Histone deacetylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Histone deacetylase

Gene product:

histone deacetylase, putative

Species:

Leishmania mexicana

UniProt:

E9AWY0_LEIMU

TriTrypDb:

LmxM.24.1370

Length:

545

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9AWY0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWY0

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	13
GO:0006476	protein deacetylation	6	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009987	cellular process	1	13
GO:0016043	cellular component organization	3	13
GO:0016570	histone modification	5	13
GO:0016575	histone deacetylation	6	13
GO:0019538	protein metabolic process	3	13
GO:0035601	protein deacylation	5	13
GO:0036211	protein modification process	4	13
GO:0043170	macromolecule metabolic process	3	13
GO:0043412	macromolecule modification	4	13
GO:0044238	primary metabolic process	2	13
GO:0071704	organic substance metabolic process	2	13
GO:0071840	cellular component organization or biogenesis	2	13
GO:0098732	macromolecule deacylation	5	13
GO:1901564	organonitrogen compound metabolic process	3	13
GO:0006355	regulation of DNA-templated transcription	6	2
GO:0006357	regulation of transcription by RNA polymerase II	7	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1903506	regulation of nucleic acid-templated transcription	7	2
GO:2001141	regulation of RNA biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004407	histone deacetylase activity	4	13
GO:0016787	hydrolase activity	2	13
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	13
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	13
GO:0019213	deacetylase activity	3	13
GO:0033558	protein lysine deacetylase activity	3	13
GO:0140096	catalytic activity, acting on a protein	2	13
GO:0005488	binding	1	3
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	301	305	PF00656	0.512
CLV_C14_Caspase3-7	521	525	PF00656	0.591
CLV_NRD_NRD_1	246	248	PF00675	0.254
CLV_NRD_NRD_1	426	428	PF00675	0.386
CLV_NRD_NRD_1	488	490	PF00675	0.434
CLV_NRD_NRD_1	70	72	PF00675	0.627
CLV_NRD_NRD_1	82	84	PF00675	0.436
CLV_PCSK_FUR_1	486	490	PF00082	0.430
CLV_PCSK_KEX2_1	246	248	PF00082	0.254
CLV_PCSK_KEX2_1	426	428	PF00082	0.401
CLV_PCSK_KEX2_1	432	434	PF00082	0.387
CLV_PCSK_KEX2_1	488	490	PF00082	0.397
CLV_PCSK_KEX2_1	513	515	PF00082	0.674
CLV_PCSK_KEX2_1	82	84	PF00082	0.419
CLV_PCSK_PC1ET2_1	432	434	PF00082	0.411
CLV_PCSK_PC1ET2_1	513	515	PF00082	0.674
CLV_PCSK_SKI1_1	133	137	PF00082	0.312
CLV_PCSK_SKI1_1	246	250	PF00082	0.297
CLV_PCSK_SKI1_1	277	281	PF00082	0.286
CLV_PCSK_SKI1_1	326	330	PF00082	0.261
CLV_PCSK_SKI1_1	489	493	PF00082	0.502
CLV_PCSK_SKI1_1	523	527	PF00082	0.694
DEG_APCC_DBOX_1	325	333	PF00400	0.470
DEG_SCF_TRCP1_1	504	510	PF00400	0.428
DEG_SPOP_SBC_1	54	58	PF00917	0.550
DOC_ANK_TNKS_1	502	509	PF00023	0.520
