RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein 38, putative

Species:

Leishmania mexicana

UniProt:

E9AWW4_LEIMU

TriTrypDb:

LmxM.24.1220

Length:

540

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AWW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWW4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	6
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.564
CLV_C14_Caspase3-7	90	94	PF00656	0.586
CLV_NRD_NRD_1	110	112	PF00675	0.601
CLV_NRD_NRD_1	176	178	PF00675	0.549
CLV_NRD_NRD_1	295	297	PF00675	0.487
CLV_NRD_NRD_1	462	464	PF00675	0.554
CLV_PCSK_KEX2_1	110	112	PF00082	0.616
CLV_PCSK_KEX2_1	295	297	PF00082	0.445
CLV_PCSK_KEX2_1	407	409	PF00082	0.562
CLV_PCSK_KEX2_1	462	464	PF00082	0.518
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.707
CLV_PCSK_PC1ET2_1	407	409	PF00082	0.562
CLV_PCSK_SKI1_1	14	18	PF00082	0.554
CLV_PCSK_SKI1_1	172	176	PF00082	0.486
CLV_PCSK_SKI1_1	288	292	PF00082	0.428
CLV_PCSK_SKI1_1	309	313	PF00082	0.439
CLV_PCSK_SKI1_1	351	355	PF00082	0.379
CLV_PCSK_SKI1_1	377	381	PF00082	0.461
CLV_PCSK_SKI1_1	383	387	PF00082	0.424
CLV_PCSK_SKI1_1	435	439	PF00082	0.454
CLV_PCSK_SKI1_1	462	466	PF00082	0.554
CLV_PCSK_SKI1_1	529	533	PF00082	0.687
CLV_Separin_Metazoa	412	416	PF03568	0.535
DEG_SPOP_SBC_1	187	191	PF00917	0.548
DOC_CKS1_1	159	164	PF01111	0.568
DOC_CKS1_1	338	343	PF01111	0.506
DOC_CKS1_1	490	495	PF01111	0.539
DOC_CYCLIN_yCln2_LP_2	80	83	PF00134	0.567
DOC_PP1_RVXF_1	170	176	PF00149	0.492
DOC_PP1_RVXF_1	286	293	PF00149	0.488
DOC_PP1_RVXF_1	353	360	PF00149	0.337
DOC_PP1_RVXF_1	384	390	PF00149	0.377
DOC_PP2B_LxvP_1	218	221	PF13499	0.608
DOC_PP2B_LxvP_1	80	83	PF13499	0.567
DOC_USP7_MATH_1	117	121	PF00917	0.609
DOC_USP7_MATH_1	124	128	PF00917	0.576
DOC_USP7_MATH_1	162	166	PF00917	0.449
DOC_USP7_MATH_1	18	22	PF00917	0.575
DOC_USP7_MATH_1	195	199	PF00917	0.664
DOC_USP7_MATH_1	221	225	PF00917	0.558
DOC_USP7_MATH_1	233	237	PF00917	0.706
DOC_USP7_MATH_1	244	248	PF00917	0.587
DOC_USP7_MATH_1	263	267	PF00917	0.655
DOC_USP7_MATH_1	300	304	PF00917	0.479
DOC_USP7_MATH_1	305	309	PF00917	0.516
DOC_USP7_MATH_1	36	40	PF00917	0.615
DOC_USP7_MATH_1	395	399	PF00917	0.626
DOC_USP7_MATH_1	76	80	PF00917	0.615
DOC_USP7_MATH_1	88	92	PF00917	0.538
DOC_USP7_MATH_1	94	98	PF00917	0.476
DOC_USP7_UBL2_3	108	112	PF12436	0.721
DOC_USP7_UBL2_3	386	390	PF12436	0.403
DOC_USP7_UBL2_3	435	439	PF12436	0.400
DOC_USP7_UBL2_3	92	96	PF12436	0.685
DOC_WW_Pin1_4	158	163	PF00397	0.483
DOC_WW_Pin1_4	201	206	PF00397	0.740
DOC_WW_Pin1_4	22	27	PF00397	0.569
