Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AWV8_LEIMU

TriTrypDb:

LmxM.24.1160

Length:

976

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWV8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWV8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.582
CLV_C14_Caspase3-7	269	273	PF00656	0.576
CLV_C14_Caspase3-7	492	496	PF00656	0.542
CLV_C14_Caspase3-7	922	926	PF00656	0.614
CLV_NRD_NRD_1	152	154	PF00675	0.505
CLV_NRD_NRD_1	254	256	PF00675	0.624
CLV_NRD_NRD_1	26	28	PF00675	0.618
CLV_NRD_NRD_1	278	280	PF00675	0.518
CLV_NRD_NRD_1	349	351	PF00675	0.501
CLV_NRD_NRD_1	481	483	PF00675	0.368
CLV_NRD_NRD_1	544	546	PF00675	0.651
CLV_NRD_NRD_1	855	857	PF00675	0.539
CLV_NRD_NRD_1	88	90	PF00675	0.497
CLV_NRD_NRD_1	880	882	PF00675	0.576
CLV_NRD_NRD_1	884	886	PF00675	0.572
CLV_NRD_NRD_1	914	916	PF00675	0.536
CLV_PCSK_FUR_1	881	885	PF00082	0.616
CLV_PCSK_KEX2_1	152	154	PF00082	0.505
CLV_PCSK_KEX2_1	254	256	PF00082	0.624
CLV_PCSK_KEX2_1	26	28	PF00082	0.618
CLV_PCSK_KEX2_1	278	280	PF00082	0.518
CLV_PCSK_KEX2_1	349	351	PF00082	0.498
CLV_PCSK_KEX2_1	424	426	PF00082	0.401
CLV_PCSK_KEX2_1	544	546	PF00082	0.651
CLV_PCSK_KEX2_1	855	857	PF00082	0.539
CLV_PCSK_KEX2_1	88	90	PF00082	0.497
CLV_PCSK_KEX2_1	880	882	PF00082	0.576
CLV_PCSK_KEX2_1	883	885	PF00082	0.579
CLV_PCSK_KEX2_1	914	916	PF00082	0.536
CLV_PCSK_KEX2_1	957	959	PF00082	0.575
CLV_PCSK_PC1ET2_1	424	426	PF00082	0.401
CLV_PCSK_PC1ET2_1	957	959	PF00082	0.575
CLV_PCSK_PC7_1	880	886	PF00082	0.614
CLV_PCSK_SKI1_1	20	24	PF00082	0.704
CLV_PCSK_SKI1_1	424	428	PF00082	0.564
CLV_PCSK_SKI1_1	64	68	PF00082	0.717
CLV_PCSK_SKI1_1	766	770	PF00082	0.704
CLV_PCSK_SKI1_1	856	860	PF00082	0.599
DEG_APCC_DBOX_1	15	23	PF00400	0.724
DEG_APCC_DBOX_1	331	339	PF00400	0.541
DEG_APCC_DBOX_1	847	855	PF00400	0.532
DEG_Nend_UBRbox_3	1	3	PF02207	0.714
DEG_SCF_FBW7_1	33	39	PF00400	0.537
DEG_SPOP_SBC_1	624	628	PF00917	0.696
DEG_SPOP_SBC_1	646	650	PF00917	0.609
DEG_SPOP_SBC_1	776	780	PF00917	0.658
DOC_CKS1_1	33	38	PF01111	0.693
DOC_CYCLIN_RxL_1	569	581	PF00134	0.665
DOC_MAPK_gen_1	482	489	PF00069	0.564
DOC_MAPK_gen_1	883	892	PF00069	0.612
DOC_MAPK_MEF2A_6	681	689	PF00069	0.541
DOC_PP2B_LxvP_1	799	802	PF13499	0.686
DOC_PP4_FxxP_1	66	69	PF00568	0.716
DOC_USP7_MATH_1	135	139	PF00917	0.572
DOC_USP7_MATH_1	168	172	PF00917	0.584
DOC_USP7_MATH_1	173	177	PF00917	0.589
DOC_USP7_MATH_1	248	252	PF00917	0.652
DOC_USP7_MATH_1	292	296	PF00917	0.559
