Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWV9_LEIMU

TriTrypDb:

LmxM.24.1170

Length:

1173

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 7
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWV9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	255	259	PF00656	0.602
CLV_C14_Caspase3-7	275	279	PF00656	0.456
CLV_C14_Caspase3-7	514	518	PF00656	0.418
CLV_C14_Caspase3-7	871	875	PF00656	0.428
CLV_C14_Caspase3-7	941	945	PF00656	0.704
CLV_NRD_NRD_1	1001	1003	PF00675	0.568
CLV_NRD_NRD_1	1157	1159	PF00675	0.483
CLV_NRD_NRD_1	345	347	PF00675	0.599
CLV_NRD_NRD_1	436	438	PF00675	0.564
CLV_NRD_NRD_1	469	471	PF00675	0.529
CLV_NRD_NRD_1	576	578	PF00675	0.512
CLV_NRD_NRD_1	862	864	PF00675	0.457
CLV_PCSK_KEX2_1	1001	1003	PF00082	0.568
CLV_PCSK_KEX2_1	1147	1149	PF00082	0.518
CLV_PCSK_KEX2_1	345	347	PF00082	0.599
CLV_PCSK_KEX2_1	436	438	PF00082	0.566
CLV_PCSK_KEX2_1	469	471	PF00082	0.601
CLV_PCSK_KEX2_1	576	578	PF00082	0.512
CLV_PCSK_KEX2_1	588	590	PF00082	0.569
CLV_PCSK_KEX2_1	862	864	PF00082	0.457
CLV_PCSK_PC1ET2_1	1147	1149	PF00082	0.574
CLV_PCSK_PC1ET2_1	588	590	PF00082	0.537
CLV_PCSK_PC7_1	858	864	PF00082	0.293
CLV_PCSK_SKI1_1	164	168	PF00082	0.499
CLV_PCSK_SKI1_1	267	271	PF00082	0.644
CLV_PCSK_SKI1_1	346	350	PF00082	0.615
CLV_PCSK_SKI1_1	400	404	PF00082	0.557
CLV_PCSK_SKI1_1	436	440	PF00082	0.513
CLV_PCSK_SKI1_1	472	476	PF00082	0.466
CLV_PCSK_SKI1_1	706	710	PF00082	0.531
CLV_PCSK_SKI1_1	722	726	PF00082	0.503
CLV_PCSK_SKI1_1	982	986	PF00082	0.489
DEG_APCC_DBOX_1	705	713	PF00400	0.526
DEG_SPOP_SBC_1	715	719	PF00917	0.613
DOC_ANK_TNKS_1	551	558	PF00023	0.458
DOC_CKS1_1	767	772	PF01111	0.421
DOC_CYCLIN_RxL_1	433	443	PF00134	0.431
DOC_MAPK_gen_1	469	475	PF00069	0.479
DOC_MAPK_gen_1	576	586	PF00069	0.504
DOC_MAPK_gen_1	80	89	PF00069	0.787
DOC_MAPK_HePTP_8	574	586	PF00069	0.487
DOC_MAPK_MEF2A_6	561	569	PF00069	0.535
DOC_MAPK_MEF2A_6	577	586	PF00069	0.578
DOC_PP2B_LxvP_1	147	150	PF13499	0.554
DOC_PP2B_LxvP_1	277	280	PF13499	0.475
DOC_PP2B_LxvP_1	349	352	PF13499	0.645
DOC_PP2B_LxvP_1	528	531	PF13499	0.487
DOC_PP2B_LxvP_1	636	639	PF13499	0.640
DOC_PP2B_LxvP_1	734	737	PF13499	0.674
DOC_PP4_FxxP_1	262	265	PF00568	0.557
DOC_USP7_MATH_1	158	162	PF00917	0.655
DOC_USP7_MATH_1	183	187	PF00917	0.552
DOC_USP7_MATH_1	20	24	PF00917	0.558
DOC_USP7_MATH_1	252	256	PF00917	0.643
DOC_USP7_MATH_1	377	381	PF00917	0.658
DOC_USP7_MATH_1	444	448	PF00917	0.464
DOC_USP7_MATH_1	531	535	PF00917	0.589
DOC_USP7_MATH_1	593	597	PF00917	0.571
DOC_USP7_MATH_1	71	75	PF00917	0.707
