TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWX8_LEIMU

TriTrypDb:

LmxM.24.1350

Length:

888

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWX8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.316
CLV_C14_Caspase3-7	228	232	PF00656	0.450
CLV_C14_Caspase3-7	495	499	PF00656	0.523
CLV_C14_Caspase3-7	526	530	PF00656	0.596
CLV_NRD_NRD_1	173	175	PF00675	0.511
CLV_NRD_NRD_1	326	328	PF00675	0.556
CLV_NRD_NRD_1	344	346	PF00675	0.671
CLV_NRD_NRD_1	49	51	PF00675	0.418
CLV_NRD_NRD_1	492	494	PF00675	0.644
CLV_NRD_NRD_1	588	590	PF00675	0.477
CLV_NRD_NRD_1	620	622	PF00675	0.595
CLV_NRD_NRD_1	637	639	PF00675	0.334
CLV_NRD_NRD_1	647	649	PF00675	0.375
CLV_NRD_NRD_1	652	654	PF00675	0.361
CLV_NRD_NRD_1	668	670	PF00675	0.509
CLV_NRD_NRD_1	682	684	PF00675	0.400
CLV_NRD_NRD_1	761	763	PF00675	0.354
CLV_NRD_NRD_1	792	794	PF00675	0.242
CLV_NRD_NRD_1	818	820	PF00675	0.631
CLV_NRD_NRD_1	853	855	PF00675	0.446
CLV_NRD_NRD_1	862	864	PF00675	0.458
CLV_PCSK_FUR_1	49	53	PF00082	0.426
CLV_PCSK_FUR_1	789	793	PF00082	0.254
CLV_PCSK_KEX2_1	173	175	PF00082	0.511
CLV_PCSK_KEX2_1	344	346	PF00082	0.650
CLV_PCSK_KEX2_1	49	51	PF00082	0.431
CLV_PCSK_KEX2_1	588	590	PF00082	0.472
CLV_PCSK_KEX2_1	619	621	PF00082	0.556
CLV_PCSK_KEX2_1	637	639	PF00082	0.328
CLV_PCSK_KEX2_1	647	649	PF00082	0.380
CLV_PCSK_KEX2_1	652	654	PF00082	0.374
CLV_PCSK_KEX2_1	667	669	PF00082	0.547
CLV_PCSK_KEX2_1	682	684	PF00082	0.428
CLV_PCSK_KEX2_1	761	763	PF00082	0.368
CLV_PCSK_KEX2_1	791	793	PF00082	0.252
CLV_PCSK_KEX2_1	818	820	PF00082	0.668
CLV_PCSK_KEX2_1	852	854	PF00082	0.491
CLV_PCSK_KEX2_1	862	864	PF00082	0.454
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.312
CLV_PCSK_PC1ET2_1	852	854	PF00082	0.516
CLV_PCSK_PC7_1	648	654	PF00082	0.412
CLV_PCSK_SKI1_1	123	127	PF00082	0.633
CLV_PCSK_SKI1_1	167	171	PF00082	0.495
CLV_PCSK_SKI1_1	28	32	PF00082	0.417
CLV_PCSK_SKI1_1	308	312	PF00082	0.580
CLV_PCSK_SKI1_1	494	498	PF00082	0.398
CLV_PCSK_SKI1_1	570	574	PF00082	0.424
CLV_PCSK_SKI1_1	658	662	PF00082	0.378
CLV_PCSK_SKI1_1	746	750	PF00082	0.251
DEG_APCC_DBOX_1	214	222	PF00400	0.495
DEG_COP1_1	129	139	PF00400	0.346
DEG_Nend_UBRbox_2	1	3	PF02207	0.773
DOC_ANK_TNKS_1	155	162	PF00023	0.425
DOC_CDC14_PxL_1	179	187	PF14671	0.377
DOC_MAPK_gen_1	588	598	PF00069	0.516
DOC_MAPK_gen_1	608	617	PF00069	0.372
DOC_MAPK_MEF2A_6	34	41	PF00069	0.570
DOC_MAPK_MEF2A_6	592	600	PF00069	0.501
DOC_PP2B_LxvP_1	113	116	PF13499	0.621
DOC_PP4_FxxP_1	511	514	PF00568	0.559