DOC_WW_Pin1_4	337	342	PF00397	0.442
DOC_WW_Pin1_4	38	43	PF00397	0.586
DOC_WW_Pin1_4	473	478	PF00397	0.633
DOC_WW_Pin1_4	489	494	PF00397	0.576
LIG_14-3-3_CanoR_1	307	312	PF00244	0.413
LIG_14-3-3_CanoR_1	345	354	PF00244	0.441
LIG_14-3-3_CanoR_1	418	426	PF00244	0.466
LIG_14-3-3_CanoR_1	480	485	PF00244	0.615
LIG_14-3-3_CanoR_1	511	520	PF00244	0.580
LIG_Actin_WH2_2	149	166	PF00022	0.544
LIG_BIR_III_2	241	245	PF00653	0.472
LIG_BRCT_BRCA1_1	276	280	PF00533	0.420
LIG_eIF4E_1	274	280	PF01652	0.461
LIG_FHA_1	158	164	PF00498	0.462
LIG_FHA_1	187	193	PF00498	0.688
LIG_FHA_1	197	203	PF00498	0.725
LIG_FHA_1	206	212	PF00498	0.448
LIG_FHA_1	297	303	PF00498	0.384
LIG_FHA_1	313	319	PF00498	0.399
LIG_FHA_1	325	331	PF00498	0.408
LIG_FHA_1	514	520	PF00498	0.655
LIG_FHA_1	68	74	PF00498	0.721
LIG_FHA_2	468	474	PF00498	0.624
LIG_FHA_2	85	91	PF00498	0.482
LIG_LIR_Gen_1	135	144	PF02991	0.373
LIG_LIR_Gen_1	340	347	PF02991	0.402
LIG_LIR_Nem_3	135	141	PF02991	0.376
LIG_LIR_Nem_3	340	346	PF02991	0.405
LIG_LIR_Nem_3	447	451	PF02991	0.477
LIG_LIR_Nem_3	500	504	PF02991	0.525
LIG_LIR_Nem_3	505	510	PF02991	0.499
LIG_LIR_Nem_3	6	10	PF02991	0.530
LIG_MYND_1	477	481	PF01753	0.607
LIG_Pex14_2	138	142	PF04695	0.301
LIG_SH2_CRK	448	452	PF00017	0.480
LIG_SH2_GRB2like	362	365	PF00017	0.475
LIG_SH2_NCK_1	60	64	PF00017	0.521
LIG_SH2_PTP2	343	346	PF00017	0.396
LIG_SH2_PTP2	7	10	PF00017	0.637
LIG_SH2_STAT5	343	346	PF00017	0.396
LIG_SH2_STAT5	7	10	PF00017	0.637
LIG_SH3_3	165	171	PF00018	0.446
LIG_SH3_3	173	179	PF00018	0.485
LIG_SH3_3	199	205	PF00018	0.577
LIG_SH3_3	30	36	PF00018	0.502
LIG_SH3_3	335	341	PF00018	0.462
LIG_SH3_3	487	493	PF00018	0.612
LIG_SH3_3	519	525	PF00018	0.536
LIG_Sin3_3	314	321	PF02671	0.379
LIG_TRAF2_1	409	412	PF00917	0.532
MOD_CDK_SPxK_1	158	164	PF00069	0.517
MOD_CDK_SPxxK_3	473	480	PF00069	0.586
MOD_CK1_1	115	121	PF00069	0.622
MOD_CK1_1	145	151	PF00069	0.533
MOD_CK1_1	185	191	PF00069	0.611
MOD_CK1_1	203	209	PF00069	0.667
MOD_CK1_1	236	242	PF00069	0.785
MOD_CK1_1	303	309	PF00069	0.460
MOD_CK1_1	406	412	PF00069	0.519
MOD_CK1_1	467	473	PF00069	0.531
MOD_CK1_1	512	518	PF00069	0.634
MOD_CK2_1	406	412	PF00069	0.489
MOD_CK2_1	467	473	PF00069	0.618
MOD_Cter_Amidation	105	108	PF01082	0.653
MOD_GlcNHglycan	114	117	PF01048	0.622
MOD_GlcNHglycan	119	122	PF01048	0.577
MOD_GlcNHglycan	126	129	PF01048	0.515
MOD_GlcNHglycan	246	249	PF01048	0.630
MOD_GlcNHglycan	260	263	PF01048	0.491
MOD_GlcNHglycan	265	268	PF01048	0.645
MOD_GlcNHglycan	38	41	PF01048	0.647
MOD_GlcNHglycan	397	400	PF01048	0.606
