Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AWU5_LEIMU

TriTrypDb:

LmxM.24.1040

Length:

1013

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWU5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWU5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	4
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.746
CLV_NRD_NRD_1	209	211	PF00675	0.789
CLV_NRD_NRD_1	255	257	PF00675	0.625
CLV_NRD_NRD_1	258	260	PF00675	0.621
CLV_NRD_NRD_1	378	380	PF00675	0.710
CLV_NRD_NRD_1	600	602	PF00675	0.690
CLV_NRD_NRD_1	649	651	PF00675	0.787
CLV_NRD_NRD_1	667	669	PF00675	0.563
CLV_NRD_NRD_1	714	716	PF00675	0.793
CLV_NRD_NRD_1	717	719	PF00675	0.739
CLV_PCSK_FUR_1	253	257	PF00082	0.706
CLV_PCSK_FUR_1	376	380	PF00082	0.707
CLV_PCSK_FUR_1	715	719	PF00082	0.779
CLV_PCSK_KEX2_1	209	211	PF00082	0.789
CLV_PCSK_KEX2_1	255	257	PF00082	0.619
CLV_PCSK_KEX2_1	258	260	PF00082	0.625
CLV_PCSK_KEX2_1	378	380	PF00082	0.710
CLV_PCSK_KEX2_1	716	718	PF00082	0.785
CLV_PCSK_PC1ET2_1	716	718	PF00082	0.785
CLV_PCSK_PC7_1	251	257	PF00082	0.772
CLV_PCSK_PC7_1	712	718	PF00082	0.719
CLV_PCSK_SKI1_1	229	233	PF00082	0.762
CLV_PCSK_SKI1_1	460	464	PF00082	0.586
CLV_PCSK_SKI1_1	651	655	PF00082	0.757
CLV_PCSK_SKI1_1	681	685	PF00082	0.786
CLV_PCSK_SKI1_1	687	691	PF00082	0.675
CLV_Separin_Metazoa	849	853	PF03568	0.625
DEG_APCC_DBOX_1	389	397	PF00400	0.770
DEG_APCC_DBOX_1	972	980	PF00400	0.658
DEG_Nend_Nbox_1	1	3	PF02207	0.494
DEG_SCF_FBW7_1	896	903	PF00400	0.569
DEG_SPOP_SBC_1	131	135	PF00917	0.808
DEG_SPOP_SBC_1	306	310	PF00917	0.675
DEG_SPOP_SBC_1	611	615	PF00917	0.742
DEG_SPOP_SBC_1	727	731	PF00917	0.634
DOC_CDC14_PxL_1	397	405	PF14671	0.634
DOC_CDC14_PxL_1	808	816	PF14671	0.639
DOC_CKS1_1	619	624	PF01111	0.799
DOC_CKS1_1	897	902	PF01111	0.580
DOC_CKS1_1	942	947	PF01111	0.686
DOC_CKS1_1	972	977	PF01111	0.679
DOC_CYCLIN_RxL_1	648	655	PF00134	0.729
DOC_CYCLIN_RxL_1	973	984	PF00134	0.416
DOC_CYCLIN_yCln2_LP_2	151	157	PF00134	0.789
DOC_CYCLIN_yCln2_LP_2	570	576	PF00134	0.707
DOC_CYCLIN_yCln2_LP_2	639	645	PF00134	0.770
DOC_CYCLIN_yCln2_LP_2	794	800	PF00134	0.796
DOC_MAPK_gen_1	460	469	PF00069	0.500
DOC_MAPK_gen_1	948	956	PF00069	0.406
DOC_MAPK_MEF2A_6	1003	1010	PF00069	0.696
DOC_MAPK_MEF2A_6	105	113	PF00069	0.568
DOC_MAPK_MEF2A_6	793	800	PF00069	0.784
