Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania mexicana

UniProt:

E9AWZ5_LEIMU

TriTrypDb:

LmxM.24.1490

Length:

435

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	6
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	6
GO:0005840	ribosome	5	5
GO:0032991	protein-containing complex	1	5
GO:0043228	non-membrane-bounded organelle	3	5
GO:0043232	intracellular non-membrane-bounded organelle	4	5
GO:1990904	ribonucleoprotein complex	2	5

Expansion

Sequence features

E9AWZ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWZ5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.395
CLV_C14_Caspase3-7	378	382	PF00656	0.514
CLV_NRD_NRD_1	186	188	PF00675	0.428
CLV_PCSK_KEX2_1	186	188	PF00082	0.480
CLV_PCSK_KEX2_1	193	195	PF00082	0.446
CLV_PCSK_KEX2_1	197	199	PF00082	0.413
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.560
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.553
CLV_PCSK_SKI1_1	193	197	PF00082	0.441
CLV_PCSK_SKI1_1	198	202	PF00082	0.409
CLV_PCSK_SKI1_1	229	233	PF00082	0.298
CLV_PCSK_SKI1_1	35	39	PF00082	0.489
CLV_PCSK_SKI1_1	431	435	PF00082	0.396
CLV_PCSK_SKI1_1	79	83	PF00082	0.433
DEG_APCC_DBOX_1	287	295	PF00400	0.479
DEG_APCC_DBOX_1	78	86	PF00400	0.430
DEG_MDM2_SWIB_1	163	171	PF02201	0.355
DEG_Nend_UBRbox_1	1	4	PF02207	0.726
DEG_SCF_FBW7_1	1	8	PF00400	0.699
DOC_CKS1_1	339	344	PF01111	0.398
DOC_MAPK_gen_1	392	402	PF00069	0.427
DOC_MAPK_JIP1_4	99	105	PF00069	0.532
DOC_MAPK_MEF2A_6	395	404	PF00069	0.421
DOC_PP2B_PxIxI_1	161	167	PF00149	0.408
DOC_USP7_MATH_1	141	145	PF00917	0.479
DOC_USP7_MATH_1	223	227	PF00917	0.444
DOC_USP7_MATH_1	307	311	PF00917	0.554
DOC_USP7_MATH_1	316	320	PF00917	0.366
DOC_USP7_UBL2_3	193	197	PF12436	0.552
DOC_WW_Pin1_4	1	6	PF00397	0.711
DOC_WW_Pin1_4	335	340	PF00397	0.637
DOC_WW_Pin1_4	405	410	PF00397	0.409
DOC_WW_Pin1_4	424	429	PF00397	0.536
LIG_14-3-3_CanoR_1	186	190	PF00244	0.444
LIG_14-3-3_CanoR_1	329	337	PF00244	0.471
LIG_APCC_ABBA_1	119	124	PF00400	0.387
LIG_APCC_ABBA_1	129	134	PF00400	0.398
LIG_APCC_ABBA_1	160	165	PF00400	0.334
LIG_BRCT_BRCA1_1	266	270	PF00533	0.338
LIG_BRCT_BRCA1_1	400	404	PF00533	0.392
LIG_FHA_1	2	8	PF00498	0.644
LIG_FHA_1	204	210	PF00498	0.521
LIG_FHA_1	228	234	PF00498	0.534
LIG_FHA_1	394	400	PF00498	0.402
LIG_FHA_1	425	431	PF00498	0.394
LIG_FHA_1	67	73	PF00498	0.694
LIG_FHA_1	99	105	PF00498	0.427
LIG_FHA_2	243	249	PF00498	0.386
LIG_LIR_Gen_1	211	222	PF02991	0.534
LIG_LIR_Gen_1	245	252	PF02991	0.351
LIG_LIR_Nem_3	211	217	PF02991	0.534
LIG_LIR_Nem_3	245	249	PF02991	0.358
LIG_MYND_3	114	118	PF01753	0.230
LIG_Pex14_2	163	167	PF04695	0.317
LIG_SH2_CRK	289	293	PF00017	0.446
LIG_SH2_NCK_1	122	126	PF00017	0.425
LIG_SH2_SRC	122	125	PF00017	0.417
LIG_SH2_SRC	130	133	PF00017	0.392
LIG_SH2_STAP1	191	195	PF00017	0.574
LIG_SH2_STAT5	120	123	PF00017	0.378
LIG_SH2_STAT5	130	133	PF00017	0.392
LIG_SH2_STAT5	26	29	PF00017	0.601
LIG_SH2_STAT5	424	427	PF00017	0.383
LIG_SH2_STAT5	53	56	PF00017	0.569
