F-box domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

F-box domain/Galactose oxidase, central domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AWU3_LEIMU

TriTrypDb:

LmxM.24.1020

Length:

1010

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWU3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	350	354	PF00656	0.638
CLV_C14_Caspase3-7	616	620	PF00656	0.699
CLV_NRD_NRD_1	248	250	PF00675	0.405
CLV_NRD_NRD_1	337	339	PF00675	0.573
CLV_NRD_NRD_1	377	379	PF00675	0.657
CLV_NRD_NRD_1	606	608	PF00675	0.701
CLV_NRD_NRD_1	635	637	PF00675	0.711
CLV_NRD_NRD_1	638	640	PF00675	0.692
CLV_NRD_NRD_1	667	669	PF00675	0.693
CLV_NRD_NRD_1	718	720	PF00675	0.755
CLV_NRD_NRD_1	739	741	PF00675	0.620
CLV_PCSK_FUR_1	636	640	PF00082	0.715
CLV_PCSK_KEX2_1	112	114	PF00082	0.671
CLV_PCSK_KEX2_1	248	250	PF00082	0.405
CLV_PCSK_KEX2_1	285	287	PF00082	0.489
CLV_PCSK_KEX2_1	336	338	PF00082	0.678
CLV_PCSK_KEX2_1	377	379	PF00082	0.657
CLV_PCSK_KEX2_1	608	610	PF00082	0.684
CLV_PCSK_KEX2_1	635	637	PF00082	0.711
CLV_PCSK_KEX2_1	638	640	PF00082	0.692
CLV_PCSK_KEX2_1	667	669	PF00082	0.606
CLV_PCSK_KEX2_1	718	720	PF00082	0.752
CLV_PCSK_KEX2_1	739	741	PF00082	0.620
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.671
CLV_PCSK_PC1ET2_1	285	287	PF00082	0.489
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.678
CLV_PCSK_PC1ET2_1	608	610	PF00082	0.729
CLV_PCSK_PC7_1	663	669	PF00082	0.549
CLV_PCSK_SKI1_1	109	113	PF00082	0.660
CLV_PCSK_SKI1_1	48	52	PF00082	0.405
CLV_PCSK_SKI1_1	696	700	PF00082	0.692
CLV_PCSK_SKI1_1	704	708	PF00082	0.613
CLV_Separin_Metazoa	947	951	PF03568	0.674
DEG_APCC_DBOX_1	47	55	PF00400	0.405
DEG_SPOP_SBC_1	132	136	PF00917	0.693
DEG_SPOP_SBC_1	477	481	PF00917	0.594
DEG_SPOP_SBC_1	885	889	PF00917	0.679
DOC_ANK_TNKS_1	864	871	PF00023	0.619
DOC_CKS1_1	225	230	PF01111	0.555
DOC_CKS1_1	483	488	PF01111	0.716
DOC_CKS1_1	726	731	PF01111	0.682
DOC_CYCLIN_RxL_1	816	824	PF00134	0.670
DOC_CYCLIN_yCln2_LP_2	79	85	PF00134	0.356
DOC_MAPK_FxFP_2	105	108	PF00069	0.662
DOC_MAPK_gen_1	488	497	PF00069	0.648
DOC_MAPK_gen_1	88	97	PF00069	0.636
DOC_PP1_RVXF_1	991	997	PF00149	0.624
DOC_PP2B_LxvP_1	536	539	PF13499	0.592
DOC_PP4_FxxP_1	105	108	PF00568	0.662
DOC_PP4_FxxP_1	562	565	PF00568	0.591
DOC_PP4_FxxP_1	787	790	PF00568	0.663
DOC_USP7_MATH_1	115	119	PF00917	0.804
DOC_USP7_MATH_1	120	124	PF00917	0.742
DOC_USP7_MATH_1	131	135	PF00917	0.568
DOC_USP7_MATH_1	146	150	PF00917	0.613
DOC_USP7_MATH_1	160	164	PF00917	0.661
