SURF6 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Surfeit locus protein 6, putative

Species:

Leishmania mexicana

UniProt:

E9AWW0_LEIMU

TriTrypDb:

LmxM.24.1180

Length:

252

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	7
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	8
GO:0005730	nucleolus	5	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

E9AWW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWW0

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0022613	ribonucleoprotein complex biogenesis	4	1
GO:0042273	ribosomal large subunit biogenesis	5	1
GO:0042274	ribosomal small subunit biogenesis	5	1
GO:0044085	cellular component biogenesis	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.304
CLV_NRD_NRD_1	159	161	PF00675	0.316
CLV_NRD_NRD_1	16	18	PF00675	0.641
CLV_NRD_NRD_1	197	199	PF00675	0.299
CLV_NRD_NRD_1	241	243	PF00675	0.672
CLV_NRD_NRD_1	39	41	PF00675	0.581
CLV_NRD_NRD_1	4	6	PF00675	0.754
CLV_NRD_NRD_1	50	52	PF00675	0.415
CLV_PCSK_FUR_1	173	177	PF00082	0.213
CLV_PCSK_KEX2_1	109	111	PF00082	0.304
CLV_PCSK_KEX2_1	158	160	PF00082	0.374
CLV_PCSK_KEX2_1	16	18	PF00082	0.641
CLV_PCSK_KEX2_1	163	165	PF00082	0.352
CLV_PCSK_KEX2_1	168	170	PF00082	0.372
CLV_PCSK_KEX2_1	175	177	PF00082	0.345
CLV_PCSK_KEX2_1	209	211	PF00082	0.628
CLV_PCSK_KEX2_1	39	41	PF00082	0.601
CLV_PCSK_KEX2_1	4	6	PF00082	0.754
CLV_PCSK_KEX2_1	52	54	PF00082	0.443
CLV_PCSK_KEX2_1	93	95	PF00082	0.357
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.304
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.338
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.361
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.352
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.604
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.369
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.357
CLV_PCSK_PC7_1	159	165	PF00082	0.303
CLV_PCSK_SKI1_1	111	115	PF00082	0.311
CLV_PCSK_SKI1_1	151	155	PF00082	0.328
CLV_PCSK_SKI1_1	199	203	PF00082	0.333
CLV_PCSK_SKI1_1	53	57	PF00082	0.381
DEG_Nend_UBRbox_1	1	4	PF02207	0.658
DOC_AGCK_PIF_2	80	85	PF00069	0.297
DOC_MAPK_MEF2A_6	71	80	PF00069	0.203
DOC_USP7_MATH_1	58	62	PF00917	0.375
DOC_USP7_UBL2_3	154	158	PF12436	0.298
DOC_USP7_UBL2_3	202	206	PF12436	0.295
DOC_USP7_UBL2_3	227	231	PF12436	0.653
DOC_USP7_UBL2_3	239	243	PF12436	0.590
DOC_USP7_UBL2_3	89	93	PF12436	0.357
DOC_WW_Pin1_4	7	12	PF00397	0.592
LIG_14-3-3_CanoR_1	110	119	PF00244	0.311
LIG_14-3-3_CanoR_1	164	170	PF00244	0.297
LIG_14-3-3_CanoR_1	192	196	PF00244	0.194
LIG_14-3-3_CanoR_1	4	13	PF00244	0.502
LIG_14-3-3_CanoR_1	57	67	PF00244	0.506
LIG_CtBP_PxDLS_1	75	79	PF00389	0.297
LIG_FHA_1	8	14	PF00498	0.564
LIG_FHA_2	112	118	PF00498	0.322
LIG_Integrin_isoDGR_2	18	20	PF01839	0.517
LIG_LIR_Gen_1	84	91	PF02991	0.357
LIG_LIR_Nem_3	77	83	PF02991	0.301
LIG_NRBOX	100	106	PF00104	0.357
LIG_NRP_CendR_1	249	252	PF00754	0.678
LIG_PTB_Apo_2	79	86	PF02174	0.322
LIG_SH3_2	34	39	PF14604	0.499
LIG_SH3_3	31	37	PF00018	0.625
LIG_SUMO_SIM_par_1	74	79	PF11976	0.376
MOD_CK1_1	45	51	PF00069	0.570
MOD_CK1_1	7	13	PF00069	0.636
MOD_Cter_Amidation	14	17	PF01082	0.686
MOD_Cter_Amidation	237	240	PF01082	0.500
MOD_Cter_Amidation	91	94	PF01082	0.357
MOD_GlcNHglycan	133	136	PF01048	0.349
MOD_GlcNHglycan	139	142	PF01048	0.367
MOD_GlcNHglycan	165	168	PF01048	0.297
MOD_GlcNHglycan	221	224	PF01048	0.792
MOD_GlcNHglycan	40	43	PF01048	0.632
MOD_GlcNHglycan	60	63	PF01048	0.258
MOD_GSK3_1	219	226	PF00069	0.639
MOD_GSK3_1	243	250	PF00069	0.635
MOD_GSK3_1	3	10	PF00069	0.698
MOD_GSK3_1	38	45	PF00069	0.706
MOD_NEK2_1	118	123	PF00069	0.447
MOD_NEK2_1	137	142	PF00069	0.226
MOD_NEK2_1	76	81	PF00069	0.328
MOD_PK_1	186	192	PF00069	0.357
MOD_PKA_1	158	164	PF00069	0.292
MOD_PKA_1	209	215	PF00069	0.461
MOD_PKA_1	4	10	PF00069	0.562
MOD_PKA_1	53	59	PF00069	0.386
MOD_PKA_2	158	164	PF00069	0.355
MOD_PKA_2	191	197	PF00069	0.221
MOD_PKA_2	209	215	PF00069	0.490
MOD_PKA_2	219	225	PF00069	0.551
MOD_PKA_2	3	9	PF00069	0.631
MOD_PKA_2	38	44	PF00069	0.533
MOD_PKA_2	56	62	PF00069	0.356
MOD_PKB_1	51	59	PF00069	0.420
MOD_Plk_1	177	183	PF00069	0.396
MOD_Plk_1	186	192	PF00069	0.393
MOD_Plk_1	76	82	PF00069	0.297
MOD_Plk_1	99	105	PF00069	0.357
MOD_Plk_2-3	126	132	PF00069	0.322
MOD_Plk_4	100	106	PF00069	0.357
MOD_ProDKin_1	7	13	PF00069	0.593
MOD_SUMO_rev_2	84	91	PF00179	0.297
TRG_DiLeu_BaEn_1	100	105	PF01217	0.357
TRG_NES_CRM1_1	64	77	PF08389	0.322
TRG_NLS_Bipartite_1	39	56	PF00514	0.493
TRG_NLS_MonoCore_2	50	55	PF00514	0.194
TRG_NLS_MonoExtC_3	157	162	PF00514	0.244
TRG_NLS_MonoExtC_3	238	243	PF00514	0.519
TRG_NLS_MonoExtN_4	159	166	PF00514	0.287
TRG_NLS_MonoExtN_4	51	56	PF00514	0.194

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5P3	Leptomonas seymouri	74%	100%
A0A3S7WYB0	Leishmania donovani	85%	100%
A4HDH5	Leishmania braziliensis	76%	100%
A4I0V6	Leishmania infantum	85%	100%
D0A787	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
Q4QAL4	Leishmania major	85%	100%