RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWW6_LEIMU

TriTrypDb:

LmxM.24.1240

Length:

609

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWW6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWW6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	548	552	PF00656	0.502
CLV_MEL_PAP_1	452	458	PF00089	0.252
CLV_NRD_NRD_1	17	19	PF00675	0.412
CLV_NRD_NRD_1	186	188	PF00675	0.372
CLV_NRD_NRD_1	361	363	PF00675	0.456
CLV_NRD_NRD_1	406	408	PF00675	0.388
CLV_NRD_NRD_1	448	450	PF00675	0.591
CLV_PCSK_KEX2_1	186	188	PF00082	0.390
CLV_PCSK_KEX2_1	363	365	PF00082	0.465
CLV_PCSK_KEX2_1	406	408	PF00082	0.441
CLV_PCSK_KEX2_1	421	423	PF00082	0.266
CLV_PCSK_KEX2_1	483	485	PF00082	0.506
CLV_PCSK_KEX2_1	572	574	PF00082	0.446
CLV_PCSK_KEX2_1	602	604	PF00082	0.498
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.514
CLV_PCSK_PC1ET2_1	421	423	PF00082	0.318
CLV_PCSK_PC1ET2_1	483	485	PF00082	0.516
CLV_PCSK_PC1ET2_1	572	574	PF00082	0.461
CLV_PCSK_PC1ET2_1	602	604	PF00082	0.498
CLV_PCSK_SKI1_1	123	127	PF00082	0.470
CLV_PCSK_SKI1_1	154	158	PF00082	0.446
CLV_PCSK_SKI1_1	18	22	PF00082	0.428
CLV_PCSK_SKI1_1	364	368	PF00082	0.496
CLV_PCSK_SKI1_1	397	401	PF00082	0.393
CLV_PCSK_SKI1_1	476	480	PF00082	0.467
CLV_PCSK_SKI1_1	533	537	PF00082	0.463
CLV_PCSK_SKI1_1	602	606	PF00082	0.406
DEG_Nend_Nbox_1	1	3	PF02207	0.609
DEG_SCF_FBW7_2	116	121	PF00400	0.350
DEG_SPOP_SBC_1	441	445	PF00917	0.554
DOC_ANK_TNKS_1	454	461	PF00023	0.341
DOC_CKS1_1	554	559	PF01111	0.416
DOC_CYCLIN_RxL_1	600	607	PF00134	0.457
DOC_CYCLIN_yClb5_NLxxxL_5	409	418	PF00134	0.351
DOC_MAPK_gen_1	186	194	PF00069	0.338
DOC_MAPK_gen_1	294	304	PF00069	0.341
DOC_MAPK_gen_1	420	427	PF00069	0.330
DOC_MAPK_gen_1	517	526	PF00069	0.420
DOC_MAPK_gen_1	571	577	PF00069	0.397
DOC_MAPK_JIP1_4	261	267	PF00069	0.483
DOC_MAPK_MEF2A_6	186	194	PF00069	0.338
DOC_MAPK_MEF2A_6	294	302	PF00069	0.355
DOC_MAPK_MEF2A_6	519	528	PF00069	0.415
DOC_PP1_RVXF_1	448	455	PF00149	0.461
DOC_PP1_RVXF_1	459	465	PF00149	0.250
DOC_PP2B_LxvP_1	334	337	PF13499	0.345
DOC_PP4_FxxP_1	312	315	PF00568	0.404
DOC_SPAK_OSR1_1	187	191	PF12202	0.375
DOC_SPAK_OSR1_1	276	280	PF12202	0.480
DOC_USP7_MATH_1	315	319	PF00917	0.469
DOC_USP7_MATH_1	59	63	PF00917	0.553
DOC_USP7_UBL2_3	411	415	PF12436	0.386
DOC_USP7_UBL2_3	479	483	PF12436	0.434
DOC_WW_Pin1_4	114	119	PF00397	0.464
DOC_WW_Pin1_4	379	384	PF00397	0.519