DOC_USP7_MATH_1	714	718	PF00917	0.637
DOC_USP7_MATH_1	724	728	PF00917	0.578
DOC_USP7_MATH_1	745	749	PF00917	0.516
DOC_USP7_MATH_1	928	932	PF00917	0.681
DOC_USP7_UBL2_3	287	291	PF12436	0.533
DOC_WW_Pin1_4	1039	1044	PF00397	0.765
DOC_WW_Pin1_4	104	109	PF00397	0.673
DOC_WW_Pin1_4	156	161	PF00397	0.693
DOC_WW_Pin1_4	261	266	PF00397	0.568
DOC_WW_Pin1_4	326	331	PF00397	0.484
DOC_WW_Pin1_4	445	450	PF00397	0.722
DOC_WW_Pin1_4	67	72	PF00397	0.667
DOC_WW_Pin1_4	673	678	PF00397	0.534
DOC_WW_Pin1_4	694	699	PF00397	0.511
DOC_WW_Pin1_4	722	727	PF00397	0.750
DOC_WW_Pin1_4	766	771	PF00397	0.433
DOC_WW_Pin1_4	889	894	PF00397	0.536
LIG_14-3-3_CanoR_1	1056	1062	PF00244	0.572
LIG_14-3-3_CanoR_1	1130	1139	PF00244	0.701
LIG_14-3-3_CanoR_1	21	26	PF00244	0.609
LIG_14-3-3_CanoR_1	440	449	PF00244	0.536
LIG_14-3-3_CanoR_1	561	565	PF00244	0.629
LIG_14-3-3_CanoR_1	684	692	PF00244	0.426
LIG_14-3-3_CanoR_1	833	838	PF00244	0.561
LIG_14-3-3_CanoR_1	993	1003	PF00244	0.693
LIG_BIR_II_1	1	5	PF00653	0.554
LIG_BIR_III_4	942	946	PF00653	0.580
LIG_CaM_NSCaTE_8	704	711	PF13499	0.326
LIG_Clathr_ClatBox_1	604	608	PF01394	0.313
LIG_CSL_BTD_1	528	531	PF09270	0.428
LIG_CtBP_PxDLS_1	244	248	PF00389	0.680
LIG_CtBP_PxDLS_1	948	952	PF00389	0.452
LIG_deltaCOP1_diTrp_1	416	424	PF00928	0.514
LIG_eIF4E_1	946	952	PF01652	0.470
LIG_FHA_1	1028	1034	PF00498	0.581
LIG_FHA_1	1063	1069	PF00498	0.675
LIG_FHA_1	1105	1111	PF00498	0.653
LIG_FHA_1	136	142	PF00498	0.610
LIG_FHA_1	165	171	PF00498	0.725
LIG_FHA_1	279	285	PF00498	0.576
LIG_FHA_1	441	447	PF00498	0.645
LIG_FHA_1	648	654	PF00498	0.586
LIG_FHA_1	71	77	PF00498	0.610
LIG_FHA_1	976	982	PF00498	0.651
LIG_FHA_2	1027	1033	PF00498	0.575
LIG_FHA_2	105	111	PF00498	0.522
LIG_FHA_2	230	236	PF00498	0.711
LIG_FHA_2	509	515	PF00498	0.410
LIG_FHA_2	597	603	PF00498	0.571
LIG_FHA_2	695	701	PF00498	0.469
LIG_FHA_2	906	912	PF00498	0.498
LIG_GBD_Chelix_1	1165	1173	PF00786	0.426
LIG_GBD_Chelix_1	912	920	PF00786	0.502
LIG_HP1_1	893	897	PF01393	0.424
LIG_LIR_Apic_2	1069	1075	PF02991	0.750
LIG_LIR_Apic_2	260	265	PF02991	0.555
LIG_LIR_Apic_2	786	791	PF02991	0.547
LIG_LIR_Apic_2	8	14	PF02991	0.599
LIG_LIR_Gen_1	296	303	PF02991	0.543
LIG_LIR_Gen_1	599	607	PF02991	0.531
LIG_LIR_Gen_1	728	739	PF02991	0.617
LIG_LIR_Gen_1	810	820	PF02991	0.470
LIG_LIR_Gen_1	84	93	PF02991	0.632
LIG_LIR_LC3C_4	971	975	PF02991	0.489
LIG_LIR_Nem_3	296	302	PF02991	0.507
LIG_LIR_Nem_3	418	424	PF02991	0.573
LIG_LIR_Nem_3	563	567	PF02991	0.432
LIG_LIR_Nem_3	599	604	PF02991	0.543
LIG_LIR_Nem_3	728	734	PF02991	0.638
LIG_LIR_Nem_3	810	815	PF02991	0.385
