AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWZ2_LEIMU

TriTrypDb:

LmxM.24.1460

Length:

829

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWZ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWZ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	241	245	PF00656	0.660
CLV_C14_Caspase3-7	247	251	PF00656	0.602
CLV_C14_Caspase3-7	34	38	PF00656	0.477
CLV_C14_Caspase3-7	535	539	PF00656	0.585
CLV_C14_Caspase3-7	540	544	PF00656	0.573
CLV_NRD_NRD_1	144	146	PF00675	0.643
CLV_NRD_NRD_1	171	173	PF00675	0.580
CLV_NRD_NRD_1	195	197	PF00675	0.622
CLV_NRD_NRD_1	208	210	PF00675	0.718
CLV_NRD_NRD_1	379	381	PF00675	0.369
CLV_NRD_NRD_1	399	401	PF00675	0.633
CLV_NRD_NRD_1	44	46	PF00675	0.730
CLV_NRD_NRD_1	447	449	PF00675	0.564
CLV_NRD_NRD_1	472	474	PF00675	0.527
CLV_NRD_NRD_1	486	488	PF00675	0.394
CLV_NRD_NRD_1	529	531	PF00675	0.666
CLV_NRD_NRD_1	578	580	PF00675	0.432
CLV_NRD_NRD_1	80	82	PF00675	0.614
CLV_NRD_NRD_1	813	815	PF00675	0.621
CLV_NRD_NRD_1	86	88	PF00675	0.509
CLV_PCSK_FUR_1	206	210	PF00082	0.595
CLV_PCSK_KEX2_1	10	12	PF00082	0.460
CLV_PCSK_KEX2_1	144	146	PF00082	0.641
CLV_PCSK_KEX2_1	173	175	PF00082	0.619
CLV_PCSK_KEX2_1	189	191	PF00082	0.613
CLV_PCSK_KEX2_1	195	197	PF00082	0.606
CLV_PCSK_KEX2_1	208	210	PF00082	0.663
CLV_PCSK_KEX2_1	379	381	PF00082	0.443
CLV_PCSK_KEX2_1	434	436	PF00082	0.472
CLV_PCSK_KEX2_1	44	46	PF00082	0.732
CLV_PCSK_KEX2_1	446	448	PF00082	0.475
CLV_PCSK_KEX2_1	472	474	PF00082	0.527
CLV_PCSK_KEX2_1	486	488	PF00082	0.394
CLV_PCSK_KEX2_1	529	531	PF00082	0.634
CLV_PCSK_KEX2_1	578	580	PF00082	0.378
CLV_PCSK_KEX2_1	80	82	PF00082	0.614
CLV_PCSK_KEX2_1	813	815	PF00082	0.621
CLV_PCSK_KEX2_1	86	88	PF00082	0.509
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.460
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.619
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.572
CLV_PCSK_PC1ET2_1	434	436	PF00082	0.472
CLV_PCSK_PC7_1	574	580	PF00082	0.419
CLV_PCSK_PC7_1	76	82	PF00082	0.501
CLV_PCSK_PC7_1	809	815	PF00082	0.594
CLV_PCSK_SKI1_1	301	305	PF00082	0.681
CLV_PCSK_SKI1_1	337	341	PF00082	0.478
CLV_PCSK_SKI1_1	379	383	PF00082	0.505
CLV_PCSK_SKI1_1	487	491	PF00082	0.399
CLV_PCSK_SKI1_1	530	534	PF00082	0.641
