Putative DNAJ-domain protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNAJ-domain protein, putative

Species:

Leishmania mexicana

UniProt:

E9AWX2_LEIMU

TriTrypDb:

LmxM.24.1300

Length:

808

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWX2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWX2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	477	481	PF00656	0.456
CLV_C14_Caspase3-7	653	657	PF00656	0.606
CLV_C14_Caspase3-7	775	779	PF00656	0.399
CLV_NRD_NRD_1	163	165	PF00675	0.422
CLV_NRD_NRD_1	215	217	PF00675	0.410
CLV_NRD_NRD_1	221	223	PF00675	0.425
CLV_NRD_NRD_1	273	275	PF00675	0.746
CLV_NRD_NRD_1	3	5	PF00675	0.723
CLV_NRD_NRD_1	747	749	PF00675	0.631
CLV_NRD_NRD_1	85	87	PF00675	0.794
CLV_PCSK_KEX2_1	163	165	PF00082	0.422
CLV_PCSK_KEX2_1	215	217	PF00082	0.486
CLV_PCSK_KEX2_1	221	223	PF00082	0.508
CLV_PCSK_KEX2_1	273	275	PF00082	0.746
CLV_PCSK_KEX2_1	3	5	PF00082	0.723
CLV_PCSK_KEX2_1	548	550	PF00082	0.505
CLV_PCSK_KEX2_1	558	560	PF00082	0.475
CLV_PCSK_KEX2_1	85	87	PF00082	0.794
CLV_PCSK_PC1ET2_1	548	550	PF00082	0.360
CLV_PCSK_PC1ET2_1	558	560	PF00082	0.339
CLV_PCSK_PC7_1	544	550	PF00082	0.449
CLV_PCSK_SKI1_1	14	18	PF00082	0.417
CLV_PCSK_SKI1_1	216	220	PF00082	0.519
CLV_PCSK_SKI1_1	514	518	PF00082	0.543
CLV_PCSK_SKI1_1	544	548	PF00082	0.375
CLV_PCSK_SKI1_1	558	562	PF00082	0.519
CLV_PCSK_SKI1_1	67	71	PF00082	0.415
CLV_PCSK_SKI1_1	743	747	PF00082	0.438
CLV_PCSK_SKI1_1	9	13	PF00082	0.483
DEG_APCC_DBOX_1	13	21	PF00400	0.439
DEG_APCC_DBOX_1	543	551	PF00400	0.440
DEG_APCC_DBOX_1	66	74	PF00400	0.435
DEG_Nend_Nbox_1	1	3	PF02207	0.599
DEG_SCF_TRCP1_1	402	407	PF00400	0.477
DEG_SPOP_SBC_1	121	125	PF00917	0.616
DOC_CKS1_1	143	148	PF01111	0.509
DOC_CKS1_1	420	425	PF01111	0.333
DOC_CKS1_1	435	440	PF01111	0.438
DOC_CYCLIN_RxL_1	14	25	PF00134	0.335
DOC_CYCLIN_yClb1_LxF_4	727	733	PF00134	0.403
DOC_CYCLIN_yCln2_LP_2	683	689	PF00134	0.436
DOC_CYCLIN_yCln2_LP_2	782	788	PF00134	0.362
DOC_MAPK_gen_1	333	340	PF00069	0.403
DOC_MAPK_MEF2A_6	205	214	PF00069	0.375
DOC_MAPK_MEF2A_6	333	340	PF00069	0.356
DOC_MAPK_NFAT4_5	333	341	PF00069	0.362
DOC_PP2B_LxvP_1	782	785	PF13499	0.350
DOC_PP4_FxxP_1	143	146	PF00568	0.490
DOC_PP4_FxxP_1	263	266	PF00568	0.435
DOC_PP4_FxxP_1	420	423	PF00568	0.344
DOC_USP7_MATH_1	101	105	PF00917	0.607
DOC_USP7_MATH_1	122	126	PF00917	0.671
DOC_USP7_MATH_1	286	290	PF00917	0.686