DOC_CYCLIN_yCln2_LP_2	32	38	PF00134	0.592
DOC_MAPK_gen_1	432	440	PF00069	0.405
DOC_MAPK_gen_1	79	88	PF00069	0.299
DOC_MAPK_MEF2A_6	254	262	PF00069	0.492
DOC_MAPK_MEF2A_6	406	415	PF00069	0.468
DOC_MAPK_MEF2A_6	432	440	PF00069	0.377
DOC_PP1_RVXF_1	460	467	PF00149	0.284
DOC_PP1_RVXF_1	82	89	PF00149	0.382
DOC_PP2B_LxvP_1	413	416	PF13499	0.441
DOC_PP4_FxxP_1	174	177	PF00568	0.445
DOC_PP4_FxxP_1	439	442	PF00568	0.505
DOC_USP7_MATH_1	177	181	PF00917	0.539
DOC_USP7_MATH_1	193	197	PF00917	0.478
DOC_USP7_MATH_1	199	203	PF00917	0.475
DOC_USP7_MATH_1	230	234	PF00917	0.448
DOC_USP7_MATH_1	328	332	PF00917	0.544
DOC_USP7_MATH_1	48	52	PF00917	0.552
DOC_USP7_MATH_1	75	79	PF00917	0.539
DOC_WW_Pin1_4	12	17	PF00397	0.690
DOC_WW_Pin1_4	23	28	PF00397	0.680
DOC_WW_Pin1_4	427	432	PF00397	0.602
DOC_WW_Pin1_4	44	49	PF00397	0.693
DOC_WW_Pin1_4	64	69	PF00397	0.590
LIG_14-3-3_CanoR_1	133	140	PF00244	0.470
LIG_14-3-3_CanoR_1	277	282	PF00244	0.469
LIG_14-3-3_CanoR_1	326	336	PF00244	0.470
LIG_14-3-3_CanoR_1	49	54	PF00244	0.615
LIG_APCC_ABBA_1	436	441	PF00400	0.375
LIG_BIR_II_1	1	5	PF00653	0.595
LIG_BRCT_BRCA1_1	166	170	PF00533	0.532
LIG_BRCT_BRCA1_1	30	34	PF00533	0.739
LIG_BRCT_BRCA1_1	452	456	PF00533	0.385
LIG_BRCT_BRCA1_2	166	172	PF00533	0.512
LIG_CaM_IQ_9	461	477	PF13499	0.442
LIG_eIF4E_1	98	104	PF01652	0.473
LIG_FHA_1	278	284	PF00498	0.486
LIG_FHA_1	364	370	PF00498	0.480
LIG_FHA_1	377	383	PF00498	0.403
LIG_FHA_1	433	439	PF00498	0.353
LIG_FHA_1	468	474	PF00498	0.530
LIG_FHA_1	479	485	PF00498	0.493
LIG_FHA_1	64	70	PF00498	0.648
LIG_FHA_2	134	140	PF00498	0.470
LIG_FHA_2	519	525	PF00498	0.747
LIG_FHA_2	56	62	PF00498	0.693
LIG_GBD_Chelix_1	241	249	PF00786	0.286
LIG_GBD_Chelix_1	350	358	PF00786	0.245
LIG_Integrin_RGD_1	211	213	PF01839	0.312
LIG_LIR_Apic_2	173	177	PF02991	0.470
LIG_LIR_Gen_1	123	134	PF02991	0.395
LIG_LIR_Gen_1	190	199	PF02991	0.470
LIG_LIR_Gen_1	233	243	PF02991	0.486
LIG_LIR_Nem_3	123	129	PF02991	0.395
LIG_LIR_Nem_3	190	195	PF02991	0.445
LIG_LIR_Nem_3	233	238	PF02991	0.486
LIG_LIR_Nem_3	419	425	PF02991	0.333
LIG_Pex14_2	170	174	PF04695	0.501
LIG_Pex14_2	188	192	PF04695	0.368
LIG_Pex14_2	286	290	PF04695	0.486
LIG_PTB_Apo_2	285	292	PF02174	0.445
LIG_Rb_LxCxE_1	202	215	PF01857	0.445
LIG_SH2_CRK	126	130	PF00017	0.393
LIG_SH2_CRK	252	256	PF00017	0.512
LIG_SH2_PTP2	257	260	PF00017	0.544
LIG_SH2_SRC	98	101	PF00017	0.402
LIG_SH2_STAT5	148	151	PF00017	0.486
LIG_SH2_STAT5	257	260	PF00017	0.445
LIG_SH2_STAT5	321	324	PF00017	0.486
LIG_SH2_STAT5	414	417	PF00017	0.335
LIG_SH2_STAT5	87	90	PF00017	0.316
LIG_SH3_3	183	189	PF00018	0.445
LIG_SH3_3	307	313	PF00018	0.449
LIG_SH3_3	428	434	PF00018	0.394
LIG_SH3_3	441	447	PF00018	0.403
LIG_SUMO_SIM_par_1	371	376	PF11976	0.440
LIG_TRAF2_1	136	139	PF00917	0.434
LIG_TRAF2_1	497	500	PF00917	0.478
LIG_TRAF2_1	540	543	PF00917	0.448
LIG_TRAF2_1	59	62	PF00917	0.622
LIG_TYR_ITIM	255	260	PF00017	0.486
