Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AX00_LEIMU

TriTrypDb:

LmxM.24.1550

Length:

955

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AX00

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX00

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.522
CLV_C14_Caspase3-7	306	310	PF00656	0.733
CLV_NRD_NRD_1	131	133	PF00675	0.832
CLV_NRD_NRD_1	201	203	PF00675	0.665
CLV_NRD_NRD_1	562	564	PF00675	0.727
CLV_NRD_NRD_1	640	642	PF00675	0.760
CLV_NRD_NRD_1	720	722	PF00675	0.632
CLV_NRD_NRD_1	73	75	PF00675	0.597
CLV_NRD_NRD_1	765	767	PF00675	0.830
CLV_NRD_NRD_1	787	789	PF00675	0.678
CLV_NRD_NRD_1	877	879	PF00675	0.720
CLV_NRD_NRD_1	96	98	PF00675	0.546
CLV_PCSK_KEX2_1	131	133	PF00082	0.832
CLV_PCSK_KEX2_1	201	203	PF00082	0.665
CLV_PCSK_KEX2_1	561	563	PF00082	0.728
CLV_PCSK_KEX2_1	640	642	PF00082	0.760
CLV_PCSK_KEX2_1	720	722	PF00082	0.632
CLV_PCSK_KEX2_1	73	75	PF00082	0.597
CLV_PCSK_KEX2_1	758	760	PF00082	0.713
CLV_PCSK_KEX2_1	765	767	PF00082	0.817
CLV_PCSK_KEX2_1	787	789	PF00082	0.678
CLV_PCSK_KEX2_1	877	879	PF00082	0.709
CLV_PCSK_KEX2_1	95	97	PF00082	0.549
CLV_PCSK_PC1ET2_1	758	760	PF00082	0.524
CLV_PCSK_SKI1_1	160	164	PF00082	0.699
CLV_PCSK_SKI1_1	185	189	PF00082	0.700
CLV_PCSK_SKI1_1	622	626	PF00082	0.700
CLV_PCSK_SKI1_1	63	67	PF00082	0.613
CLV_PCSK_SKI1_1	688	692	PF00082	0.635
CLV_PCSK_SKI1_1	758	762	PF00082	0.577
CLV_PCSK_SKI1_1	926	930	PF00082	0.660
CLV_PCSK_SKI1_1	936	940	PF00082	0.577
CLV_Separin_Metazoa	604	608	PF03568	0.601
DEG_APCC_DBOX_1	184	192	PF00400	0.604
DEG_APCC_DBOX_1	526	534	PF00400	0.658
DEG_APCC_DBOX_1	935	943	PF00400	0.722
DEG_Nend_Nbox_1	1	3	PF02207	0.652
DEG_SCF_FBW7_1	142	147	PF00400	0.515
DEG_SCF_FBW7_1	288	294	PF00400	0.821
DEG_SPOP_SBC_1	363	367	PF00917	0.556
DOC_ANK_TNKS_1	111	118	PF00023	0.675
DOC_CDC14_PxL_1	468	476	PF14671	0.783
DOC_CKS1_1	288	293	PF01111	0.748
DOC_CYCLIN_RxL_1	182	190	PF00134	0.721
DOC_CYCLIN_yCln2_LP_2	469	475	PF00134	0.608
DOC_MAPK_gen_1	607	614	PF00069	0.602
DOC_MAPK_gen_1	640	647	PF00069	0.659
DOC_MAPK_gen_1	727	735	PF00069	0.670
DOC_MAPK_MEF2A_6	640	647	PF00069	0.751
DOC_MAPK_MEF2A_6	729	737	PF00069	0.693
DOC_PP2B_LxvP_1	380	383	PF13499	0.697
DOC_PP2B_LxvP_1	469	472	PF13499	0.686
DOC_PP2B_LxvP_1	682	685	PF13499	0.654
DOC_PP4_MxPP_1	462	465	PF00568	0.679
DOC_USP7_MATH_1	121	125	PF00917	0.731
DOC_USP7_MATH_1	221	225	PF00917	0.775
DOC_USP7_MATH_1	227	231	PF00917	0.732
DOC_USP7_MATH_1	291	295	PF00917	0.724
DOC_USP7_MATH_1	346	350	PF00917	0.762
DOC_USP7_MATH_1	482	486	PF00917	0.691
DOC_USP7_MATH_1	581	585	PF00917	0.769