DOC_USP7_MATH_1	312	316	PF00917	0.385
DOC_USP7_MATH_1	400	404	PF00917	0.574
DOC_USP7_MATH_1	431	435	PF00917	0.529
DOC_USP7_UBL2_3	219	223	PF12436	0.349
DOC_USP7_UBL2_3	501	505	PF12436	0.671
DOC_WW_Pin1_4	126	131	PF00397	0.705
DOC_WW_Pin1_4	142	147	PF00397	0.527
DOC_WW_Pin1_4	20	25	PF00397	0.285
DOC_WW_Pin1_4	26	31	PF00397	0.242
DOC_WW_Pin1_4	419	424	PF00397	0.388
DOC_WW_Pin1_4	434	439	PF00397	0.454
DOC_WW_Pin1_4	479	484	PF00397	0.728
DOC_WW_Pin1_4	504	509	PF00397	0.617
DOC_WW_Pin1_4	585	590	PF00397	0.555
DOC_WW_Pin1_4	756	761	PF00397	0.484
DOC_WW_Pin1_4	767	772	PF00397	0.449
DOC_WW_Pin1_4	9	14	PF00397	0.491
LIG_14-3-3_CanoR_1	114	122	PF00244	0.603
LIG_14-3-3_CanoR_1	163	169	PF00244	0.443
LIG_14-3-3_CanoR_1	18	23	PF00244	0.386
LIG_14-3-3_CanoR_1	288	297	PF00244	0.486
LIG_14-3-3_CanoR_1	301	309	PF00244	0.546
LIG_14-3-3_CanoR_1	345	353	PF00244	0.381
LIG_14-3-3_CanoR_1	39	43	PF00244	0.292
LIG_14-3-3_CanoR_1	60	68	PF00244	0.313
LIG_14-3-3_CanoR_1	85	95	PF00244	0.725
LIG_Actin_WH2_2	529	546	PF00022	0.383
LIG_APCC_ABBA_1	617	622	PF00400	0.545
LIG_APCC_ABBA_1	634	639	PF00400	0.319
LIG_BIR_III_2	480	484	PF00653	0.481
LIG_BIR_III_4	656	660	PF00653	0.552
LIG_BRCT_BRCA1_1	62	66	PF00533	0.378
LIG_FHA_1	143	149	PF00498	0.566
LIG_FHA_1	191	197	PF00498	0.444
LIG_FHA_1	23	29	PF00498	0.363
LIG_FHA_1	318	324	PF00498	0.405
LIG_FHA_1	405	411	PF00498	0.499
LIG_FHA_1	435	441	PF00498	0.574
LIG_FHA_1	466	472	PF00498	0.483
LIG_FHA_1	531	537	PF00498	0.449
LIG_FHA_1	688	694	PF00498	0.483
LIG_FHA_1	704	710	PF00498	0.585
LIG_FHA_2	145	151	PF00498	0.551
LIG_FHA_2	605	611	PF00498	0.391
LIG_FHA_2	679	685	PF00498	0.364
LIG_FHA_2	757	763	PF00498	0.416
LIG_HP1_1	254	258	PF01393	0.418
LIG_LIR_Apic_2	129	135	PF02991	0.627
LIG_LIR_Apic_2	418	423	PF02991	0.342
LIG_LIR_Gen_1	226	236	PF02991	0.509
LIG_LIR_Gen_1	330	339	PF02991	0.376
LIG_LIR_Gen_1	574	580	PF02991	0.551
LIG_LIR_Nem_3	226	232	PF02991	0.507
LIG_LIR_Nem_3	330	334	PF02991	0.378
LIG_LIR_Nem_3	462	466	PF02991	0.428
LIG_LIR_Nem_3	522	528	PF02991	0.484
LIG_LIR_Nem_3	56	62	PF02991	0.269
LIG_LIR_Nem_3	574	579	PF02991	0.604
LIG_LIR_Nem_3	612	617	PF02991	0.337
LIG_LYPXL_L_2	310	319	PF13949	0.396
LIG_MYND_1	46	50	PF01753	0.271
LIG_NRBOX	792	798	PF00104	0.428
LIG_PDZ_Class_2	803	808	PF00595	0.599
LIG_Pex14_1	614	618	PF04695	0.424
LIG_Pex14_2	637	641	PF04695	0.441
