Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AWY7_LEIMU

TriTrypDb:

LmxM.24.1435

Length:

914

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWY7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWY7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	26	30	PF00656	0.729
CLV_C14_Caspase3-7	346	350	PF00656	0.629
CLV_C14_Caspase3-7	632	636	PF00656	0.568
CLV_C14_Caspase3-7	637	641	PF00656	0.543
CLV_C14_Caspase3-7	710	714	PF00656	0.562
CLV_C14_Caspase3-7	761	765	PF00656	0.812
CLV_MEL_PAP_1	466	472	PF00089	0.750
CLV_NRD_NRD_1	131	133	PF00675	0.581
CLV_NRD_NRD_1	382	384	PF00675	0.804
CLV_NRD_NRD_1	676	678	PF00675	0.823
CLV_NRD_NRD_1	734	736	PF00675	0.682
CLV_NRD_NRD_1	749	751	PF00675	0.588
CLV_NRD_NRD_1	886	888	PF00675	0.571
CLV_NRD_NRD_1	906	908	PF00675	0.776
CLV_NRD_NRD_1	909	911	PF00675	0.802
CLV_PCSK_FUR_1	677	681	PF00082	0.773
CLV_PCSK_FUR_1	907	911	PF00082	0.755
CLV_PCSK_KEX2_1	131	133	PF00082	0.581
CLV_PCSK_KEX2_1	675	677	PF00082	0.820
CLV_PCSK_KEX2_1	679	681	PF00082	0.792
CLV_PCSK_KEX2_1	734	736	PF00082	0.702
CLV_PCSK_KEX2_1	749	751	PF00082	0.564
CLV_PCSK_KEX2_1	886	888	PF00082	0.687
CLV_PCSK_KEX2_1	906	908	PF00082	0.659
CLV_PCSK_KEX2_1	909	911	PF00082	0.802
CLV_PCSK_PC1ET2_1	679	681	PF00082	0.800
CLV_PCSK_PC7_1	675	681	PF00082	0.547
CLV_PCSK_SKI1_1	383	387	PF00082	0.687
CLV_PCSK_SKI1_1	405	409	PF00082	0.695
CLV_PCSK_SKI1_1	426	430	PF00082	0.608
CLV_PCSK_SKI1_1	649	653	PF00082	0.522
CLV_PCSK_SKI1_1	676	680	PF00082	0.837
CLV_PCSK_SKI1_1	723	727	PF00082	0.797
CLV_PCSK_SKI1_1	799	803	PF00082	0.776
DEG_APCC_DBOX_1	722	730	PF00400	0.530
DEG_SPOP_SBC_1	285	289	PF00917	0.605
DEG_SPOP_SBC_1	341	345	PF00917	0.700
DEG_SPOP_SBC_1	399	403	PF00917	0.723
DEG_SPOP_SBC_1	545	549	PF00917	0.664
DEG_SPOP_SBC_1	592	596	PF00917	0.573
DEG_SPOP_SBC_1	619	623	PF00917	0.561
DEG_SPOP_SBC_1	79	83	PF00917	0.687
DOC_ANK_TNKS_1	187	194	PF00023	0.776
DOC_ANK_TNKS_1	227	234	PF00023	0.541
DOC_CKS1_1	174	179	PF01111	0.541
DOC_CYCLIN_yCln2_LP_2	335	341	PF00134	0.515
DOC_CYCLIN_yCln2_LP_2	694	700	PF00134	0.630
DOC_MAPK_gen_1	383	389	PF00069	0.803
DOC_MAPK_gen_1	658	666	PF00069	0.737
DOC_MAPK_MEF2A_6	475	482	PF00069	0.545
DOC_PP2B_LxvP_1	335	338	PF13499	0.517
DOC_PP2B_LxvP_1	385	388	PF13499	0.720
