_STAP1	522	526	PF00017	0.592
LIG_SH2_STAP1	53	57	PF00017	0.565
LIG_SH2_STAT5	169	172	PF00017	0.465
LIG_SH2_STAT5	174	177	PF00017	0.440
LIG_SH2_STAT5	249	252	PF00017	0.520
LIG_SH2_STAT5	258	261	PF00017	0.490
LIG_SH2_STAT5	306	309	PF00017	0.563
LIG_SH2_STAT5	395	398	PF00017	0.596
LIG_SH2_STAT5	402	405	PF00017	0.486
LIG_SH2_STAT5	53	56	PF00017	0.577
LIG_SH3_3	285	291	PF00018	0.613
LIG_SH3_3	379	385	PF00018	0.527
LIG_SH3_3	40	46	PF00018	0.556
LIG_SH3_3	477	483	PF00018	0.611
LIG_SUMO_SIM_anti_2	153	159	PF11976	0.262
LIG_SUMO_SIM_par_1	117	123	PF11976	0.418
LIG_SUMO_SIM_par_1	223	231	PF11976	0.481
LIG_SUMO_SIM_par_1	53	60	PF11976	0.554
LIG_SUMO_SIM_par_1	530	538	PF11976	0.467
LIG_SUMO_SIM_par_1	553	560	PF11976	0.563
LIG_SUMO_SIM_par_1	72	79	PF11976	0.329
LIG_TRAF2_1	329	332	PF00917	0.641
LIG_TRAF2_1	535	538	PF00917	0.426
LIG_TRAF2_2	291	296	PF00917	0.624
LIG_TRFH_1	450	454	PF08558	0.391
LIG_UBA3_1	555	562	PF00899	0.510
LIG_WRC_WIRS_1	229	234	PF05994	0.432
LIG_WRC_WIRS_1	498	503	PF05994	0.566
MOD_CDK_SPK_2	15	20	PF00069	0.443
MOD_CDK_SPK_2	479	484	PF00069	0.568
MOD_CDK_SPxxK_3	479	486	PF00069	0.645
MOD_CK1_1	104	110	PF00069	0.226
MOD_CK1_1	223	229	PF00069	0.485
MOD_CK1_1	417	423	PF00069	0.546
MOD_CK1_1	433	439	PF00069	0.654
MOD_CK1_1	482	488	PF00069	0.566
MOD_CK1_1	84	90	PF00069	0.530
MOD_CK2_1	111	117	PF00069	0.510
MOD_CK2_1	239	245	PF00069	0.455
MOD_CK2_1	325	331	PF00069	0.459
MOD_CK2_1	505	511	PF00069	0.416
MOD_CK2_1	532	538	PF00069	0.437
MOD_CK2_1	586	592	PF00069	0.587
MOD_GlcNHglycan	122	125	PF01048	0.399
MOD_GlcNHglycan	327	330	PF01048	0.645
MOD_GlcNHglycan	339	342	PF01048	0.744
MOD_GlcNHglycan	385	388	PF01048	0.468
MOD_GlcNHglycan	423	426	PF01048	0.627
MOD_GlcNHglycan	435	438	PF01048	0.647
MOD_GlcNHglycan	502	505	PF01048	0.466
MOD_GSK3_1	107	114	PF00069	0.421
MOD_GSK3_1	142	149	PF00069	0.445
MOD_GSK3_1	15	22	PF00069	0.522
MOD_GSK3_1	349	356	PF00069	0.731
MOD_GSK3_1	408	415	PF00069	0.551
MOD_GSK3_1	417	424	PF00069	0.558
MOD_GSK3_1	426	433	PF00069	0.622
MOD_GSK3_1	448	455	PF00069	0.506
MOD_GSK3_1	470	477	PF00069	0.599
MOD_GSK3_1	57	64	PF00069	0.526
MOD_GSK3_1	72	79	PF00069	0.532
MOD_GSK3_1	84	91	PF00069	0.512
MOD_LATS_1	468	474	PF00433	0.579
MOD_N-GLC_1	250	255	PF02516	0.512
MOD_N-GLC_1	337	342	PF02516	0.759
MOD_N-GLC_1	408	413	PF02516	0.710
MOD_NEK2_1	324	329	PF00069	0.597
MOD_NEK2_1	414	419	PF00069	0.611
MOD_NEK2_1	57	62	PF00069	0.484
MOD_PK_1	412	418	PF00069	0.572
MOD_PK_1	474	480	PF00069	0.639
MOD_PKA_1	220	226	PF00069	0.489
MOD_PKA_1	474	480	PF00069	0.605
MOD_PKA_1	81	87	PF00069	0.454
MOD_PKA_2	19	25	PF00069	0.501
MOD_PKA_2	417	423	PF00069	0.668
MOD_Plk_1	223	229	PF00069	0.575
MOD_Plk_1	250	256	PF00069	0.555
MOD_Plk_1	569	575	PF00069	0.620
MOD_Plk_1	57	63	PF00069	0.477
MOD_Plk_1	586	592	PF00069	0.518
MOD_Plk_1	7	13	PF00069	0.498
MOD_Plk_2-3	353	359	PF00069	0.508
MOD_Plk_2-3	505	511	PF00069	0.493
MOD_Plk_2-3	586	592	PF00069	0.604
MOD_Plk_4	117	123	PF00069	0.447
MOD_Plk_4	228	234	PF00069	0.432
MOD_Plk_4	362	368	PF00069	0.360
MOD_Plk_4	376	382	PF00069	0.568
MOD_Plk_4	452	458	PF00069	0.456
MOD_Plk_4	474	480	PF00069	0.694
MOD_Plk_4	497	503	PF00069	0.556
MOD_Plk_4	569	575	PF00069	0.629
MOD_Plk_4	57	63	PF00069	0.520
MOD_ProDKin_1	15	21	PF00069	0.444
MOD_ProDKin_1	287	293	PF00069	0.525
MOD_ProDKin_1	306	312	PF00069	0.530
MOD_ProDKin_1	479	485	PF00069	0.562
MOD_SUMO_rev_2	557	564	PF00179	0.514
TRG_DiLeu_BaEn_1	362	367	PF01217	0.378
TRG_DiLeu_BaEn_2	585	591	PF01217	0.555
TRG_DiLeu_BaLyEn_6	513	518	PF01217	0.363
TRG_DiLeu_BaLyEn_6	551	556	PF01217	0.404
TRG_DiLeu_BaLyEn_6	69	74	PF01217	0.441
TRG_ENDOCYTIC_2	174	177	PF00928	0.462
TRG_ENDOCYTIC_2	203	206	PF00928	0.525
TRG_ENDOCYTIC_2	23	26	PF00928	0.433
TRG_ENDOCYTIC_2	258	261	PF00928	0.372
TRG_ENDOCYTIC_2	39	42	PF00928	0.442
TRG_ER_diArg_1	219	222	PF00400	0.511
TRG_ER_diArg_1	301	304	PF00400	0.426
TRG_ER_diArg_1	483	486	PF00400	0.712
TRG_Pf-PMV_PEXEL_1	516	520	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCU8	Leptomonas seymouri	64%	100%
A0A0S4JJW4	Bodo saltans	31%	100%
A0A1X0NW77	Trypanosomatidae	40%	89%
A0A3S7WYG2	Leishmania donovani	91%	100%
A0A422N8J0	Trypanosoma rangeli	41%	97%
A4HDI5	Leishmania braziliensis	78%	100%
C9ZWF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	99%
E9AH63	Leishmania infantum	92%	100%
Q4QAH5	Leishmania major	91%	100%
V5BK17	Trypanosoma cruzi	41%	100%