IgE-dependent histamine-releasing factor,putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

IgE-dependent histamine-releasing factor, putative

Species:

Leishmania mexicana

UniProt:

E9AWZ6_LEIMU

TriTrypDb:

LmxM.24.1500

Length:

276

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWZ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	245	249	PF00656	0.672
CLV_NRD_NRD_1	65	67	PF00675	0.859
CLV_NRD_NRD_1	75	77	PF00675	0.648
CLV_PCSK_KEX2_1	65	67	PF00082	0.859
CLV_PCSK_KEX2_1	75	77	PF00082	0.648
CLV_PCSK_SKI1_1	108	112	PF00082	0.472
CLV_PCSK_SKI1_1	202	206	PF00082	0.472
CLV_PCSK_SKI1_1	214	218	PF00082	0.322
CLV_PCSK_SKI1_1	226	230	PF00082	0.322
DOC_CYCLIN_RxL_1	196	209	PF00134	0.672
DOC_MAPK_DCC_7	98	107	PF00069	0.741
DOC_MAPK_MEF2A_6	98	107	PF00069	0.741
DOC_PP2B_LxvP_1	100	103	PF13499	0.747
DOC_PP4_FxxP_1	237	240	PF00568	0.672
DOC_PP4_FxxP_1	99	102	PF00568	0.751
DOC_USP7_MATH_1	80	84	PF00917	0.793
DOC_USP7_UBL2_3	226	230	PF12436	0.672
DOC_USP7_UBL2_3	268	272	PF12436	0.672
DOC_WW_Pin1_4	15	20	PF00397	0.866
DOC_WW_Pin1_4	258	263	PF00397	0.672
DOC_WW_Pin1_4	29	34	PF00397	0.605
DOC_WW_Pin1_4	41	46	PF00397	0.584
DOC_WW_Pin1_4	93	98	PF00397	0.766
LIG_14-3-3_CanoR_1	182	188	PF00244	0.672
LIG_Actin_RPEL_3	68	87	PF02755	0.817
LIG_APCC_ABBA_1	107	112	PF00400	0.672
LIG_BRCT_BRCA1_1	47	51	PF00533	0.793
LIG_BRCT_BRCA1_1	95	99	PF00533	0.765
LIG_FHA_1	104	110	PF00498	0.572
LIG_FHA_1	162	168	PF00498	0.672
LIG_FHA_2	113	119	PF00498	0.672
LIG_FHA_2	184	190	PF00498	0.672
LIG_LIR_Apic_2	234	240	PF02991	0.672
LIG_LIR_Apic_2	96	102	PF02991	0.755
LIG_LIR_Gen_1	233	240	PF02991	0.672
LIG_LIR_Gen_1	48	56	PF02991	0.801
LIG_LIR_Nem_3	233	238	PF02991	0.672
LIG_LIR_Nem_3	48	54	PF02991	0.795
LIG_NRBOX	49	55	PF00104	0.800
LIG_PDZ_Class_3	271	276	PF00595	0.747
LIG_PTB_Apo_2	177	184	PF02174	0.672
LIG_PTB_Phospho_1	177	183	PF10480	0.672
LIG_SH2_NCK_1	188	192	PF00017	0.672
LIG_SH2_PTP2	141	144	PF00017	0.672
LIG_SH2_SRC	141	144	PF00017	0.672
LIG_SH2_STAT3	200	203	PF00017	0.672
LIG_SH2_STAT5	135	138	PF00017	0.672
LIG_SH2_STAT5	141	144	PF00017	0.597
LIG_SH2_STAT5	183	186	PF00017	0.672
LIG_SH2_STAT5	265	268	PF00017	0.672
LIG_SH3_1	27	33	PF00018	0.860
LIG_SH3_3	27	33	PF00018	0.545
LIG_SH3_3	39	45	PF00018	0.586
LIG_SH3_3	74	80	PF00018	0.802
LIG_SH3_3	9	15	PF00018	0.866
LIG_SUMO_SIM_par_1	52	57	PF11976	0.809
MOD_CDK_SPK_2	258	263	PF00069	0.672
MOD_CDK_SPK_2	93	98	PF00069	0.766
MOD_CDK_SPxxK_3	15	22	PF00069	0.865
MOD_CDK_SPxxK_3	29	36	PF00069	0.600
MOD_CK1_1	49	55	PF00069	0.800
MOD_CK1_1	93	99	PF00069	0.767
MOD_CK2_1	112	118	PF00069	0.672
MOD_Cter_Amidation	73	76	PF01082	0.842
MOD_GlcNHglycan	151	154	PF01048	0.472
MOD_GlcNHglycan	83	86	PF01048	0.792
MOD_GSK3_1	31	38	PF00069	0.835
MOD_GSK3_1	41	48	PF00069	0.619
MOD_GSK3_1	54	61	PF00069	0.595
MOD_LATS_1	64	70	PF00433	0.858
MOD_N-GLC_2	123	125	PF02516	0.472
MOD_NEK2_1	46	51	PF00069	0.794
MOD_NEK2_1	54	59	PF00069	0.682
MOD_NEK2_1	81	86	PF00069	0.798
MOD_NEK2_2	103	108	PF00069	0.721
MOD_PKA_1	36	42	PF00069	0.811
MOD_PKA_2	181	187	PF00069	0.672
MOD_Plk_1	184	190	PF00069	0.672
MOD_Plk_4	189	195	PF00069	0.672
MOD_Plk_4	36	42	PF00069	0.811
MOD_Plk_4	46	52	PF00069	0.618
MOD_Plk_4	90	96	PF00069	0.775
MOD_ProDKin_1	15	21	PF00069	0.864
MOD_ProDKin_1	258	264	PF00069	0.672
MOD_ProDKin_1	29	35	PF00069	0.602
MOD_ProDKin_1	41	47	PF00069	0.585
MOD_ProDKin_1	93	99	PF00069	0.767
MOD_SUMO_for_1	271	274	PF00179	0.735
MOD_SUMO_rev_2	206	216	PF00179	0.672
TRG_DiLeu_BaEn_2	233	239	PF01217	0.672
TRG_ENDOCYTIC_2	141	144	PF00928	0.672
TRG_ENDOCYTIC_2	235	238	PF00928	0.672
TRG_ER_diArg_1	65	67	PF00400	0.859
TRG_ER_diArg_1	75	77	PF00400	0.648
TRG_NLS_MonoCore_2	23	28	PF00514	0.880
TRG_NLS_MonoExtN_4	21	28	PF00514	0.876
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	227	231	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	66	71	PF00026	0.861

Homologs


Protein	Taxonomy	Sequence identity	Coverage
Q54RX1	Dictyostelium discoideum	27%	100%