LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Uncharacterized protein (Npk1-related protein kinase-like)

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein (Npk1-related protein kinase-like)
Gene product:
protein kinase, putative
Species:
Leishmania mexicana
UniProt:
E9AWZ0_LEIMU
TriTrypDb:
LmxM.24.1450
Length:
604

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 2
Pissara et al. no yes: 16
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 30
NetGPI no yes: 0, no: 30
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 4
GO:0005634 nucleus 5 3
GO:0005737 cytoplasm 2 3
GO:0005829 cytosol 2 1
GO:0031974 membrane-enclosed lumen 2 2
GO:0031981 nuclear lumen 5 2
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 2
GO:0043226 organelle 2 3
GO:0043227 membrane-bounded organelle 3 3
GO:0043229 intracellular organelle 3 3
GO:0043231 intracellular membrane-bounded organelle 4 3
GO:0043233 organelle lumen 3 2
GO:0070013 intracellular organelle lumen 4 2
GO:0097014 ciliary plasm 5 2
GO:0099568 cytoplasmic region 3 2
GO:0005654 nucleoplasm 2 1

Expansion

Sequence features

E9AWZ0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWZ0

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 31
GO:0006793 phosphorus metabolic process 3 31
GO:0006796 phosphate-containing compound metabolic process 4 31
GO:0006807 nitrogen compound metabolic process 2 31
GO:0008152 metabolic process 1 31
GO:0009987 cellular process 1 31
GO:0016310 phosphorylation 5 31
GO:0019538 protein metabolic process 3 31
GO:0036211 protein modification process 4 31
GO:0043170 macromolecule metabolic process 3 31
GO:0043412 macromolecule modification 4 31
GO:0044237 cellular metabolic process 2 31
GO:0044238 primary metabolic process 2 31
GO:0071704 organic substance metabolic process 2 31
GO:1901564 organonitrogen compound metabolic process 3 31
GO:0000281 mitotic cytokinesis 4 1
GO:0000910 cytokinesis 3 1
GO:0007165 signal transduction 2 4
GO:0022402 cell cycle process 2 1
GO:0035556 intracellular signal transduction 3 3
GO:0050789 regulation of biological process 2 4
GO:0050794 regulation of cellular process 3 4
GO:0061640 cytoskeleton-dependent cytokinesis 4 1
GO:0065007 biological regulation 1 4
GO:1903047 mitotic cell cycle process 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 31
GO:0003824 catalytic activity 1 31
GO:0004672 protein kinase activity 3 31
GO:0005488 binding 1 31
GO:0005524 ATP binding 5 31
GO:0016301 kinase activity 4 31
GO:0016740 transferase activity 2 31
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 31
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 31
GO:0017076 purine nucleotide binding 4 31
GO:0030554 adenyl nucleotide binding 5 31
GO:0032553 ribonucleotide binding 3 31
GO:0032555 purine ribonucleotide binding 4 31
GO:0032559 adenyl ribonucleotide binding 5 31
GO:0035639 purine ribonucleoside triphosphate binding 4 31
GO:0036094 small molecule binding 2 31
GO:0043167 ion binding 2 31
GO:0043168 anion binding 3 31
GO:0097159 organic cyclic compound binding 2 31
GO:0097367 carbohydrate derivative binding 2 31
GO:0140096 catalytic activity, acting on a protein 2 31
GO:1901265 nucleoside phosphate binding 3 31
GO:1901363 heterocyclic compound binding 2 31
GO:0004674 protein serine/threonine kinase activity 4 14
GO:0106310 protein serine kinase activity 4 1
GO:0004707 MAP kinase activity 5 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 248 252 PF00656 0.552
CLV_C14_Caspase3-7 506 510 PF00656 0.264
CLV_NRD_NRD_1 135 137 PF00675 0.552
CLV_NRD_NRD_1 163 165 PF00675 0.584
