Hypothetical predicted transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical predicted transmembrane protein

Species:

Leishmania mexicana

UniProt:

E9AWY4_LEIMU

TriTrypDb:

LmxM.24.1410

Length:

904

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 8, no: 2
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9AWY4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWY4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.470
CLV_C14_Caspase3-7	474	478	PF00656	0.422
CLV_C14_Caspase3-7	58	62	PF00656	0.353
CLV_NRD_NRD_1	162	164	PF00675	0.598
CLV_NRD_NRD_1	357	359	PF00675	0.480
CLV_NRD_NRD_1	392	394	PF00675	0.543
CLV_NRD_NRD_1	575	577	PF00675	0.682
CLV_NRD_NRD_1	663	665	PF00675	0.503
CLV_NRD_NRD_1	737	739	PF00675	0.733
CLV_PCSK_FUR_1	735	739	PF00082	0.644
CLV_PCSK_KEX2_1	162	164	PF00082	0.597
CLV_PCSK_KEX2_1	392	394	PF00082	0.543
CLV_PCSK_KEX2_1	737	739	PF00082	0.675
CLV_PCSK_SKI1_1	165	169	PF00082	0.555
CLV_PCSK_SKI1_1	265	269	PF00082	0.620
CLV_PCSK_SKI1_1	643	647	PF00082	0.578
CLV_Separin_Metazoa	321	325	PF03568	0.299
DEG_APCC_DBOX_1	224	232	PF00400	0.279
DEG_ODPH_VHL_1	349	362	PF01847	0.287
DEG_SPOP_SBC_1	126	130	PF00917	0.519
DEG_SPOP_SBC_1	30	34	PF00917	0.481
DEG_SPOP_SBC_1	667	671	PF00917	0.399
DEG_SPOP_SBC_1	747	751	PF00917	0.404
DEG_SPOP_SBC_1	95	99	PF00917	0.371
DOC_ANK_TNKS_1	467	474	PF00023	0.411
DOC_CKS1_1	569	574	PF01111	0.456
DOC_CYCLIN_RxL_1	262	272	PF00134	0.359
DOC_CYCLIN_yCln2_LP_2	10	16	PF00134	0.355
DOC_MAPK_gen_1	392	398	PF00069	0.318
DOC_MAPK_gen_1	576	583	PF00069	0.339
DOC_MAPK_gen_1	805	814	PF00069	0.393
DOC_MAPK_MEF2A_6	225	232	PF00069	0.286
DOC_MAPK_MEF2A_6	758	765	PF00069	0.319
DOC_MAPK_MEF2A_6	808	816	PF00069	0.345
DOC_PP1_RVXF_1	811	817	PF00149	0.260
DOC_PP2B_LxvP_1	10	13	PF13499	0.357
DOC_PP2B_LxvP_1	396	399	PF13499	0.444
DOC_PP4_FxxP_1	691	694	PF00568	0.475
DOC_PP4_FxxP_1	715	718	PF00568	0.383
DOC_USP7_MATH_1	126	130	PF00917	0.421
DOC_USP7_MATH_1	30	34	PF00917	0.481
DOC_USP7_MATH_1	515	519	PF00917	0.358
DOC_USP7_MATH_1	570	574	PF00917	0.388
DOC_USP7_MATH_1	633	637	PF00917	0.394
DOC_USP7_MATH_1	641	645	PF00917	0.443
DOC_USP7_MATH_1	663	667	PF00917	0.443
DOC_USP7_MATH_1	695	699	PF00917	0.396
DOC_USP7_MATH_1	747	751	PF00917	0.480
DOC_USP7_MATH_1	757	761	PF00917	0.475
DOC_USP7_MATH_1	792	796	PF00917	0.434
DOC_USP7_MATH_1	95	99	PF00917	0.394
DOC_WW_Pin1_4	129	134	PF00397	0.447
DOC_WW_Pin1_4	26	31	PF00397	0.397
DOC_WW_Pin1_4	504	509	PF00397	0.502
DOC_WW_Pin1_4	568	573	PF00397	0.428
DOC_WW_Pin1_4	654	659	PF00397	0.393
