Hypothetical predicted multipass transmembrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical predicted multipass transmembrane protein

Species:

Leishmania mexicana

UniProt:

E9AWV0_LEIMU

TriTrypDb:

LmxM.24.1090

Length:

527

Annotations

LeishMANIAdb annotations

This highly expanded family of Kinetoplastid transporters is likely responsible for the uptake of critical nutrients. Might be a thiamine transporter if relate to human SLC35F proteins.. Localization: Cell surface (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	18
GO:0110165	cellular anatomical entity	1	18

Expansion

Sequence features

E9AWV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWV0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.314
CLV_NRD_NRD_1	174	176	PF00675	0.345
CLV_NRD_NRD_1	330	332	PF00675	0.351
CLV_NRD_NRD_1	493	495	PF00675	0.434
CLV_PCSK_KEX2_1	10	12	PF00082	0.453
CLV_PCSK_KEX2_1	176	178	PF00082	0.352
CLV_PCSK_KEX2_1	330	332	PF00082	0.446
CLV_PCSK_KEX2_1	492	494	PF00082	0.433
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.364
CLV_PCSK_PC1ET2_1	330	332	PF00082	0.476
CLV_PCSK_PC1ET2_1	492	494	PF00082	0.442
CLV_PCSK_SKI1_1	122	126	PF00082	0.280
CLV_PCSK_SKI1_1	14	18	PF00082	0.343
CLV_PCSK_SKI1_1	344	348	PF00082	0.314
CLV_PCSK_SKI1_1	482	486	PF00082	0.365
CLV_PCSK_SKI1_1	504	508	PF00082	0.320
DEG_APCC_DBOX_1	235	243	PF00400	0.544
DEG_Nend_UBRbox_1	1	4	PF02207	0.581
DEG_SCF_FBW7_2	319	326	PF00400	0.497
DOC_CKS1_1	320	325	PF01111	0.691
DOC_CYCLIN_yCln2_LP_2	361	367	PF00134	0.313
DOC_MAPK_gen_1	175	184	PF00069	0.529
DOC_MAPK_HePTP_8	456	468	PF00069	0.379
DOC_MAPK_MEF2A_6	28	36	PF00069	0.612
DOC_MAPK_MEF2A_6	344	352	PF00069	0.513
DOC_MAPK_MEF2A_6	399	408	PF00069	0.405
DOC_MAPK_MEF2A_6	459	468	PF00069	0.379
DOC_MAPK_NFAT4_5	399	407	PF00069	0.405
DOC_MAPK_RevD_3	319	332	PF00069	0.483
DOC_PP2B_LxvP_1	244	247	PF13499	0.588
DOC_PP4_FxxP_1	203	206	PF00568	0.376
DOC_USP7_MATH_1	300	304	PF00917	0.695
DOC_USP7_MATH_1	4	8	PF00917	0.605
DOC_USP7_MATH_1	435	439	PF00917	0.437
DOC_USP7_MATH_1	498	502	PF00917	0.689
DOC_WW_Pin1_4	144	149	PF00397	0.327
DOC_WW_Pin1_4	262	267	PF00397	0.782
DOC_WW_Pin1_4	282	287	PF00397	0.698
DOC_WW_Pin1_4	319	324	PF00397	0.709
DOC_WW_Pin1_4	419	424	PF00397	0.508
LIG_14-3-3_CanoR_1	28	36	PF00244	0.560
LIG_14-3-3_CanoR_1	385	389	PF00244	0.363
LIG_BIR_III_2	366	370	PF00653	0.355
LIG_BRCT_BRCA1_1	180	184	PF00533	0.387