DOC_USP7_MATH_1	212	216	PF00917	0.747
DOC_USP7_MATH_1	283	287	PF00917	0.636
DOC_USP7_MATH_1	340	344	PF00917	0.701
DOC_USP7_MATH_1	399	403	PF00917	0.677
DOC_USP7_MATH_1	418	422	PF00917	0.766
DOC_USP7_MATH_1	431	435	PF00917	0.579
DOC_USP7_MATH_1	436	440	PF00917	0.569
DOC_USP7_MATH_1	508	512	PF00917	0.737
DOC_USP7_MATH_1	524	528	PF00917	0.628
DOC_USP7_MATH_1	541	545	PF00917	0.821
DOC_USP7_MATH_1	586	590	PF00917	0.783
DOC_USP7_MATH_1	592	596	PF00917	0.712
DOC_USP7_MATH_1	620	624	PF00917	0.575
DOC_USP7_MATH_1	69	73	PF00917	0.609
DOC_USP7_MATH_1	79	83	PF00917	0.658
DOC_USP7_MATH_1	791	795	PF00917	0.672
DOC_USP7_MATH_1	882	886	PF00917	0.789
DOC_USP7_MATH_1	98	102	PF00917	0.635
DOC_WW_Pin1_4	166	171	PF00397	0.797
DOC_WW_Pin1_4	173	178	PF00397	0.542
DOC_WW_Pin1_4	204	209	PF00397	0.785
DOC_WW_Pin1_4	238	243	PF00397	0.711
DOC_WW_Pin1_4	278	283	PF00397	0.744
DOC_WW_Pin1_4	327	332	PF00397	0.828
DOC_WW_Pin1_4	426	431	PF00397	0.734
DOC_WW_Pin1_4	453	458	PF00397	0.766
DOC_WW_Pin1_4	498	503	PF00397	0.770
DOC_WW_Pin1_4	534	539	PF00397	0.798
DOC_WW_Pin1_4	587	592	PF00397	0.719
DOC_WW_Pin1_4	593	598	PF00397	0.681
DOC_WW_Pin1_4	615	620	PF00397	0.809
DOC_WW_Pin1_4	623	628	PF00397	0.829
DOC_WW_Pin1_4	641	646	PF00397	0.781
DOC_WW_Pin1_4	733	738	PF00397	0.526
DOC_WW_Pin1_4	888	893	PF00397	0.670
DOC_WW_Pin1_4	94	99	PF00397	0.789
LIG_14-3-3_CanoR_1	188	192	PF00244	0.853
LIG_14-3-3_CanoR_1	322	326	PF00244	0.701
LIG_14-3-3_CanoR_1	362	369	PF00244	0.624
LIG_14-3-3_CanoR_1	383	388	PF00244	0.683
LIG_14-3-3_CanoR_1	585	591	PF00244	0.789
LIG_14-3-3_CanoR_1	649	654	PF00244	0.535
LIG_14-3-3_CanoR_1	78	88	PF00244	0.701
LIG_14-3-3_CanoR_1	815	822	PF00244	0.634
LIG_14-3-3_CanoR_1	94	98	PF00244	0.647
LIG_APCC_ABBA_1	664	669	PF00400	0.821
LIG_BIR_II_1	1	5	PF00653	0.809
LIG_BIR_III_2	296	300	PF00653	0.785
LIG_BIR_III_2	6	10	PF00653	0.562
LIG_BIR_III_4	261	265	PF00653	0.529
LIG_BRCT_BRCA1_1	216	220	PF00533	0.548
LIG_BRCT_BRCA1_1	437	441	PF00533	0.748
LIG_DLG_GKlike_1	830	838	PF00625	0.702
LIG_eIF4E_1	811	817	PF01652	0.739
LIG_FHA_1	114	120	PF00498	0.589
LIG_FHA_1	220	226	PF00498	0.806
LIG_FHA_1	285	291	PF00498	0.691
LIG_FHA_1	293	299	PF00498	0.758
LIG_FHA_1	373	379	PF00498	0.793
LIG_FHA_1	570	576	PF00498	0.856
LIG_FHA_1	609	615	PF00498	0.692
LIG_FHA_1	641	647	PF00498	0.654