LIG_WRC_WIRS_1	322	327	PF05994	0.468
MOD_CDK_SPK_2	427	432	PF00069	0.442
MOD_CDK_SPK_2	44	49	PF00069	0.604
MOD_CDK_SPxK_1	427	433	PF00069	0.439
MOD_CDK_SPxxK_3	64	71	PF00069	0.544
MOD_CK1_1	15	21	PF00069	0.695
MOD_CK1_1	23	29	PF00069	0.667
MOD_CK1_1	324	330	PF00069	0.542
MOD_CK1_1	37	43	PF00069	0.736
MOD_CK1_1	44	50	PF00069	0.716
MOD_CK1_1	57	63	PF00069	0.662
MOD_CK2_1	133	139	PF00069	0.435
MOD_CK2_1	23	29	PF00069	0.693
MOD_CK2_1	55	61	PF00069	0.565
MOD_CK2_1	64	70	PF00069	0.660
MOD_Cter_Amidation	80	83	PF01082	0.463
MOD_GlcNHglycan	10	13	PF01048	0.790
MOD_GlcNHglycan	122	125	PF01048	0.266
MOD_GlcNHglycan	145	148	PF01048	0.240
MOD_GlcNHglycan	17	20	PF01048	0.569
MOD_GlcNHglycan	232	235	PF01048	0.276
MOD_GlcNHglycan	36	39	PF01048	0.614
MOD_GlcNHglycan	42	46	PF01048	0.619
MOD_GlcNHglycan	504	507	PF01048	0.562
MOD_GlcNHglycan	509	512	PF01048	0.766
MOD_GlcNHglycan	516	519	PF01048	0.666
MOD_GlcNHglycan	532	535	PF01048	0.607
MOD_GlcNHglycan	61	65	PF01048	0.669
MOD_GSK3_1	19	26	PF00069	0.555
MOD_GSK3_1	324	331	PF00069	0.490
MOD_GSK3_1	359	366	PF00069	0.512
MOD_GSK3_1	37	44	PF00069	0.697
MOD_GSK3_1	49	56	PF00069	0.674
MOD_GSK3_1	514	521	PF00069	0.698
MOD_GSK3_1	60	67	PF00069	0.615
MOD_GSK3_1	8	15	PF00069	0.711
MOD_LATS_1	131	137	PF00433	0.512
MOD_N-GLC_1	518	523	PF02516	0.589
MOD_NEK2_1	115	120	PF00069	0.428
MOD_NEK2_1	143	148	PF00069	0.453
MOD_NEK2_1	194	199	PF00069	0.479
MOD_NEK2_1	279	284	PF00069	0.486
MOD_NEK2_1	358	363	PF00069	0.486
MOD_NEK2_1	404	409	PF00069	0.541
MOD_NEK2_1	450	455	PF00069	0.406
MOD_NEK2_1	460	465	PF00069	0.300
MOD_NEK2_1	478	483	PF00069	0.408
MOD_NEK2_2	321	326	PF00069	0.468
MOD_PIKK_1	177	183	PF00454	0.573
MOD_PIKK_1	194	200	PF00454	0.353
MOD_PIKK_1	363	369	PF00454	0.501
MOD_PIKK_1	495	501	PF00454	0.475
MOD_PK_1	49	55	PF00069	0.493
MOD_PKA_1	432	438	PF00069	0.396
MOD_PKA_2	104	110	PF00069	0.445
MOD_PKA_2	299	305	PF00069	0.512
MOD_PKA_2	376	382	PF00069	0.468
MOD_PKA_2	432	438	PF00069	0.364
MOD_PKA_2	48	54	PF00069	0.550
MOD_PKA_2	502	508	PF00069	0.514
MOD_Plk_1	164	170	PF00069	0.515
MOD_Plk_1	212	218	PF00069	0.468
MOD_Plk_1	28	34	PF00069	0.673
MOD_Plk_1	89	95	PF00069	0.394
MOD_Plk_2-3	371	377	PF00069	0.440
MOD_Plk_4	328	334	PF00069	0.526
MOD_Plk_4	376	382	PF00069	0.445
MOD_ProDKin_1	12	18	PF00069	0.690
MOD_ProDKin_1	23	29	PF00069	0.678
MOD_ProDKin_1	427	433	PF00069	0.599
MOD_ProDKin_1	44	50	PF00069	0.694
MOD_ProDKin_1	64	70	PF00069	0.590
MOD_SUMO_rev_2	67	73	PF00179	0.492
TRG_DiLeu_BaEn_1	190	195	PF01217	0.470
TRG_DiLeu_BaLyEn_6	244	249	PF01217	0.445
TRG_ENDOCYTIC_2	126	129	PF00928	0.393
TRG_ENDOCYTIC_2	252	255	PF00928	0.468
TRG_ENDOCYTIC_2	257	260	PF00928	0.468
TRG_ENDOCYTIC_2	387	390	PF00928	0.428
TRG_ER_diArg_1	245	247	PF00400	0.454
TRG_ER_diArg_1	425	427	PF00400	0.363
TRG_ER_diArg_1	486	489	PF00400	0.497
TRG_Pf-PMV_PEXEL_1	254	259	PF00026	0.286