DOC_WW_Pin1_4	704	709	PF00397	0.333
DOC_WW_Pin1_4	783	788	PF00397	0.451
DOC_WW_Pin1_4	823	828	PF00397	0.425
LIG_14-3-3_CanoR_1	195	205	PF00244	0.383
LIG_14-3-3_CanoR_1	31	41	PF00244	0.385
LIG_14-3-3_CanoR_1	428	433	PF00244	0.531
LIG_14-3-3_CanoR_1	576	584	PF00244	0.453
LIG_14-3-3_CanoR_1	640	646	PF00244	0.470
LIG_14-3-3_CanoR_1	758	762	PF00244	0.368
LIG_14-3-3_CanoR_1	808	813	PF00244	0.345
LIG_Actin_WH2_2	342	360	PF00022	0.243
LIG_APCC_ABBA_1	832	837	PF00400	0.360
LIG_BIR_III_2	896	900	PF00653	0.619
LIG_BRCT_BRCA1_1	37	41	PF00533	0.388
LIG_BRCT_BRCA1_1	767	771	PF00533	0.415
LIG_BRCT_BRCA1_1	819	823	PF00533	0.326
LIG_FHA_1	197	203	PF00498	0.385
LIG_FHA_1	286	292	PF00498	0.391
LIG_FHA_1	330	336	PF00498	0.393
LIG_FHA_1	35	41	PF00498	0.447
LIG_FHA_1	401	407	PF00498	0.445
LIG_FHA_1	505	511	PF00498	0.509
LIG_FHA_1	538	544	PF00498	0.487
LIG_FHA_1	564	570	PF00498	0.392
LIG_FHA_1	612	618	PF00498	0.292
LIG_FHA_1	625	631	PF00498	0.373
LIG_FHA_1	726	732	PF00498	0.532
LIG_FHA_1	747	753	PF00498	0.410
LIG_FHA_1	877	883	PF00498	0.180
LIG_FHA_1	898	904	PF00498	0.571
LIG_FHA_2	285	291	PF00498	0.325
LIG_FHA_2	332	338	PF00498	0.491
LIG_FHA_2	369	375	PF00498	0.274
LIG_FHA_2	56	62	PF00498	0.366
LIG_FHA_2	606	612	PF00498	0.401
LIG_FHA_2	669	675	PF00498	0.456
LIG_FHA_2	705	711	PF00498	0.305
LIG_FHA_2	757	763	PF00498	0.438
LIG_FHA_2	97	103	PF00498	0.445
LIG_GBD_Chelix_1	529	537	PF00786	0.471
LIG_LIR_Apic_2	222	226	PF02991	0.366
LIG_LIR_Apic_2	25	30	PF02991	0.523
LIG_LIR_Gen_1	168	179	PF02991	0.344
LIG_LIR_Gen_1	207	218	PF02991	0.356
LIG_LIR_Gen_1	261	268	PF02991	0.392
LIG_LIR_Gen_1	344	353	PF02991	0.346
LIG_LIR_Gen_1	488	499	PF02991	0.483
LIG_LIR_Gen_1	547	555	PF02991	0.466
LIG_LIR_Gen_1	61	70	PF02991	0.380
LIG_LIR_Gen_1	649	658	PF02991	0.425
LIG_LIR_Gen_1	720	726	PF02991	0.378
LIG_LIR_Gen_1	795	806	PF02991	0.415
LIG_LIR_Nem_3	168	174	PF02991	0.341
LIG_LIR_Nem_3	207	213	PF02991	0.361
LIG_LIR_Nem_3	215	220	PF02991	0.271
LIG_LIR_Nem_3	261	266	PF02991	0.330
LIG_LIR_Nem_3	344	349	PF02991	0.310
LIG_LIR_Nem_3	409	415	PF02991	0.342
LIG_LIR_Nem_3	451	456	PF02991	0.418
LIG_LIR_Nem_3	488	494	PF02991	0.425
LIG_LIR_Nem_3	547	552	PF02991	0.470
LIG_LIR_Nem_3	603	609	PF02991	0.445
LIG_LIR_Nem_3	61	67	PF02991	0.397
LIG_LIR_Nem_3	649	653	PF02991	0.423
LIG_LIR_Nem_3	720	724	PF02991	0.283
LIG_LIR_Nem_3	795	801	PF02991	0.405
LIG_LIR_Nem_3	822	828	PF02991	0.363
LIG_NRBOX	877	883	PF00104	0.376
LIG_NRBOX	887	893	PF00104	0.317
LIG_PCNA_yPIPBox_3	265	278	PF02747	0.358
LIG_PDZ_Class_2	899	904	PF00595	0.635