CLV_PCSK_SKI1_1	718	722	PF00082	0.416
CLV_PCSK_SKI1_1	802	806	PF00082	0.495
CLV_PCSK_SKI1_1	87	91	PF00082	0.549
DEG_APCC_DBOX_1	126	134	PF00400	0.631
DEG_APCC_DBOX_1	447	455	PF00400	0.501
DEG_ODPH_VHL_1	7	20	PF01847	0.461
DEG_SCF_FBW7_1	140	146	PF00400	0.479
DEG_SCF_FBW7_1	506	513	PF00400	0.507
DEG_SPOP_SBC_1	261	265	PF00917	0.579
DEG_SPOP_SBC_1	417	421	PF00917	0.543
DEG_SPOP_SBC_1	631	635	PF00917	0.579
DEG_SPOP_SBC_1	657	661	PF00917	0.479
DOC_AGCK_PIF_1	325	330	PF00069	0.529
DOC_ANK_TNKS_1	32	39	PF00023	0.477
DOC_CKS1_1	140	145	PF01111	0.569
DOC_CKS1_1	218	223	PF01111	0.687
DOC_CKS1_1	514	519	PF01111	0.521
DOC_CYCLIN_RxL_1	346	354	PF00134	0.318
DOC_CYCLIN_yCln2_LP_2	304	310	PF00134	0.587
DOC_CYCLIN_yCln2_LP_2	344	350	PF00134	0.415
DOC_MAPK_DCC_7	578	586	PF00069	0.424
DOC_MAPK_DCC_7	601	609	PF00069	0.508
DOC_MAPK_gen_1	16	25	PF00069	0.530
DOC_MAPK_gen_1	368	377	PF00069	0.434
DOC_MAPK_gen_1	578	586	PF00069	0.449
DOC_MAPK_HePTP_8	576	588	PF00069	0.418
DOC_MAPK_MEF2A_6	578	586	PF00069	0.424
DOC_MAPK_MEF2A_6	601	609	PF00069	0.508
DOC_PP2B_LxvP_1	344	347	PF13499	0.408
DOC_PP2B_LxvP_1	40	43	PF13499	0.600
DOC_PP2B_LxvP_1	426	429	PF13499	0.448
DOC_SPAK_OSR1_1	360	364	PF12202	0.492
DOC_USP7_MATH_1	143	147	PF00917	0.526
DOC_USP7_MATH_1	158	162	PF00917	0.651
DOC_USP7_MATH_1	176	180	PF00917	0.608
DOC_USP7_MATH_1	182	186	PF00917	0.676
DOC_USP7_MATH_1	24	28	PF00917	0.575
DOC_USP7_MATH_1	261	265	PF00917	0.800
DOC_USP7_MATH_1	31	35	PF00917	0.541
DOC_USP7_MATH_1	385	389	PF00917	0.469
DOC_USP7_MATH_1	417	421	PF00917	0.614
DOC_USP7_MATH_1	504	508	PF00917	0.451
DOC_USP7_MATH_1	539	543	PF00917	0.520
DOC_USP7_MATH_1	627	631	PF00917	0.647
DOC_USP7_MATH_1	656	660	PF00917	0.486
DOC_USP7_MATH_1	737	741	PF00917	0.579
DOC_USP7_MATH_1	749	753	PF00917	0.678
DOC_WW_Pin1_4	125	130	PF00397	0.570
DOC_WW_Pin1_4	139	144	PF00397	0.574
DOC_WW_Pin1_4	217	222	PF00397	0.634
DOC_WW_Pin1_4	457	462	PF00397	0.511
DOC_WW_Pin1_4	506	511	PF00397	0.507
DOC_WW_Pin1_4	513	518	PF00397	0.534
DOC_WW_Pin1_4	633	638	PF00397	0.626
DOC_WW_Pin1_4	659	664	PF00397	0.583
DOC_WW_Pin1_4	704	709	PF00397	0.567
DOC_WW_Pin1_4	81	86	PF00397	0.622
LIG_14-3-3_CanoR_1	144	150	PF00244	0.558
LIG_14-3-3_CanoR_1	283	293	PF00244	0.494
