AKAP7_NLS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AKAP7 2'5' RNA ligase-like domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AWU7_LEIMU

TriTrypDb:

LmxM.24.1060

Length:

508

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AWU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWU7

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016874	ligase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.543
CLV_NRD_NRD_1	221	223	PF00675	0.657
CLV_NRD_NRD_1	319	321	PF00675	0.312
CLV_NRD_NRD_1	434	436	PF00675	0.350
CLV_NRD_NRD_1	446	448	PF00675	0.315
CLV_NRD_NRD_1	49	51	PF00675	0.671
CLV_NRD_NRD_1	491	493	PF00675	0.267
CLV_NRD_NRD_1	58	60	PF00675	0.496
CLV_PCSK_KEX2_1	221	223	PF00082	0.657
CLV_PCSK_KEX2_1	26	28	PF00082	0.597
CLV_PCSK_KEX2_1	319	321	PF00082	0.312
CLV_PCSK_KEX2_1	434	436	PF00082	0.351
CLV_PCSK_KEX2_1	49	51	PF00082	0.638
CLV_PCSK_KEX2_1	491	493	PF00082	0.267
CLV_PCSK_KEX2_1	58	60	PF00082	0.457
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.597
CLV_PCSK_SKI1_1	139	143	PF00082	0.596
CLV_PCSK_SKI1_1	327	331	PF00082	0.330
CLV_PCSK_SKI1_1	434	438	PF00082	0.330
CLV_PCSK_SKI1_1	459	463	PF00082	0.257
CLV_PCSK_SKI1_1	477	481	PF00082	0.399
CLV_PCSK_SKI1_1	50	54	PF00082	0.680
DEG_APCC_DBOX_1	32	40	PF00400	0.603
DEG_APCC_DBOX_1	365	373	PF00400	0.530
DEG_COP1_1	205	215	PF00400	0.649
DEG_SCF_FBW7_1	4	10	PF00400	0.453
DOC_CDC14_PxL_1	479	487	PF14671	0.550
DOC_CKS1_1	144	149	PF01111	0.541
DOC_CKS1_1	4	9	PF01111	0.456
DOC_MAPK_DCC_7	477	487	PF00069	0.530
DOC_MAPK_gen_1	319	325	PF00069	0.476
DOC_MAPK_gen_1	432	441	PF00069	0.502
DOC_MAPK_MEF2A_6	307	314	PF00069	0.473
DOC_MAPK_MEF2A_6	432	441	PF00069	0.502
DOC_MAPK_NFAT4_5	307	315	PF00069	0.447
DOC_PP2B_LxvP_1	315	318	PF13499	0.466
DOC_PP4_FxxP_1	141	144	PF00568	0.643
DOC_PP4_FxxP_1	387	390	PF00568	0.467
DOC_PP4_FxxP_1	480	483	PF00568	0.530
DOC_USP7_MATH_1	288	292	PF00917	0.532
DOC_USP7_MATH_1	296	300	PF00917	0.486
DOC_USP7_MATH_1	333	337	PF00917	0.502
DOC_USP7_MATH_1	430	434	PF00917	0.493
DOC_USP7_MATH_1	7	11	PF00917	0.675
DOC_USP7_UBL2_3	444	448	PF12436	0.530
DOC_WW_Pin1_4	143	148	PF00397	0.720
DOC_WW_Pin1_4	194	199	PF00397	0.638
DOC_WW_Pin1_4	211	216	PF00397	0.591
DOC_WW_Pin1_4	3	8	PF00397	0.552
DOC_WW_Pin1_4	79	84	PF00397	0.537
LIG_14-3-3_CanoR_1	139	144	PF00244	0.575
LIG_Actin_WH2_2	357	373	PF00022	0.372
LIG_APCC_ABBA_1	37	42	PF00400	0.607
LIG_BIR_II_1	1	5	PF00653	0.581
LIG_BIR_III_2	457	461	PF00653	0.515
LIG_BRCT_BRCA1_1	229	233	PF00533	0.480
LIG_BRCT_BRCA1_1	452	456	PF00533	0.467
LIG_FHA_1	135	141	PF00498	0.579
LIG_FHA_1	232	238	PF00498	0.284
LIG_FHA_1	250	256	PF00498	0.466
LIG_FHA_1	296	302	PF00498	0.453
LIG_FHA_1	303	309	PF00498	0.501
LIG_FHA_2	118	124	PF00498	0.703
LIG_FHA_2	13	19	PF00498	0.597
LIG_FHA_2	379	385	PF00498	0.372
LIG_FHA_2	438	444	PF00498	0.574
LIG_LIR_Apic_2	384	390	PF02991	0.458
LIG_LIR_Gen_1	17	24	PF02991	0.459
LIG_LIR_Gen_1	178	185	PF02991	0.480
LIG_LIR_Gen_1	230	241	PF02991	0.277
LIG_LIR_Nem_3	137	141	PF02991	0.631
LIG_LIR_Nem_3	17	22	PF02991	0.669
LIG_LIR_Nem_3	178	184	PF02991	0.577
LIG_LIR_Nem_3	230	236	PF02991	0.277
LIG_LIR_Nem_3	394	400	PF02991	0.465
LIG_PDZ_Class_2	503	508	PF00595	0.465
LIG_Pex14_2	334	338	PF04695	0.530
LIG_PTB_Apo_2	132	139	PF02174	0.503
LIG_PTB_Phospho_1	132	138	PF10480	0.499