LIG_FHA_2	194	200	PF00498	0.578
LIG_FHA_2	389	395	PF00498	0.648
LIG_FHA_2	630	636	PF00498	0.559
LIG_FHA_2	691	697	PF00498	0.546
LIG_FHA_2	783	789	PF00498	0.756
LIG_FHA_2	856	862	PF00498	0.840
LIG_FHA_2	863	869	PF00498	0.779
LIG_Integrin_isoDGR_2	134	136	PF01839	0.793
LIG_LIR_Apic_2	739	745	PF02991	0.540
LIG_LIR_Gen_1	438	445	PF02991	0.745
LIG_LIR_Gen_1	464	472	PF02991	0.742
LIG_LIR_Nem_3	438	444	PF02991	0.749
LIG_LIR_Nem_3	464	470	PF02991	0.741
LIG_NRP_CendR_1	911	914	PF00754	0.549
LIG_Pex14_2	254	258	PF04695	0.692
LIG_PROFILIN_1	518	524	PF00235	0.535
LIG_SH2_CRK	467	471	PF00017	0.828
LIG_SH2_CRK	742	746	PF00017	0.537
LIG_SH2_NCK_1	467	471	PF00017	0.828
LIG_SH2_STAP1	667	671	PF00017	0.812
LIG_SH2_STAT3	811	814	PF00017	0.743
LIG_SH2_STAT5	309	312	PF00017	0.818
LIG_SH2_STAT5	811	814	PF00017	0.674
LIG_SH2_STAT5	834	837	PF00017	0.770
LIG_SH3_1	561	567	PF00018	0.857
LIG_SH3_3	276	282	PF00018	0.692
LIG_SH3_3	351	357	PF00018	0.738
LIG_SH3_3	483	489	PF00018	0.817
LIG_SH3_3	515	521	PF00018	0.614
LIG_SH3_3	561	567	PF00018	0.814
LIG_SH3_3	624	630	PF00018	0.825
LIG_SH3_3	819	825	PF00018	0.554
LIG_SUMO_SIM_par_1	202	207	PF11976	0.765
LIG_SUMO_SIM_par_1	572	584	PF11976	0.832
LIG_TRAF2_1	183	186	PF00917	0.850
LIG_TRAF2_1	30	33	PF00917	0.611
LIG_TRAF2_1	316	319	PF00917	0.547
LIG_TYR_ITIM	465	470	PF00017	0.826
LIG_WW_3	75	79	PF00397	0.778
MOD_CDC14_SPxK_1	97	100	PF00782	0.639
MOD_CDK_SPxK_1	94	100	PF00069	0.638
MOD_CK1_1	166	172	PF00069	0.702
MOD_CK1_1	179	185	PF00069	0.629
MOD_CK1_1	211	217	PF00069	0.749
MOD_CK1_1	241	247	PF00069	0.684
MOD_CK1_1	286	292	PF00069	0.686
MOD_CK1_1	320	326	PF00069	0.702
MOD_CK1_1	327	333	PF00069	0.719
MOD_CK1_1	343	349	PF00069	0.576
MOD_CK1_1	400	406	PF00069	0.789
MOD_CK1_1	434	440	PF00069	0.579
MOD_CK1_1	503	509	PF00069	0.608
MOD_CK1_1	544	550	PF00069	0.703
MOD_CK1_1	595	601	PF00069	0.685
MOD_CK1_1	618	624	PF00069	0.761
MOD_CK1_1	626	632	PF00069	0.808
MOD_CK1_1	63	69	PF00069	0.742
MOD_CK1_1	782	788	PF00069	0.543
MOD_CK1_1	81	87	PF00069	0.716
MOD_CK1_1	833	839	PF00069	0.681
MOD_CK1_1	891	897	PF00069	0.728
MOD_CK1_1	90	96	PF00069	0.619
MOD_CK2_1	179	185	PF00069	0.851
MOD_CK2_1	193	199	PF00069	0.611
MOD_CK2_1	25	31	PF00069	0.786
MOD_CK2_1	388	394	PF00069	0.640