DOC_USP7_MATH_1	20	24	PF00917	0.418
DOC_USP7_MATH_1	213	217	PF00917	0.494
DOC_USP7_MATH_1	245	249	PF00917	0.611
DOC_USP7_MATH_1	279	283	PF00917	0.577
DOC_USP7_MATH_1	427	431	PF00917	0.592
DOC_USP7_MATH_1	787	791	PF00917	0.454
DOC_USP7_MATH_1	807	811	PF00917	0.443
DOC_WW_Pin1_4	437	442	PF00397	0.316
LIG_14-3-3_CanoR_1	215	219	PF00244	0.385
LIG_14-3-3_CanoR_1	28	33	PF00244	0.563
LIG_14-3-3_CanoR_1	459	463	PF00244	0.600
LIG_14-3-3_CanoR_1	52	62	PF00244	0.376
LIG_14-3-3_CanoR_1	538	542	PF00244	0.559
LIG_14-3-3_CanoR_1	558	566	PF00244	0.563
LIG_14-3-3_CanoR_1	878	884	PF00244	0.530
LIG_Actin_WH2_2	140	158	PF00022	0.337
LIG_BIR_III_4	450	454	PF00653	0.430
LIG_BRCT_BRCA1_1	816	820	PF00533	0.549
LIG_CaM_IQ_9	629	645	PF13499	0.390
LIG_CaM_IQ_9	699	714	PF13499	0.442
LIG_CaM_IQ_9	738	753	PF13499	0.438
LIG_CaM_IQ_9	768	784	PF13499	0.333
LIG_CaM_IQ_9	839	855	PF13499	0.450
LIG_FHA_1	130	136	PF00498	0.591
LIG_FHA_1	186	192	PF00498	0.426
LIG_FHA_1	215	221	PF00498	0.329
LIG_FHA_1	245	251	PF00498	0.479
LIG_FHA_1	255	261	PF00498	0.450
LIG_FHA_1	383	389	PF00498	0.327
LIG_FHA_1	443	449	PF00498	0.508
LIG_FHA_1	485	491	PF00498	0.704
LIG_FHA_1	554	560	PF00498	0.460
LIG_FHA_1	563	569	PF00498	0.516
LIG_FHA_1	77	83	PF00498	0.464
LIG_FHA_1	878	884	PF00498	0.581
LIG_FHA_2	161	167	PF00498	0.326
LIG_FHA_2	263	269	PF00498	0.593
LIG_FHA_2	419	425	PF00498	0.493
LIG_FHA_2	490	496	PF00498	0.621
LIG_LIR_Gen_1	137	147	PF02991	0.494
LIG_LIR_Gen_1	395	405	PF02991	0.379
LIG_LIR_Gen_1	429	436	PF02991	0.487
LIG_LIR_Gen_1	66	76	PF02991	0.373
LIG_LIR_Gen_1	93	102	PF02991	0.322
LIG_LIR_Nem_3	100	105	PF02991	0.340
LIG_LIR_Nem_3	137	143	PF02991	0.500
LIG_LIR_Nem_3	188	192	PF02991	0.507
LIG_LIR_Nem_3	395	400	PF02991	0.374
LIG_LIR_Nem_3	429	435	PF02991	0.424
LIG_LIR_Nem_3	64	68	PF02991	0.395
LIG_LIR_Nem_3	817	823	PF02991	0.560
LIG_LIR_Nem_3	93	98	PF02991	0.323
LIG_MAD2	793	801	PF02301	0.399
LIG_NRBOX	538	544	PF00104	0.449
LIG_PCNA_yPIPBox_3	119	131	PF02747	0.361
LIG_PCNA_yPIPBox_3	190	203	PF02747	0.343
LIG_Pex14_2	432	436	PF04695	0.533
LIG_Pex14_2	549	553	PF04695	0.453
LIG_PTB_Apo_2	349	356	PF02174	0.636
LIG_Rb_LxCxE_1	430	450	PF01857	0.231
LIG_REV1ctd_RIR_1	598	606	PF16727	0.462
LIG_SH2_CRK	737	741	PF00017	0.292
LIG_SH2_SRC	584	587	PF00017	0.337
LIG_SH2_STAP1	274	278	PF00017	0.563
LIG_SH2_STAP1	397	401	PF00017	0.417
LIG_SH2_STAP1	44	48	PF00017	0.346
LIG_SH2_STAP1	737	741	PF00017	0.297
LIG_SH2_STAT3	769	772	PF00017	0.488
LIG_SH2_STAT5	256	259	PF00017	0.384