LIG_14-3-3_CanoR_1	352	356	PF00244	0.450
LIG_14-3-3_CanoR_1	558	566	PF00244	0.355
LIG_14-3-3_CanoR_1	755	763	PF00244	0.654
LIG_14-3-3_CanoR_1	80	84	PF00244	0.616
LIG_14-3-3_CanoR_1	86	95	PF00244	0.469
LIG_Actin_WH2_2	57	74	PF00022	0.478
LIG_Actin_WH2_2	721	737	PF00022	0.382
LIG_BIR_III_2	228	232	PF00653	0.687
LIG_BRCT_BRCA1_1	357	361	PF00533	0.490
LIG_BRCT_BRCA1_1	661	665	PF00533	0.598
LIG_CSL_BTD_1	82	85	PF09270	0.494
LIG_FHA_1	614	620	PF00498	0.643
LIG_FHA_1	66	72	PF00498	0.607
LIG_FHA_1	751	757	PF00498	0.598
LIG_FHA_2	218	224	PF00498	0.759
LIG_FHA_2	237	243	PF00498	0.521
LIG_FHA_2	285	291	PF00498	0.490
LIG_FHA_2	384	390	PF00498	0.565
LIG_FHA_2	469	475	PF00498	0.538
LIG_FHA_2	506	512	PF00498	0.623
LIG_FHA_2	538	544	PF00498	0.572
LIG_FHA_2	664	670	PF00498	0.674
LIG_FHA_2	745	751	PF00498	0.675
LIG_FHA_2	88	94	PF00498	0.537
LIG_Integrin_isoDGR_2	444	446	PF01839	0.554
LIG_IRF3_LxIS_1	581	587	PF10401	0.402
LIG_LIR_Gen_1	3	12	PF02991	0.460
LIG_LIR_Gen_1	570	576	PF02991	0.403
LIG_LIR_Gen_1	721	732	PF02991	0.423
LIG_LIR_Nem_3	3	7	PF02991	0.466
LIG_LIR_Nem_3	320	325	PF02991	0.451
LIG_LIR_Nem_3	334	339	PF02991	0.547
LIG_LIR_Nem_3	570	575	PF02991	0.410
LIG_LIR_Nem_3	721	727	PF02991	0.427
LIG_LYPXL_SIV_4	31	39	PF13949	0.471
LIG_PCNA_yPIPBox_3	433	447	PF02747	0.397
LIG_Pex14_1	357	361	PF04695	0.490
LIG_Pex14_2	321	325	PF04695	0.415
LIG_Pex14_2	800	804	PF04695	0.518
LIG_SH2_CRK	336	340	PF00017	0.470
LIG_SH2_CRK	499	503	PF00017	0.394
LIG_SH2_CRK	729	733	PF00017	0.366
LIG_SH2_STAP1	328	332	PF00017	0.528
LIG_SH2_STAT3	328	331	PF00017	0.475
LIG_SH2_STAT5	187	190	PF00017	0.645
LIG_SH2_STAT5	550	553	PF00017	0.445
LIG_SH2_STAT5	780	783	PF00017	0.467
LIG_SH3_2	204	209	PF14604	0.651
LIG_SH3_3	154	160	PF00018	0.664
LIG_SH3_3	201	207	PF00018	0.658
LIG_SH3_3	228	234	PF00018	0.620
LIG_SH3_3	3	9	PF00018	0.459
LIG_SH3_3	306	312	PF00018	0.593
LIG_SH3_3	40	46	PF00018	0.603
LIG_SH3_3	458	464	PF00018	0.506
LIG_SH3_3	498	504	PF00018	0.405
LIG_SH3_3	687	693	PF00018	0.632
LIG_SH3_5	221	225	PF00018	0.529
LIG_SUMO_SIM_anti_2	492	498	PF11976	0.401
LIG_SUMO_SIM_anti_2	58	66	PF11976	0.473
LIG_SUMO_SIM_par_1	582	587	PF11976	0.380
LIG_SUMO_SIM_par_1	640	645	PF11976	0.493
LIG_TRAF2_1	612	615	PF00917	0.619