LIG_BRCT_BRCA1_1	224	228	PF00533	0.394
LIG_BRCT_BRCA1_1	386	390	PF00533	0.339
LIG_BRCT_BRCA1_1	55	59	PF00533	0.253
LIG_Clathr_ClatBox_1	309	313	PF01394	0.683
LIG_eIF4E_1	121	127	PF01652	0.540
LIG_FHA_1	275	281	PF00498	0.692
LIG_FHA_1	286	292	PF00498	0.711
LIG_FHA_1	438	444	PF00498	0.359
LIG_FHA_1	80	86	PF00498	0.355
LIG_FHA_2	498	504	PF00498	0.608
LIG_GBD_Chelix_1	192	200	PF00786	0.369
LIG_GBD_Chelix_1	349	357	PF00786	0.402
LIG_GBD_Chelix_1	467	475	PF00786	0.341
LIG_IRF3_LxIS_1	51	56	PF10401	0.317
LIG_LIR_Apic_2	201	206	PF02991	0.361
LIG_LIR_Gen_1	178	186	PF02991	0.499
LIG_LIR_Gen_1	187	196	PF02991	0.286
LIG_LIR_Gen_1	214	223	PF02991	0.311
LIG_LIR_Gen_1	359	368	PF02991	0.411
LIG_LIR_Nem_3	167	173	PF02991	0.396
LIG_LIR_Nem_3	187	191	PF02991	0.225
LIG_LIR_Nem_3	214	220	PF02991	0.301
LIG_LIR_Nem_3	359	363	PF02991	0.343
LIG_LIR_Nem_3	394	398	PF02991	0.398
LIG_LIR_Nem_3	56	62	PF02991	0.365
LIG_LIR_Nem_3	98	104	PF02991	0.485
LIG_MLH1_MIPbox_1	180	184	PF16413	0.341
LIG_NRBOX	352	358	PF00104	0.405
LIG_NRBOX	480	486	PF00104	0.610
LIG_Pex14_1	120	124	PF04695	0.577
LIG_Pex14_1	166	170	PF04695	0.450
LIG_Pex14_1	217	221	PF04695	0.314
LIG_Pex14_1	60	64	PF04695	0.317
LIG_Pex14_2	184	188	PF04695	0.426
LIG_Pex14_2	392	396	PF04695	0.290
LIG_Pex14_2	408	412	PF04695	0.416
LIG_Pex14_2	41	45	PF04695	0.418
LIG_Pex14_2	9	13	PF04695	0.611
LIG_REV1ctd_RIR_1	6	15	PF16727	0.608
LIG_SH2_CRK	101	105	PF00017	0.573
LIG_SH2_CRK	400	404	PF00017	0.246
LIG_SH2_GRB2like	417	420	PF00017	0.480
LIG_SH2_SRC	238	241	PF00017	0.523
LIG_SH2_SRC	450	453	PF00017	0.434
LIG_SH2_STAP1	276	280	PF00017	0.558
LIG_SH2_STAT5	179	182	PF00017	0.521
LIG_SH2_STAT5	221	224	PF00017	0.359
LIG_SH2_STAT5	238	241	PF00017	0.492
LIG_SH2_STAT5	276	279	PF00017	0.565
LIG_SH2_STAT5	417	420	PF00017	0.516
LIG_SH3_3	113	119	PF00018	0.543
LIG_SH3_3	251	257	PF00018	0.660
LIG_SH3_3	317	323	PF00018	0.730
LIG_SH3_3	59	65	PF00018	0.405
LIG_SUMO_SIM_anti_2	437	443	PF11976	0.341
LIG_SUMO_SIM_par_1	50	56	PF11976	0.203
LIG_TYR_ITIM	398	403	PF00017	0.228
LIG_UBA3_1	169	176	PF00899	0.588
LIG_WRC_WIRS_1	185	190	PF05994	0.338
LIG_WRC_WIRS_1	357	362	PF05994	0.399
LIG_WRC_WIRS_1	5	10	PF05994	0.563
MOD_CDK_SPxK_1	262	268	PF00069	0.646
MOD_CK1_1	129	135	PF00069	0.399
MOD_CK1_1	198	204	PF00069	0.459
MOD_CK1_1	262	268	PF00069	0.719
MOD_GlcNHglycan	128	131	PF01048	0.357
MOD_GlcNHglycan	161	164	PF01048	0.463
MOD_GlcNHglycan	200	203	PF01048	0.602