LIG_LIR_Nem_3	84	89	PF02991	0.601
LIG_LIR_Nem_3	944	949	PF02991	0.566
LIG_LYPXL_yS_3	564	567	PF13949	0.497
LIG_PCNA_PIPBox_1	499	508	PF02747	0.529
LIG_PCNA_yPIPBox_3	497	506	PF02747	0.525
LIG_PTB_Apo_2	129	136	PF02174	0.459
LIG_PTB_Apo_2	474	481	PF02174	0.449
LIG_PTB_Phospho_1	474	480	PF10480	0.451
LIG_Rb_LxCxE_1	599	617	PF01857	0.443
LIG_REV1ctd_RIR_1	491	501	PF16727	0.487
LIG_SH2_CRK	194	198	PF00017	0.577
LIG_SH2_CRK	360	364	PF00017	0.565
LIG_SH2_CRK	480	484	PF00017	0.499
LIG_SH2_CRK	788	792	PF00017	0.610
LIG_SH2_CRK	86	90	PF00017	0.708
LIG_SH2_CRK	970	974	PF00017	0.454
LIG_SH2_GRB2like	771	774	PF00017	0.481
LIG_SH2_NCK_1	299	303	PF00017	0.568
LIG_SH2_NCK_1	788	792	PF00017	0.561
LIG_SH2_PTP2	812	815	PF00017	0.460
LIG_SH2_PTP2	946	949	PF00017	0.538
LIG_SH2_SRC	119	122	PF00017	0.607
LIG_SH2_SRC	946	949	PF00017	0.538
LIG_SH2_STAP1	299	303	PF00017	0.500
LIG_SH2_STAP1	480	484	PF00017	0.415
LIG_SH2_STAP1	601	605	PF00017	0.511
LIG_SH2_STAT3	505	508	PF00017	0.551
LIG_SH2_STAT5	1085	1088	PF00017	0.418
LIG_SH2_STAT5	11	14	PF00017	0.618
LIG_SH2_STAT5	119	122	PF00017	0.639
LIG_SH2_STAT5	134	137	PF00017	0.384
LIG_SH2_STAT5	292	295	PF00017	0.436
LIG_SH2_STAT5	5	8	PF00017	0.594
LIG_SH2_STAT5	731	734	PF00017	0.645
LIG_SH2_STAT5	771	774	PF00017	0.445
LIG_SH2_STAT5	812	815	PF00017	0.460
LIG_SH2_STAT5	876	879	PF00017	0.628
LIG_SH2_STAT5	898	901	PF00017	0.405
LIG_SH2_STAT5	946	949	PF00017	0.538
LIG_SH3_3	108	114	PF00018	0.693
LIG_SH3_3	143	149	PF00018	0.580
LIG_SH3_3	398	404	PF00018	0.660
LIG_SH3_3	443	449	PF00018	0.663
LIG_SH3_3	480	486	PF00018	0.497
LIG_SH3_3	518	524	PF00018	0.504
LIG_SH3_3	843	849	PF00018	0.526
LIG_SUMO_SIM_anti_2	136	143	PF11976	0.576
LIG_SUMO_SIM_anti_2	471	477	PF11976	0.500
LIG_SUMO_SIM_anti_2	581	587	PF11976	0.504
LIG_SUMO_SIM_anti_2	891	898	PF11976	0.528
LIG_SUMO_SIM_par_1	1064	1071	PF11976	0.557
LIG_SUMO_SIM_par_1	136	143	PF11976	0.572
LIG_SUMO_SIM_par_1	5	10	PF11976	0.552
LIG_SUMO_SIM_par_1	581	587	PF11976	0.426
LIG_SUMO_SIM_par_1	955	962	PF11976	0.424
LIG_TRAF2_1	1012	1015	PF00917	0.641
LIG_TRAF2_1	698	701	PF00917	0.427
LIG_TRAF2_1	820	823	PF00917	0.485
LIG_UBA3_1	1139	1147	PF00899	0.424
LIG_UBA3_1	170	178	PF00899	0.445
LIG_UBA3_1	283	291	PF00899	0.542
LIG_Vh1_VBS_1	225	243	PF01044	0.452
LIG_WW_3	308	312	PF00397	0.591
MOD_CDC14_SPxK_1	264	267	PF00782	0.479
MOD_CDK_SPK_2	673	678	PF00069	0.508
MOD_CDK_SPxK_1	261	267	PF00069	0.481
MOD_CK1_1	1027	1033	PF00069	0.640
MOD_CK1_1	1036	1042	PF00069	0.506
MOD_CK1_1	104	110	PF00069	0.676
MOD_CK1_1	176	182	PF00069	0.682