MOD_CK2_1	574	580	PF00069	0.849
MOD_CK2_1	791	797	PF00069	0.673
MOD_CK2_1	80	86	PF00069	0.777
MOD_DYRK1A_RPxSP_1	94	98	PF00069	0.787
MOD_GlcNHglycan	1	4	PF01048	0.724
MOD_GlcNHglycan	127	130	PF01048	0.834
MOD_GlcNHglycan	165	168	PF01048	0.759
MOD_GlcNHglycan	181	184	PF01048	0.825
MOD_GlcNHglycan	214	217	PF01048	0.798
MOD_GlcNHglycan	228	231	PF01048	0.835
MOD_GlcNHglycan	258	261	PF01048	0.726
MOD_GlcNHglycan	326	329	PF01048	0.567
MOD_GlcNHglycan	420	423	PF01048	0.686
MOD_GlcNHglycan	438	441	PF01048	0.697
MOD_GlcNHglycan	449	452	PF01048	0.833
MOD_GlcNHglycan	45	48	PF01048	0.775
MOD_GlcNHglycan	470	473	PF01048	0.576
MOD_GlcNHglycan	510	513	PF01048	0.785
MOD_GlcNHglycan	514	517	PF01048	0.730
MOD_GlcNHglycan	543	546	PF01048	0.761
MOD_GlcNHglycan	572	575	PF01048	0.777
MOD_GlcNHglycan	637	640	PF01048	0.814
MOD_GlcNHglycan	649	652	PF01048	0.667
MOD_GlcNHglycan	71	74	PF01048	0.668
MOD_GlcNHglycan	772	776	PF01048	0.675
MOD_GlcNHglycan	794	797	PF01048	0.699
MOD_GlcNHglycan	798	802	PF01048	0.628
MOD_GlcNHglycan	806	809	PF01048	0.686
MOD_GlcNHglycan	817	820	PF01048	0.512
MOD_GlcNHglycan	835	838	PF01048	0.806
MOD_GlcNHglycan	870	873	PF01048	0.799
MOD_GlcNHglycan	875	878	PF01048	0.722
MOD_GSK3_1	175	182	PF00069	0.738
MOD_GSK3_1	204	211	PF00069	0.811
MOD_GSK3_1	249	256	PF00069	0.689
MOD_GSK3_1	273	280	PF00069	0.740
MOD_GSK3_1	285	292	PF00069	0.582
MOD_GSK3_1	307	314	PF00069	0.762
MOD_GSK3_1	317	324	PF00069	0.633
MOD_GSK3_1	340	347	PF00069	0.801
MOD_GSK3_1	363	370	PF00069	0.726
MOD_GSK3_1	374	381	PF00069	0.573
MOD_GSK3_1	383	390	PF00069	0.668
MOD_GSK3_1	394	401	PF00069	0.601
MOD_GSK3_1	408	415	PF00069	0.664
MOD_GSK3_1	43	50	PF00069	0.802
MOD_GSK3_1	431	438	PF00069	0.830
MOD_GSK3_1	447	454	PF00069	0.840
MOD_GSK3_1	457	464	PF00069	0.649
MOD_GSK3_1	496	503	PF00069	0.839
MOD_GSK3_1	508	515	PF00069	0.651
MOD_GSK3_1	541	548	PF00069	0.821
MOD_GSK3_1	570	577	PF00069	0.852
MOD_GSK3_1	587	594	PF00069	0.669
MOD_GSK3_1	59	66	PF00069	0.577
MOD_GSK3_1	615	622	PF00069	0.681
MOD_GSK3_1	641	648	PF00069	0.670
MOD_GSK3_1	686	693	PF00069	0.759
MOD_GSK3_1	760	767	PF00069	0.842
MOD_GSK3_1	778	785	PF00069	0.537
MOD_GSK3_1	797	804	PF00069	0.532
MOD_GSK3_1	86	93	PF00069	0.657
MOD_GSK3_1	868	875	PF00069	0.849
MOD_GSK3_1	94	101	PF00069	0.672