DOC_MAPK_MEF2A_6	948	956	PF00069	0.698
DOC_MAPK_MEF2A_6	977	985	PF00069	0.599
DOC_PP1_RVXF_1	505	512	PF00149	0.492
DOC_PP2B_LxvP_1	570	573	PF13499	0.783
DOC_PP2B_LxvP_1	639	642	PF13499	0.772
DOC_PP2B_LxvP_1	794	797	PF13499	0.808
DOC_PP2B_LxvP_1	932	935	PF13499	0.729
DOC_PP4_FxxP_1	277	280	PF00568	0.709
DOC_SPAK_OSR1_1	847	851	PF12202	0.404
DOC_USP7_MATH_1	131	135	PF00917	0.753
DOC_USP7_MATH_1	137	141	PF00917	0.665
DOC_USP7_MATH_1	165	169	PF00917	0.795
DOC_USP7_MATH_1	211	215	PF00917	0.813
DOC_USP7_MATH_1	306	310	PF00917	0.786
DOC_USP7_MATH_1	381	385	PF00917	0.673
DOC_USP7_MATH_1	41	45	PF00917	0.532
DOC_USP7_MATH_1	417	421	PF00917	0.614
DOC_USP7_MATH_1	443	447	PF00917	0.776
DOC_USP7_MATH_1	539	543	PF00917	0.780
DOC_USP7_MATH_1	544	548	PF00917	0.709
DOC_USP7_MATH_1	611	615	PF00917	0.825
DOC_USP7_MATH_1	782	786	PF00917	0.616
DOC_USP7_MATH_1	98	102	PF00917	0.555
DOC_WW_Pin1_4	150	155	PF00397	0.752
DOC_WW_Pin1_4	156	161	PF00397	0.666
DOC_WW_Pin1_4	180	185	PF00397	0.640
DOC_WW_Pin1_4	239	244	PF00397	0.757
DOC_WW_Pin1_4	309	314	PF00397	0.698
DOC_WW_Pin1_4	44	49	PF00397	0.526
DOC_WW_Pin1_4	445	450	PF00397	0.627
DOC_WW_Pin1_4	533	538	PF00397	0.785
DOC_WW_Pin1_4	618	623	PF00397	0.805
DOC_WW_Pin1_4	673	678	PF00397	0.552
DOC_WW_Pin1_4	76	81	PF00397	0.534
DOC_WW_Pin1_4	866	871	PF00397	0.777
DOC_WW_Pin1_4	883	888	PF00397	0.417
DOC_WW_Pin1_4	896	901	PF00397	0.652
DOC_WW_Pin1_4	926	931	PF00397	0.819
DOC_WW_Pin1_4	941	946	PF00397	0.512
DOC_WW_Pin1_4	966	971	PF00397	0.808
LIG_14-3-3_CanoR_1	148	152	PF00244	0.499
LIG_14-3-3_CanoR_1	320	326	PF00244	0.621
LIG_14-3-3_CanoR_1	331	339	PF00244	0.602
LIG_14-3-3_CanoR_1	38	48	PF00244	0.531
LIG_14-3-3_CanoR_1	383	393	PF00244	0.775
LIG_14-3-3_CanoR_1	428	436	PF00244	0.689
LIG_14-3-3_CanoR_1	530	538	PF00244	0.777
LIG_14-3-3_CanoR_1	687	695	PF00244	0.690
LIG_14-3-3_CanoR_1	84	88	PF00244	0.557
LIG_Actin_WH2_2	836	854	PF00022	0.405
LIG_APCC_ABBA_1	796	801	PF00400	0.785
LIG_BIR_III_2	164	168	PF00653	0.720
LIG_BIR_III_2	925	929	PF00653	0.756
LIG_BRCT_BRCA1_1	286	290	PF00533	0.703
LIG_Clathr_ClatBox_1	682	686	PF01394	0.686
LIG_deltaCOP1_diTrp_1	829	832	PF00928	0.522
LIG_eIF4E_1	626	632	PF01652	0.776
LIG_FHA_1	117	123	PF00498	0.794
LIG_FHA_1	198	204	PF00498	0.549
