Glycosyltransferase family 61 protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWY8_LEIMU

TriTrypDb:

LmxM.24.1436

Length:

425

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AWY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWY8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016740	transferase activity	2	8
GO:0016757	glycosyltransferase activity	3	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.474
CLV_NRD_NRD_1	251	253	PF00675	0.356
CLV_NRD_NRD_1	325	327	PF00675	0.496
CLV_PCSK_FUR_1	249	253	PF00082	0.312
CLV_PCSK_KEX2_1	249	251	PF00082	0.353
CLV_PCSK_KEX2_1	325	327	PF00082	0.587
CLV_PCSK_KEX2_1	379	381	PF00082	0.435
CLV_PCSK_KEX2_1	387	389	PF00082	0.549
CLV_PCSK_KEX2_1	41	43	PF00082	0.659
CLV_PCSK_PC1ET2_1	379	381	PF00082	0.435
CLV_PCSK_PC1ET2_1	387	389	PF00082	0.549
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.659
CLV_PCSK_SKI1_1	105	109	PF00082	0.551
CLV_PCSK_SKI1_1	42	46	PF00082	0.576
DEG_APCC_DBOX_1	251	259	PF00400	0.338
DEG_Nend_UBRbox_4	1	3	PF02207	0.545
DEG_SPOP_SBC_1	122	126	PF00917	0.401
DOC_CKS1_1	223	228	PF01111	0.433
DOC_MAPK_gen_1	101	110	PF00069	0.337
DOC_MAPK_gen_1	249	258	PF00069	0.393
DOC_MAPK_gen_1	390	398	PF00069	0.378
DOC_MAPK_JIP1_4	252	258	PF00069	0.278
DOC_MAPK_MEF2A_6	302	310	PF00069	0.245
DOC_PP1_RVXF_1	103	110	PF00149	0.488
DOC_PP1_RVXF_1	252	258	PF00149	0.390
DOC_PP1_RVXF_1	274	281	PF00149	0.306
DOC_PP4_FxxP_1	135	138	PF00568	0.469
DOC_PP4_FxxP_1	169	172	PF00568	0.516
DOC_PP4_FxxP_1	223	226	PF00568	0.480
DOC_USP7_MATH_1	121	125	PF00917	0.660
DOC_USP7_MATH_1	14	18	PF00917	0.599
DOC_USP7_MATH_1	227	231	PF00917	0.458
DOC_USP7_MATH_1	290	294	PF00917	0.198
DOC_USP7_MATH_1	358	362	PF00917	0.247
DOC_USP7_UBL2_3	41	45	PF12436	0.648
DOC_USP7_UBL2_3	98	102	PF12436	0.340
DOC_WW_Pin1_4	138	143	PF00397	0.615
DOC_WW_Pin1_4	222	227	PF00397	0.469
LIG_14-3-3_CanoR_1	402	406	PF00244	0.400
LIG_Actin_WH2_2	28	43	PF00022	0.582
LIG_APCC_ABBA_1	280	285	PF00400	0.478
LIG_APCC_ABBAyCdc20_2	105	111	PF00400	0.332
LIG_BRCT_BRCA1_1	140	144	PF00533	0.642
LIG_Clathr_ClatBox_1	407	411	PF01394	0.285
LIG_CSL_BTD_1	231	234	PF09270	0.491
LIG_FHA_1	20	26	PF00498	0.706
LIG_FHA_1	223	229	PF00498	0.468
LIG_FHA_1	34	40	PF00498	0.535
LIG_FHA_1	63	69	PF00498	0.558
LIG_FHA_2	235	241	PF00498	0.541
LIG_FHA_2	322	328	PF00498	0.308
LIG_FHA_2	329	335	PF00498	0.322
LIG_FHA_2	401	407	PF00498	0.278
LIG_KLC1_Yacidic_2	281	285	PF13176	0.338
LIG_LIR_Apic_2	221	226	PF02991	0.338
LIG_LIR_Apic_2	345	351	PF02991	0.315
LIG_LIR_Gen_1	27	35	PF02991	0.608
LIG_LIR_Gen_1	403	412	PF02991	0.387
LIG_LIR_Nem_3	140	146	PF02991	0.636
LIG_LIR_Nem_3	27	31	PF02991	0.617
LIG_LIR_Nem_3	277	283	PF02991	0.384
LIG_LIR_Nem_3	334	338	PF02991	0.404
LIG_LIR_Nem_3	403	408	PF02991	0.449
LIG_MLH1_MIPbox_1	140	144	PF16413	0.687
LIG_Pex14_2	165	169	PF04695	0.549
LIG_Pex14_2	87	91	PF04695	0.551
LIG_PTB_Apo_2	192	199	PF02174	0.479
LIG_SH2_CRK	405	409	PF00017	0.394
LIG_SH2_CRK	46	50	PF00017	0.392
LIG_SH2_CRK	9	13	PF00017	0.569
LIG_SH2_GRB2like	28	31	PF00017	0.588
LIG_SH2_NCK_1	338	342	PF00017	0.301
LIG_SH2_NCK_1	405	409	PF00017	0.394
LIG_SH2_PTP2	359	362	PF00017	0.353