MOD_GlcNHglycan	323	326	PF01048	0.507
MOD_GlcNHglycan	375	378	PF01048	0.485
MOD_GlcNHglycan	500	503	PF01048	0.472
MOD_GSK3_1	129	136	PF00069	0.386
MOD_N-GLC_1	71	76	PF02516	0.577
MOD_NEK2_1	126	131	PF00069	0.374
MOD_NEK2_1	184	189	PF00069	0.353
MOD_NEK2_1	196	201	PF00069	0.384
MOD_NEK2_1	222	227	PF00069	0.368
MOD_NEK2_1	259	264	PF00069	0.760
MOD_NEK2_1	280	285	PF00069	0.687
MOD_NEK2_1	356	361	PF00069	0.393
MOD_NEK2_1	402	407	PF00069	0.342
MOD_NEK2_1	408	413	PF00069	0.320
MOD_NEK2_1	53	58	PF00069	0.273
MOD_NEK2_1	88	93	PF00069	0.343
MOD_NEK2_2	4	9	PF00069	0.607
MOD_PIKK_1	27	33	PF00454	0.453
MOD_PIKK_1	292	298	PF00454	0.705
MOD_PIKK_1	332	338	PF00454	0.658
MOD_PIKK_1	71	77	PF00454	0.351
MOD_PKA_2	259	265	PF00069	0.756
MOD_PKA_2	27	33	PF00069	0.636
MOD_PKA_2	384	390	PF00069	0.383
MOD_Plk_1	451	457	PF00069	0.414
MOD_Plk_1	71	77	PF00069	0.351
MOD_Plk_2-3	274	280	PF00069	0.711
MOD_Plk_4	134	140	PF00069	0.379
MOD_Plk_4	178	184	PF00069	0.475
MOD_Plk_4	222	228	PF00069	0.372
MOD_Plk_4	356	362	PF00069	0.409
MOD_Plk_4	391	397	PF00069	0.319
MOD_Plk_4	4	10	PF00069	0.643
MOD_Plk_4	408	414	PF00069	0.326
MOD_Plk_4	424	430	PF00069	0.447
MOD_Plk_4	437	443	PF00069	0.328
MOD_Plk_4	79	85	PF00069	0.376
MOD_ProDKin_1	144	150	PF00069	0.325
MOD_ProDKin_1	262	268	PF00069	0.784
MOD_ProDKin_1	282	288	PF00069	0.698
MOD_ProDKin_1	319	325	PF00069	0.701
MOD_ProDKin_1	419	425	PF00069	0.510
MOD_SUMO_for_1	16	19	PF00179	0.430
MOD_SUMO_for_1	486	489	PF00179	0.644
TRG_ENDOCYTIC_2	101	104	PF00928	0.558
TRG_ENDOCYTIC_2	121	124	PF00928	0.375
TRG_ENDOCYTIC_2	179	182	PF00928	0.506
TRG_ENDOCYTIC_2	400	403	PF00928	0.237
TRG_ER_diArg_1	113	116	PF00400	0.608
TRG_ER_diArg_1	9	11	PF00400	0.666
TRG_NES_CRM1_1	355	366	PF08389	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J6C9	Bodo saltans	24%	100%
A0A0S4J9G3	Bodo saltans	25%	100%
A0A0S4JFU7	Bodo saltans	25%	100%
A0A1X0NW47	Trypanosomatidae	48%	100%
A0A1X0P8U7	Trypanosomatidae	25%	100%
A0A3R7KUT2	Trypanosoma rangeli	48%	100%
A0A3S5H7D1	Leishmania donovani	89%	100%
A0A422NMM7	Trypanosoma rangeli	29%	99%
A4H3M6	Leishmania braziliensis	26%	100%
A4HDG5	Leishmania braziliensis	75%	100%
A4I0U6	Leishmania infantum	90%	100%
D0A268	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	98%
D0A775	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
Q4QAM4	Leishmania major	88%	98%
V5BAL2	Trypanosoma cruzi	53%	100%
V5C284	Trypanosoma cruzi	28%	100%