Putative DNAJ domain protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNAJ domain protein, putative

Species:

Leishmania mexicana

UniProt:

E9AWU9_LEIMU

TriTrypDb:

LmxM.24.1080

Length:

433

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9AWU9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWU9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	81	85	PF00656	0.579
CLV_NRD_NRD_1	137	139	PF00675	0.381
CLV_NRD_NRD_1	293	295	PF00675	0.341
CLV_NRD_NRD_1	305	307	PF00675	0.381
CLV_NRD_NRD_1	343	345	PF00675	0.501
CLV_NRD_NRD_1	37	39	PF00675	0.411
CLV_NRD_NRD_1	394	396	PF00675	0.241
CLV_NRD_NRD_1	426	428	PF00675	0.286
CLV_PCSK_FUR_1	298	302	PF00082	0.429
CLV_PCSK_FUR_1	303	307	PF00082	0.449
CLV_PCSK_KEX2_1	293	295	PF00082	0.333
CLV_PCSK_KEX2_1	300	302	PF00082	0.357
CLV_PCSK_KEX2_1	305	307	PF00082	0.375
CLV_PCSK_KEX2_1	343	345	PF00082	0.517
CLV_PCSK_KEX2_1	37	39	PF00082	0.411
CLV_PCSK_KEX2_1	394	396	PF00082	0.296
CLV_PCSK_KEX2_1	425	427	PF00082	0.271
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.422
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.312
CLV_PCSK_PC7_1	301	307	PF00082	0.452
CLV_PCSK_PC7_1	390	396	PF00082	0.333
CLV_PCSK_PC7_1	422	428	PF00082	0.268
CLV_PCSK_SKI1_1	195	199	PF00082	0.357
CLV_PCSK_SKI1_1	395	399	PF00082	0.259
CLV_PCSK_SKI1_1	54	58	PF00082	0.314
DEG_Nend_Nbox_1	1	3	PF02207	0.622
DEG_SCF_FBW7_2	49	55	PF00400	0.484
DEG_SPOP_SBC_1	354	358	PF00917	0.776
DEG_SPOP_SBC_1	78	82	PF00917	0.549
DOC_AGCK_PIF_1	194	199	PF00069	0.573
DOC_CKS1_1	12	17	PF01111	0.509
DOC_CKS1_1	49	54	PF01111	0.489
DOC_CYCLIN_RxL_1	373	384	PF00134	0.455
DOC_MAPK_gen_1	303	311	PF00069	0.632
DOC_PP1_RVXF_1	14	21	PF00149	0.535
DOC_PP2B_LxvP_1	259	262	PF13499	0.392
DOC_USP7_MATH_1	101	105	PF00917	0.456
DOC_USP7_MATH_1	354	358	PF00917	0.754
DOC_WW_Pin1_4	11	16	PF00397	0.547
DOC_WW_Pin1_4	202	207	PF00397	0.515
DOC_WW_Pin1_4	48	53	PF00397	0.607
LIG_14-3-3_CanoR_1	222	226	PF00244	0.578
LIG_14-3-3_CanoR_1	247	254	PF00244	0.292
LIG_14-3-3_CanoR_1	317	325	PF00244	0.636
LIG_14-3-3_CanoR_1	330	335	PF00244	0.555
LIG_14-3-3_CanoR_1	343	351	PF00244	0.696
LIG_14-3-3_CanoR_1	4	9	PF00244	0.634
LIG_14-3-3_CanoR_1	65	71	PF00244	0.515
LIG_14-3-3_CanoR_1	89	95	PF00244	0.615
LIG_BRCT_BRCA1_1	359	363	PF00533	0.586
LIG_BRCT_BRCA1_1	52	56	PF00533	0.513
LIG_FHA_1	144	150	PF00498	0.555
LIG_FHA_1	196	202	PF00498	0.486
LIG_FHA_1	222	228	PF00498	0.508
LIG_FHA_1	246	252	PF00498	0.328
LIG_FHA_1	3	9	PF00498	0.693