MOD_N-GLC_1	764	769	PF02516	0.813
MOD_N-GLC_1	809	814	PF02516	0.716
MOD_NEK2_1	107	112	PF00069	0.779
MOD_NEK2_1	127	132	PF00069	0.805
MOD_NEK2_1	378	383	PF00069	0.611
MOD_NEK2_1	546	551	PF00069	0.699
MOD_NEK2_1	647	652	PF00069	0.740
MOD_NEK2_1	771	776	PF00069	0.640
MOD_NEK2_1	817	822	PF00069	0.608
MOD_NEK2_1	87	92	PF00069	0.709
MOD_NEK2_2	10	15	PF00069	0.667
MOD_NEK2_2	801	806	PF00069	0.768
MOD_PIKK_1	525	531	PF00454	0.764
MOD_PIKK_1	546	552	PF00454	0.768
MOD_PIKK_1	817	823	PF00454	0.547
MOD_PK_1	610	616	PF00069	0.690
MOD_PKA_1	383	389	PF00069	0.686
MOD_PKA_2	135	141	PF00069	0.730
MOD_PKA_2	187	193	PF00069	0.852
MOD_PKA_2	321	327	PF00069	0.668
MOD_PKA_2	361	367	PF00069	0.557
MOD_PKA_2	412	418	PF00069	0.662
MOD_PKA_2	447	453	PF00069	0.833
MOD_PKA_2	468	474	PF00069	0.740
MOD_PKA_2	53	59	PF00069	0.775
MOD_PKA_2	541	547	PF00069	0.712
MOD_PKA_2	586	592	PF00069	0.792
MOD_PKA_2	792	798	PF00069	0.646
MOD_PKA_2	905	911	PF00069	0.613
MOD_PKA_2	93	99	PF00069	0.786
MOD_PKB_1	601	609	PF00069	0.645
MOD_Plk_1	809	815	PF00069	0.597
MOD_Plk_1	894	900	PF00069	0.737
MOD_Plk_4	461	467	PF00069	0.745
MOD_Plk_4	574	580	PF00069	0.849
MOD_Plk_4	830	836	PF00069	0.788
MOD_ProDKin_1	166	172	PF00069	0.799
MOD_ProDKin_1	173	179	PF00069	0.540
MOD_ProDKin_1	204	210	PF00069	0.782
MOD_ProDKin_1	238	244	PF00069	0.711
MOD_ProDKin_1	278	284	PF00069	0.746
MOD_ProDKin_1	327	333	PF00069	0.828
MOD_ProDKin_1	426	432	PF00069	0.734
MOD_ProDKin_1	453	459	PF00069	0.764
MOD_ProDKin_1	498	504	PF00069	0.766
MOD_ProDKin_1	534	540	PF00069	0.800
MOD_ProDKin_1	587	593	PF00069	0.721
MOD_ProDKin_1	615	621	PF00069	0.812
MOD_ProDKin_1	623	629	PF00069	0.829
MOD_ProDKin_1	641	647	PF00069	0.777
MOD_ProDKin_1	733	739	PF00069	0.527
MOD_ProDKin_1	888	894	PF00069	0.663
MOD_ProDKin_1	94	100	PF00069	0.793
TRG_DiLeu_BaLyEn_6	642	647	PF01217	0.757
TRG_ENDOCYTIC_2	467	470	PF00928	0.830
TRG_ER_diArg_1	17	20	PF00400	0.805
TRG_ER_diArg_1	675	677	PF00400	0.528
TRG_ER_diArg_1	733	735	PF00400	0.706
TRG_ER_diArg_1	768	771	PF00400	0.763
TRG_ER_diArg_1	905	907	PF00400	0.758
TRG_Pf-PMV_PEXEL_1	704	709	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ID28	Leishmania donovani	77%	100%
A4HDJ8	Leishmania braziliensis	54%	98%
A4I0Y3	Leishmania infantum	77%	100%
E9ACS9	Leishmania major	77%	100%