DOC_USP7_MATH_1	655	659	PF00917	0.713
DOC_USP7_MATH_1	851	855	PF00917	0.793
DOC_USP7_MATH_1	858	862	PF00917	0.713
DOC_USP7_MATH_1	951	955	PF00917	0.571
DOC_USP7_MATH_2	432	438	PF00917	0.816
DOC_USP7_MATH_2	523	529	PF00917	0.478
DOC_WW_Pin1_4	140	145	PF00397	0.528
DOC_WW_Pin1_4	208	213	PF00397	0.724
DOC_WW_Pin1_4	214	219	PF00397	0.740
DOC_WW_Pin1_4	287	292	PF00397	0.732
DOC_WW_Pin1_4	335	340	PF00397	0.833
DOC_WW_Pin1_4	369	374	PF00397	0.817
DOC_WW_Pin1_4	453	458	PF00397	0.792
DOC_WW_Pin1_4	667	672	PF00397	0.805
DOC_WW_Pin1_4	766	771	PF00397	0.825
DOC_WW_Pin1_4	900	905	PF00397	0.654
LIG_14-3-3_CanoR_1	109	115	PF00244	0.661
LIG_14-3-3_CanoR_1	283	289	PF00244	0.801
LIG_14-3-3_CanoR_1	562	571	PF00244	0.613
LIG_14-3-3_CanoR_1	622	629	PF00244	0.720
LIG_14-3-3_CanoR_1	640	646	PF00244	0.483
LIG_14-3-3_CanoR_1	73	78	PF00244	0.615
LIG_14-3-3_CanoR_1	787	793	PF00244	0.651
LIG_BRCT_BRCA1_1	633	637	PF00533	0.724
LIG_CaM_IQ_9	88	104	PF13499	0.635
LIG_deltaCOP1_diTrp_1	154	163	PF00928	0.579
LIG_FHA_1	223	229	PF00498	0.760
LIG_FHA_1	60	66	PF00498	0.611
LIG_FHA_1	623	629	PF00498	0.709
LIG_FHA_1	676	682	PF00498	0.713
LIG_FHA_1	86	92	PF00498	0.694
LIG_FHA_1	910	916	PF00498	0.701
LIG_FHA_1	922	928	PF00498	0.567
LIG_FHA_2	156	162	PF00498	0.691
LIG_FHA_2	230	236	PF00498	0.534
LIG_FHA_2	512	518	PF00498	0.555
LIG_FHA_2	589	595	PF00498	0.481
LIG_FHA_2	795	801	PF00498	0.696
LIG_Integrin_RGD_1	125	127	PF01839	0.525
LIG_LIR_Apic_2	449	455	PF02991	0.800
LIG_LIR_Gen_1	154	163	PF02991	0.620
LIG_LIR_Gen_1	377	387	PF02991	0.686
LIG_LIR_Gen_1	600	610	PF02991	0.608
LIG_LIR_Gen_1	731	739	PF02991	0.721
LIG_LIR_LC3C_4	644	647	PF02991	0.577
LIG_LIR_Nem_3	154	159	PF02991	0.622
LIG_LIR_Nem_3	377	382	PF02991	0.709
LIG_LIR_Nem_3	543	549	PF02991	0.610
LIG_LIR_Nem_3	600	605	PF02991	0.612
LIG_LIR_Nem_3	731	735	PF02991	0.714
LIG_NRBOX	183	189	PF00104	0.716
LIG_NRBOX	254	260	PF00104	0.615
LIG_Pex14_1	795	799	PF04695	0.595
LIG_RPA_C_Fungi	716	728	PF08784	0.612
LIG_SH2_PTP2	452	455	PF00017	0.799
LIG_SH2_SRC	31	34	PF00017	0.623
LIG_SH2_STAP1	610	614	PF00017	0.602
LIG_SH2_STAT3	2	5	PF00017	0.742
LIG_SH2_STAT3	261	264	PF00017	0.745
LIG_SH2_STAT5	2	5	PF00017	0.742
LIG_SH2_STAT5	261	264	PF00017	0.551
LIG_SH2_STAT5	31	34	PF00017	0.623
LIG_SH2_STAT5	391	394	PF00017	0.738
LIG_SH2_STAT5	406	409	PF00017	0.752
LIG_SH2_STAT5	425	428	PF00017	0.536
LIG_SH2_STAT5	452	455	PF00017	0.799
LIG_SH2_STAT5	468	471	PF00017	0.521
LIG_SH2_STAT5	692	695	PF00017	0.600
LIG_SH2_STAT5	696	699	PF00017	0.603
LIG_SH2_STAT5	732	735	PF00017	0.717
LIG_SH2_STAT5	803	806	PF00017	0.716