MOD_GlcNHglycan	419	422	PF01048	0.427
MOD_GlcNHglycan	532	535	PF01048	0.671
MOD_GSK3_1	112	119	PF00069	0.616
MOD_GSK3_1	120	127	PF00069	0.587
MOD_GSK3_1	158	165	PF00069	0.514
MOD_GSK3_1	18	25	PF00069	0.558
MOD_GSK3_1	182	189	PF00069	0.614
MOD_GSK3_1	196	203	PF00069	0.547
MOD_GSK3_1	296	303	PF00069	0.452
MOD_GSK3_1	329	336	PF00069	0.357
MOD_GSK3_1	391	398	PF00069	0.560
MOD_GSK3_1	469	476	PF00069	0.705
MOD_GSK3_1	509	516	PF00069	0.527
MOD_GSK3_1	63	70	PF00069	0.686
MOD_GSK3_1	84	91	PF00069	0.526
MOD_N-GLC_1	312	317	PF02516	0.386
MOD_N-GLC_1	467	472	PF02516	0.671
MOD_N-GLC_1	67	72	PF02516	0.729
MOD_NEK2_1	312	317	PF00069	0.376
MOD_NEK2_1	426	431	PF00069	0.520
MOD_NEK2_1	444	449	PF00069	0.397
MOD_PIKK_1	509	515	PF00454	0.560
MOD_PK_1	307	313	PF00069	0.469
MOD_PKA_1	390	396	PF00069	0.533
MOD_PKA_2	417	423	PF00069	0.467
MOD_Plk_1	182	188	PF00069	0.634
MOD_Plk_1	216	222	PF00069	0.575
MOD_Plk_1	286	292	PF00069	0.532
MOD_Plk_1	312	318	PF00069	0.382
MOD_Plk_4	274	280	PF00069	0.484
MOD_Plk_4	288	294	PF00069	0.378
MOD_Plk_4	312	318	PF00069	0.403
MOD_Plk_4	339	345	PF00069	0.372
MOD_Plk_4	76	82	PF00069	0.579
MOD_ProDKin_1	158	164	PF00069	0.482
MOD_ProDKin_1	201	207	PF00069	0.743
MOD_ProDKin_1	22	28	PF00069	0.572
MOD_ProDKin_1	337	343	PF00069	0.444
MOD_ProDKin_1	38	44	PF00069	0.586
MOD_ProDKin_1	473	479	PF00069	0.633
MOD_ProDKin_1	489	495	PF00069	0.574
MOD_SUMO_for_1	325	328	PF00179	0.480
MOD_SUMO_for_1	385	388	PF00179	0.385
MOD_SUMO_rev_2	366	373	PF00179	0.356
MOD_SUMO_rev_2	526	531	PF00179	0.665
MOD_SUMO_rev_2	89	94	PF00179	0.667
TRG_DiLeu_BaLyEn_6	342	347	PF01217	0.513
TRG_ENDOCYTIC_2	343	346	PF00928	0.396
TRG_ENDOCYTIC_2	448	451	PF00928	0.510
TRG_ENDOCYTIC_2	7	10	PF00928	0.637
TRG_ER_diArg_1	295	297	PF00400	0.487
TRG_ER_diArg_1	461	463	PF00400	0.511
TRG_ER_diArg_1	536	539	PF00400	0.592
TRG_NLS_MonoCore_2	106	111	PF00514	0.700
TRG_NLS_MonoExtC_3	106	111	PF00514	0.700
TRG_NLS_MonoExtN_4	107	114	PF00514	0.640
TRG_Pf-PMV_PEXEL_1	345	350	PF00026	0.492
TRG_Pf-PMV_PEXEL_1	383	388	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	408	412	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	521	526	PF00026	0.635

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC49	Leptomonas seymouri	65%	100%
A0A0S4J510	Bodo saltans	37%	100%
A0A3S7WYC8	Leishmania donovani	93%	99%
A0A422NQ46	Trypanosoma rangeli	44%	100%
A4HDH9	Leishmania braziliensis	77%	99%
A4I0W0	Leishmania infantum	94%	99%
D0A792	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
Q4QAL0	Leishmania major	91%	100%