LIG_FHA_1	320	326	PF00498	0.658
LIG_FHA_1	503	509	PF00498	0.586
LIG_FHA_1	653	659	PF00498	0.748
LIG_FHA_1	678	684	PF00498	0.779
LIG_FHA_1	705	711	PF00498	0.662
LIG_FHA_1	879	885	PF00498	0.654
LIG_FHA_1	937	943	PF00498	0.736
LIG_FHA_2	372	378	PF00498	0.736
LIG_FHA_2	844	850	PF00498	0.567
LIG_FHA_2	953	959	PF00498	0.696
LIG_LIR_Apic_2	126	131	PF02991	0.800
LIG_LIR_Apic_2	275	280	PF02991	0.631
LIG_LIR_Gen_1	153	162	PF02991	0.797
LIG_LIR_Gen_1	803	813	PF02991	0.719
LIG_LIR_Gen_1	846	856	PF02991	0.410
LIG_LIR_Nem_3	153	158	PF02991	0.792
LIG_LIR_Nem_3	261	267	PF02991	0.765
LIG_LIR_Nem_3	349	353	PF02991	0.541
LIG_LIR_Nem_3	425	430	PF02991	0.616
LIG_LIR_Nem_3	803	808	PF02991	0.729
LIG_LIR_Nem_3	846	851	PF02991	0.402
LIG_LYPXL_yS_3	400	403	PF13949	0.638
LIG_MYND_3	811	815	PF01753	0.705
LIG_PCNA_PIPBox_1	356	365	PF02747	0.737
LIG_PCNA_yPIPBox_3	580	588	PF02747	0.597
LIG_PDZ_Class_1	1008	1013	PF00595	0.399
LIG_Pex14_1	587	591	PF04695	0.781
LIG_RPA_C_Fungi	508	520	PF08784	0.677
LIG_SH2_CRK	999	1003	PF00017	0.734
LIG_SH2_NCK_1	124	128	PF00017	0.746
LIG_SH2_PTP2	128	131	PF00017	0.807
LIG_SH2_SRC	124	127	PF00017	0.667
LIG_SH2_SRC	362	365	PF00017	0.741
LIG_SH2_SRC	591	594	PF00017	0.784
LIG_SH2_SRC	626	629	PF00017	0.782
LIG_SH2_STAP1	124	128	PF00017	0.804
LIG_SH2_STAP1	339	343	PF00017	0.609
LIG_SH2_STAP1	436	440	PF00017	0.659
LIG_SH2_STAT5	128	131	PF00017	0.791
LIG_SH2_STAT5	362	365	PF00017	0.741
LIG_SH2_STAT5	626	629	PF00017	0.782
LIG_SH2_STAT5	645	648	PF00017	0.472
LIG_SH2_STAT5	816	819	PF00017	0.739
LIG_SH2_STAT5	844	847	PF00017	0.684
LIG_SH2_STAT5	978	981	PF00017	0.395
LIG_SH3_3	446	452	PF00018	0.615
LIG_SH3_3	757	763	PF00018	0.638
LIG_SH3_3	851	857	PF00018	0.719
LIG_SH3_3	884	890	PF00018	0.585
LIG_SH3_3	894	900	PF00018	0.629
LIG_SH3_3	925	931	PF00018	0.831
LIG_SH3_3	964	970	PF00018	0.651
LIG_SUMO_SIM_anti_2	680	686	PF11976	0.692
LIG_SUMO_SIM_par_1	199	204	PF11976	0.726
LIG_SUMO_SIM_par_1	680	686	PF11976	0.692
LIG_SUMO_SIM_par_1	893	899	PF11976	0.562
LIG_SUMO_SIM_par_1	980	987	PF11976	0.668
LIG_TRAF2_1	691	694	PF00917	0.592
LIG_TRAF2_1	903	906	PF00917	0.681
LIG_TYR_ITIM	976	981	PF00017	0.407
MOD_CDK_SPK_2	896	901	PF00069	0.572
MOD_CDK_SPxK_1	971	977	PF00069	0.664
MOD_CDK_SPxxK_3	900	907	PF00069	0.726