MOD_CK1_1	229	235	PF00069	0.589
MOD_CK1_1	319	325	PF00069	0.694
MOD_CK1_1	340	346	PF00069	0.628
MOD_CK1_1	393	399	PF00069	0.593
MOD_CK1_1	533	539	PF00069	0.610
MOD_CK1_1	596	602	PF00069	0.511
MOD_CK1_1	625	631	PF00069	0.522
MOD_CK1_1	676	682	PF00069	0.527
MOD_CK1_1	718	724	PF00069	0.756
MOD_CK1_1	748	754	PF00069	0.504
MOD_CK1_1	959	965	PF00069	0.519
MOD_CK2_1	104	110	PF00069	0.595
MOD_CK2_1	326	332	PF00069	0.498
MOD_CK2_1	596	602	PF00069	0.577
MOD_CK2_1	63	69	PF00069	0.636
MOD_CK2_1	694	700	PF00069	0.463
MOD_CK2_1	800	806	PF00069	0.545
MOD_CK2_1	838	844	PF00069	0.645
MOD_CK2_1	905	911	PF00069	0.444
MOD_CK2_1	928	934	PF00069	0.705
MOD_Cter_Amidation	343	346	PF01082	0.594
MOD_GlcNHglycan	1026	1029	PF01048	0.654
MOD_GlcNHglycan	1057	1060	PF01048	0.708
MOD_GlcNHglycan	1121	1125	PF01048	0.683
MOD_GlcNHglycan	125	128	PF01048	0.557
MOD_GlcNHglycan	150	153	PF01048	0.756
MOD_GlcNHglycan	175	178	PF01048	0.708
MOD_GlcNHglycan	180	183	PF01048	0.761
MOD_GlcNHglycan	216	219	PF01048	0.596
MOD_GlcNHglycan	321	324	PF01048	0.693
MOD_GlcNHglycan	339	342	PF01048	0.472
MOD_GlcNHglycan	379	382	PF01048	0.694
MOD_GlcNHglycan	391	395	PF01048	0.804
MOD_GlcNHglycan	405	408	PF01048	0.565
MOD_GlcNHglycan	533	536	PF01048	0.590
MOD_GlcNHglycan	595	598	PF01048	0.544
MOD_GlcNHglycan	624	627	PF01048	0.505
MOD_GlcNHglycan	65	68	PF01048	0.800
MOD_GlcNHglycan	712	715	PF01048	0.544
MOD_GlcNHglycan	722	725	PF01048	0.711
MOD_GlcNHglycan	749	753	PF01048	0.682
MOD_GlcNHglycan	802	805	PF01048	0.681
MOD_GlcNHglycan	846	849	PF01048	0.734
MOD_GlcNHglycan	901	905	PF01048	0.546
MOD_GlcNHglycan	938	941	PF01048	0.696
MOD_GSK3_1	1015	1022	PF00069	0.644
MOD_GSK3_1	1064	1071	PF00069	0.628
MOD_GSK3_1	133	140	PF00069	0.574
MOD_GSK3_1	173	180	PF00069	0.577
MOD_GSK3_1	377	384	PF00069	0.723
MOD_GSK3_1	440	447	PF00069	0.649
MOD_GSK3_1	54	61	PF00069	0.614
MOD_GSK3_1	625	632	PF00069	0.473
MOD_GSK3_1	63	70	PF00069	0.569
MOD_GSK3_1	71	78	PF00069	0.506
MOD_GSK3_1	710	717	PF00069	0.535
MOD_GSK3_1	718	725	PF00069	0.622
MOD_GSK3_1	828	835	PF00069	0.510
MOD_GSK3_1	879	886	PF00069	0.695
MOD_GSK3_1	952	959	PF00069	0.442
MOD_N-GLC_1	531	536	PF02516	0.410
MOD_N-GLC_1	685	690	PF02516	0.308
MOD_N-GLC_1	934	939	PF02516	0.744
MOD_N-GLC_2	687	689	PF02516	0.460
MOD_NEK2_1	135	140	PF00069	0.493
MOD_NEK2_1	173	178	PF00069	0.511
MOD_NEK2_1	303	308	PF00069	0.607
MOD_NEK2_1	353	358	PF00069	0.535
MOD_NEK2_1	363	368	PF00069	0.463
MOD_NEK2_1	629	634	PF00069	0.781
MOD_NEK2_1	7	12	PF00069	0.605
MOD_OFUCOSY	673	680	PF10250	0.436
MOD_PIKK_1	200	206	PF00454	0.562