LIG_SH2_STAT5	304	307	PF00017	0.516
LIG_SH2_STAT5	377	380	PF00017	0.424
LIG_SH2_STAT5	584	587	PF00017	0.391
LIG_SH2_STAT5	635	638	PF00017	0.465
LIG_SH2_STAT5	655	658	PF00017	0.460
LIG_SH2_STAT5	68	71	PF00017	0.448
LIG_SH2_STAT5	744	747	PF00017	0.418
LIG_SH2_STAT5	94	97	PF00017	0.473
LIG_SH3_3	105	111	PF00018	0.436
LIG_SH3_3	347	353	PF00018	0.476
LIG_SH3_3	365	371	PF00018	0.461
LIG_SH3_3	459	465	PF00018	0.540
LIG_SH3_3	478	484	PF00018	0.616
LIG_SH3_3	81	87	PF00018	0.471
LIG_SUMO_SIM_anti_2	216	222	PF11976	0.446
LIG_SUMO_SIM_anti_2	657	664	PF11976	0.377
LIG_SUMO_SIM_par_1	216	222	PF11976	0.267
LIG_SUMO_SIM_par_1	246	254	PF11976	0.362
LIG_SUMO_SIM_par_1	657	664	PF11976	0.377
LIG_TRAF2_1	548	551	PF00917	0.445
LIG_TRAF2_1	641	644	PF00917	0.509
LIG_TRAF2_1	868	871	PF00917	0.512
LIG_UBA3_1	38	42	PF00899	0.393
LIG_WRC_WIRS_1	21	26	PF05994	0.466
LIG_WRC_WIRS_1	563	568	PF05994	0.477
MOD_CK1_1	234	240	PF00069	0.692
MOD_CK1_1	266	272	PF00069	0.426
MOD_CK1_1	810	816	PF00069	0.601
MOD_CK1_1	879	885	PF00069	0.531
MOD_CK2_1	160	166	PF00069	0.496
MOD_CK2_1	205	211	PF00069	0.410
MOD_CK2_1	234	240	PF00069	0.509
MOD_CK2_1	262	268	PF00069	0.450
MOD_CK2_1	353	359	PF00069	0.660
MOD_CK2_1	418	424	PF00069	0.483
MOD_CK2_1	489	495	PF00069	0.621
MOD_Cter_Amidation	586	589	PF01082	0.618
MOD_Cter_Amidation	645	648	PF01082	0.409
MOD_GlcNHglycan	100	105	PF01048	0.362
MOD_GlcNHglycan	11	14	PF01048	0.549
MOD_GlcNHglycan	55	58	PF01048	0.477
MOD_GlcNHglycan	560	563	PF01048	0.571
MOD_GlcNHglycan	591	595	PF01048	0.456
MOD_GlcNHglycan	809	812	PF01048	0.534
MOD_GSK3_1	181	188	PF00069	0.529
MOD_GSK3_1	234	241	PF00069	0.679
MOD_GSK3_1	259	266	PF00069	0.410
MOD_GSK3_1	279	286	PF00069	0.588
MOD_GSK3_1	330	337	PF00069	0.650
MOD_GSK3_1	558	565	PF00069	0.600
MOD_GSK3_1	807	814	PF00069	0.550
MOD_GSK3_1	9	16	PF00069	0.591
MOD_LATS_1	7	13	PF00433	0.438
MOD_N-GLC_1	234	239	PF02516	0.439
MOD_N-GLC_1	263	268	PF02516	0.346
MOD_N-GLC_1	28	33	PF02516	0.384
MOD_NEK2_1	143	148	PF00069	0.377
MOD_NEK2_1	185	190	PF00069	0.482
MOD_NEK2_1	251	256	PF00069	0.347
MOD_NEK2_1	294	299	PF00069	0.505
MOD_NEK2_1	400	405	PF00069	0.468
MOD_NEK2_1	418	423	PF00069	0.402
MOD_NEK2_1	442	447	PF00069	0.459
MOD_NEK2_1	458	463	PF00069	0.594
MOD_NEK2_1	63	68	PF00069	0.481
MOD_NEK2_1	661	666	PF00069	0.482
MOD_NEK2_1	678	683	PF00069	0.459
MOD_NEK2_1	730	735	PF00069	0.599
MOD_NEK2_1	845	850	PF00069	0.513
MOD_NEK2_2	13	18	PF00069	0.505
MOD_NEK2_2	427	432	PF00069	0.436