LIG_SH3_3	336	342	PF00018	0.626
LIG_SH3_3	403	409	PF00018	0.405
LIG_SUMO_SIM_par_1	153	159	PF11976	0.479
LIG_SUMO_SIM_par_1	398	403	PF11976	0.532
LIG_TRAF2_1	43	46	PF00917	0.702
MOD_CDK_SPxxK_3	424	431	PF00069	0.247
MOD_CK1_1	145	151	PF00069	0.530
MOD_CK1_1	338	344	PF00069	0.615
MOD_CK1_1	393	399	PF00069	0.385
MOD_CK1_1	415	421	PF00069	0.485
MOD_CK1_1	8	14	PF00069	0.578
MOD_CK2_1	201	207	PF00069	0.409
MOD_CK2_1	242	248	PF00069	0.377
MOD_CK2_1	84	90	PF00069	0.616
MOD_GlcNHglycan	223	226	PF01048	0.299
MOD_GlcNHglycan	266	269	PF01048	0.315
MOD_GlcNHglycan	309	312	PF01048	0.543
MOD_GlcNHglycan	318	321	PF01048	0.452
MOD_GlcNHglycan	381	385	PF01048	0.510
MOD_GlcNHglycan	414	417	PF01048	0.490
MOD_GSK3_1	1	8	PF00069	0.695
MOD_GSK3_1	141	148	PF00069	0.385
MOD_GSK3_1	185	192	PF00069	0.511
MOD_GSK3_1	223	230	PF00069	0.294
MOD_GSK3_1	325	332	PF00069	0.547
MOD_GSK3_1	351	358	PF00069	0.366
MOD_GSK3_1	94	101	PF00069	0.517
MOD_N-GLC_1	189	194	PF02516	0.531
MOD_NEK2_1	103	108	PF00069	0.498
MOD_NEK2_1	142	147	PF00069	0.434
MOD_NEK2_1	264	269	PF00069	0.333
MOD_NEK2_1	270	275	PF00069	0.361
MOD_NEK2_1	315	320	PF00069	0.371
MOD_NEK2_1	330	335	PF00069	0.544
MOD_NEK2_1	353	358	PF00069	0.436
MOD_NEK2_1	364	369	PF00069	0.371
MOD_NEK2_1	388	393	PF00069	0.525
MOD_NEK2_1	400	405	PF00069	0.418
MOD_NEK2_1	412	417	PF00069	0.410
MOD_NEK2_1	422	427	PF00069	0.391
MOD_NEK2_2	208	213	PF00069	0.380
MOD_NEK2_2	227	232	PF00069	0.301
MOD_PK_1	395	401	PF00069	0.463
MOD_PKA_2	185	191	PF00069	0.471
MOD_PKA_2	379	385	PF00069	0.493
MOD_Plk_1	227	233	PF00069	0.301
MOD_Plk_1	270	276	PF00069	0.391
MOD_Plk_1	351	357	PF00069	0.366
MOD_Plk_1	66	72	PF00069	0.673
MOD_Plk_1	94	100	PF00069	0.531
MOD_Plk_2-3	84	90	PF00069	0.658
MOD_Plk_4	142	148	PF00069	0.476
MOD_Plk_4	150	156	PF00069	0.434
MOD_Plk_4	270	276	PF00069	0.418
MOD_Plk_4	395	401	PF00069	0.475
MOD_ProDKin_1	1	7	PF00069	0.705
MOD_ProDKin_1	335	341	PF00069	0.632
MOD_ProDKin_1	405	411	PF00069	0.402
MOD_ProDKin_1	424	430	PF00069	0.531
MOD_SUMO_rev_2	30	40	PF00179	0.689
TRG_DiLeu_BaEn_1	261	266	PF01217	0.361
TRG_DiLeu_BaEn_2	295	301	PF01217	0.439
TRG_ENDOCYTIC_2	246	249	PF00928	0.356
TRG_NLS_MonoExtN_4	35	42	PF00514	0.606
TRG_Pf-PMV_PEXEL_1	198	203	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	79	83	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0A8	Leptomonas seymouri	79%	100%
A0A0S4IX69	Bodo saltans	53%	98%
A0A1X0NW69	Trypanosomatidae	57%	100%
A0A3Q8IBY9	Leishmania donovani	94%	100%
A0A3R7K1J8	Trypanosoma rangeli	55%	100%
A1Z8D0	Drosophila melanogaster	28%	95%
A4HDJ1	Leishmania braziliensis	89%	100%
A4I0Y7	Leishmania infantum	94%	100%
C9ZWG2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
P21304	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	76%
Q13610	Homo sapiens	33%	87%
Q2HJ56	Bos taurus	33%	87%
Q4QAI2	Leishmania major	93%	100%
Q99LL5	Mus musculus	31%	87%
Q9P775	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	84%
V5BFJ2	Trypanosoma cruzi	55%	100%