MOD_CDK_SPxxK_3	941	948	PF00069	0.761
MOD_CDK_SPxxK_3	966	973	PF00069	0.540
MOD_CK1_1	169	175	PF00069	0.594
MOD_CK1_1	197	203	PF00069	0.729
MOD_CK1_1	214	220	PF00069	0.513
MOD_CK1_1	309	315	PF00069	0.655
MOD_CK1_1	321	327	PF00069	0.694
MOD_CK1_1	384	390	PF00069	0.662
MOD_CK1_1	43	49	PF00069	0.527
MOD_CK1_1	444	450	PF00069	0.857
MOD_CK1_1	54	60	PF00069	0.509
MOD_CK1_1	542	548	PF00069	0.776
MOD_CK1_1	729	735	PF00069	0.817
MOD_CK1_1	768	774	PF00069	0.874
MOD_CK1_1	789	795	PF00069	0.747
MOD_CK1_1	806	812	PF00069	0.423
MOD_CK1_1	885	891	PF00069	0.661
MOD_CK2_1	111	117	PF00069	0.735
MOD_CK2_1	371	377	PF00069	0.695
MOD_CK2_1	688	694	PF00069	0.481
MOD_CK2_1	716	722	PF00069	0.783
MOD_CK2_1	843	849	PF00069	0.561
MOD_CK2_1	900	906	PF00069	0.764
MOD_CK2_1	987	993	PF00069	0.655
MOD_GlcNHglycan	139	142	PF01048	0.739
MOD_GlcNHglycan	216	219	PF01048	0.531
MOD_GlcNHglycan	431	434	PF01048	0.707
MOD_GlcNHglycan	437	441	PF01048	0.644
MOD_GlcNHglycan	541	544	PF01048	0.806
MOD_GlcNHglycan	551	554	PF01048	0.676
MOD_GlcNHglycan	615	618	PF01048	0.827
MOD_GlcNHglycan	623	626	PF01048	0.650
MOD_GlcNHglycan	664	667	PF01048	0.778
MOD_GlcNHglycan	805	808	PF01048	0.638
MOD_GlcNHglycan	818	821	PF01048	0.534
MOD_GlcNHglycan	873	876	PF01048	0.699
MOD_GlcNHglycan	958	962	PF01048	0.765
MOD_GSK3_1	107	114	PF00069	0.671
MOD_GSK3_1	129	136	PF00069	0.573
MOD_GSK3_1	137	144	PF00069	0.706
MOD_GSK3_1	165	172	PF00069	0.770
MOD_GSK3_1	173	180	PF00069	0.705
MOD_GSK3_1	216	223	PF00069	0.780
MOD_GSK3_1	284	291	PF00069	0.752
MOD_GSK3_1	297	304	PF00069	0.608
MOD_GSK3_1	305	312	PF00069	0.695
MOD_GSK3_1	319	326	PF00069	0.500
MOD_GSK3_1	39	46	PF00069	0.531
MOD_GSK3_1	441	448	PF00069	0.790
MOD_GSK3_1	542	549	PF00069	0.824
MOD_GSK3_1	669	676	PF00069	0.737
MOD_GSK3_1	782	789	PF00069	0.693
MOD_GSK3_1	8	15	PF00069	0.494
MOD_GSK3_1	816	823	PF00069	0.672
MOD_GSK3_1	878	885	PF00069	0.630
MOD_GSK3_1	896	903	PF00069	0.447
MOD_GSK3_1	926	933	PF00069	0.786
MOD_GSK3_1	936	943	PF00069	0.661
MOD_GSK3_1	952	959	PF00069	0.522
MOD_NEK2_1	1006	1011	PF00069	0.677
MOD_NEK2_1	232	237	PF00069	0.657
MOD_NEK2_1	319	324	PF00069	0.710
MOD_NEK2_1	34	39	PF00069	0.537
MOD_NEK2_1	40	45	PF00069	0.529
MOD_NEK2_1	800	805	PF00069	0.449
MOD_NEK2_1	83	88	PF00069	0.534
MOD_NEK2_1	871	876	PF00069	0.701