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCD3	Leptomonas seymouri	80%	100%
A0A1X0NVQ2	Trypanosomatidae	72%	100%
A0A3Q8IC47	Leishmania donovani	95%	100%
A0A3S7WWE6	Leishmania donovani	39%	100%
A0A422N1V5	Trypanosoma rangeli	71%	100%
A4HBR4	Leishmania braziliensis	38%	100%
A4HDK5	Leishmania braziliensis	94%	100%
A4HZ67	Leishmania infantum	39%	100%
A4I0X6	Leishmania infantum	95%	100%
E9AV34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
O15379	Homo sapiens	36%	100%
O88895	Mus musculus	37%	100%
P56520	Gallus gallus	37%	100%
P64375	Staphylococcus aureus (strain Mu50 / ATCC 700699)	28%	100%
P64376	Staphylococcus aureus (strain N315)	28%	100%
Q28DV3	Xenopus tropicalis	37%	100%
Q4QAJ4	Leishmania major	94%	100%
Q4QCE7	Leishmania major	39%	100%
Q4SFA0	Tetraodon nigroviridis	36%	100%
Q5HF39	Staphylococcus aureus (strain COL)	28%	100%
Q5RB76	Pongo abelii	36%	100%
Q6G8J2	Staphylococcus aureus (strain MSSA476)	28%	100%
Q6GFX3	Staphylococcus aureus (strain MRSA252)	28%	100%
Q6IRL9	Xenopus laevis	37%	100%
Q6P6W3	Rattus norvegicus	37%	100%
Q7SXM0	Danio rerio	39%	100%
Q803C3	Danio rerio	36%	100%
Q8NW34	Staphylococcus aureus (strain MW2)	28%	100%