LIG_SH2_STAP1	87	91	PF00017	0.688
LIG_SH2_STAT5	500	503	PF00017	0.523
LIG_SH3_3	105	111	PF00018	0.632
LIG_SH3_3	112	118	PF00018	0.530
LIG_SH3_3	141	147	PF00018	0.585
LIG_SH3_3	209	215	PF00018	0.665
LIG_SH3_3	234	240	PF00018	0.465
LIG_SH3_CIN85_PxpxPR_1	147	152	PF14604	0.599
LIG_SUMO_SIM_anti_2	311	316	PF11976	0.550
LIG_SUMO_SIM_anti_2	360	365	PF11976	0.372
LIG_SUMO_SIM_par_1	310	316	PF11976	0.435
LIG_TRAF2_1	171	174	PF00917	0.566
LIG_TRAF2_1	464	467	PF00917	0.467
LIG_TRFH_1	79	83	PF08558	0.535
LIG_TYR_ITIM	395	400	PF00017	0.447
LIG_WRC_WIRS_1	258	263	PF05994	0.530
LIG_WW_3	55	59	PF00397	0.437
MOD_CDK_SPxxK_3	143	150	PF00069	0.541
MOD_CK1_1	214	220	PF00069	0.553
MOD_CK1_1	290	296	PF00069	0.561
MOD_CK1_1	348	354	PF00069	0.588
MOD_CK2_1	378	384	PF00069	0.372
MOD_CK2_1	416	422	PF00069	0.498
MOD_Cter_Amidation	47	50	PF01082	0.696
MOD_GlcNHglycan	158	161	PF01048	0.772
MOD_GlcNHglycan	229	232	PF01048	0.679
MOD_GlcNHglycan	294	297	PF01048	0.321
MOD_GlcNHglycan	335	338	PF01048	0.302
MOD_GlcNHglycan	355	358	PF01048	0.315
MOD_GlcNHglycan	496	499	PF01048	0.278
MOD_GSK3_1	139	146	PF00069	0.604
MOD_GSK3_1	227	234	PF00069	0.525
MOD_GSK3_1	284	291	PF00069	0.532
MOD_GSK3_1	292	299	PF00069	0.533
MOD_GSK3_1	3	10	PF00069	0.611
MOD_GSK3_1	353	360	PF00069	0.517
MOD_GSK3_1	401	408	PF00069	0.433
MOD_N-GLC_1	134	139	PF02516	0.655
MOD_N-GLC_1	249	254	PF02516	0.265
MOD_N-GLC_1	401	406	PF02516	0.172
MOD_NEK2_1	129	134	PF00069	0.492
MOD_NEK2_1	156	161	PF00069	0.582
MOD_NEK2_1	292	297	PF00069	0.536
MOD_NEK2_1	308	313	PF00069	0.389
MOD_NEK2_1	416	421	PF00069	0.504
MOD_NEK2_1	437	442	PF00069	0.447
MOD_NEK2_1	501	506	PF00069	0.502
MOD_NEK2_2	502	507	PF00069	0.467
MOD_OFUCOSY	114	121	PF10250	0.483
MOD_PIKK_1	216	222	PF00454	0.620
MOD_PIKK_1	267	273	PF00454	0.418
MOD_PKA_2	189	195	PF00069	0.627
MOD_Plk_1	134	140	PF00069	0.573
MOD_Plk_1	249	255	PF00069	0.465
MOD_Plk_1	357	363	PF00069	0.457
MOD_Plk_1	502	508	PF00069	0.520
MOD_Plk_4	250	256	PF00069	0.553
MOD_Plk_4	308	314	PF00069	0.504
MOD_Plk_4	391	397	PF00069	0.530
MOD_Plk_4	437	443	PF00069	0.447
MOD_Plk_4	496	502	PF00069	0.502
MOD_ProDKin_1	143	149	PF00069	0.721
MOD_ProDKin_1	194	200	PF00069	0.638
MOD_ProDKin_1	211	217	PF00069	0.591
MOD_ProDKin_1	3	9	PF00069	0.547
MOD_ProDKin_1	79	85	PF00069	0.541
MOD_SUMO_rev_2	474	479	PF00179	0.372
TRG_DiLeu_BaLyEn_6	124	129	PF01217	0.575
TRG_DiLeu_BaLyEn_6	365	370	PF01217	0.409
TRG_ENDOCYTIC_2	138	141	PF00928	0.565
TRG_ENDOCYTIC_2	266	269	PF00928	0.415
TRG_ENDOCYTIC_2	397	400	PF00928	0.447
TRG_ER_diArg_1	318	320	PF00400	0.502
TRG_ER_diArg_1	434	436	PF00400	0.555
TRG_ER_diArg_1	49	51	PF00400	0.674
TRG_ER_diArg_1	490	492	PF00400	0.515
TRG_ER_diArg_1	57	59	PF00400	0.508
TRG_NES_CRM1_1	72	84	PF08389	0.433
TRG_NLS_Bipartite_1	434	451	PF00514	0.515
TRG_NLS_MonoExtN_4	444	451	PF00514	0.467
TRG_Pf-PMV_PEXEL_1	414	418	PF00026	0.296
TRG_Pf-PMV_PEXEL_1	459	463	PF00026	0.316
TRG_Pf-PMV_PEXEL_1	477	481	PF00026	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5X3	Leptomonas seymouri	58%	100%
A0A3S7WYE0	Leishmania donovani	90%	86%
A0A422MP50	Trypanosoma rangeli	26%	100%
A4HDG2	Leishmania braziliensis	76%	100%
A4I0U3	Leishmania infantum	90%	86%
C9ZVE7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
Q4QAM7	Leishmania major	88%	100%
V5B5P9	Trypanosoma cruzi	25%	100%