MOD_NEK2_1	882	887	PF00069	0.459
MOD_NEK2_1	92	97	PF00069	0.518
MOD_NEK2_1	940	945	PF00069	0.775
MOD_NEK2_1	952	957	PF00069	0.487
MOD_NEK2_2	107	112	PF00069	0.488
MOD_NEK2_2	782	787	PF00069	0.569
MOD_PIKK_1	319	325	PF00454	0.706
MOD_PIKK_1	406	412	PF00454	0.738
MOD_PIKK_1	417	423	PF00454	0.706
MOD_PIKK_1	496	502	PF00454	0.818
MOD_PIKK_1	562	568	PF00454	0.742
MOD_PIKK_1	765	771	PF00454	0.870
MOD_PIKK_1	959	965	PF00454	0.730
MOD_PKA_1	716	722	PF00069	0.705
MOD_PKA_2	12	18	PF00069	0.513
MOD_PKA_2	147	153	PF00069	0.499
MOD_PKA_2	319	325	PF00069	0.629
MOD_PKA_2	330	336	PF00069	0.613
MOD_PKA_2	600	606	PF00069	0.492
MOD_PKA_2	716	722	PF00069	0.705
MOD_PKA_2	83	89	PF00069	0.531
MOD_PKA_2	956	962	PF00069	0.667
MOD_Plk_1	107	113	PF00069	0.488
MOD_Plk_1	141	147	PF00069	0.519
MOD_Plk_4	147	153	PF00069	0.713
MOD_Plk_4	583	589	PF00069	0.691
MOD_Plk_4	626	632	PF00069	0.776
MOD_ProDKin_1	150	156	PF00069	0.752
MOD_ProDKin_1	180	186	PF00069	0.635
MOD_ProDKin_1	239	245	PF00069	0.757
MOD_ProDKin_1	309	315	PF00069	0.694
MOD_ProDKin_1	44	50	PF00069	0.527
MOD_ProDKin_1	445	451	PF00069	0.625
MOD_ProDKin_1	533	539	PF00069	0.783
MOD_ProDKin_1	618	624	PF00069	0.803
MOD_ProDKin_1	673	679	PF00069	0.549
MOD_ProDKin_1	76	82	PF00069	0.537
MOD_ProDKin_1	866	872	PF00069	0.775
MOD_ProDKin_1	883	889	PF00069	0.420
MOD_ProDKin_1	896	902	PF00069	0.651
MOD_ProDKin_1	926	932	PF00069	0.818
MOD_ProDKin_1	941	947	PF00069	0.507
MOD_ProDKin_1	966	972	PF00069	0.803
MOD_SUMO_for_1	247	250	PF00179	0.746
MOD_SUMO_rev_2	364	372	PF00179	0.686
TRG_DiLeu_BaEn_4	66	72	PF01217	0.543
TRG_DiLeu_BaLyEn_6	490	495	PF01217	0.530
TRG_DiLeu_BaLyEn_6	88	93	PF01217	0.520
TRG_ENDOCYTIC_2	338	341	PF00928	0.590
TRG_ENDOCYTIC_2	350	353	PF00928	0.484
TRG_ENDOCYTIC_2	400	403	PF00928	0.735
TRG_ENDOCYTIC_2	978	981	PF00928	0.395
TRG_ENDOCYTIC_2	999	1002	PF00928	0.730
TRG_ER_diArg_1	208	210	PF00400	0.779
TRG_ER_diArg_1	251	254	PF00400	0.777
TRG_ER_diArg_1	647	650	PF00400	0.690
TRG_ER_diArg_1	69	72	PF00400	0.544
TRG_ER_diArg_1	715	718	PF00400	0.716
TRG_ER_diArg_1	947	950	PF00400	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WYA9	Leishmania donovani	85%	100%
A4HDG0	Leishmania braziliensis	68%	99%
A4I0U1	Leishmania infantum	85%	100%
Q4QAM9	Leishmania major	84%	99%