MOD_PIKK_1	205	211	PF00454	0.568
MOD_PIKK_1	22	28	PF00454	0.445
MOD_PIKK_1	768	774	PF00454	0.487
MOD_PK_1	131	137	PF00069	0.437
MOD_PKA_2	214	220	PF00069	0.280
MOD_PKA_2	353	359	PF00069	0.686
MOD_PKA_2	458	464	PF00069	0.512
MOD_PKA_2	484	490	PF00069	0.716
MOD_PKA_2	537	543	PF00069	0.469
MOD_PKA_2	730	736	PF00069	0.530
MOD_PKA_2	877	883	PF00069	0.583
MOD_Plk_1	100	106	PF00069	0.553
MOD_Plk_1	234	240	PF00069	0.570
MOD_Plk_1	245	251	PF00069	0.445
MOD_Plk_1	267	273	PF00069	0.467
MOD_Plk_1	28	34	PF00069	0.395
MOD_Plk_1	63	69	PF00069	0.514
MOD_Plk_4	245	251	PF00069	0.425
MOD_Plk_4	267	273	PF00069	0.585
MOD_Plk_4	413	419	PF00069	0.536
MOD_Plk_4	427	433	PF00069	0.340
MOD_Plk_4	43	49	PF00069	0.386
MOD_Plk_4	458	464	PF00069	0.597
MOD_Plk_4	468	474	PF00069	0.440
MOD_Plk_4	537	543	PF00069	0.467
MOD_Plk_4	736	742	PF00069	0.273
MOD_ProDKin_1	437	443	PF00069	0.316
MOD_SUMO_for_1	543	546	PF00179	0.549
MOD_SUMO_for_1	575	578	PF00179	0.454
MOD_SUMO_rev_2	124	132	PF00179	0.623
MOD_SUMO_rev_2	826	836	PF00179	0.523
TRG_DiLeu_BaEn_1	166	171	PF01217	0.366
TRG_DiLeu_BaEn_1	657	662	PF01217	0.377
TRG_DiLeu_BaLyEn_6	34	39	PF01217	0.536
TRG_DiLeu_BaLyEn_6	444	449	PF01217	0.487
TRG_ENDOCYTIC_2	397	400	PF00928	0.511
TRG_ENDOCYTIC_2	642	645	PF00928	0.388
TRG_ENDOCYTIC_2	675	678	PF00928	0.448
TRG_ENDOCYTIC_2	68	71	PF00928	0.441
TRG_ENDOCYTIC_2	737	740	PF00928	0.292
TRG_ENDOCYTIC_2	94	97	PF00928	0.451
TRG_ER_diArg_1	173	175	PF00400	0.547
TRG_ER_diArg_1	298	301	PF00400	0.408
TRG_ER_diArg_1	48	50	PF00400	0.386
TRG_ER_diArg_1	619	621	PF00400	0.571
TRG_ER_diArg_1	636	638	PF00400	0.293
TRG_ER_diArg_1	667	669	PF00400	0.474
TRG_ER_diArg_1	751	754	PF00400	0.365
TRG_ER_diArg_1	788	791	PF00400	0.466
TRG_ER_diArg_1	792	794	PF00400	0.450
TRG_ER_diArg_1	818	820	PF00400	0.700
TRG_ER_diArg_1	853	855	PF00400	0.461
TRG_NES_CRM1_1	557	571	PF08389	0.515
TRG_NLS_MonoExtN_4	49	54	PF00514	0.300
TRG_Pf-PMV_PEXEL_1	173	178	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	223	227	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	608	613	PF00026	0.631

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSD4	Leptomonas seymouri	48%	100%
A0A1X0NVS1	Trypanosomatidae	28%	100%
A0A3Q8IBX8	Leishmania donovani	88%	100%
A0A422NP16	Trypanosoma rangeli	29%	100%
A4HDK7	Leishmania braziliensis	74%	100%
A4I0X4	Leishmania infantum	88%	100%
C9ZWH3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
Q4QAJ6	Leishmania major	87%	100%
V5AVI0	Trypanosoma cruzi	28%	100%