HpcH_HpaI domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HpcH/HpaI aldolase/citrate lyase family, putative

Species:

Leishmania mexicana

UniProt:

E9AWY9_LEIMU

TriTrypDb:

LmxM.24.1440

Length:

531

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWY9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWY9

Function

Biological processes
Term	Name	Level	Count
GO:0019222	regulation of metabolic process	3	1
GO:0030656	regulation of vitamin metabolic process	5	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0062012	regulation of small molecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0106064	regulation of cobalamin metabolic process	6	1
GO:1901401	regulation of tetrapyrrole metabolic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016829	lyase activity	2	3
GO:0016830	carbon-carbon lyase activity	3	1
GO:0016833	oxo-acid-lyase activity	4	1
GO:0047777	(S)-citramalyl-CoA lyase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.627
CLV_C14_Caspase3-7	450	454	PF00656	0.531
CLV_NRD_NRD_1	106	108	PF00675	0.594
CLV_NRD_NRD_1	192	194	PF00675	0.346
CLV_NRD_NRD_1	396	398	PF00675	0.337
CLV_NRD_NRD_1	47	49	PF00675	0.777
CLV_NRD_NRD_1	481	483	PF00675	0.632
CLV_NRD_NRD_1	521	523	PF00675	0.708
CLV_PCSK_KEX2_1	106	108	PF00082	0.587
CLV_PCSK_KEX2_1	191	193	PF00082	0.359
CLV_PCSK_KEX2_1	2	4	PF00082	0.663
CLV_PCSK_KEX2_1	396	398	PF00082	0.339
CLV_PCSK_KEX2_1	47	49	PF00082	0.777
CLV_PCSK_KEX2_1	521	523	PF00082	0.708
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.359
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.550
CLV_PCSK_SKI1_1	154	158	PF00082	0.288
CLV_PCSK_SKI1_1	466	470	PF00082	0.487
CLV_PCSK_SKI1_1	76	80	PF00082	0.547
DEG_Nend_UBRbox_1	1	4	PF02207	0.744
DOC_CDC14_PxL_1	167	175	PF14671	0.590
DOC_CKS1_1	332	337	PF01111	0.557
DOC_CYCLIN_RxL_1	80	88	PF00134	0.530
DOC_MAPK_gen_1	463	471	PF00069	0.538
DOC_MAPK_gen_1	81	89	PF00069	0.566
DOC_MAPK_MEF2A_6	81	89	PF00069	0.470
DOC_MAPK_RevD_3	178	192	PF00069	0.384
DOC_PP1_RVXF_1	152	159	PF00149	0.400
DOC_PP2B_LxvP_1	157	160	PF13499	0.504
DOC_PP2B_LxvP_1	328	331	PF13499	0.530
DOC_PP4_FxxP_1	296	299	PF00568	0.492
DOC_PP4_FxxP_1	386	389	PF00568	0.559
DOC_USP7_MATH_1	46	50	PF00917	0.724
DOC_USP7_MATH_1	70	74	PF00917	0.702
DOC_USP7_UBL2_3	479	483	PF12436	0.616
DOC_WW_Pin1_4	139	144	PF00397	0.668
DOC_WW_Pin1_4	241	246	PF00397	0.490
DOC_WW_Pin1_4	295	300	PF00397	0.490
DOC_WW_Pin1_4	331	336	PF00397	0.506
DOC_WW_Pin1_4	423	428	PF00397	0.513
DOC_WW_Pin1_4	520	525	PF00397	0.824
DOC_WW_Pin1_4	61	66	PF00397	0.636
LIG_14-3-3_CanoR_1	396	400	PF00244	0.561
LIG_14-3-3_CanoR_1	47	51	PF00244	0.744
LIG_14-3-3_CterR_2	528	531	PF00244	0.818
LIG_BIR_III_2	233	237	PF00653	0.541
LIG_BRCT_BRCA1_1	154	158	PF00533	0.530
LIG_BRCT_BRCA1_1	57	61	PF00533	0.744
LIG_CaM_IQ_9	202	218	PF13499	0.683
LIG_Clathr_ClatBox_1	404	408	PF01394	0.546
LIG_FHA_1	249	255	PF00498	0.561
LIG_FHA_1	25	31	PF00498	0.760
LIG_FHA_1	276	282	PF00498	0.491
LIG_FHA_1	365	371	PF00498	0.555
LIG_FHA_1	488	494	PF00498	0.734
LIG_FHA_2	340	346	PF00498	0.464
LIG_FHA_2	424	430	PF00498	0.524
LIG_FHA_2	448	454	PF00498	0.560
LIG_LIR_Apic_2	284	288	PF02991	0.492
LIG_LIR_Apic_2	383	389	PF02991	0.561
LIG_LIR_Nem_3	233	238	PF02991	0.548
LIG_LIR_Nem_3	244	250	PF02991	0.522
LIG_LIR_Nem_3	88	92	PF02991	0.603
LIG_LYPXL_yS_3	235	238	PF13949	0.443
LIG_NRBOX	257	263	PF00104	0.530
LIG_SH2_CRK	247	251	PF00017	0.384