MOD_PIKK_1	393	399	PF00454	0.708
MOD_PIKK_1	644	650	PF00454	0.709
MOD_PIKK_1	790	796	PF00454	0.667
MOD_PIKK_1	879	885	PF00454	0.632
MOD_PKA_1	1001	1007	PF00069	0.495
MOD_PKA_2	1001	1007	PF00069	0.675
MOD_PKA_2	1019	1025	PF00069	0.652
MOD_PKA_2	1055	1061	PF00069	0.731
MOD_PKA_2	1062	1068	PF00069	0.622
MOD_PKA_2	1129	1135	PF00069	0.457
MOD_PKA_2	20	26	PF00069	0.474
MOD_PKA_2	252	258	PF00069	0.607
MOD_PKA_2	468	474	PF00069	0.499
MOD_PKA_2	560	566	PF00069	0.643
MOD_PKA_2	832	838	PF00069	0.682
MOD_PKA_2	921	927	PF00069	0.561
MOD_PKA_2	992	998	PF00069	0.620
MOD_Plk_1	1068	1074	PF00069	0.654
MOD_Plk_1	267	273	PF00069	0.666
MOD_Plk_1	390	396	PF00069	0.521
MOD_Plk_1	629	635	PF00069	0.688
MOD_Plk_1	685	691	PF00069	0.302
MOD_Plk_1	7	13	PF00069	0.605
MOD_Plk_2-3	1064	1070	PF00069	0.562
MOD_Plk_2-3	542	548	PF00069	0.462
MOD_Plk_4	1068	1074	PF00069	0.668
MOD_Plk_4	137	143	PF00069	0.646
MOD_Plk_4	279	285	PF00069	0.576
MOD_Plk_4	363	369	PF00069	0.530
MOD_Plk_4	7	13	PF00069	0.541
MOD_Plk_4	783	789	PF00069	0.580
MOD_ProDKin_1	1039	1045	PF00069	0.762
MOD_ProDKin_1	104	110	PF00069	0.673
MOD_ProDKin_1	156	162	PF00069	0.690
MOD_ProDKin_1	261	267	PF00069	0.567
MOD_ProDKin_1	326	332	PF00069	0.479
MOD_ProDKin_1	445	451	PF00069	0.729
MOD_ProDKin_1	67	73	PF00069	0.666
MOD_ProDKin_1	673	679	PF00069	0.536
MOD_ProDKin_1	694	700	PF00069	0.512
MOD_ProDKin_1	722	728	PF00069	0.749
MOD_ProDKin_1	766	772	PF00069	0.426
MOD_ProDKin_1	889	895	PF00069	0.525
MOD_SUMO_rev_2	454	464	PF00179	0.547
TRG_DiLeu_BaEn_1	600	605	PF01217	0.388
TRG_DiLeu_BaEn_4	1014	1020	PF01217	0.502
TRG_ENDOCYTIC_2	194	197	PF00928	0.584
TRG_ENDOCYTIC_2	299	302	PF00928	0.600
TRG_ENDOCYTIC_2	360	363	PF00928	0.559
TRG_ENDOCYTIC_2	480	483	PF00928	0.510
TRG_ENDOCYTIC_2	564	567	PF00928	0.501
TRG_ENDOCYTIC_2	601	604	PF00928	0.439
TRG_ENDOCYTIC_2	731	734	PF00928	0.645
TRG_ENDOCYTIC_2	812	815	PF00928	0.460
TRG_ENDOCYTIC_2	86	89	PF00928	0.611
TRG_ENDOCYTIC_2	946	949	PF00928	0.538
TRG_ENDOCYTIC_2	970	973	PF00928	0.583
TRG_ER_diArg_1	1001	1003	PF00400	0.568
TRG_ER_diArg_1	435	437	PF00400	0.569
TRG_ER_diArg_1	469	472	PF00400	0.554
TRG_ER_diArg_1	862	865	PF00400	0.472
TRG_NES_CRM1_1	602	617	PF08389	0.319
TRG_Pf-PMV_PEXEL_1	346	350	PF00026	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I480	Leptomonas seymouri	37%	100%
A0A3S7WYG5	Leishmania donovani	86%	95%
A0A422NQA5	Trypanosoma rangeli	24%	100%
A4HDH4	Leishmania braziliensis	68%	99%
A4I0V5	Leishmania infantum	86%	92%
Q4QAL5	Leishmania major	85%	100%
V5BVQ3	Trypanosoma cruzi	24%	100%