DOC_USP7_MATH_1	366	370	PF00917	0.556
DOC_USP7_MATH_1	41	45	PF00917	0.666
DOC_USP7_MATH_1	454	458	PF00917	0.404
DOC_USP7_MATH_1	532	536	PF00917	0.622
DOC_USP7_MATH_1	614	618	PF00917	0.643
DOC_USP7_MATH_1	647	651	PF00917	0.611
DOC_USP7_MATH_1	696	700	PF00917	0.670
DOC_USP7_MATH_1	776	780	PF00917	0.599
DOC_USP7_MATH_1	842	846	PF00917	0.673
DOC_USP7_MATH_1	903	907	PF00917	0.730
DOC_WW_Pin1_4	10	15	PF00397	0.659
DOC_WW_Pin1_4	20	25	PF00397	0.558
DOC_WW_Pin1_4	244	249	PF00397	0.589
DOC_WW_Pin1_4	263	268	PF00397	0.482
DOC_WW_Pin1_4	3	8	PF00397	0.668
DOC_WW_Pin1_4	32	37	PF00397	0.632
DOC_WW_Pin1_4	43	48	PF00397	0.582
DOC_WW_Pin1_4	550	555	PF00397	0.664
DOC_WW_Pin1_4	568	573	PF00397	0.549
DOC_WW_Pin1_4	65	70	PF00397	0.738
DOC_WW_Pin1_4	679	684	PF00397	0.714
DOC_WW_Pin1_4	691	696	PF00397	0.631
DOC_WW_Pin1_4	73	78	PF00397	0.660
DOC_WW_Pin1_4	766	771	PF00397	0.741
DOC_WW_Pin1_4	838	843	PF00397	0.705
DOC_WW_Pin1_4	899	904	PF00397	0.715
DOC_WW_Pin1_4	98	103	PF00397	0.670
LIG_14-3-3_CanoR_1	120	126	PF00244	0.541
LIG_14-3-3_CanoR_1	27	36	PF00244	0.685
LIG_14-3-3_CanoR_1	375	383	PF00244	0.380
LIG_14-3-3_CanoR_1	444	452	PF00244	0.457
LIG_14-3-3_CanoR_1	509	515	PF00244	0.447
LIG_14-3-3_CanoR_1	533	539	PF00244	0.561
LIG_14-3-3_CanoR_1	610	614	PF00244	0.735
LIG_14-3-3_CanoR_1	64	69	PF00244	0.715
LIG_14-3-3_CanoR_1	914	919	PF00244	0.568
LIG_14-3-3_CanoR_1	94	102	PF00244	0.704
LIG_Actin_WH2_2	847	862	PF00022	0.594
LIG_BRCT_BRCA1_1	48	52	PF00533	0.626
LIG_CaM_NSCaTE_8	339	346	PF13499	0.478
LIG_CtBP_PxDLS_1	267	271	PF00389	0.543
LIG_eIF4E_1	277	283	PF01652	0.440
LIG_EVH1_2	604	608	PF00568	0.553
LIG_FHA_1	176	182	PF00498	0.510
LIG_FHA_1	318	324	PF00498	0.549
LIG_FHA_1	338	344	PF00498	0.350
LIG_FHA_1	392	398	PF00498	0.583
LIG_FHA_1	592	598	PF00498	0.700
LIG_FHA_1	767	773	PF00498	0.728
LIG_FHA_1	82	88	PF00498	0.715
LIG_FHA_1	887	893	PF00498	0.615
LIG_FHA_2	254	260	PF00498	0.675
LIG_FHA_2	365	371	PF00498	0.653
LIG_FHA_2	625	631	PF00498	0.659
LIG_FHA_2	787	793	PF00498	0.637
LIG_FHA_2	807	813	PF00498	0.597
LIG_LIR_Apic_2	65	69	PF02991	0.714
LIG_LIR_Apic_2	651	657	PF02991	0.699
LIG_LIR_Apic_2	706	710	PF02991	0.615
LIG_LIR_Gen_1	337	346	PF02991	0.545
LIG_LIR_Gen_1	392	400	PF02991	0.573
LIG_LIR_Gen_1	948	959	PF02991	0.586
LIG_LIR_LC3C_4	617	622	PF02991	0.695
LIG_LIR_Nem_3	337	342	PF02991	0.545
LIG_LIR_Nem_3	392	398	PF02991	0.575
LIG_LIR_Nem_3	948	954	PF02991	0.594
LIG_PCNA_yPIPBox_3	944	958	PF02747	0.391
LIG_RPA_C_Fungi	870	882	PF08784	0.548
LIG_SH2_CRK	280	284	PF00017	0.498
LIG_SH2_CRK	395	399	PF00017	0.509
LIG_SH2_CRK	707	711	PF00017	0.613
LIG_SH2_NCK_1	38	42	PF00017	0.597
LIG_SH2_NCK_1	951	955	PF00017	0.588
LIG_SH2_SRC	341	344	PF00017	0.438
LIG_SH2_SRC	791	794	PF00017	0.561
LIG_SH2_SRC	951	954	PF00017	0.588
LIG_SH2_STAP1	38	42	PF00017	0.681
LIG_SH2_STAT5	341	344	PF00017	0.550
LIG_SH2_STAT5	38	41	PF00017	0.527
LIG_SH3_2	657	662	PF14604	0.554
LIG_SH3_3	101	107	PF00018	0.600
LIG_SH3_3	109	115	PF00018	0.669
LIG_SH3_3	359	365	PF00018	0.562
LIG_SH3_3	601	607	PF00018	0.745
LIG_SH3_3	654	660	PF00018	0.548
LIG_SUMO_SIM_anti_2	617	623	PF11976	0.697
LIG_SUMO_SIM_par_1	210	215	PF11976	0.586
LIG_SUMO_SIM_par_1	334	340	PF11976	0.345
LIG_SUMO_SIM_par_1	617	623	PF11976	0.697
LIG_TRAF2_1	157	160	PF00917	0.540
LIG_TRAF2_1	433	436	PF00917	0.501
LIG_TRAF2_1	559	562	PF00917	0.650
LIG_TRAF2_1	809	812	PF00917	0.552
LIG_TRAF2_1	932	935	PF00917	0.569
MOD_CDK_SPK_2	3	8	PF00069	0.614
MOD_CDK_SPK_2	766	771	PF00069	0.706
MOD_CDK_SPxK_1	10	16	PF00069	0.698
MOD_CDK_SPxK_1	20	26	PF00069	0.589
MOD_CDK_SPxK_1	568	574	PF00069	0.672
MOD_CDK_SPxxK_3	20	27	PF00069	0.596
MOD_CDK_SPxxK_3	65	72	PF00069	0.711
MOD_CK1_1	121	127	PF00069	0.582
MOD_CK1_1	171	177	PF00069	0.623
MOD_CK1_1	228	234	PF00069	0.710
MOD_CK1_1	266	272	PF00069	0.702
MOD_CK1_1	28	34	PF00069	0.708
MOD_CK1_1	3	9	PF00069	0.545
MOD_CK1_1	337	343	PF00069	0.348
MOD_CK1_1	46	52	PF00069	0.528
MOD_CK1_1	54	60	PF00069	0.618
MOD_CK1_1	577	583	PF00069	0.710
MOD_CK1_1	623	629	PF00069	0.701
MOD_CK1_1	670	676	PF00069	0.746
MOD_CK1_1	68	74	PF00069	0.577
MOD_CK1_1	753	759	PF00069	0.682
MOD_CK1_1	764	770	PF00069	0.625
MOD_CK1_1	834	840	PF00069	0.708
MOD_CK1_1	895	901	PF00069	0.683
MOD_CK1_1	902	908	PF00069	0.650
MOD_CK1_1	97	103	PF00069	0.552
MOD_CK2_1	364	370	PF00069	0.510
MOD_CK2_1	524	530	PF00069	0.729
MOD_CK2_1	806	812	PF00069	0.711
MOD_Cter_Amidation	542	545	PF01082	0.693
MOD_Cter_Amidation	912	915	PF01082	0.532
MOD_DYRK1A_RPxSP_1	766	770	PF00069	0.704
MOD_GlcNHglycan	125	128	PF01048	0.706
MOD_GlcNHglycan	131	134	PF01048	0.754
MOD_GlcNHglycan	170	173	PF01048	0.598
MOD_GlcNHglycan	204	207	PF01048	0.447
MOD_GlcNHglycan	227	230	PF01048	0.700
MOD_GlcNHglycan	27	30	PF01048	0.608
MOD_GlcNHglycan	294	297	PF01048	0.562
MOD_GlcNHglycan	3	6	PF01048	0.701
MOD_GlcNHglycan	344	347	PF01048	0.523
MOD_GlcNHglycan	43	46	PF01048	0.595
MOD_GlcNHglycan	456	459	PF01048	0.515
MOD_GlcNHglycan	526	529	PF01048	0.728
MOD_GlcNHglycan	534	537	PF01048	0.629
MOD_GlcNHglycan	538	541	PF01048	0.600
MOD_GlcNHglycan	56	59	PF01048	0.553
MOD_GlcNHglycan	561	566	PF01048	0.651
MOD_GlcNHglycan	622	625	PF01048	0.747
MOD_GlcNHglycan	699	702	PF01048	0.551
MOD_GlcNHglycan	753	756	PF01048	0.743
MOD_GlcNHglycan	766	769	PF01048	0.607
MOD_GlcNHglycan	779	782	PF01048	0.616
MOD_GlcNHglycan	817	820	PF01048	0.714
MOD_GlcNHglycan	844	847	PF01048	0.613
MOD_GlcNHglycan	877	880	PF01048	0.420
MOD_GlcNHglycan	897	900	PF01048	0.658
MOD_GlcNHglycan	91	94	PF01048	0.593
MOD_GSK3_1	171	178	PF00069	0.569
MOD_GSK3_1	183	190	PF00069	0.527
MOD_GSK3_1	240	247	PF00069	0.582
MOD_GSK3_1	262	269	PF00069	0.750
MOD_GSK3_1	28	35	PF00069	0.698
MOD_GSK3_1	364	371	PF00069	0.660
MOD_GSK3_1	387	394	PF00069	0.499
MOD_GSK3_1	41	48	PF00069	0.590
MOD_GSK3_1	50	57	PF00069	0.610
MOD_GSK3_1	532	539	PF00069	0.706
MOD_GSK3_1	544	551	PF00069	0.560
MOD_GSK3_1	561	568	PF00069	0.673
MOD_GSK3_1	574	581	PF00069	0.583
MOD_GSK3_1	620	627	PF00069	0.702
MOD_GSK3_1	64	71	PF00069	0.580
MOD_GSK3_1	667	674	PF00069	0.700
MOD_GSK3_1	687	694	PF00069	0.573
MOD_GSK3_1	807	814	PF00069	0.596
MOD_GSK3_1	834	841	PF00069	0.709
MOD_GSK3_1	871	878	PF00069	0.422
MOD_GSK3_1	895	902	PF00069	0.688
MOD_GSK3_1	94	101	PF00069	0.629
MOD_N-GLC_1	1	6	PF02516	0.707
MOD_N-GLC_1	129	134	PF02516	0.673
MOD_N-GLC_1	183	188	PF02516	0.635
MOD_N-GLC_1	379	384	PF02516	0.524
MOD_N-GLC_1	521	526	PF02516	0.687
MOD_N-GLC_1	624	629	PF02516	0.719
MOD_N-GLC_1	892	897	PF02516	0.645
MOD_NEK2_1	1	6	PF00069	0.749
MOD_NEK2_1	123	128	PF00069	0.614
MOD_NEK2_1	189	194	PF00069	0.446
MOD_NEK2_1	227	232	PF00069	0.646
MOD_NEK2_1	25	30	PF00069	0.693
MOD_NEK2_1	287	292	PF00069	0.580
MOD_NEK2_1	342	347	PF00069	0.554
MOD_NEK2_1	477	482	PF00069	0.557
MOD_NEK2_1	50	55	PF00069	0.689
MOD_NEK2_1	508	513	PF00069	0.462
MOD_NEK2_1	578	583	PF00069	0.603
MOD_NEK2_1	620	625	PF00069	0.681
MOD_NEK2_1	80	85	PF00069	0.567
MOD_NEK2_2	248	253	PF00069	0.653
MOD_PIKK_1	118	124	PF00454	0.587
MOD_PIKK_1	36	42	PF00454	0.525
MOD_PIKK_1	459	465	PF00454	0.426
MOD_PK_1	548	554	PF00069	0.593
MOD_PK_1	655	661	PF00069	0.629
MOD_PK_1	914	920	PF00069	0.523
MOD_PKA_1	544	550	PF00069	0.574
MOD_PKA_1	914	920	PF00069	0.523
MOD_PKA_2	25	31	PF00069	0.603
MOD_PKA_2	253	259	PF00069	0.629
MOD_PKA_2	348	354	PF00069	0.638
MOD_PKA_2	374	380	PF00069	0.393
MOD_PKA_2	443	449	PF00069	0.497
MOD_PKA_2	508	514	PF00069	0.472