DOC_USP7_MATH_1	185	189	PF00917	0.676
DOC_USP7_MATH_1	19	23	PF00917	0.411
DOC_USP7_MATH_1	2	6	PF00917	0.620
DOC_USP7_MATH_1	287	291	PF00917	0.405
DOC_USP7_MATH_1	405	409	PF00917	0.579
DOC_USP7_MATH_1	449	453	PF00917	0.694
DOC_USP7_MATH_1	592	596	PF00917	0.587
DOC_USP7_MATH_1	680	684	PF00917	0.726
DOC_USP7_MATH_1	694	698	PF00917	0.600
DOC_USP7_MATH_1	761	765	PF00917	0.658
DOC_USP7_MATH_1	806	810	PF00917	0.719
DOC_USP7_MATH_1	815	819	PF00917	0.594
DOC_USP7_MATH_1	859	863	PF00917	0.559
DOC_USP7_MATH_1	886	890	PF00917	0.657
DOC_USP7_MATH_1	906	910	PF00917	0.641
DOC_WW_Pin1_4	121	126	PF00397	0.693
DOC_WW_Pin1_4	224	229	PF00397	0.692
DOC_WW_Pin1_4	24	29	PF00397	0.546
DOC_WW_Pin1_4	453	458	PF00397	0.622
DOC_WW_Pin1_4	482	487	PF00397	0.715
DOC_WW_Pin1_4	523	528	PF00397	0.661
DOC_WW_Pin1_4	553	558	PF00397	0.659
DOC_WW_Pin1_4	588	593	PF00397	0.706
DOC_WW_Pin1_4	725	730	PF00397	0.753
DOC_WW_Pin1_4	731	736	PF00397	0.697
DOC_WW_Pin1_4	852	857	PF00397	0.683
DOC_WW_Pin1_4	879	884	PF00397	0.713
DOC_WW_Pin1_4	894	899	PF00397	0.593
LIG_14-3-3_CanoR_1	119	125	PF00244	0.657
LIG_14-3-3_CanoR_1	165	173	PF00244	0.698
LIG_14-3-3_CanoR_1	286	294	PF00244	0.405
LIG_14-3-3_CanoR_1	322	331	PF00244	0.405
LIG_14-3-3_CanoR_1	34	43	PF00244	0.555
LIG_14-3-3_CanoR_1	403	413	PF00244	0.614
LIG_14-3-3_CanoR_1	516	525	PF00244	0.680
LIG_14-3-3_CanoR_1	52	58	PF00244	0.220
LIG_14-3-3_CanoR_1	636	644	PF00244	0.718
LIG_14-3-3_CanoR_1	718	725	PF00244	0.724
LIG_14-3-3_CanoR_1	739	746	PF00244	0.578
LIG_14-3-3_CanoR_1	860	869	PF00244	0.557
LIG_14-3-3_CanoR_1	982	987	PF00244	0.629
LIG_14-3-3_CanoR_1	993	997	PF00244	0.530
LIG_Actin_WH2_2	10	27	PF00022	0.551
LIG_Actin_WH2_2	39	54	PF00022	0.405
LIG_Actin_WH2_2	625	640	PF00022	0.545
LIG_APCC_ABBA_1	421	426	PF00400	0.581
LIG_BIR_III_4	649	653	PF00653	0.693
LIG_Clathr_ClatBox_1	840	844	PF01394	0.520
LIG_deltaCOP1_diTrp_1	380	387	PF00928	0.523
LIG_FHA_1	164	170	PF00498	0.522
LIG_FHA_1	189	195	PF00498	0.686
LIG_FHA_1	197	203	PF00498	0.624
LIG_FHA_1	225	231	PF00498	0.564
LIG_FHA_1	311	317	PF00498	0.405
LIG_FHA_1	478	484	PF00498	0.644
LIG_FHA_1	570	576	PF00498	0.639
LIG_FHA_1	728	734	PF00498	0.681
LIG_FHA_1	778	784	PF00498	0.634
LIG_FHA_1	806	812	PF00498	0.706
LIG_FHA_1	911	917	PF00498	0.657
LIG_FHA_1	987	993	PF00498	0.599
LIG_FHA_2	348	354	PF00498	0.633
LIG_FHA_2	532	538	PF00498	0.544
LIG_FHA_2	54	60	PF00498	0.405
LIG_FHA_2	611	617	PF00498	0.741
LIG_FHA_2	643	649	PF00498	0.671
LIG_FHA_2	964	970	PF00498	0.730
LIG_LIR_Apic_2	407	413	PF02991	0.665