LIG_SH2_STAT5	844	847	PF00017	0.624
LIG_SH3_3	170	176	PF00018	0.660
LIG_SH3_3	550	556	PF00018	0.718
LIG_SH3_3	74	80	PF00018	0.612
LIG_SH3_3	845	851	PF00018	0.639
LIG_Sin3_3	895	902	PF02671	0.744
LIG_SUMO_SIM_par_1	733	738	PF11976	0.701
LIG_SUMO_SIM_par_1	843	849	PF11976	0.645
LIG_SUMO_SIM_par_1	869	875	PF11976	0.639
LIG_TRAF2_1	522	525	PF00917	0.774
LIG_TRAF2_1	591	594	PF00917	0.653
LIG_TRAF2_1	779	782	PF00917	0.689
LIG_TRAF2_1	8	11	PF00917	0.406
MOD_CDC14_SPxK_1	338	341	PF00782	0.532
MOD_CDK_SPxK_1	335	341	PF00069	0.536
MOD_CK1_1	137	143	PF00069	0.613
MOD_CK1_1	217	223	PF00069	0.828
MOD_CK1_1	243	249	PF00069	0.694
MOD_CK1_1	284	290	PF00069	0.837
MOD_CK1_1	345	351	PF00069	0.761
MOD_CK1_1	478	484	PF00069	0.735
MOD_CK1_1	485	491	PF00069	0.637
MOD_CK1_1	631	637	PF00069	0.702
MOD_CK1_1	660	666	PF00069	0.618
MOD_CK1_1	769	775	PF00069	0.566
MOD_CK1_1	824	830	PF00069	0.634
MOD_CK1_1	900	906	PF00069	0.655
MOD_CK2_1	155	161	PF00069	0.696
MOD_CK2_1	481	487	PF00069	0.752
MOD_CK2_1	511	517	PF00069	0.741
MOD_CK2_1	518	524	PF00069	0.761
MOD_CK2_1	588	594	PF00069	0.577
MOD_CK2_1	794	800	PF00069	0.708
MOD_Cter_Amidation	718	721	PF01082	0.625
MOD_DYRK1A_RPxSP_1	766	770	PF00069	0.745
MOD_GlcNHglycan	112	115	PF01048	0.616
MOD_GlcNHglycan	121	124	PF01048	0.714
MOD_GlcNHglycan	136	139	PF01048	0.707
MOD_GlcNHglycan	179	182	PF01048	0.730
MOD_GlcNHglycan	196	199	PF01048	0.472
MOD_GlcNHglycan	242	245	PF01048	0.803
MOD_GlcNHglycan	283	286	PF01048	0.788
MOD_GlcNHglycan	293	296	PF01048	0.701
MOD_GlcNHglycan	344	347	PF01048	0.793
MOD_GlcNHglycan	348	351	PF01048	0.763
MOD_GlcNHglycan	355	358	PF01048	0.706
MOD_GlcNHglycan	366	369	PF01048	0.733
MOD_GlcNHglycan	436	439	PF01048	0.748
MOD_GlcNHglycan	480	483	PF01048	0.709
MOD_GlcNHglycan	484	487	PF01048	0.674
MOD_GlcNHglycan	49	52	PF01048	0.604
MOD_GlcNHglycan	520	523	PF01048	0.767
MOD_GlcNHglycan	538	541	PF01048	0.650
MOD_GlcNHglycan	566	569	PF01048	0.614
MOD_GlcNHglycan	583	586	PF01048	0.793
MOD_GlcNHglycan	68	71	PF01048	0.569
MOD_GlcNHglycan	712	715	PF01048	0.523
MOD_GlcNHglycan	818	821	PF01048	0.698
MOD_GlcNHglycan	860	863	PF01048	0.677
MOD_GlcNHglycan	900	903	PF01048	0.660
MOD_GlcNHglycan	919	922	PF01048	0.407
MOD_GlcNHglycan	942	945	PF01048	0.756
MOD_GSK3_1	132	139	PF00069	0.766
MOD_GSK3_1	140	147	PF00069	0.514
MOD_GSK3_1	217	224	PF00069	0.693
MOD_GSK3_1	287	294	PF00069	0.769
MOD_GSK3_1	342	349	PF00069	0.790
MOD_GSK3_1	353	360	PF00069	0.804
MOD_GSK3_1	478	485	PF00069	0.692
MOD_GSK3_1	507	514	PF00069	0.662
MOD_GSK3_1	821	828	PF00069	0.637
MOD_GSK3_1	917	924	PF00069	0.635