MOD_PKA_2	532	538	PF00069	0.558
MOD_PKA_2	544	550	PF00069	0.574
MOD_PKA_2	591	597	PF00069	0.700
MOD_PKA_2	609	615	PF00069	0.539
MOD_PKA_2	732	738	PF00069	0.715
MOD_PKA_2	812	818	PF00069	0.709
MOD_PKA_2	886	892	PF00069	0.611
MOD_PKA_2	913	919	PF00069	0.650
MOD_Plk_1	287	293	PF00069	0.523
MOD_Plk_1	299	305	PF00069	0.461
MOD_Plk_1	379	385	PF00069	0.599
MOD_Plk_1	391	397	PF00069	0.460
MOD_Plk_1	892	898	PF00069	0.650
MOD_Plk_2-3	807	813	PF00069	0.555
MOD_Plk_4	240	246	PF00069	0.657
MOD_Plk_4	266	272	PF00069	0.525
MOD_Plk_4	334	340	PF00069	0.541
MOD_Plk_4	379	385	PF00069	0.523
MOD_Plk_4	46	52	PF00069	0.721
MOD_Plk_4	510	516	PF00069	0.550
MOD_Plk_4	615	621	PF00069	0.690
MOD_ProDKin_1	10	16	PF00069	0.663
MOD_ProDKin_1	20	26	PF00069	0.558
MOD_ProDKin_1	244	250	PF00069	0.591
MOD_ProDKin_1	263	269	PF00069	0.472
MOD_ProDKin_1	3	9	PF00069	0.670
MOD_ProDKin_1	32	38	PF00069	0.632
MOD_ProDKin_1	43	49	PF00069	0.583
MOD_ProDKin_1	550	556	PF00069	0.663
MOD_ProDKin_1	568	574	PF00069	0.551
MOD_ProDKin_1	65	71	PF00069	0.735
MOD_ProDKin_1	679	685	PF00069	0.712
MOD_ProDKin_1	691	697	PF00069	0.630
MOD_ProDKin_1	73	79	PF00069	0.661
MOD_ProDKin_1	766	772	PF00069	0.743
MOD_ProDKin_1	838	844	PF00069	0.703
MOD_ProDKin_1	899	905	PF00069	0.716
MOD_ProDKin_1	98	104	PF00069	0.665
MOD_SUMO_for_1	448	451	PF00179	0.420
MOD_SUMO_rev_2	492	498	PF00179	0.542
MOD_SUMO_rev_2	665	670	PF00179	0.700
TRG_DiLeu_BaEn_1	331	336	PF01217	0.500
TRG_DiLeu_BaEn_1	562	567	PF01217	0.654
TRG_DiLeu_BaLyEn_6	319	324	PF01217	0.549
TRG_ENDOCYTIC_2	280	283	PF00928	0.542
TRG_ENDOCYTIC_2	395	398	PF00928	0.514
TRG_ENDOCYTIC_2	470	473	PF00928	0.575
TRG_ENDOCYTIC_2	951	954	PF00928	0.588
TRG_ER_diArg_1	152	154	PF00400	0.481
TRG_ER_diArg_1	25	27	PF00400	0.621
TRG_ER_diArg_1	277	279	PF00400	0.576
TRG_ER_diArg_1	675	678	PF00400	0.751
TRG_ER_diArg_1	848	851	PF00400	0.594
TRG_ER_diArg_1	854	856	PF00400	0.570
TRG_ER_diArg_1	87	89	PF00400	0.498
TRG_ER_diArg_1	880	883	PF00400	0.613
TRG_NES_CRM1_1	927	942	PF08389	0.603
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	403	407	PF00026	0.492
TRG_Pf-PMV_PEXEL_1	411	415	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	499	504	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	931	935	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WYH7	Leishmania donovani	76%	94%
A4HDH3	Leishmania braziliensis	56%	95%
A4I0V4	Leishmania infantum	76%	95%
Q4QAL6	Leishmania major	77%	100%