DOC_WW_Pin1_4	553	558	PF00397	0.646
LIG_14-3-3_CanoR_1	186	191	PF00244	0.406
LIG_14-3-3_CanoR_1	377	381	PF00244	0.479
LIG_14-3-3_CanoR_1	461	465	PF00244	0.474
LIG_APCC_ABBA_1	116	121	PF00400	0.507
LIG_BRCT_BRCA1_1	578	582	PF00533	0.391
LIG_Clathr_ClatBox_1	191	195	PF01394	0.297
LIG_FHA_1	206	212	PF00498	0.522
LIG_FHA_1	218	224	PF00498	0.711
LIG_FHA_2	326	332	PF00498	0.300
LIG_GBD_Chelix_1	427	435	PF00786	0.454
LIG_HCF-1_HBM_1	429	432	PF13415	0.508
LIG_Integrin_isoDGR_2	68	70	PF01839	0.487
LIG_Integrin_RGD_1	177	179	PF01839	0.386
LIG_LIR_Apic_2	310	315	PF02991	0.400
LIG_LIR_Gen_1	328	337	PF02991	0.453
LIG_LIR_Gen_1	429	440	PF02991	0.561
LIG_LIR_Gen_1	579	590	PF02991	0.392
LIG_LIR_Gen_1	595	606	PF02991	0.447
LIG_LIR_LC3C_4	189	194	PF02991	0.373
LIG_LIR_Nem_3	328	332	PF02991	0.399
LIG_LIR_Nem_3	371	376	PF02991	0.305
LIG_LIR_Nem_3	429	435	PF02991	0.519
LIG_LIR_Nem_3	579	585	PF02991	0.499
LIG_LIR_Nem_3	595	601	PF02991	0.290
LIG_MAD2	561	569	PF02301	0.584
LIG_Pex14_1	82	86	PF04695	0.321
LIG_Pex14_2	277	281	PF04695	0.316
LIG_Pex14_2	594	598	PF04695	0.425
LIG_Pex14_2	78	82	PF04695	0.400
LIG_RPA_C_Fungi	2	14	PF08784	0.462
LIG_SH2_CRK	432	436	PF00017	0.549
LIG_SH2_SRC	234	237	PF00017	0.591
LIG_SH2_STAP1	219	223	PF00017	0.711
LIG_SH2_STAT5	175	178	PF00017	0.394
LIG_SH2_STAT5	201	204	PF00017	0.337
LIG_SH2_STAT5	219	222	PF00017	0.567
LIG_SH2_STAT5	234	237	PF00017	0.462
LIG_SH3_2	233	238	PF14604	0.667
LIG_SH3_3	200	206	PF00018	0.387
LIG_SH3_3	230	236	PF00018	0.687
LIG_SH3_3	551	557	PF00018	0.552
LIG_SH3_3	559	565	PF00018	0.607
LIG_SH3_3	587	593	PF00018	0.351
LIG_SUMO_SIM_anti_2	189	197	PF11976	0.389
LIG_SUMO_SIM_par_1	189	197	PF11976	0.323
LIG_SUMO_SIM_par_1	200	208	PF11976	0.368
LIG_SUMO_SIM_par_1	302	308	PF11976	0.369
LIG_SUMO_SIM_par_1	524	529	PF11976	0.241
LIG_TRAF2_1	328	331	PF00917	0.368
LIG_TRFH_1	81	85	PF08558	0.333
LIG_UBA3_1	16	21	PF00899	0.379
LIG_UBA3_1	474	483	PF00899	0.366
LIG_WRC_WIRS_1	485	490	PF05994	0.368
MOD_CK1_1	270	276	PF00069	0.428
MOD_CK1_1	305	311	PF00069	0.373
MOD_CK1_1	511	517	PF00069	0.376
MOD_CK1_1	64	70	PF00069	0.595
MOD_CK2_1	201	207	PF00069	0.374
MOD_CK2_1	269	275	PF00069	0.392
MOD_CK2_1	325	331	PF00069	0.409
MOD_GlcNHglycan	102	105	PF01048	0.704
MOD_GlcNHglycan	170	173	PF01048	0.480
MOD_GlcNHglycan	432	435	PF01048	0.421
MOD_GlcNHglycan	557	560	PF01048	0.584
MOD_GlcNHglycan	586	589	PF01048	0.394
MOD_GlcNHglycan	88	91	PF01048	0.659