LIG_TRAF2_1	622	625	PF00917	0.510
LIG_TYR_ITIM	727	732	PF00017	0.360
LIG_WRC_WIRS_1	1	6	PF05994	0.466
LIG_WW_2	503	506	PF00397	0.383
LIG_WW_3	203	207	PF00397	0.583
MOD_CDK_SPK_2	139	144	PF00069	0.531
MOD_CDK_SPK_2	81	86	PF00069	0.498
MOD_CDK_SPxK_1	139	145	PF00069	0.569
MOD_CDK_SPxK_1	81	87	PF00069	0.566
MOD_CDK_SPxxK_3	704	711	PF00069	0.551
MOD_CK1_1	118	124	PF00069	0.523
MOD_CK1_1	146	152	PF00069	0.534
MOD_CK1_1	161	167	PF00069	0.678
MOD_CK1_1	185	191	PF00069	0.643
MOD_CK1_1	418	424	PF00069	0.611
MOD_CK1_1	630	636	PF00069	0.600
MOD_CK1_1	65	71	PF00069	0.544
MOD_CK1_1	659	665	PF00069	0.604
MOD_CK1_1	744	750	PF00069	0.639
MOD_CK2_1	229	235	PF00069	0.689
MOD_CK2_1	284	290	PF00069	0.496
MOD_CK2_1	383	389	PF00069	0.554
MOD_CK2_1	468	474	PF00069	0.493
MOD_CK2_1	522	528	PF00069	0.553
MOD_CK2_1	744	750	PF00069	0.743
MOD_Cter_Amidation	398	401	PF01082	0.556
MOD_Cter_Amidation	444	447	PF01082	0.560
MOD_Cter_Amidation	78	81	PF01082	0.501
MOD_GlcNHglycan	120	123	PF01048	0.560
MOD_GlcNHglycan	182	185	PF01048	0.651
MOD_GlcNHglycan	255	258	PF01048	0.636
MOD_GlcNHglycan	26	29	PF01048	0.555
MOD_GlcNHglycan	264	267	PF01048	0.572
MOD_GlcNHglycan	33	36	PF01048	0.570
MOD_GlcNHglycan	357	360	PF01048	0.500
MOD_GlcNHglycan	421	424	PF01048	0.746
MOD_GlcNHglycan	491	494	PF01048	0.429
MOD_GlcNHglycan	629	632	PF01048	0.761
MOD_GlcNHglycan	644	647	PF01048	0.436
MOD_GlcNHglycan	672	675	PF01048	0.748
MOD_GlcNHglycan	701	704	PF01048	0.554
MOD_GlcNHglycan	742	746	PF01048	0.635
MOD_GlcNHglycan	818	823	PF01048	0.588
MOD_GSK3_1	114	121	PF00069	0.528
MOD_GSK3_1	139	146	PF00069	0.665
MOD_GSK3_1	176	183	PF00069	0.676
MOD_GSK3_1	351	358	PF00069	0.447
MOD_GSK3_1	415	422	PF00069	0.603
MOD_GSK3_1	506	513	PF00069	0.609
MOD_GSK3_1	516	523	PF00069	0.598
MOD_GSK3_1	533	540	PF00069	0.657
MOD_GSK3_1	586	593	PF00069	0.356
MOD_GSK3_1	627	634	PF00069	0.649
MOD_GSK3_1	63	70	PF00069	0.487
MOD_GSK3_1	659	666	PF00069	0.584
MOD_GSK3_1	712	719	PF00069	0.366
MOD_GSK3_1	737	744	PF00069	0.561
MOD_GSK3_1	750	757	PF00069	0.688
MOD_LATS_1	611	617	PF00433	0.631
MOD_NEK2_1	167	172	PF00069	0.697
MOD_NEK2_1	253	258	PF00069	0.644
MOD_NEK2_1	351	356	PF00069	0.341
MOD_NEK2_1	383	388	PF00069	0.447
MOD_NEK2_1	452	457	PF00069	0.702