CLV_NRD_NRD_1 241 243 PF00675 0.638
CLV_NRD_NRD_1 326 328 PF00675 0.286
CLV_NRD_NRD_1 484 486 PF00675 0.301
CLV_NRD_NRD_1 51 53 PF00675 0.472
CLV_PCSK_KEX2_1 134 136 PF00082 0.582
CLV_PCSK_KEX2_1 163 165 PF00082 0.587
CLV_PCSK_KEX2_1 227 229 PF00082 0.545
CLV_PCSK_KEX2_1 24 26 PF00082 0.400
CLV_PCSK_KEX2_1 241 243 PF00082 0.644
CLV_PCSK_KEX2_1 326 328 PF00082 0.210
CLV_PCSK_KEX2_1 484 486 PF00082 0.297
CLV_PCSK_KEX2_1 586 588 PF00082 0.383
CLV_PCSK_KEX2_1 98 100 PF00082 0.558
CLV_PCSK_PC1ET2_1 134 136 PF00082 0.582
CLV_PCSK_PC1ET2_1 227 229 PF00082 0.548
CLV_PCSK_PC1ET2_1 24 26 PF00082 0.387
CLV_PCSK_PC1ET2_1 586 588 PF00082 0.299
CLV_PCSK_PC1ET2_1 98 100 PF00082 0.558
CLV_PCSK_PC7_1 582 588 PF00082 0.291
CLV_PCSK_SKI1_1 172 176 PF00082 0.531
CLV_PCSK_SKI1_1 361 365 PF00082 0.294
CLV_PCSK_SKI1_1 37 41 PF00082 0.394
CLV_PCSK_SKI1_1 422 426 PF00082 0.303
CLV_PCSK_SKI1_1 454 458 PF00082 0.362
CLV_PCSK_SKI1_1 484 488 PF00082 0.330
DEG_SPOP_SBC_1 196 200 PF00917 0.545
DOC_CKS1_1 130 135 PF01111 0.557
DOC_CKS1_1 260 265 PF01111 0.543
DOC_CKS1_1 497 502 PF01111 0.336
DOC_MAPK_gen_1 454 463 PF00069 0.324
DOC_PP1_RVXF_1 392 399 PF00149 0.262
DOC_PP1_RVXF_1 474 481 PF00149 0.275
DOC_PP4_FxxP_1 121 124 PF00568 0.573
DOC_PP4_FxxP_1 233 236 PF00568 0.519
DOC_USP7_MATH_1 183 187 PF00917 0.621
DOC_USP7_MATH_1 284 288 PF00917 0.534
DOC_USP7_MATH_1 345 349 PF00917 0.267
DOC_USP7_MATH_1 59 63 PF00917 0.553
DOC_USP7_MATH_1 65 69 PF00917 0.572
DOC_USP7_MATH_2 124 130 PF00917 0.542
DOC_USP7_UBL2_3 53 57 PF12436 0.499
DOC_USP7_UBL2_3 93 97 PF12436 0.540
DOC_WW_Pin1_4 104 109 PF00397 0.559
DOC_WW_Pin1_4 112 117 PF00397 0.549
DOC_WW_Pin1_4 129 134 PF00397 0.648
DOC_WW_Pin1_4 179 184 PF00397 0.531
DOC_WW_Pin1_4 259 264 PF00397 0.573
DOC_WW_Pin1_4 302 307 PF00397 0.501
DOC_WW_Pin1_4 496 501 PF00397 0.343
DOC_WW_Pin1_4 566 571 PF00397 0.258
LIG_14-3-3_CanoR_1 135 140 PF00244 0.553
LIG_14-3-3_CanoR_1 228 234 PF00244 0.590
LIG_14-3-3_CanoR_1 246 255 PF00244 0.523
LIG_14-3-3_CanoR_1 433 440 PF00244 0.274
LIG_APCC_ABBA_1 405 410 PF00400 0.267
LIG_BIR_III_4 509 513 PF00653 0.264
LIG_BRCT_BRCA1_1 25 29 PF00533 0.404
LIG_EVH1_2 229 233 PF00568 0.549
LIG_FHA_1 230 236 PF00498 0.562
LIG_FHA_1 297 303 PF00498 0.583
LIG_FHA_1 362 368 PF00498 0.451
LIG_FHA_1 434 440 PF00498 0.251
LIG_FHA_1 485 491 PF00498 0.303
LIG_FHA_2 246 252 PF00498 0.568
LIG_FHA_2 463 469 PF00498 0.346
LIG_FHA_2 527 533 PF00498 0.288
LIG_LIR_Apic_2 120 124 PF02991 0.574
LIG_LIR_Apic_2 231 236 PF02991 0.520
LIG_LIR_Apic_2 499 505 PF02991 0.331
LIG_LIR_Gen_1 299 309 PF02991 0.445
LIG_LIR_Gen_1 346 357 PF02991 0.390
LIG_LIR_Nem_3 299 304 PF02991 0.501
LIG_LIR_Nem_3 335 339 PF02991 0.355
LIG_LIR_Nem_3 346 352 PF02991 0.336
LIG_LIR_Nem_3 392 396 PF02991 0.342
LIG_SH2_CRK 336 340 PF00017 0.309
LIG_SH2_SRC 445 448 PF00017 0.288
LIG_SH2_STAP1 298 302 PF00017 0.443
LIG_SH2_STAP1 517 521 PF00017 0.318
LIG_SH2_STAT5 298 301 PF00017 0.447
LIG_SH2_STAT5 340 343 PF00017 0.323
LIG_SH2_STAT5 397 400 PF00017 0.305
LIG_SH2_STAT5 411 414 PF00017 0.392
LIG_SH2_STAT5 445 448 PF00017 0.327
LIG_SH3_1 423 429 PF00018 0.245
LIG_SH3_2 538 543 PF14604 0.311
LIG_SH3_3 103 109 PF00018 0.561
LIG_SH3_3 217 223 PF00018 0.627
LIG_SH3_3 257 263 PF00018 0.575
LIG_SH3_3 423 429 PF00018 0.313
LIG_SH3_3 535 541 PF00018 0.315
LIG_SH3_3 58 64 PF00018 0.522
LIG_SH3_3 71 77 PF00018 0.517
LIG_Sin3_3 41 48 PF02671 0.431
LIG_SUMO_SIM_par_1 371 376 PF11976 0.275
LIG_TRAF2_1 200 203 PF00917 0.543
LIG_TRAF2_1 291 294 PF00917 0.470
LIG_TRAF2_1 564 567 PF00917 0.267