LIG_Pex14_1	363	367	PF04695	0.339
LIG_SH2_CRK	210	214	PF00017	0.400
LIG_SH2_CRK	491	495	PF00017	0.429
LIG_SH2_CRK	798	802	PF00017	0.416
LIG_SH2_GRB2like	798	801	PF00017	0.350
LIG_SH2_NCK_1	179	183	PF00017	0.283
LIG_SH2_NCK_1	798	802	PF00017	0.354
LIG_SH2_PTP2	263	266	PF00017	0.276
LIG_SH2_PTP2	27	30	PF00017	0.427
LIG_SH2_SRC	609	612	PF00017	0.306
LIG_SH2_SRC	836	839	PF00017	0.439
LIG_SH2_STAP1	210	214	PF00017	0.318
LIG_SH2_STAP1	3	7	PF00017	0.386
LIG_SH2_STAP1	609	613	PF00017	0.426
LIG_SH2_STAT5	146	149	PF00017	0.444
LIG_SH2_STAT5	218	221	PF00017	0.381
LIG_SH2_STAT5	263	266	PF00017	0.307
LIG_SH2_STAT5	27	30	PF00017	0.396
LIG_SH2_STAT5	549	552	PF00017	0.361
LIG_SH2_STAT5	660	663	PF00017	0.367
LIG_SH2_STAT5	798	801	PF00017	0.346
LIG_SH2_STAT5	867	870	PF00017	0.331
LIG_SH2_STAT5	890	893	PF00017	0.411
LIG_SH3_3	293	299	PF00018	0.388
LIG_SH3_3	369	375	PF00018	0.344
LIG_SH3_3	532	538	PF00018	0.331
LIG_SH3_3	566	572	PF00018	0.445
LIG_SH3_3	691	697	PF00018	0.280
LIG_Sin3_3	880	887	PF02671	0.171
LIG_SUMO_SIM_anti_2	311	317	PF11976	0.317
LIG_SUMO_SIM_anti_2	579	585	PF11976	0.346
LIG_SUMO_SIM_anti_2	879	885	PF11976	0.201
LIG_SUMO_SIM_par_1	277	285	PF11976	0.268
LIG_SUMO_SIM_par_1	528	534	PF11976	0.334
LIG_SUMO_SIM_par_1	53	59	PF11976	0.381
LIG_SUMO_SIM_par_1	611	618	PF11976	0.321
LIG_SUMO_SIM_par_1	630	637	PF11976	0.464
LIG_SUMO_SIM_par_1	890	896	PF11976	0.507
LIG_TRAF2_1	187	190	PF00917	0.463
LIG_TRAF2_1	827	830	PF00917	0.484
LIG_TYR_ITIM	888	893	PF00017	0.414
LIG_UBA3_1	63	69	PF00899	0.355
MOD_CDK_SPK_2	26	31	PF00069	0.311
MOD_CDK_SPxxK_3	504	511	PF00069	0.449
MOD_CK1_1	129	135	PF00069	0.482
MOD_CK1_1	180	186	PF00069	0.374
MOD_CK1_1	236	242	PF00069	0.486
MOD_CK1_1	29	35	PF00069	0.537
MOD_CK1_1	339	345	PF00069	0.359
MOD_CK1_1	420	426	PF00069	0.441
MOD_CK1_1	431	437	PF00069	0.485
MOD_CK1_1	579	585	PF00069	0.483
MOD_CK1_1	666	672	PF00069	0.454
MOD_CK1_1	673	679	PF00069	0.412
MOD_CK1_1	783	789	PF00069	0.388
MOD_CK1_1	842	848	PF00069	0.540
MOD_CK1_1	849	855	PF00069	0.586
MOD_CK2_1	183	189	PF00069	0.408
MOD_CK2_1	339	345	PF00069	0.428
MOD_CK2_1	415	421	PF00069	0.419
MOD_CK2_1	605	611	PF00069	0.400
MOD_CK2_1	668	674	PF00069	0.566
MOD_CK2_1	704	710	PF00069	0.303
MOD_CK2_1	756	762	PF00069	0.443
MOD_CK2_1	823	829	PF00069	0.468
MOD_GlcNHglycan	129	132	PF01048	0.728
MOD_GlcNHglycan	138	141	PF01048	0.597
MOD_GlcNHglycan	179	182	PF01048	0.629
MOD_GlcNHglycan	206	209	PF01048	0.563
MOD_GlcNHglycan	240	243	PF01048	0.771
MOD_GlcNHglycan	274	277	PF01048	0.622
MOD_GlcNHglycan	36	40	PF01048	0.690
MOD_GlcNHglycan	424	427	PF01048	0.699
MOD_GlcNHglycan	436	439	PF01048	0.635
MOD_GlcNHglycan	486	490	PF01048	0.550
MOD_GlcNHglycan	523	526	PF01048	0.714
MOD_GlcNHglycan	545	549	PF01048	0.623
MOD_GlcNHglycan	558	561	PF01048	0.686
MOD_GlcNHglycan	572	575	PF01048	0.564
MOD_GlcNHglycan	665	668	PF01048	0.702
MOD_GlcNHglycan	676	679	PF01048	0.618
MOD_GlcNHglycan	691	694	PF01048	0.496
MOD_GlcNHglycan	697	700	PF01048	0.576
MOD_GlcNHglycan	70	73	PF01048	0.628
MOD_GlcNHglycan	738	741	PF01048	0.747
MOD_GlcNHglycan	766	770	PF01048	0.630
MOD_GlcNHglycan	777	780	PF01048	0.518
MOD_GlcNHglycan	794	797	PF01048	0.518
MOD_GlcNHglycan	818	822	PF01048	0.513
MOD_GlcNHglycan	840	844	PF01048	0.674
MOD_GlcNHglycan	848	851	PF01048	0.694
MOD_GlcNHglycan	854	857	PF01048	0.654
MOD_GSK3_1	125	132	PF00069	0.528
MOD_GSK3_1	157	164	PF00069	0.367
MOD_GSK3_1	180	187	PF00069	0.511
MOD_GSK3_1	22	29	PF00069	0.504
MOD_GSK3_1	232	239	PF00069	0.488
MOD_GSK3_1	280	287	PF00069	0.376
MOD_GSK3_1	30	37	PF00069	0.484
MOD_GSK3_1	331	338	PF00069	0.453
MOD_GSK3_1	398	405	PF00069	0.434
MOD_GSK3_1	605	612	PF00069	0.343
MOD_GSK3_1	613	620	PF00069	0.343
MOD_GSK3_1	624	631	PF00069	0.302
MOD_GSK3_1	639	646	PF00069	0.359
MOD_GSK3_1	659	666	PF00069	0.299
MOD_GSK3_1	669	676	PF00069	0.445
MOD_GSK3_1	747	754	PF00069	0.489
MOD_GSK3_1	757	764	PF00069	0.437
MOD_GSK3_1	792	799	PF00069	0.291
MOD_GSK3_1	819	826	PF00069	0.351
MOD_GSK3_1	841	848	PF00069	0.603
MOD_GSK3_1	872	879	PF00069	0.386
MOD_N-GLC_1	270	275	PF02516	0.557
MOD_N-GLC_1	415	420	PF02516	0.588
MOD_N-GLC_1	556	561	PF02516	0.659
MOD_N-GLC_1	600	605	PF02516	0.572
MOD_N-GLC_1	628	633	PF02516	0.564
MOD_N-GLC_1	799	804	PF02516	0.603
MOD_NEK2_1	157	162	PF00069	0.406
MOD_NEK2_1	177	182	PF00069	0.258
MOD_NEK2_1	22	27	PF00069	0.475
MOD_NEK2_1	281	286	PF00069	0.326
MOD_NEK2_1	291	296	PF00069	0.321
MOD_NEK2_1	329	334	PF00069	0.460
MOD_NEK2_1	335	340	PF00069	0.435
MOD_NEK2_1	414	419	PF00069	0.400
MOD_NEK2_1	422	427	PF00069	0.410
MOD_NEK2_1	490	495	PF00069	0.409
MOD_NEK2_1	613	618	PF00069	0.339
MOD_NEK2_1	63	68	PF00069	0.399
MOD_NEK2_1	659	664	PF00069	0.404
MOD_NEK2_1	724	729	PF00069	0.395
MOD_NEK2_1	748	753	PF00069	0.413
MOD_NEK2_1	765	770	PF00069	0.391
MOD_NEK2_1	819	824	PF00069	0.318
MOD_NEK2_1	96	101	PF00069	0.502
MOD_NEK2_2	719	724	PF00069	0.462
MOD_PIKK_1	420	426	PF00454	0.338
MOD_PIKK_1	600	606	PF00454	0.398
MOD_PIKK_1	725	731	PF00454	0.463
MOD_PKA_1	576	582	PF00069	0.455
MOD_PKA_2	161	167	PF00069	0.372
MOD_PKA_2	196	202	PF00069	0.378