LIG_Pex14_2	732	736	PF04695	0.325
LIG_REV1ctd_RIR_1	188	198	PF16727	0.395
LIG_SH2_CRK	592	596	PF00017	0.499
LIG_SH2_PTP2	787	790	PF00017	0.381
LIG_SH2_SRC	195	198	PF00017	0.380
LIG_SH2_SRC	787	790	PF00017	0.381
LIG_SH2_STAT3	37	40	PF00017	0.289
LIG_SH2_STAT3	623	626	PF00017	0.299
LIG_SH2_STAT3	96	99	PF00017	0.501
LIG_SH2_STAT5	195	198	PF00017	0.392
LIG_SH2_STAT5	224	227	PF00017	0.459
LIG_SH2_STAT5	229	232	PF00017	0.471
LIG_SH2_STAT5	37	40	PF00017	0.271
LIG_SH2_STAT5	618	621	PF00017	0.436
LIG_SH2_STAT5	623	626	PF00017	0.390
LIG_SH2_STAT5	717	720	PF00017	0.383
LIG_SH2_STAT5	729	732	PF00017	0.367
LIG_SH2_STAT5	787	790	PF00017	0.381
LIG_SH3_3	47	53	PF00018	0.289
LIG_SH3_3	639	645	PF00018	0.474
LIG_SH3_3	719	725	PF00018	0.408
LIG_SUMO_SIM_anti_2	337	342	PF11976	0.426
LIG_SUMO_SIM_par_1	18	23	PF11976	0.470
LIG_SUMO_SIM_par_1	792	799	PF11976	0.440
LIG_TRFH_1	562	566	PF08558	0.452
LIG_UBA3_1	540	548	PF00899	0.379
LIG_WRC_WIRS_1	165	170	PF05994	0.509
LIG_WRC_WIRS_1	729	734	PF05994	0.330
MOD_CDC14_SPxK_1	588	591	PF00782	0.500
MOD_CDC14_SPxK_1	770	773	PF00782	0.467
MOD_CDK_SPK_2	9	14	PF00069	0.473
MOD_CDK_SPxK_1	585	591	PF00069	0.513
MOD_CDK_SPxK_1	767	773	PF00069	0.443
MOD_CK1_1	123	129	PF00069	0.757
MOD_CK1_1	284	290	PF00069	0.694
MOD_CK1_1	359	365	PF00069	0.632
MOD_CK1_1	373	379	PF00069	0.312
MOD_CK1_1	419	425	PF00069	0.443
MOD_CK1_1	434	440	PF00069	0.446
MOD_CK1_1	87	93	PF00069	0.771
MOD_CK2_1	516	522	PF00069	0.520
MOD_CK2_1	604	610	PF00069	0.398
MOD_Cter_Amidation	83	86	PF01082	0.656
MOD_DYRK1A_RPxSP_1	9	13	PF00069	0.517
MOD_GlcNHglycan	180	183	PF01048	0.532
MOD_GlcNHglycan	199	202	PF01048	0.236
MOD_GlcNHglycan	283	286	PF01048	0.736
MOD_GlcNHglycan	347	350	PF01048	0.402
MOD_GlcNHglycan	355	361	PF01048	0.559
MOD_GlcNHglycan	374	378	PF01048	0.481
MOD_GlcNHglycan	402	405	PF01048	0.555
MOD_GlcNHglycan	495	498	PF01048	0.621
MOD_GlcNHglycan	666	669	PF01048	0.536
MOD_GlcNHglycan	80	83	PF01048	0.730
MOD_GlcNHglycan	89	92	PF01048	0.777
MOD_GSK3_1	116	123	PF00069	0.711
MOD_GSK3_1	18	25	PF00069	0.311
MOD_GSK3_1	186	193	PF00069	0.284
MOD_GSK3_1	284	291	PF00069	0.611
MOD_GSK3_1	355	362	PF00069	0.612
MOD_GSK3_1	400	407	PF00069	0.582
MOD_GSK3_1	489	496	PF00069	0.731
MOD_GSK3_1	516	523	PF00069	0.513
MOD_GSK3_1	524	531	PF00069	0.392
MOD_GSK3_1	550	557	PF00069	0.479
MOD_GSK3_1	574	581	PF00069	0.661
MOD_N-GLC_1	53	58	PF02516	0.387