LIG_WRC_WIRS_1 390 395 PF05994 0.267
MOD_CDK_SPK_2 129 134 PF00069 0.577
MOD_CDK_SPxK_1 129 135 PF00069 0.567
MOD_CDK_SPxxK_3 129 136 PF00069 0.555
MOD_CK1_1 125 131 PF00069 0.583
MOD_CK1_1 138 144 PF00069 0.551
MOD_CK1_1 259 265 PF00069 0.556
MOD_CK1_1 317 323 PF00069 0.446
MOD_CK1_1 491 497 PF00069 0.299
MOD_CK1_1 515 521 PF00069 0.363
MOD_CK2_1 114 120 PF00069 0.576
MOD_CK2_1 175 181 PF00069 0.520
MOD_CK2_1 197 203 PF00069 0.586
MOD_CK2_1 288 294 PF00069 0.482
MOD_CK2_1 526 532 PF00069 0.265
MOD_GlcNHglycan 100 103 PF01048 0.565
MOD_GlcNHglycan 116 119 PF01048 0.516
MOD_GlcNHglycan 148 151 PF01048 0.581
MOD_GlcNHglycan 157 160 PF01048 0.547
MOD_GlcNHglycan 25 28 PF01048 0.579
MOD_GlcNHglycan 290 293 PF01048 0.495
MOD_GlcNHglycan 417 420 PF01048 0.278
MOD_GlcNHglycan 440 443 PF01048 0.373
MOD_GlcNHglycan 509 513 PF01048 0.314
MOD_GlcNHglycan 514 517 PF01048 0.399
MOD_GlcNHglycan 544 547 PF01048 0.302
MOD_GlcNHglycan 554 557 PF01048 0.361
MOD_GlcNHglycan 67 70 PF01048 0.577
MOD_GlcNHglycan 74 77 PF01048 0.638
MOD_GSK3_1 122 129 PF00069 0.532
MOD_GSK3_1 146 153 PF00069 0.546
MOD_GSK3_1 175 182 PF00069 0.534
MOD_GSK3_1 264 271 PF00069 0.579
MOD_GSK3_1 284 291 PF00069 0.593
MOD_GSK3_1 296 303 PF00069 0.438
MOD_GSK3_1 313 320 PF00069 0.335
MOD_GSK3_1 397 404 PF00069 0.286
MOD_GSK3_1 427 434 PF00069 0.245
MOD_GSK3_1 484 491 PF00069 0.329
MOD_GSK3_1 492 499 PF00069 0.363
MOD_GSK3_1 508 515 PF00069 0.364
MOD_GSK3_1 522 529 PF00069 0.352
MOD_GSK3_1 554 561 PF00069 0.314
MOD_GSK3_1 98 105 PF00069 0.565
MOD_N-GLC_1 317 322 PF02516 0.388
MOD_N-GLC_2 389 391 PF02516 0.267
MOD_NEK2_1 1 6 PF00069 0.401
MOD_NEK2_1 155 160 PF00069 0.517
MOD_NEK2_1 197 202 PF00069 0.624
MOD_NEK2_1 313 318 PF00069 0.422
MOD_NEK2_1 462 467 PF00069 0.313
MOD_NEK2_1 552 557 PF00069 0.311
MOD_NEK2_2 284 289 PF00069 0.496
MOD_NEK2_2 345 350 PF00069 0.287
MOD_NEK2_2 82 87 PF00069 0.533
MOD_PIKK_1 198 204 PF00454 0.534
MOD_PIKK_1 268 274 PF00454 0.540
MOD_PIKK_1 433 439 PF00454 0.334
MOD_PIKK_1 445 451 PF00454 0.229
MOD_PIKK_1 468 474 PF00454 0.292
MOD_PIKK_1 488 494 PF00454 0.384
MOD_PK_1 256 262 PF00069 0.545
MOD_PKA_1 135 141 PF00069 0.542
MOD_PKA_1 326 332 PF00069 0.232
MOD_PKA_1 484 490 PF00069 0.267
MOD_PKA_1 586 592 PF00069 0.363
MOD_PKA_1 97 103 PF00069 0.563
MOD_PKA_2 135 141 PF00069 0.553
MOD_PKA_2 167 173 PF00069 0.642
MOD_PKA_2 245 251 PF00069 0.499
MOD_PKA_2 288 294 PF00069 0.517
MOD_PKA_2 326 332 PF00069 0.240
MOD_PKA_2 484 490 PF00069 0.301
MOD_PKA_2 51 57 PF00069 0.463
MOD_PKA_2 586 592 PF00069 0.345
MOD_PKA_2 98 104 PF00069 0.565
MOD_Plk_1 125 131 PF00069 0.542
MOD_Plk_1 151 157 PF00069 0.534
MOD_Plk_4 326 332 PF00069 0.258
MOD_Plk_4 335 341 PF00069 0.319
MOD_Plk_4 427 433 PF00069 0.301
MOD_Plk_4 492 498 PF00069 0.300
MOD_ProDKin_1 104 110 PF00069 0.555
MOD_ProDKin_1 112 118 PF00069 0.549
MOD_ProDKin_1 129 135 PF00069 0.652
MOD_ProDKin_1 179 185 PF00069 0.532
MOD_ProDKin_1 259 265 PF00069 0.574
MOD_ProDKin_1 302 308 PF00069 0.500
MOD_ProDKin_1 496 502 PF00069 0.343
MOD_ProDKin_1 566 572 PF00069 0.258
MOD_SUMO_for_1 601 604 PF00179 0.409
MOD_SUMO_rev_2 251 258 PF00179 0.533
MOD_SUMO_rev_2 90 100 PF00179 0.517
TRG_ENDOCYTIC_2 336 339 PF00928 0.335
TRG_ENDOCYTIC_2 340 343 PF00928 0.339
TRG_ER_diArg_1 163 165 PF00400 0.584
TRG_ER_diArg_1 240 242 PF00400 0.639
TRG_ER_diArg_1 325 327 PF00400 0.354
TRG_ER_diArg_1 484 486 PF00400 0.308
TRG_NES_CRM1_1 365 378 PF08389 0.290
TRG_NLS_MonoExtC_3 421 426 PF00514 0.293
TRG_NLS_MonoExtN_4 133 138 PF00514 0.546
TRG_Pf-PMV_PEXEL_1 163 167 PF00026 0.516
TRG_Pf-PMV_PEXEL_1 484 488 PF00026 0.267