MOD_LATS_1	756	762	PF00433	0.530
MOD_NEK2_1	136	141	PF00069	0.823
MOD_NEK2_1	152	157	PF00069	0.465
MOD_NEK2_1	259	264	PF00069	0.547
MOD_NEK2_1	66	71	PF00069	0.611
MOD_NEK2_1	677	682	PF00069	0.691
MOD_NEK2_1	72	77	PF00069	0.615
MOD_NEK2_1	897	902	PF00069	0.669
MOD_NEK2_1	940	945	PF00069	0.573
MOD_NEK2_2	794	799	PF00069	0.622
MOD_PIKK_1	597	603	PF00454	0.726
MOD_PKA_1	73	79	PF00069	0.717
MOD_PKA_1	758	764	PF00069	0.522
MOD_PKA_2	152	158	PF00069	0.651
MOD_PKA_2	259	265	PF00069	0.742
MOD_PKA_2	298	304	PF00069	0.605
MOD_PKA_2	404	410	PF00069	0.768
MOD_PKA_2	660	666	PF00069	0.722
MOD_PKA_2	72	78	PF00069	0.616
MOD_PKA_2	758	764	PF00069	0.814
MOD_PKB_1	561	569	PF00069	0.640
MOD_Plk_1	525	531	PF00069	0.651
MOD_Plk_1	549	555	PF00069	0.718
MOD_Plk_1	631	637	PF00069	0.723
MOD_Plk_2-3	324	330	PF00069	0.674
MOD_Plk_2-3	511	517	PF00069	0.558
MOD_Plk_4	374	380	PF00069	0.812
MOD_Plk_4	485	491	PF00069	0.773
MOD_Plk_4	549	555	PF00069	0.718
MOD_Plk_4	631	637	PF00069	0.723
MOD_Plk_4	641	647	PF00069	0.592
MOD_Plk_4	677	683	PF00069	0.709
MOD_Plk_4	73	79	PF00069	0.717
MOD_Plk_4	794	800	PF00069	0.623
MOD_Plk_4	821	827	PF00069	0.692
MOD_Plk_4	879	885	PF00069	0.601
MOD_Plk_4	928	934	PF00069	0.537
MOD_ProDKin_1	140	146	PF00069	0.525
MOD_ProDKin_1	208	214	PF00069	0.730
MOD_ProDKin_1	219	225	PF00069	0.726
MOD_ProDKin_1	287	293	PF00069	0.732
MOD_ProDKin_1	335	341	PF00069	0.835
MOD_ProDKin_1	369	375	PF00069	0.816
MOD_ProDKin_1	453	459	PF00069	0.791
MOD_ProDKin_1	667	673	PF00069	0.804
MOD_ProDKin_1	766	772	PF00069	0.825
MOD_ProDKin_1	900	906	PF00069	0.655
MOD_SUMO_rev_2	161	170	PF00179	0.593
TRG_DiLeu_BaEn_1	749	754	PF01217	0.642
TRG_DiLeu_BaEn_1	894	899	PF01217	0.735
TRG_DiLeu_BaEn_4	525	531	PF01217	0.675
TRG_DiLeu_BaLyEn_6	77	82	PF01217	0.699
TRG_DiLeu_BaLyEn_6	923	928	PF01217	0.429
TRG_ENDOCYTIC_2	732	735	PF00928	0.717
TRG_ENDOCYTIC_2	834	837	PF00928	0.693
TRG_ER_diArg_1	130	132	PF00400	0.829
TRG_ER_diArg_1	201	203	PF00400	0.665
TRG_ER_diArg_1	561	563	PF00400	0.728
TRG_ER_diArg_1	606	609	PF00400	0.599
TRG_ER_diArg_1	640	642	PF00400	0.760
TRG_ER_diArg_1	72	74	PF00400	0.601
TRG_ER_diArg_1	764	766	PF00400	0.822
TRG_ER_diArg_1	877	879	PF00400	0.607
TRG_ER_diArg_1	95	97	PF00400	0.552
TRG_NES_CRM1_1	316	329	PF08389	0.721
TRG_Pf-PMV_PEXEL_1	185	190	PF00026	0.713
TRG_Pf-PMV_PEXEL_1	63	68	PF00026	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I728	Leptomonas seymouri	38%	100%
A0A3S7WYF6	Leishmania donovani	89%	100%
A4HDI6	Leishmania braziliensis	72%	100%
E9AH62	Leishmania infantum	89%	100%
Q4QAH6	Leishmania major	87%	100%