LIG_FHA_1	90	96	PF00498	0.626
LIG_FHA_2	331	337	PF00498	0.705
LIG_FHA_2	79	85	PF00498	0.679
LIG_Integrin_RGD_1	129	131	PF01839	0.298
LIG_LIR_Gen_1	278	286	PF02991	0.424
LIG_LIR_Gen_1	45	52	PF02991	0.531
LIG_LIR_Nem_3	111	117	PF02991	0.464
LIG_LIR_Nem_3	191	197	PF02991	0.488
LIG_LIR_Nem_3	221	226	PF02991	0.510
LIG_LIR_Nem_3	278	283	PF02991	0.424
LIG_LIR_Nem_3	391	396	PF02991	0.480
LIG_LIR_Nem_3	416	421	PF02991	0.487
LIG_LIR_Nem_3	45	49	PF02991	0.518
LIG_LIR_Nem_3	53	59	PF02991	0.460
LIG_LYPXL_yS_3	289	292	PF13949	0.584
LIG_Pex14_2	208	212	PF04695	0.523
LIG_Pex14_2	284	288	PF04695	0.349
LIG_PTB_Apo_2	238	245	PF02174	0.496
LIG_PTB_Apo_2	70	77	PF02174	0.480
LIG_PTB_Phospho_1	238	244	PF10480	0.512
LIG_PTB_Phospho_1	70	76	PF10480	0.473
LIG_REV1ctd_RIR_1	281	289	PF16727	0.276
LIG_SH2_CRK	375	379	PF00017	0.437
LIG_SH2_CRK	393	397	PF00017	0.468
LIG_SH2_CRK	418	422	PF00017	0.466
LIG_SH2_STAP1	223	227	PF00017	0.476
LIG_SH2_STAP1	280	284	PF00017	0.307
LIG_SH2_STAT5	10	13	PF00017	0.599
LIG_SH2_STAT5	223	226	PF00017	0.464
LIG_SH2_STAT5	238	241	PF00017	0.474
LIG_SH2_STAT5	244	247	PF00017	0.296
LIG_SH2_STAT5	46	49	PF00017	0.530
LIG_SH2_STAT5	60	63	PF00017	0.435
LIG_SH2_STAT5	94	97	PF00017	0.556
LIG_SH3_3	231	237	PF00018	0.483
LIG_SH3_3	365	371	PF00018	0.612
LIG_SH3_3	9	15	PF00018	0.559
LIG_TYR_ITIM	44	49	PF00017	0.610
LIG_WRC_WIRS_1	180	185	PF05994	0.574
MOD_CDK_SPK_2	11	16	PF00069	0.547
MOD_CDK_SPxK_1	48	54	PF00069	0.492
MOD_CK1_1	156	162	PF00069	0.521
MOD_CK1_1	186	192	PF00069	0.524
MOD_CK1_1	353	359	PF00069	0.750
MOD_CK1_1	361	367	PF00069	0.750
MOD_CK1_1	77	83	PF00069	0.599
MOD_CK1_1	87	93	PF00069	0.530
MOD_CK2_1	101	107	PF00069	0.567
MOD_CK2_1	213	219	PF00069	0.387
MOD_CK2_1	382	388	PF00069	0.436
MOD_Cter_Amidation	35	38	PF01082	0.416
MOD_GlcNHglycan	185	188	PF01048	0.352
MOD_GlcNHglycan	21	25	PF01048	0.421
MOD_GlcNHglycan	227	230	PF01048	0.299
MOD_GlcNHglycan	352	355	PF01048	0.561
MOD_GlcNHglycan	363	366	PF01048	0.533
MOD_GlcNHglycan	390	393	PF01048	0.269
MOD_GlcNHglycan	62	65	PF01048	0.317
MOD_GlcNHglycan	81	84	PF01048	0.414
MOD_GSK3_1	175	182	PF00069	0.560
MOD_GSK3_1	221	228	PF00069	0.500
MOD_GSK3_1	246	253	PF00069	0.361
MOD_GSK3_1	330	337	PF00069	0.599
MOD_GSK3_1	350	357	PF00069	0.773
MOD_GSK3_1	4	11	PF00069	0.551
MOD_GSK3_1	74	81	PF00069	0.547
MOD_GSK3_1	84	91	PF00069	0.591
MOD_N-GLC_1	108	113	PF02516	0.287
MOD_N-GLC_1	318	323	PF02516	0.531
MOD_N-GLC_1	72	77	PF02516	0.412
MOD_N-GLC_1	78	83	PF02516	0.483
MOD_NEK2_1	133	138	PF00069	0.570