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HTF0 Leptomonas seymouri 60% 96%
A0A3Q8ICW9 Leishmania donovani 91% 100%
A0A3Q8IH39 Leishmania donovani 21% 100%
A0A3Q8ITZ9 Leishmania donovani 25% 100%
A0A3Q8IVR8 Leishmania donovani 25% 100%
A0A3S5H5G0 Leishmania donovani 25% 100%
A4H459 Leishmania braziliensis 25% 100%
A4H601 Leishmania braziliensis 22% 100%
A4H9U7 Leishmania braziliensis 23% 100%
A4HDJ5 Leishmania braziliensis 80% 100%
A4HFA1 Leishmania braziliensis 26% 100%
A4HLJ9 Leishmania braziliensis 25% 100%
A4HNT2 Leishmania braziliensis 24% 100%
A4HSE2 Leishmania infantum 25% 100%
A4HUC8 Leishmania infantum 21% 100%
A4I0Y4 Leishmania infantum 91% 100%
A4I910 Leishmania infantum 25% 100%
A4ICR2 Leishmania infantum 25% 100%
C9ZL78 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
E9AJJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9AKB7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9AN28 Leishmania mexicana (strain MHOM/GT/2001/U1103) 21% 100%
E9ASJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9B3X5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
Q4Q204 Leishmania major 25% 100%
Q4Q449 Leishmania major 25% 100%
Q4QAI6 Leishmania major 89% 99%
Q4QHJ8 Leishmania major 21% 100%
Q4QJJ0 Leishmania major 25% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS