Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWV4_LEIMU

TriTrypDb:

LmxM.24.1125

Length:

802

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWV4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.668
CLV_C14_Caspase3-7	3	7	PF00656	0.864
CLV_C14_Caspase3-7	324	328	PF00656	0.646
CLV_C14_Caspase3-7	691	695	PF00656	0.551
CLV_NRD_NRD_1	191	193	PF00675	0.630
CLV_NRD_NRD_1	219	221	PF00675	0.573
CLV_NRD_NRD_1	293	295	PF00675	0.875
CLV_NRD_NRD_1	305	307	PF00675	0.666
CLV_NRD_NRD_1	312	314	PF00675	0.848
CLV_NRD_NRD_1	425	427	PF00675	0.726
CLV_NRD_NRD_1	67	69	PF00675	0.543
CLV_NRD_NRD_1	713	715	PF00675	0.581
CLV_NRD_NRD_1	785	787	PF00675	0.390
CLV_PCSK_KEX2_1	191	193	PF00082	0.638
CLV_PCSK_KEX2_1	292	294	PF00082	0.883
CLV_PCSK_KEX2_1	311	313	PF00082	0.876
CLV_PCSK_KEX2_1	425	427	PF00082	0.723
CLV_PCSK_KEX2_1	67	69	PF00082	0.547
CLV_PCSK_KEX2_1	727	729	PF00082	0.758
CLV_PCSK_KEX2_1	785	787	PF00082	0.390
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.668
CLV_PCSK_PC1ET2_1	727	729	PF00082	0.758
CLV_PCSK_PC7_1	63	69	PF00082	0.621
CLV_PCSK_PC7_1	781	787	PF00082	0.378
CLV_PCSK_SKI1_1	477	481	PF00082	0.646
CLV_PCSK_SKI1_1	570	574	PF00082	0.708
DEG_APCC_DBOX_1	476	484	PF00400	0.395
DEG_SPOP_SBC_1	328	332	PF00917	0.602
DOC_CKS1_1	369	374	PF01111	0.587
DOC_CKS1_1	99	104	PF01111	0.824
DOC_CYCLIN_yClb3_PxF_3	149	157	PF00134	0.668
DOC_CYCLIN_yCln2_LP_2	787	793	PF00134	0.807
DOC_MAPK_gen_1	292	303	PF00069	0.553
DOC_MAPK_gen_1	389	396	PF00069	0.650
DOC_MAPK_gen_1	473	480	PF00069	0.598
DOC_MAPK_gen_1	785	793	PF00069	0.597
DOC_MAPK_MEF2A_6	786	795	PF00069	0.807
DOC_PP2B_LxvP_1	90	93	PF13499	0.808
DOC_PP4_FxxP_1	668	671	PF00568	0.327
DOC_PP4_MxPP_1	361	364	PF00568	0.473
DOC_USP7_MATH_1	158	162	PF00917	0.876
DOC_USP7_MATH_1	180	184	PF00917	0.877
DOC_USP7_MATH_1	187	191	PF00917	0.790
DOC_USP7_MATH_1	328	332	PF00917	0.578
DOC_USP7_MATH_1	418	422	PF00917	0.603
DOC_USP7_MATH_1	560	564	PF00917	0.431
DOC_USP7_MATH_1	575	579	PF00917	0.521
DOC_USP7_MATH_1	617	621	PF00917	0.525
DOC_USP7_MATH_1	735	739	PF00917	0.561
DOC_USP7_UBL2_3	307	311	PF12436	0.457
DOC_WW_Pin1_4	19	24	PF00397	0.865
DOC_WW_Pin1_4	278	283	PF00397	0.619
DOC_WW_Pin1_4	286	291	PF00397	0.546
DOC_WW_Pin1_4	368	373	PF00397	0.606
DOC_WW_Pin1_4	384	389	PF00397	0.539
DOC_WW_Pin1_4	396	401	PF00397	0.493
DOC_WW_Pin1_4	432	437	PF00397	0.600
DOC_WW_Pin1_4	515	520	PF00397	0.564
DOC_WW_Pin1_4	581	586	PF00397	0.601
DOC_WW_Pin1_4	742	747	PF00397	0.512
DOC_WW_Pin1_4	94	99	PF00397	0.808
LIG_14-3-3_CanoR_1	130	137	PF00244	0.685
LIG_14-3-3_CanoR_1	175	184	PF00244	0.677
LIG_14-3-3_CanoR_1	208	217	PF00244	0.766
LIG_14-3-3_CanoR_1	220	224	PF00244	0.663
LIG_14-3-3_CanoR_1	312	321	PF00244	0.528
LIG_14-3-3_CanoR_1	559	565	PF00244	0.584
LIG_14-3-3_CanoR_1	82	90	PF00244	0.796
LIG_BIR_II_1	1	5	PF00653	0.812
LIG_CtBP_PxDLS_1	500	504	PF00389	0.400
LIG_deltaCOP1_diTrp_1	383	393	PF00928	0.452
LIG_FHA_1	700	706	PF00498	0.492
LIG_FHA_2	385	391	PF00498	0.658
LIG_FHA_2	689	695	PF00498	0.556
LIG_FHA_2	83	89	PF00498	0.745
LIG_HCF-1_HBM_1	514	517	PF13415	0.414
LIG_LIR_Apic_2	276	282	PF02991	0.617
LIG_LIR_Apic_2	665	671	PF02991	0.387
LIG_LIR_Gen_1	390	401	PF02991	0.550
LIG_LIR_Gen_1	598	607	PF02991	0.607
LIG_LIR_Gen_1	87	96	PF02991	0.741
LIG_LIR_Nem_3	245	251	PF02991	0.790
LIG_LIR_Nem_3	390	396	PF02991	0.557
LIG_LIR_Nem_3	399	404	PF02991	0.555
LIG_LIR_Nem_3	506	511	PF02991	0.622
LIG_LIR_Nem_3	598	604	PF02991	0.606
LIG_LIR_Nem_3	750	755	PF02991	0.474
LIG_LIR_Nem_3	87	92	PF02991	0.763
LIG_LYPXL_yS_3	789	792	PF13949	0.809
LIG_MYND_1	23	27	PF01753	0.868
LIG_MYND_1	282	286	PF01753	0.625
LIG_Pex14_1	545	549	PF04695	0.494
LIG_PTAP_UEV_1	28	33	PF05743	0.655
LIG_PTB_Apo_2	600	607	PF02174	0.553
LIG_SH2_CRK	248	252	PF00017	0.802
LIG_SH2_CRK	279	283	PF00017	0.620
LIG_SH2_CRK	601	605	PF00017	0.609
LIG_SH2_CRK	685	689	PF00017	0.583
LIG_SH2_GRB2like	601	604	PF00017	0.555
LIG_SH2_NCK_1	114	118	PF00017	0.664
LIG_SH2_NCK_1	601	605	PF00017	0.553
LIG_SH2_SRC	114	117	PF00017	0.663
LIG_SH2_STAP1	701	705	PF00017	0.494
LIG_SH2_STAT3	703	706	PF00017	0.342
LIG_SH2_STAT5	241	244	PF00017	0.756
LIG_SH2_STAT5	401	404	PF00017	0.510
LIG_SH2_STAT5	487	490	PF00017	0.607
LIG_SH2_STAT5	509	512	PF00017	0.622
LIG_SH2_STAT5	549	552	PF00017	0.507
LIG_SH2_STAT5	646	649	PF00017	0.597
LIG_SH2_STAT5	653	656	PF00017	0.500
LIG_SH2_STAT5	701	704	PF00017	0.541
LIG_SH3_1	359	365	PF00018	0.650
LIG_SH3_1	67	73	PF00018	0.876
LIG_SH3_2	288	293	PF14604	0.537
LIG_SH3_2	372	377	PF14604	0.614
LIG_SH3_2	95	100	PF14604	0.664
LIG_SH3_3	146	152	PF00018	0.662
LIG_SH3_3	248	254	PF00018	0.785
LIG_SH3_3	26	32	PF00018	0.863
LIG_SH3_3	285	291	PF00018	0.574
LIG_SH3_3	298	304	PF00018	0.674
LIG_SH3_3	357	363	PF00018	0.651
LIG_SH3_3	366	372	PF00018	0.566
LIG_SH3_3	579	585	PF00018	0.604
LIG_SH3_3	67	73	PF00018	0.876
LIG_SH3_3	790	796	PF00018	0.808
LIG_SH3_3	90	96	PF00018	0.799
LIG_SH3_4	307	314	PF00018	0.463
LIG_SH3_CIN85_PxpxPR_1	372	377	PF14604	0.558
LIG_SUMO_SIM_anti_2	322	327	PF11976	0.537
LIG_SUMO_SIM_par_1	789	794	PF11976	0.754
LIG_TYR_ITIM	787	792	PF00017	0.770
LIG_WW_3	289	293	PF00397	0.674
LIG_WW_3	374	378	PF00397	0.743
LIG_WW_3	97	101	PF00397	0.571
MOD_CDC14_SPxK_1	289	292	PF00782	0.789
MOD_CDC14_SPxK_1	97	100	PF00782	0.570
MOD_CDK_SPK_2	278	283	PF00069	0.786
MOD_CDK_SPK_2	384	389	PF00069	0.768
MOD_CDK_SPxK_1	286	292	PF00069	0.789
MOD_CDK_SPxK_1	94	100	PF00069	0.571
MOD_CDK_SPxxK_3	286	293	PF00069	0.790
MOD_CDK_SPxxK_3	384	391	PF00069	0.766
MOD_CK1_1	150	156	PF00069	0.825
MOD_CK1_1	219	225	PF00069	0.620
MOD_CK1_1	315	321	PF00069	0.694
MOD_CK1_1	330	336	PF00069	0.745
MOD_CK1_1	340	346	PF00069	0.715
MOD_CK1_1	384	390	PF00069	0.553
MOD_CK1_1	432	438	PF00069	0.767
MOD_CK1_1	584	590	PF00069	0.672
MOD_CK1_1	602	608	PF00069	0.481
MOD_CK1_1	619	625	PF00069	0.704
MOD_CK1_1	648	654	PF00069	0.647
MOD_CK1_1	745	751	PF00069	0.679
MOD_CK2_1	311	317	PF00069	0.688
MOD_CK2_1	33	39	PF00069	0.864
MOD_CK2_1	384	390	PF00069	0.845
MOD_CK2_1	735	741	PF00069	0.641
MOD_DYRK1A_RPxSP_1	94	98	PF00069	0.568
MOD_GlcNHglycan	107	110	PF01048	0.779
MOD_GlcNHglycan	160	163	PF01048	0.692
MOD_GlcNHglycan	168	171	PF01048	0.685
MOD_GlcNHglycan	178	181	PF01048	0.765
MOD_GlcNHglycan	210	213	PF01048	0.756
MOD_GlcNHglycan	431	434	PF01048	0.622
MOD_GlcNHglycan	522	526	PF01048	0.562
MOD_GlcNHglycan	619	622	PF01048	0.670
MOD_GlcNHglycan	721	724	PF01048	0.751
MOD_GSK3_1	176	183	PF00069	0.760
MOD_GSK3_1	19	26	PF00069	0.760
MOD_GSK3_1	243	250	PF00069	0.585
MOD_GSK3_1	263	270	PF00069	0.199
MOD_GSK3_1	274	281	PF00069	0.782
MOD_GSK3_1	282	289	PF00069	0.693
MOD_GSK3_1	311	318	PF00069	0.705
MOD_GSK3_1	396	403	PF00069	0.730
MOD_GSK3_1	533	540	PF00069	0.770
MOD_GSK3_1	615	622	PF00069	0.772
MOD_GSK3_1	626	633	PF00069	0.507
MOD_GSK3_1	706	713	PF00069	0.709
MOD_GSK3_1	78	85	PF00069	0.617
MOD_GSK3_1	94	101	PF00069	0.864
MOD_LATS_1	309	315	PF00433	0.784
MOD_N-GLC_1	4	9	PF02516	0.776
MOD_N-GLC_1	602	607	PF02516	0.483
MOD_N-GLC_1	77	82	PF02516	0.764
MOD_NEK2_1	136	141	PF00069	0.700
MOD_NEK2_1	242	247	PF00069	0.556