MOD_PKA_2	224	230	PF00069	0.262
MOD_PKA_2	30	36	PF00069	0.398
MOD_PKA_2	434	440	PF00069	0.544
MOD_PKA_2	639	645	PF00069	0.419
MOD_PKA_2	663	669	PF00069	0.380
MOD_PKA_2	736	742	PF00069	0.453
MOD_PKA_2	757	763	PF00069	0.283
MOD_PKB_1	163	171	PF00069	0.349
MOD_Plk_1	157	163	PF00069	0.479
MOD_Plk_1	270	276	PF00069	0.423
MOD_Plk_1	335	341	PF00069	0.392
MOD_Plk_1	35	41	PF00069	0.462
MOD_Plk_1	415	421	PF00069	0.429
MOD_Plk_1	485	491	PF00069	0.423
MOD_Plk_1	628	634	PF00069	0.361
MOD_Plk_1	761	767	PF00069	0.402
MOD_Plk_1	799	805	PF00069	0.363
MOD_Plk_1	85	91	PF00069	0.372
MOD_Plk_4	219	225	PF00069	0.323
MOD_Plk_4	22	28	PF00069	0.527
MOD_Plk_4	259	265	PF00069	0.412
MOD_Plk_4	336	342	PF00069	0.413
MOD_Plk_4	406	412	PF00069	0.341
MOD_Plk_4	448	454	PF00069	0.513
MOD_Plk_4	579	585	PF00069	0.467
MOD_Plk_4	719	725	PF00069	0.364
MOD_ProDKin_1	129	135	PF00069	0.443
MOD_ProDKin_1	26	32	PF00069	0.398
MOD_ProDKin_1	504	510	PF00069	0.503
MOD_ProDKin_1	568	574	PF00069	0.430
MOD_ProDKin_1	654	660	PF00069	0.398
MOD_ProDKin_1	704	710	PF00069	0.337
MOD_ProDKin_1	783	789	PF00069	0.451
MOD_ProDKin_1	823	829	PF00069	0.426
MOD_SUMO_for_1	155	158	PF00179	0.444
MOD_SUMO_rev_2	573	579	PF00179	0.394
TRG_DiLeu_BaEn_1	189	194	PF01217	0.417
TRG_DiLeu_BaEn_1	6	11	PF01217	0.436
TRG_DiLeu_BaEn_4	189	195	PF01217	0.414
TRG_DiLeu_BaEn_4	829	835	PF01217	0.309
TRG_DiLeu_BaLyEn_6	262	267	PF01217	0.399
TRG_DiLeu_LyEn_5	189	194	PF01217	0.417
TRG_ENDOCYTIC_2	210	213	PF00928	0.327
TRG_ENDOCYTIC_2	217	220	PF00928	0.307
TRG_ENDOCYTIC_2	263	266	PF00928	0.403
TRG_ENDOCYTIC_2	411	414	PF00928	0.361
TRG_ENDOCYTIC_2	491	494	PF00928	0.418
TRG_ENDOCYTIC_2	549	552	PF00928	0.361
TRG_ENDOCYTIC_2	721	724	PF00928	0.317
TRG_ENDOCYTIC_2	798	801	PF00928	0.410
TRG_ENDOCYTIC_2	890	893	PF00928	0.414
TRG_ER_diArg_1	161	163	PF00400	0.392
TRG_ER_diArg_1	194	197	PF00400	0.448
TRG_ER_diArg_1	391	393	PF00400	0.337
TRG_ER_diArg_1	427	430	PF00400	0.527
TRG_ER_diArg_1	735	738	PF00400	0.451
TRG_ER_diArg_1	812	815	PF00400	0.384
TRG_NES_CRM1_1	308	321	PF08389	0.367
TRG_NES_CRM1_1	804	818	PF08389	0.236
TRG_Pf-PMV_PEXEL_1	265	269	PF00026	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3L3	Leptomonas seymouri	50%	100%
A0A1X0PBB4	Trypanosomatidae	25%	93%
A0A3R7KLJ4	Trypanosoma rangeli	25%	93%
A0A3S5H7D3	Leishmania donovani	88%	95%
A4HDK1	Leishmania braziliensis	75%	100%
A4I0Y0	Leishmania infantum	89%	95%
C9ZLZ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	97%
Q4QAJ0	Leishmania major	88%	100%
V5BQI0	Trypanosoma cruzi	24%	99%