LIG_SH2_SRC	303	306	PF00017	0.216
LIG_SH2_STAP1	28	32	PF00017	0.588
LIG_SH2_STAP1	303	307	PF00017	0.216
LIG_SH2_STAP1	374	378	PF00017	0.383
LIG_SH2_STAT5	163	166	PF00017	0.477
LIG_SH2_STAT5	224	227	PF00017	0.482
LIG_SH2_STAT5	283	286	PF00017	0.342
LIG_SH2_STAT5	288	291	PF00017	0.307
LIG_SH2_STAT5	299	302	PF00017	0.406
LIG_SH2_STAT5	359	362	PF00017	0.320
LIG_SH2_STAT5	69	72	PF00017	0.620
LIG_SH3_3	8	14	PF00018	0.525
LIG_TYR_ITIM	44	49	PF00017	0.554
LIG_TYR_ITSM	401	408	PF00017	0.282
MOD_CDK_SPxxK_3	222	229	PF00069	0.510
MOD_CK1_1	136	142	PF00069	0.551
MOD_CK1_1	17	23	PF00069	0.578
MOD_CK1_1	24	30	PF00069	0.589
MOD_CK1_1	270	276	PF00069	0.261
MOD_CK1_1	328	334	PF00069	0.425
MOD_CK1_1	62	68	PF00069	0.517
MOD_CK2_1	207	213	PF00069	0.416
MOD_CK2_1	234	240	PF00069	0.404
MOD_CK2_1	290	296	PF00069	0.390
MOD_CK2_1	321	327	PF00069	0.198
MOD_CK2_1	328	334	PF00069	0.334
MOD_CK2_1	78	84	PF00069	0.609
MOD_GlcNHglycan	184	187	PF01048	0.508
MOD_GlcNHglycan	209	212	PF01048	0.503
MOD_GlcNHglycan	229	232	PF01048	0.570
MOD_GlcNHglycan	292	295	PF01048	0.338
MOD_GlcNHglycan	354	357	PF01048	0.434
MOD_GlcNHglycan	4	7	PF01048	0.629
MOD_GlcNHglycan	61	64	PF01048	0.675
MOD_GSK3_1	15	22	PF00069	0.627
MOD_GSK3_1	178	185	PF00069	0.571
MOD_GSK3_1	214	221	PF00069	0.479
MOD_GSK3_1	266	273	PF00069	0.261
MOD_GSK3_1	286	293	PF00069	0.247
MOD_GSK3_1	321	328	PF00069	0.374
MOD_GSK3_1	369	376	PF00069	0.424
MOD_GSK3_1	396	403	PF00069	0.370
MOD_N-GLC_1	14	19	PF02516	0.627
MOD_N-GLC_1	33	38	PF02516	0.552
MOD_NEK2_1	182	187	PF00069	0.534
MOD_NEK2_1	321	326	PF00069	0.309
MOD_NEK2_1	369	374	PF00069	0.598
MOD_NEK2_1	396	401	PF00069	0.556
MOD_NEK2_1	59	64	PF00069	0.505
MOD_PIKK_1	283	289	PF00454	0.338
MOD_PK_1	218	224	PF00069	0.328
MOD_PKA_1	325	331	PF00069	0.465
MOD_PKA_2	325	331	PF00069	0.294
MOD_PKA_2	401	407	PF00069	0.383
MOD_Plk_1	14	20	PF00069	0.629
MOD_Plk_1	214	220	PF00069	0.330
MOD_Plk_1	266	272	PF00069	0.198
MOD_Plk_4	218	224	PF00069	0.390
MOD_Plk_4	267	273	PF00069	0.397
MOD_Plk_4	343	349	PF00069	0.410
MOD_Plk_4	358	364	PF00069	0.295
MOD_Plk_4	67	73	PF00069	0.645
MOD_Plk_4	78	84	PF00069	0.539
MOD_ProDKin_1	138	144	PF00069	0.615
MOD_ProDKin_1	222	228	PF00069	0.460
MOD_SUMO_for_1	378	381	PF00179	0.468
MOD_SUMO_rev_2	361	370	PF00179	0.490
MOD_SUMO_rev_2	381	389	PF00179	0.401
MOD_SUMO_rev_2	92	99	PF00179	0.545
TRG_DiLeu_BaEn_4	84	90	PF01217	0.554
TRG_DiLeu_BaLyEn_6	251	256	PF01217	0.288
TRG_ENDOCYTIC_2	187	190	PF00928	0.446
TRG_ENDOCYTIC_2	28	31	PF00928	0.588
TRG_ENDOCYTIC_2	303	306	PF00928	0.216
TRG_ENDOCYTIC_2	359	362	PF00928	0.282
TRG_ENDOCYTIC_2	405	408	PF00928	0.364
TRG_ENDOCYTIC_2	46	49	PF00928	0.539
TRG_ENDOCYTIC_2	69	72	PF00928	0.559
TRG_ENDOCYTIC_2	9	12	PF00928	0.613
TRG_ER_diArg_1	249	252	PF00400	0.273
TRG_ER_diArg_1	389	392	PF00400	0.400
TRG_Pf-PMV_PEXEL_1	330	334	PF00026	0.317
TRG_Pf-PMV_PEXEL_1	380	385	PF00026	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBV1	Leptomonas seymouri	56%	67%
A0A0N1PD55	Leptomonas seymouri	24%	67%
A0A0S4J0X7	Bodo saltans	28%	69%
A0A1X0NW39	Trypanosomatidae	26%	74%
A4HDJ7	Leishmania braziliensis	74%	100%
V5BJI5	Trypanosoma cruzi	23%	73%