Putative dynein light chain

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dynein light chain, putative

Species:

Leishmania mexicana

UniProt:

E9AWU4_LEIMU

TriTrypDb:

LmxM.24.1030

Length:

210

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	10
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1

Expansion

Sequence features

E9AWU4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWU4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.265
CLV_NRD_NRD_1	21	23	PF00675	0.430
CLV_PCSK_KEX2_1	20	22	PF00082	0.477
CLV_PCSK_KEX2_1	208	210	PF00082	0.547
CLV_PCSK_SKI1_1	44	48	PF00082	0.391
CLV_PCSK_SKI1_1	85	89	PF00082	0.250
DEG_APCC_DBOX_1	19	27	PF00400	0.571
DOC_CDC14_PxL_1	184	192	PF14671	0.450
DOC_MAPK_gen_1	101	108	PF00069	0.450
DOC_MAPK_gen_1	189	198	PF00069	0.450
DOC_MAPK_gen_1	85	95	PF00069	0.450
DOC_MAPK_MEF2A_6	65	72	PF00069	0.446
DOC_PP2B_LxvP_1	106	109	PF13499	0.450
DOC_PP4_MxPP_1	50	53	PF00568	0.431
LIG_BIR_II_1	1	5	PF00653	0.486
LIG_eIF4E_1	137	143	PF01652	0.463
LIG_FHA_1	72	78	PF00498	0.473
LIG_FHA_2	123	129	PF00498	0.463
LIG_FHA_2	145	151	PF00498	0.450
LIG_FHA_2	53	59	PF00498	0.560
LIG_FHA_2	61	67	PF00498	0.498
LIG_LIR_Gen_1	117	124	PF02991	0.450
LIG_LIR_Gen_1	145	153	PF02991	0.452
LIG_LIR_Gen_1	178	188	PF02991	0.476
LIG_LIR_Nem_3	112	118	PF02991	0.450
LIG_LIR_Nem_3	145	149	PF02991	0.454
LIG_LIR_Nem_3	178	184	PF02991	0.482
LIG_LRP6_Inhibitor_1	95	101	PF00058	0.250
LIG_MAD2	44	52	PF02301	0.413
LIG_MYND_3	108	112	PF01753	0.506
LIG_NRP_CendR_1	208	210	PF00754	0.547
LIG_SH2_CRK	181	185	PF00017	0.492
LIG_SH2_NCK_1	118	122	PF00017	0.450
LIG_SH3_3	194	200	PF00018	0.463
LIG_SH3_3	37	43	PF00018	0.404
LIG_SUMO_SIM_anti_2	158	164	PF11976	0.463
LIG_SUMO_SIM_par_1	36	42	PF11976	0.316
LIG_TRAF2_1	175	178	PF00917	0.481
LIG_TRAF2_1	29	32	PF00917	0.512
LIG_TRAF2_1	39	42	PF00917	0.399
LIG_UBA3_1	183	189	PF00899	0.463
LIG_UBA3_1	47	56	PF00899	0.400
MOD_CK1_1	172	178	PF00069	0.543
MOD_CK1_1	2	8	PF00069	0.570
MOD_CK2_1	142	148	PF00069	0.451
MOD_CK2_1	172	178	PF00069	0.463
MOD_CK2_1	3	9	PF00069	0.448
MOD_CK2_1	60	66	PF00069	0.534
MOD_GlcNHglycan	171	174	PF01048	0.344
MOD_N-GLC_2	154	156	PF02516	0.250
MOD_NEK2_1	1	6	PF00069	0.567
MOD_NEK2_1	114	119	PF00069	0.450
MOD_NEK2_1	136	141	PF00069	0.450
MOD_NEK2_1	142	147	PF00069	0.450
MOD_NEK2_1	169	174	PF00069	0.530
MOD_NEK2_1	30	35	PF00069	0.485
MOD_NEK2_1	70	75	PF00069	0.287
MOD_Plk_1	59	65	PF00069	0.449
MOD_Plk_2-3	60	66	PF00069	0.534
MOD_SUMO_for_1	109	112	PF00179	0.469
TRG_DiLeu_BaEn_1	42	47	PF01217	0.379
TRG_ENDOCYTIC_2	118	121	PF00928	0.462
TRG_ENDOCYTIC_2	179	182	PF00928	0.475
TRG_ER_diArg_1	19	22	PF00400	0.455
TRG_ER_diArg_1	208	210	PF00400	0.550
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.250

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A096MJZ0	Rattus norvegicus	42%	100%
A0A0N1PBU3	Leptomonas seymouri	90%	100%
A0A0S4JQV7	Bodo saltans	70%	99%
A0A1X0NVY4	Trypanosomatidae	78%	100%
A0A3Q8IC25	Leishmania donovani	98%	100%
A0A3R7LR73	Trypanosoma rangeli	76%	100%
A4HDF9	Leishmania braziliensis	93%	100%
A4I0U0	Leishmania infantum	98%	100%
D0A771	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	100%
D0A8W7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	73%
E9ATS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	67%
Q05A62	Mus musculus	43%	100%
Q28G94	Xenopus tropicalis	43%	100%
Q2KID4	Bos taurus	43%	100%
Q4LDG9	Homo sapiens	43%	100%
Q4QAN0	Leishmania major	98%	100%
Q641R9	Xenopus laevis	44%	100%
Q6DHB1	Danio rerio	45%	100%
Q8T888	Ciona intestinalis	42%	100%
Q9XHH2	Chlamydomonas reinhardtii	49%	100%