Peptidyl-prolyl cis-trans isomerase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peptidyl-prolyl cis-trans isomerase-like protein

Species:

Leishmania mexicana

UniProt:

E9AWX4_LEIMU

TriTrypDb:

LmxM.24.1315

Length:

242

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AWX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWX4

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0018193	peptidyl-amino acid modification	5	9
GO:0018208	peptidyl-proline modification	6	9
GO:0019538	protein metabolic process	3	9
GO:0036211	protein modification process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0044238	primary metabolic process	2	9
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	9
GO:0003824	catalytic activity	1	9
GO:0016853	isomerase activity	2	9
GO:0016859	cis-trans isomerase activity	3	9
GO:0140096	catalytic activity, acting on a protein	2	9
GO:0005488	binding	1	1
GO:0016018	cyclosporin A binding	4	1
GO:0033218	amide binding	2	1
GO:0042277	peptide binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	226	228	PF00675	0.375
CLV_NRD_NRD_1	34	36	PF00675	0.527
CLV_NRD_NRD_1	48	50	PF00675	0.719
CLV_PCSK_KEX2_1	34	36	PF00082	0.603
DEG_Nend_Nbox_1	1	3	PF02207	0.494
DEG_SPOP_SBC_1	9	13	PF00917	0.463
DOC_PP1_RVXF_1	193	200	PF00149	0.296
DOC_USP7_MATH_1	211	215	PF00917	0.368
DOC_USP7_MATH_1	3	7	PF00917	0.418
DOC_USP7_UBL2_3	112	116	PF12436	0.296
DOC_USP7_UBL2_3	50	54	PF12436	0.551
DOC_WW_Pin1_4	90	95	PF00397	0.337
LIG_14-3-3_CanoR_1	168	174	PF00244	0.355
LIG_14-3-3_CanoR_1	8	18	PF00244	0.432
LIG_BRCT_BRCA1_1	169	173	PF00533	0.261
LIG_BRCT_BRCA1_1	175	179	PF00533	0.261
LIG_Clathr_ClatBox_1	71	75	PF01394	0.384
LIG_DCNL_PONY_1	1	4	PF03556	0.493
LIG_FHA_1	133	139	PF00498	0.362
LIG_FHA_2	169	175	PF00498	0.346
LIG_LIR_Gen_1	12	21	PF02991	0.475
LIG_LIR_Gen_1	176	187	PF02991	0.355
LIG_LIR_Gen_1	22	29	PF02991	0.506
LIG_LIR_Gen_1	236	242	PF02991	0.424
LIG_LIR_Nem_3	12	18	PF02991	0.518
LIG_LIR_Nem_3	176	182	PF02991	0.264
LIG_LIR_Nem_3	22	28	PF02991	0.460
LIG_LIR_Nem_3	78	84	PF02991	0.301
LIG_MLH1_MIPbox_1	175	179	PF16413	0.261
LIG_Pex14_2	15	19	PF04695	0.478
LIG_PTB_Apo_2	119	126	PF02174	0.355
LIG_SH2_CRK	161	165	PF00017	0.337
LIG_SH2_CRK	81	85	PF00017	0.355
LIG_SH2_STAT5	232	235	PF00017	0.386
LIG_SH3_3	34	40	PF00018	0.518
LIG_SH3_3	41	47	PF00018	0.485
LIG_SUMO_SIM_par_1	82	87	PF11976	0.337
LIG_UBA3_1	71	76	PF00899	0.388
LIG_WW_3	46	50	PF00397	0.729
MOD_CDK_SPK_2	90	95	PF00069	0.337
MOD_CK1_1	107	113	PF00069	0.276
MOD_CK1_1	126	132	PF00069	0.148
MOD_CK1_1	169	175	PF00069	0.355
MOD_CK1_1	59	65	PF00069	0.563
MOD_CK1_1	90	96	PF00069	0.415
MOD_Cter_Amidation	32	35	PF01082	0.425
MOD_GlcNHglycan	104	107	PF01048	0.223
MOD_GlcNHglycan	218	222	PF01048	0.473
MOD_GlcNHglycan	25	28	PF01048	0.537
MOD_GlcNHglycan	58	61	PF01048	0.567
MOD_GlcNHglycan	89	92	PF01048	0.337
MOD_GSK3_1	102	109	PF00069	0.382
MOD_GSK3_1	162	169	PF00069	0.287
MOD_GSK3_1	4	11	PF00069	0.423
MOD_N-GLC_1	102	107	PF02516	0.283
MOD_NEK2_1	10	15	PF00069	0.485
MOD_NEK2_1	166	171	PF00069	0.287
MOD_NEK2_1	173	178	PF00069	0.341
MOD_NEK2_1	4	9	PF00069	0.449
MOD_PIKK_1	173	179	PF00454	0.374
MOD_PKA_2	123	129	PF00069	0.281
MOD_PKA_2	167	173	PF00069	0.296
MOD_PKA_2	183	189	PF00069	0.261
MOD_PKA_2	23	29	PF00069	0.490
MOD_Plk_1	235	241	PF00069	0.406
MOD_Plk_4	10	16	PF00069	0.523
MOD_ProDKin_1	90	96	PF00069	0.337
TRG_DiLeu_BaEn_1	32	37	PF01217	0.513
TRG_ENDOCYTIC_2	161	164	PF00928	0.337
TRG_ENDOCYTIC_2	239	242	PF00928	0.563
TRG_ENDOCYTIC_2	25	28	PF00928	0.537
TRG_ENDOCYTIC_2	81	84	PF00928	0.355
TRG_ER_diArg_1	34	36	PF00400	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D1	Leptomonas seymouri	66%	100%
A0A0N0P523	Leptomonas seymouri	32%	88%
A0A0S4J351	Bodo saltans	29%	91%
A0A1X0ND98	Trypanosomatidae	40%	100%
A0A1X0NXG7	Trypanosomatidae	29%	93%
A0A3R7RE54	Trypanosoma rangeli	31%	94%
A0A3S5H7U6	Leishmania donovani	26%	94%
A0A3S7WXF4	Leishmania donovani	31%	82%
A0A3S7WYD9	Leishmania donovani	90%	100%
A4HCL8	Leishmania braziliensis	27%	82%
A4HDL1	Leishmania braziliensis	78%	100%
A4HLM4	Leishmania braziliensis	28%	100%
A4I042	Leishmania infantum	31%	82%
A4I0X0	Leishmania infantum	90%	100%
A4I935	Leishmania infantum	26%	94%
C9ZUX8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	80%
C9ZWH7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B400	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	95%
P29117	Rattus norvegicus	31%	100%
P52011	Caenorhabditis elegans	30%	100%
Q38867	Arabidopsis thaliana	31%	100%
Q38900	Arabidopsis thaliana	30%	100%
Q4G338	Haemonchus contortus	32%	75%
Q4Q424	Leishmania major	27%	100%
Q4QAK0	Leishmania major	92%	100%
Q4QBH1	Leishmania major	31%	82%
Q99KR7	Mus musculus	30%	100%
V5B2A0	Trypanosoma cruzi	31%	94%