MOD_N-GLC_1	554	559	PF02516	0.436
MOD_N-GLC_1	60	65	PF02516	0.421
MOD_NEK2_1	176	181	PF00069	0.569
MOD_NEK2_1	190	195	PF00069	0.455
MOD_NEK2_1	372	377	PF00069	0.519
MOD_NEK2_1	488	493	PF00069	0.557
MOD_NEK2_1	516	521	PF00069	0.497
MOD_NEK2_1	524	529	PF00069	0.344
MOD_NEK2_1	567	572	PF00069	0.391
MOD_NEK2_1	736	741	PF00069	0.417
MOD_NEK2_2	101	106	PF00069	0.569
MOD_PIKK_1	489	495	PF00454	0.653
MOD_PIKK_1	678	684	PF00454	0.394
MOD_PKA_1	85	91	PF00069	0.600
MOD_PKA_2	287	293	PF00069	0.409
MOD_PKA_2	300	306	PF00069	0.517
MOD_PKA_2	38	44	PF00069	0.292
MOD_PKA_2	567	573	PF00069	0.545
MOD_PKA_2	650	656	PF00069	0.691
MOD_PKA_2	703	709	PF00069	0.526
MOD_PKA_2	84	90	PF00069	0.646
MOD_Plk_1	149	155	PF00069	0.500
MOD_Plk_1	278	284	PF00069	0.613
MOD_Plk_1	574	580	PF00069	0.538
MOD_Plk_1	697	703	PF00069	0.365
MOD_Plk_2-3	327	333	PF00069	0.392
MOD_Plk_4	186	192	PF00069	0.294
MOD_Plk_4	436	442	PF00069	0.469
MOD_Plk_4	520	526	PF00069	0.578
MOD_Plk_4	567	573	PF00069	0.453
MOD_Plk_4	650	656	PF00069	0.444
MOD_Plk_4	728	734	PF00069	0.334
MOD_ProDKin_1	126	132	PF00069	0.705
MOD_ProDKin_1	142	148	PF00069	0.515
MOD_ProDKin_1	20	26	PF00069	0.285
MOD_ProDKin_1	419	425	PF00069	0.377
MOD_ProDKin_1	434	440	PF00069	0.446
MOD_ProDKin_1	479	485	PF00069	0.733
MOD_ProDKin_1	504	510	PF00069	0.600
MOD_ProDKin_1	585	591	PF00069	0.557
MOD_ProDKin_1	756	762	PF00069	0.484
MOD_ProDKin_1	767	773	PF00069	0.456
MOD_ProDKin_1	9	15	PF00069	0.487
MOD_SUMO_for_1	334	337	PF00179	0.407
MOD_SUMO_for_1	572	575	PF00179	0.490
MOD_SUMO_rev_2	299	309	PF00179	0.396
TRG_DiLeu_BaEn_1	436	441	PF01217	0.429
TRG_ENDOCYTIC_2	229	232	PF00928	0.511
TRG_ENDOCYTIC_2	638	641	PF00928	0.470
TRG_ENDOCYTIC_2	729	732	PF00928	0.370
TRG_ER_diArg_1	162	164	PF00400	0.438
TRG_ER_diArg_1	2	4	PF00400	0.719
TRG_ER_diArg_1	214	216	PF00400	0.493
TRG_ER_diArg_1	541	544	PF00400	0.382
TRG_Pf-PMV_PEXEL_1	559	563	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.289

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JIX4	Bodo saltans	29%	75%
A0A1X0NVN0	Trypanosomatidae	42%	97%
A0A3Q8ICX0	Leishmania donovani	95%	100%
A0A422NQ56	Trypanosoma rangeli	41%	96%
A4HDL7	Leishmania braziliensis	88%	100%
A4I0W8	Leishmania infantum	95%	100%
D0A799	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	96%
Q4QAK2	Leishmania major	94%	100%
V5BAJ1	Trypanosoma cruzi	40%	96%