MOD_NEK2_1	337	342	PF00069	0.609
MOD_NEK2_1	394	399	PF00069	0.524
MOD_NEK2_1	507	512	PF00069	0.790
MOD_NEK2_1	521	526	PF00069	0.561
MOD_NEK2_1	533	538	PF00069	0.644
MOD_NEK2_1	624	629	PF00069	0.505
MOD_NEK2_1	645	650	PF00069	0.517
MOD_NEK2_1	755	760	PF00069	0.448
MOD_NEK2_2	180	185	PF00069	0.790
MOD_NEK2_2	274	279	PF00069	0.783
MOD_OFUCOSY	630	635	PF10250	0.669
MOD_OFUCOSY	704	710	PF10250	0.603
MOD_PIKK_1	173	179	PF00454	0.790
MOD_PIKK_1	337	343	PF00454	0.864
MOD_PIKK_1	537	543	PF00454	0.767
MOD_PKA_1	311	317	PF00069	0.785
MOD_PKA_2	129	135	PF00069	0.578
MOD_PKA_2	150	156	PF00069	0.767
MOD_PKA_2	219	225	PF00069	0.687
MOD_PKA_2	267	273	PF00069	0.365
MOD_PKA_2	295	301	PF00069	0.702
MOD_PKA_2	311	317	PF00069	0.703
MOD_PKA_2	558	564	PF00069	0.737
MOD_Plk_1	243	249	PF00069	0.580
MOD_Plk_1	274	280	PF00069	0.804
MOD_Plk_1	602	608	PF00069	0.483
MOD_Plk_1	664	670	PF00069	0.466
MOD_Plk_4	243	249	PF00069	0.580
MOD_Plk_4	274	280	PF00069	0.782
MOD_Plk_4	584	590	PF00069	0.672
MOD_Plk_4	602	608	PF00069	0.469
MOD_Plk_4	716	722	PF00069	0.456
MOD_ProDKin_1	19	25	PF00069	0.854
MOD_ProDKin_1	278	284	PF00069	0.789
MOD_ProDKin_1	286	292	PF00069	0.688
MOD_ProDKin_1	368	374	PF00069	0.766
MOD_ProDKin_1	384	390	PF00069	0.673
MOD_ProDKin_1	396	402	PF00069	0.610
MOD_ProDKin_1	432	438	PF00069	0.758
MOD_ProDKin_1	515	521	PF00069	0.711
MOD_ProDKin_1	581	587	PF00069	0.761
MOD_ProDKin_1	742	748	PF00069	0.634
MOD_ProDKin_1	94	100	PF00069	0.774
TRG_DiLeu_BaEn_1	474	479	PF01217	0.754
TRG_DiLeu_BaLyEn_6	675	680	PF01217	0.520
TRG_DiLeu_LyEn_5	474	479	PF01217	0.462
TRG_ENDOCYTIC_2	114	117	PF00928	0.568
TRG_ENDOCYTIC_2	248	251	PF00928	0.761
TRG_ENDOCYTIC_2	401	404	PF00928	0.634
TRG_ENDOCYTIC_2	508	511	PF00928	0.796
TRG_ENDOCYTIC_2	601	604	PF00928	0.775
TRG_ENDOCYTIC_2	685	688	PF00928	0.735
TRG_ENDOCYTIC_2	789	792	PF00928	0.773
TRG_ER_diArg_1	191	194	PF00400	0.852
TRG_ER_diArg_1	291	294	PF00400	0.869
TRG_ER_diArg_1	424	426	PF00400	0.665
TRG_ER_diArg_1	475	478	PF00400	0.588
TRG_ER_diArg_1	483	486	PF00400	0.674
TRG_ER_diArg_1	67	69	PF00400	0.686
TRG_ER_diArg_1	784	786	PF00400	0.456
TRG_Pf-PMV_PEXEL_1	678	683	PF00026	0.698

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICW0	Leishmania donovani	84%	100%
A4HDG9	Leishmania braziliensis	61%	100%
A4I0V0	Leishmania infantum	84%	100%
Q4QAM0	Leishmania major	84%	100%