Tudor domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWX3_LEIMU

TriTrypDb:

LmxM.24.1310

Length:

254

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AWX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWX3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	227	231	PF00656	0.518
CLV_NRD_NRD_1	3	5	PF00675	0.718
CLV_NRD_NRD_1	49	51	PF00675	0.278
CLV_PCSK_FUR_1	50	54	PF00082	0.283
CLV_PCSK_KEX2_1	52	54	PF00082	0.587
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.587
CLV_PCSK_SKI1_1	127	131	PF00082	0.477
CLV_PCSK_SKI1_1	192	196	PF00082	0.490
CLV_PCSK_SKI1_1	44	48	PF00082	0.454
DEG_MDM2_SWIB_1	56	64	PF02201	0.451
DOC_MAPK_gen_1	4	12	PF00069	0.505
DOC_MAPK_JIP1_4	19	25	PF00069	0.535
DOC_MAPK_MEF2A_6	19	27	PF00069	0.615
DOC_MAPK_MEF2A_6	205	212	PF00069	0.514
DOC_PP1_RVXF_1	125	131	PF00149	0.491
DOC_PP4_FxxP_1	232	235	PF00568	0.509
DOC_USP7_MATH_1	159	163	PF00917	0.616
DOC_USP7_MATH_1	3	7	PF00917	0.677
DOC_USP7_MATH_1	8	12	PF00917	0.665
DOC_USP7_MATH_1	80	84	PF00917	0.668
DOC_USP7_UBL2_3	205	209	PF12436	0.523
LIG_14-3-3_CanoR_1	190	195	PF00244	0.529
LIG_14-3-3_CanoR_1	4	12	PF00244	0.388
LIG_14-3-3_CanoR_1	50	60	PF00244	0.496
LIG_AP2alpha_1	228	232	PF02296	0.550
LIG_BRCT_BRCA1_1	218	222	PF00533	0.428
LIG_EH_1	74	78	PF12763	0.576
LIG_FHA_1	121	127	PF00498	0.496
LIG_FHA_1	136	142	PF00498	0.360
LIG_FHA_1	161	167	PF00498	0.564
LIG_FHA_1	169	175	PF00498	0.466
LIG_FHA_1	186	192	PF00498	0.392
LIG_FHA_2	142	148	PF00498	0.500
LIG_FHA_2	222	228	PF00498	0.379
LIG_LIR_Apic_2	230	235	PF02991	0.593
LIG_LIR_Gen_1	57	67	PF02991	0.547
LIG_LIR_Gen_1	95	104	PF02991	0.409
LIG_LIR_Nem_3	219	225	PF02991	0.406
LIG_LIR_Nem_3	57	63	PF02991	0.559
LIG_LIR_Nem_3	92	96	PF02991	0.397
LIG_MYND_1	204	208	PF01753	0.440
LIG_NRBOX	42	48	PF00104	0.287
LIG_Pex14_2	228	232	PF04695	0.523
LIG_Pex14_2	56	60	PF04695	0.525
LIG_SH2_GRB2like	216	219	PF00017	0.445
LIG_SH2_NCK_1	35	39	PF00017	0.572
LIG_SH2_SRC	216	219	PF00017	0.451
LIG_SH2_STAT3	96	99	PF00017	0.494
LIG_SH2_STAT5	107	110	PF00017	0.350
LIG_SH2_STAT5	216	219	PF00017	0.401
LIG_SH2_STAT5	96	99	PF00017	0.405
LIG_SH3_3	14	20	PF00018	0.584
LIG_SH3_3	198	204	PF00018	0.507
LIG_SH3_3	98	104	PF00018	0.452
LIG_SUMO_SIM_par_1	21	26	PF11976	0.528
LIG_TRAF2_1	162	165	PF00917	0.540
LIG_WW_3	1	5	PF00397	0.736
MOD_CK1_1	193	199	PF00069	0.537
MOD_CK1_1	221	227	PF00069	0.543
MOD_CK1_1	81	87	PF00069	0.546
MOD_CK2_1	154	160	PF00069	0.600
MOD_CK2_1	173	179	PF00069	0.414
MOD_CK2_1	221	227	PF00069	0.389
MOD_CK2_1	8	14	PF00069	0.663
MOD_Cter_Amidation	48	51	PF01082	0.393
MOD_GlcNHglycan	157	160	PF01048	0.617
MOD_GSK3_1	150	157	PF00069	0.554
MOD_GSK3_1	168	175	PF00069	0.435
MOD_GSK3_1	76	83	PF00069	0.544
MOD_N-GLC_2	231	233	PF02516	0.529
MOD_NEK2_1	120	125	PF00069	0.505
MOD_NEK2_1	154	159	PF00069	0.642
MOD_NEK2_1	23	28	PF00069	0.593
MOD_PIKK_1	183	189	PF00454	0.449
MOD_PIKK_1	78	84	PF00454	0.600
MOD_PK_1	190	196	PF00069	0.572
MOD_PKA_1	51	57	PF00069	0.525
MOD_PKA_2	18	24	PF00069	0.622
MOD_PKA_2	3	9	PF00069	0.403
MOD_PKA_2	52	58	PF00069	0.554
MOD_Plk_1	172	178	PF00069	0.476
MOD_Plk_1	23	29	PF00069	0.542
MOD_Plk_2-3	160	166	PF00069	0.613
MOD_Plk_2-3	173	179	PF00069	0.382
MOD_Plk_2-3	18	24	PF00069	0.532
MOD_Plk_4	150	156	PF00069	0.587
MOD_Plk_4	173	179	PF00069	0.489
MOD_Plk_4	18	24	PF00069	0.510
MOD_Plk_4	190	196	PF00069	0.397
MOD_Plk_4	218	224	PF00069	0.559
MOD_Plk_4	8	14	PF00069	0.498
MOD_Plk_4	85	91	PF00069	0.484
MOD_SUMO_rev_2	113	118	PF00179	0.496
MOD_SUMO_rev_2	61	69	PF00179	0.558
TRG_ER_diArg_1	41	44	PF00400	0.454
TRG_NLS_MonoCore_2	49	54	PF00514	0.560
TRG_NLS_MonoExtN_4	50	55	PF00514	0.555
TRG_Pf-PMV_PEXEL_1	127	132	PF00026	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHY5	Leptomonas seymouri	54%	100%
A0A0S4J677	Bodo saltans	23%	77%
A0A0S4JEV4	Bodo saltans	23%	77%
A0A1X0NX29	Trypanosomatidae	32%	96%
A0A3S7WYF1	Leishmania donovani	89%	100%
A4HDL2	Leishmania braziliensis	80%	100%
A4I0W9	Leishmania infantum	89%	100%
C9ZWH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	96%
Q4QAK1	Leishmania major	91%	100%
V5BAW4	Trypanosoma cruzi	32%	81%