Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWY3_LEIMU

TriTrypDb:

LmxM.24.1400

Length:

200

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWY3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWY3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	121	125	PF00656	0.515
CLV_C14_Caspase3-7	137	141	PF00656	0.577
CLV_C14_Caspase3-7	64	68	PF00656	0.634
CLV_NRD_NRD_1	115	117	PF00675	0.642
CLV_NRD_NRD_1	27	29	PF00675	0.543
CLV_NRD_NRD_1	61	63	PF00675	0.570
CLV_PCSK_KEX2_1	114	116	PF00082	0.637
CLV_PCSK_KEX2_1	159	161	PF00082	0.556
CLV_PCSK_KEX2_1	27	29	PF00082	0.522
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.582
CLV_PCSK_SKI1_1	106	110	PF00082	0.588
CLV_PCSK_SKI1_1	126	130	PF00082	0.370
CLV_PCSK_SKI1_1	133	137	PF00082	0.624
DOC_USP7_MATH_1	189	193	PF00917	0.519
DOC_USP7_MATH_1	54	58	PF00917	0.634
DOC_USP7_MATH_1	68	72	PF00917	0.469
DOC_USP7_UBL2_3	69	73	PF12436	0.537
LIG_14-3-3_CanoR_1	13	17	PF00244	0.563
LIG_14-3-3_CanoR_1	27	32	PF00244	0.587
LIG_14-3-3_CanoR_1	62	70	PF00244	0.590
LIG_14-3-3_CanoR_1	83	87	PF00244	0.594
LIG_BIR_II_1	1	5	PF00653	0.642
LIG_FHA_1	107	113	PF00498	0.660
LIG_FHA_1	13	19	PF00498	0.651
LIG_FHA_1	180	186	PF00498	0.680
LIG_FHA_2	119	125	PF00498	0.634
LIG_FHA_2	186	192	PF00498	0.542
LIG_FHA_2	28	34	PF00498	0.652
LIG_FHA_2	45	51	PF00498	0.611
LIG_FHA_2	95	101	PF00498	0.570
LIG_LIR_Nem_3	5	10	PF02991	0.540
LIG_PDZ_Class_3	195	200	PF00595	0.591
LIG_RPA_C_Fungi	23	35	PF08784	0.639
LIG_SH2_STAT5	194	197	PF00017	0.640
LIG_SH3_1	171	177	PF00018	0.622
LIG_SH3_3	171	177	PF00018	0.615
LIG_SUMO_SIM_par_1	14	19	PF11976	0.592
LIG_TRAF2_1	135	138	PF00917	0.612
LIG_TRAF2_1	151	154	PF00917	0.664
LIG_TRAF2_1	47	50	PF00917	0.636
MOD_CK2_1	185	191	PF00069	0.547
MOD_CK2_1	27	33	PF00069	0.566
MOD_CK2_1	44	50	PF00069	0.612
MOD_CK2_1	68	74	PF00069	0.604
MOD_CK2_1	82	88	PF00069	0.620
MOD_CK2_1	94	100	PF00069	0.650
MOD_GlcNHglycan	63	66	PF01048	0.652
MOD_GlcNHglycan	7	10	PF01048	0.552
MOD_GSK3_1	181	188	PF00069	0.572
MOD_GSK3_1	5	12	PF00069	0.584
MOD_N-GLC_1	44	49	PF02516	0.618
MOD_NEK2_1	118	123	PF00069	0.639
MOD_NEK2_1	185	190	PF00069	0.542
MOD_NEK2_1	37	42	PF00069	0.606
MOD_NEK2_1	94	99	PF00069	0.632
MOD_NEK2_2	189	194	PF00069	0.657
MOD_PKA_1	27	33	PF00069	0.392
MOD_PKA_2	12	18	PF00069	0.526
MOD_PKA_2	26	32	PF00069	0.562
MOD_PKA_2	61	67	PF00069	0.641
MOD_PKA_2	82	88	PF00069	0.654
MOD_Plk_1	118	124	PF00069	0.608
MOD_Plk_1	2	8	PF00069	0.629
MOD_Plk_1	54	60	PF00069	0.661
MOD_Plk_4	12	18	PF00069	0.532
MOD_Plk_4	189	195	PF00069	0.528
MOD_Plk_4	82	88	PF00069	0.606
MOD_SUMO_rev_2	137	144	PF00179	0.605
MOD_SUMO_rev_2	55	65	PF00179	0.575
TRG_DiLeu_BaEn_1	191	196	PF01217	0.523
TRG_DiLeu_BaEn_4	89	95	PF01217	0.582
TRG_ER_diArg_1	114	116	PF00400	0.636
TRG_ER_diArg_1	56	59	PF00400	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1N4	Leptomonas seymouri	72%	99%
A0A0S4JQL1	Bodo saltans	29%	98%
A0A1X0NLU8	Trypanosomatidae	40%	100%
A0A3R7MNC1	Trypanosoma rangeli	46%	93%
A0A3S7WYE8	Leishmania donovani	96%	100%
A4HDK2	Leishmania braziliensis	87%	100%
A4I0X9	Leishmania infantum	96%	100%
C9ZUU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
Q4QAJ1	Leishmania major	95%	100%