MOD_GSK3_1	100	107	PF00069	0.597
MOD_GSK3_1	197	204	PF00069	0.372
MOD_GSK3_1	207	214	PF00069	0.591
MOD_GSK3_1	315	322	PF00069	0.423
MOD_GSK3_1	436	443	PF00069	0.679
MOD_GSK3_1	460	467	PF00069	0.385
MOD_GSK3_1	60	67	PF00069	0.625
MOD_N-GLC_1	464	469	PF02516	0.378
MOD_NEK2_1	1	6	PF00069	0.536
MOD_NEK2_1	168	173	PF00069	0.465
MOD_NEK2_1	267	272	PF00069	0.413
MOD_NEK2_1	332	337	PF00069	0.349
MOD_NEK2_1	464	469	PF00069	0.382
MOD_NEK2_1	531	536	PF00069	0.352
MOD_NEK2_1	545	550	PF00069	0.521
MOD_NEK2_1	60	65	PF00069	0.539
MOD_NEK2_1	604	609	PF00069	0.574
MOD_PIKK_1	205	211	PF00454	0.607
MOD_PIKK_1	385	391	PF00454	0.419
MOD_PIKK_1	54	60	PF00454	0.649
MOD_PK_1	186	192	PF00069	0.399
MOD_PKA_1	186	192	PF00069	0.399
MOD_PKA_2	186	192	PF00069	0.399
MOD_PKA_2	296	302	PF00069	0.412
MOD_PKA_2	376	382	PF00069	0.490
MOD_PKA_2	460	466	PF00069	0.451
MOD_PKA_2	54	60	PF00069	0.498
MOD_PKB_1	362	370	PF00069	0.410
MOD_Plk_1	112	118	PF00069	0.422
MOD_Plk_1	178	184	PF00069	0.505
MOD_Plk_1	400	406	PF00069	0.495
MOD_Plk_1	436	442	PF00069	0.476
MOD_Plk_1	464	470	PF00069	0.381
MOD_Plk_1	508	514	PF00069	0.374
MOD_Plk_4	152	158	PF00069	0.530
MOD_Plk_4	170	176	PF00069	0.358
MOD_Plk_4	197	203	PF00069	0.420
MOD_Plk_4	236	242	PF00069	0.471
MOD_Plk_4	315	321	PF00069	0.430
MOD_Plk_4	464	470	PF00069	0.414
MOD_Plk_4	47	53	PF00069	0.428
MOD_ProDKin_1	114	120	PF00069	0.466
MOD_ProDKin_1	379	385	PF00069	0.520
MOD_ProDKin_1	553	559	PF00069	0.649
MOD_SUMO_for_1	399	402	PF00179	0.379
TRG_DiLeu_BaEn_4	43	49	PF01217	0.400
TRG_DiLeu_BaLyEn_6	600	605	PF01217	0.531
TRG_ENDOCYTIC_2	139	142	PF00928	0.422
TRG_ENDOCYTIC_2	432	435	PF00928	0.499
TRG_ER_diArg_1	185	187	PF00400	0.379
TRG_ER_diArg_1	405	407	PF00400	0.490
TRG_NES_CRM1_1	183	197	PF08389	0.364
TRG_NES_CRM1_1	371	381	PF08389	0.360
TRG_NLS_MonoExtN_4	569	575	PF00514	0.445
TRG_Pf-PMV_PEXEL_1	476	480	PF00026	0.374
TRG_Pf-PMV_PEXEL_1	533	537	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	547	551	PF00026	0.572

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JET7	Bodo saltans	50%	100%
A0A1X0NW11	Trypanosomatidae	57%	100%
A0A3Q8IC34	Leishmania donovani	95%	100%
A0A422NQ83	Trypanosoma rangeli	60%	100%
A4HDI1	Leishmania braziliensis	88%	99%
C6K3X8	Leptomonas seymouri	80%	100%
D0A795	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
Q4QAK8	Leishmania major	93%	100%
V5C0H3	Trypanosoma cruzi	62%	100%