LIG_SH2_NCK_1	247	251	PF00017	0.590
LIG_SH2_NCK_1	425	429	PF00017	0.597
LIG_SH2_PTP2	285	288	PF00017	0.530
LIG_SH2_SRC	247	250	PF00017	0.590
LIG_SH2_SRC	285	288	PF00017	0.508
LIG_SH2_STAT5	285	288	PF00017	0.498
LIG_SH2_STAT5	425	428	PF00017	0.505
LIG_SH2_STAT5	86	89	PF00017	0.653
LIG_SH3_3	168	174	PF00018	0.546
LIG_SH3_3	333	339	PF00018	0.384
LIG_SH3_3	6	12	PF00018	0.750
LIG_SUMO_SIM_anti_2	297	304	PF11976	0.532
LIG_SUMO_SIM_par_1	178	185	PF11976	0.512
LIG_TRAF2_1	398	401	PF00917	0.590
LIG_UBA3_1	404	410	PF00899	0.422
MOD_CDK_SPK_2	61	66	PF00069	0.692
MOD_CDK_SPxK_1	520	526	PF00069	0.825
MOD_CK1_1	298	304	PF00069	0.425
MOD_CK1_1	49	55	PF00069	0.741
MOD_CK1_1	513	519	PF00069	0.534
MOD_CK1_1	56	62	PF00069	0.728
MOD_CK2_1	395	401	PF00069	0.484
MOD_CK2_1	423	429	PF00069	0.470
MOD_GlcNHglycan	323	327	PF01048	0.432
MOD_GlcNHglycan	443	447	PF01048	0.630
MOD_GlcNHglycan	473	476	PF01048	0.619
MOD_GlcNHglycan	58	61	PF01048	0.771
MOD_GlcNHglycan	68	71	PF01048	0.519
MOD_GSK3_1	139	146	PF00069	0.655
MOD_GSK3_1	271	278	PF00069	0.443
MOD_GSK3_1	36	43	PF00069	0.697
MOD_GSK3_1	46	53	PF00069	0.777
MOD_GSK3_1	477	484	PF00069	0.674
MOD_GSK3_1	55	62	PF00069	0.743
MOD_GSK3_1	66	73	PF00069	0.614
MOD_N-GLC_1	513	518	PF02516	0.533
MOD_NEK2_1	182	187	PF00069	0.351
MOD_NEK2_1	24	29	PF00069	0.618
MOD_NEK2_1	35	40	PF00069	0.779
MOD_NEK2_1	363	368	PF00069	0.459
MOD_NEK2_1	395	400	PF00069	0.380
MOD_NEK2_1	477	482	PF00069	0.597
MOD_NEK2_1	50	55	PF00069	0.607
MOD_NEK2_2	272	277	PF00069	0.382
MOD_PIKK_1	208	214	PF00454	0.640
MOD_PKA_2	35	41	PF00069	0.765
MOD_PKA_2	395	401	PF00069	0.498
MOD_PKA_2	46	52	PF00069	0.649
MOD_PKA_2	481	487	PF00069	0.686
MOD_Plk_1	182	188	PF00069	0.443
MOD_Plk_1	447	453	PF00069	0.572
MOD_Plk_1	477	483	PF00069	0.639
MOD_Plk_1	70	76	PF00069	0.597
MOD_Plk_2-3	345	351	PF00069	0.307
MOD_Plk_2-3	448	454	PF00069	0.576
MOD_Plk_4	298	304	PF00069	0.369
MOD_Plk_4	408	414	PF00069	0.403
MOD_Plk_4	70	76	PF00069	0.587
MOD_ProDKin_1	139	145	PF00069	0.658
MOD_ProDKin_1	241	247	PF00069	0.344
MOD_ProDKin_1	295	301	PF00069	0.344
MOD_ProDKin_1	331	337	PF00069	0.366
MOD_ProDKin_1	423	429	PF00069	0.517
MOD_ProDKin_1	520	526	PF00069	0.825
MOD_ProDKin_1	61	67	PF00069	0.633
MOD_SUMO_rev_2	345	354	PF00179	0.329
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.648
TRG_DiLeu_BaLyEn_6	234	239	PF01217	0.443
TRG_DiLeu_BaLyEn_6	303	308	PF01217	0.484
TRG_DiLeu_BaLyEn_6	400	405	PF01217	0.422
TRG_ENDOCYTIC_2	235	238	PF00928	0.443
TRG_ENDOCYTIC_2	247	250	PF00928	0.443
TRG_ENDOCYTIC_2	316	319	PF00928	0.344
TRG_ENDOCYTIC_2	321	324	PF00928	0.344
TRG_ENDOCYTIC_2	86	89	PF00928	0.596
TRG_ER_diArg_1	192	195	PF00400	0.422
TRG_ER_diArg_1	395	397	PF00400	0.410
TRG_ER_diArg_1	46	48	PF00400	0.784
TRG_ER_diArg_1	520	522	PF00400	0.707
TRG_ER_diArg_1	526	529	PF00400	0.708
TRG_ER_diArg_1	92	95	PF00400	0.537
TRG_NLS_MonoExtC_3	190	195	PF00514	0.422
TRG_Pf-PMV_PEXEL_1	397	401	PF00026	0.377
TRG_Pf-PMV_PEXEL_1	403	408	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	83	88	PF00026	0.616

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHZ0	Leptomonas seymouri	56%	99%
A0A1X0NVS5	Trypanosomatidae	31%	100%
A0A3S7WYJ5	Leishmania donovani	84%	99%
A4HDJ6	Leishmania braziliensis	70%	99%
C9ZWG8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AH59	Leishmania infantum	84%	99%
Q4QAI7	Leishmania major	85%	100%
V5DBJ5	Trypanosoma cruzi	34%	100%