MOD_NEK2_1	468	473	PF00069	0.447
MOD_NEK2_1	520	525	PF00069	0.643
MOD_NEK2_1	556	561	PF00069	0.477
MOD_NEK2_1	584	589	PF00069	0.398
MOD_NEK2_1	642	647	PF00069	0.429
MOD_NEK2_1	754	759	PF00069	0.619
MOD_NEK2_2	67	72	PF00069	0.483
MOD_OFUCOSY	96	101	PF10250	0.467
MOD_PIKK_1	188	194	PF00454	0.680
MOD_PIKK_1	229	235	PF00454	0.790
MOD_PIKK_1	284	290	PF00454	0.558
MOD_PIKK_1	510	516	PF00454	0.525
MOD_PIKK_1	87	93	PF00454	0.475
MOD_PKA_2	143	149	PF00069	0.749
MOD_PKA_2	167	173	PF00069	0.658
MOD_PKA_2	185	191	PF00069	0.527
MOD_PKA_2	351	357	PF00069	0.438
MOD_PKA_2	393	399	PF00069	0.539
MOD_PKA_2	754	760	PF00069	0.590
MOD_PKA_2	79	85	PF00069	0.732
MOD_PKB_1	172	180	PF00069	0.643
MOD_Plk_1	749	755	PF00069	0.651
MOD_Plk_1	796	802	PF00069	0.463
MOD_Plk_2-3	244	250	PF00069	0.669
MOD_Plk_4	452	458	PF00069	0.576
MOD_ProDKin_1	125	131	PF00069	0.570
MOD_ProDKin_1	139	145	PF00069	0.578
MOD_ProDKin_1	217	223	PF00069	0.635
MOD_ProDKin_1	457	463	PF00069	0.505
MOD_ProDKin_1	506	512	PF00069	0.512
MOD_ProDKin_1	513	519	PF00069	0.531
MOD_ProDKin_1	633	639	PF00069	0.617
MOD_ProDKin_1	659	665	PF00069	0.595
MOD_ProDKin_1	704	710	PF00069	0.552
MOD_ProDKin_1	81	87	PF00069	0.623
MOD_SUMO_for_1	612	615	PF00179	0.572
MOD_SUMO_rev_2	402	409	PF00179	0.494
MOD_SUMO_rev_2	615	622	PF00179	0.578
TRG_DiLeu_BaLyEn_6	473	478	PF01217	0.477
TRG_DiLeu_BaLyEn_6	571	576	PF01217	0.424
TRG_ENDOCYTIC_2	336	339	PF00928	0.478
TRG_ENDOCYTIC_2	729	732	PF00928	0.459
TRG_ER_diArg_1	143	145	PF00400	0.609
TRG_ER_diArg_1	171	174	PF00400	0.600
TRG_ER_diArg_1	205	208	PF00400	0.602
TRG_ER_diArg_1	379	381	PF00400	0.364
TRG_ER_diArg_1	43	45	PF00400	0.729
TRG_ER_diArg_1	446	448	PF00400	0.531
TRG_ER_diArg_1	485	487	PF00400	0.375
TRG_ER_diArg_1	813	816	PF00400	0.555
TRG_ER_diArg_1	85	87	PF00400	0.512
TRG_NLS_MonoExtC_3	171	176	PF00514	0.582
TRG_Pf-PMV_PEXEL_1	301	305	PF00026	0.626
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	813	818	PF00026	0.602
TRG_Pf-PMV_PEXEL_1	86	91	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM86	Leptomonas seymouri	43%	100%
A0A3Q8IBE1	Leishmania donovani	81%	100%
A4HDJ4	Leishmania braziliensis	66%	99%
E9AH60	Leishmania infantum	81%	100%
Q4QAI5	Leishmania major	82%	98%