MOD_NEK2_1	153	158	PF00069	0.524
MOD_NEK2_1	179	184	PF00069	0.556
MOD_NEK2_1	2	7	PF00069	0.613
MOD_NEK2_1	225	230	PF00069	0.477
MOD_NEK2_1	239	244	PF00069	0.451
MOD_NEK2_1	269	274	PF00069	0.429
MOD_NEK2_1	8	13	PF00069	0.543
MOD_NEK2_2	101	106	PF00069	0.442
MOD_PIKK_1	108	114	PF00454	0.491
MOD_PIKK_1	319	325	PF00454	0.651
MOD_PKA_1	343	349	PF00069	0.719
MOD_PKA_2	221	227	PF00069	0.563
MOD_PKA_2	246	252	PF00069	0.341
MOD_PKA_2	329	335	PF00069	0.574
MOD_PKA_2	343	349	PF00069	0.650
MOD_PKA_2	88	94	PF00069	0.655
MOD_Plk_1	108	114	PF00069	0.495
MOD_Plk_1	195	201	PF00069	0.567
MOD_Plk_1	382	388	PF00069	0.510
MOD_Plk_1	72	78	PF00069	0.607
MOD_Plk_2-3	188	194	PF00069	0.607
MOD_Plk_4	101	107	PF00069	0.546
MOD_Plk_4	156	162	PF00069	0.572
MOD_Plk_4	204	210	PF00069	0.568
MOD_Plk_4	221	227	PF00069	0.391
MOD_Plk_4	239	245	PF00069	0.514
MOD_Plk_4	275	281	PF00069	0.269
MOD_Plk_4	330	336	PF00069	0.595
MOD_Plk_4	66	72	PF00069	0.537
MOD_ProDKin_1	11	17	PF00069	0.539
MOD_ProDKin_1	202	208	PF00069	0.515
MOD_ProDKin_1	48	54	PF00069	0.606
MOD_SUMO_for_1	214	217	PF00179	0.574
MOD_SUMO_rev_2	103	111	PF00179	0.602
MOD_SUMO_rev_2	188	197	PF00179	0.594
MOD_SUMO_rev_2	82	88	PF00179	0.681
TRG_ENDOCYTIC_2	280	283	PF00928	0.283
TRG_ENDOCYTIC_2	289	292	PF00928	0.528
TRG_ENDOCYTIC_2	375	378	PF00928	0.458
TRG_ENDOCYTIC_2	393	396	PF00928	0.468
TRG_ENDOCYTIC_2	418	421	PF00928	0.466
TRG_ENDOCYTIC_2	46	49	PF00928	0.567
TRG_ER_diArg_1	292	294	PF00400	0.550
TRG_ER_diArg_1	3	6	PF00400	0.703
TRG_ER_diArg_1	303	306	PF00400	0.566
TRG_ER_diArg_1	37	39	PF00400	0.613
TRG_ER_diArg_1	393	395	PF00400	0.495
TRG_NLS_MonoExtN_4	422	429	PF00514	0.550
TRG_Pf-PMV_PEXEL_1	419	423	PF00026	0.235

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6B2	Leptomonas seymouri	73%	100%
A0A0N1IK13	Leptomonas seymouri	23%	82%
A0A0S4IP86	Bodo saltans	45%	99%
A0A0S4ITI3	Bodo saltans	25%	85%
A0A1X0NQB1	Trypanosomatidae	25%	85%
A0A1X0NVK2	Trypanosomatidae	53%	100%
A0A3S7WSV3	Leishmania donovani	24%	83%
A0A3S7WYG6	Leishmania donovani	94%	100%
A0A422N8L2	Trypanosoma rangeli	54%	100%
A4H7H2	Leishmania braziliensis	23%	82%
A4HDG4	Leishmania braziliensis	90%	99%
A4HVV3	Leishmania infantum	26%	100%
A4I0U5	Leishmania infantum	94%	100%
D0A774	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9APK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q4QAM5	Leishmania major	95%	100%
Q4QFX4	Leishmania major	23%	83%
V5BD52	Trypanosoma cruzi	26%	85%
V5DSF1	Trypanosoma cruzi	54%	100%