LIG_LIR_Apic_2	559	565	PF02991	0.597
LIG_LIR_Apic_2	824	830	PF02991	0.665
LIG_LIR_Gen_1	187	194	PF02991	0.704
LIG_LIR_Gen_1	312	319	PF02991	0.405
LIG_LIR_Gen_1	37	47	PF02991	0.570
LIG_LIR_Gen_1	446	454	PF02991	0.693
LIG_LIR_Gen_1	504	512	PF02991	0.684
LIG_LIR_Gen_1	59	67	PF02991	0.405
LIG_LIR_Nem_3	187	192	PF02991	0.709
LIG_LIR_Nem_3	201	207	PF02991	0.618
LIG_LIR_Nem_3	256	261	PF02991	0.405
LIG_LIR_Nem_3	273	279	PF02991	0.230
LIG_LIR_Nem_3	312	317	PF02991	0.405
LIG_LIR_Nem_3	37	43	PF02991	0.568
LIG_LIR_Nem_3	446	450	PF02991	0.692
LIG_LIR_Nem_3	504	509	PF02991	0.697
LIG_LIR_Nem_3	56	60	PF02991	0.210
LIG_LIR_Nem_3	792	798	PF02991	0.604
LIG_LIR_Nem_3	844	849	PF02991	0.551
LIG_LIR_Nem_3	909	914	PF02991	0.626
LIG_MYND_1	539	543	PF01753	0.607
LIG_NRBOX	31	37	PF00104	0.514
LIG_Pex14_2	506	510	PF04695	0.563
LIG_REV1ctd_RIR_1	332	342	PF16727	0.617
LIG_REV1ctd_RIR_1	83	92	PF16727	0.620
LIG_SH2_CRK	40	44	PF00017	0.577
LIG_SH2_CRK	447	451	PF00017	0.695
LIG_SH2_CRK	60	64	PF00017	0.199
LIG_SH2_CRK	834	838	PF00017	0.609
LIG_SH2_NCK_1	40	44	PF00017	0.396
LIG_SH2_NCK_1	447	451	PF00017	0.695
LIG_SH2_NCK_1	60	64	PF00017	0.380
LIG_SH2_PTP2	563	566	PF00017	0.671
LIG_SH2_PTP2	798	801	PF00017	0.680
LIG_SH2_STAP1	246	250	PF00017	0.405
LIG_SH2_STAT5	106	109	PF00017	0.665
LIG_SH2_STAT5	53	56	PF00017	0.405
LIG_SH2_STAT5	547	550	PF00017	0.614
LIG_SH2_STAT5	563	566	PF00017	0.506
LIG_SH2_STAT5	798	801	PF00017	0.680
LIG_SH2_STAT5	834	837	PF00017	0.610
LIG_SH3_3	222	228	PF00018	0.690
LIG_SH3_3	230	236	PF00018	0.580
LIG_SH3_3	480	486	PF00018	0.642
LIG_SH3_3	495	501	PF00018	0.513
LIG_SH3_3	519	525	PF00018	0.652
LIG_SH3_3	562	568	PF00018	0.485
LIG_SH3_3	746	752	PF00018	0.512
LIG_SH3_3	796	802	PF00018	0.682
LIG_SH3_3	880	886	PF00018	0.747
LIG_SH3_3	958	964	PF00018	0.734
LIG_SUMO_SIM_anti_2	494	499	PF11976	0.512
LIG_SUMO_SIM_anti_2	808	814	PF11976	0.668
LIG_SUMO_SIM_par_1	190	196	PF11976	0.672
LIG_SUMO_SIM_par_1	315	321	PF11976	0.405
LIG_TRAF2_1	645	648	PF00917	0.684
LIG_TRAF2_1	967	970	PF00917	0.729
LIG_TYR_ITIM	220	225	PF00017	0.502
LIG_TYR_ITIM	445	450	PF00017	0.692
LIG_TYR_ITIM	58	63	PF00017	0.525
LIG_TYR_ITIM	832	837	PF00017	0.609
LIG_WRC_WIRS_1	54	59	PF05994	0.405
LIG_WRC_WIRS_1	983	988	PF05994	0.468
MOD_CDK_SPK_2	523	528	PF00069	0.661
MOD_CDK_SPK_2	731	736	PF00069	0.541
MOD_CDK_SPxK_1	482	488	PF00069	0.715
MOD_CK1_1	123	129	PF00069	0.733
MOD_CK1_1	134	140	PF00069	0.627
MOD_CK1_1	163	169	PF00069	0.676
MOD_CK1_1	188	194	PF00069	0.665
MOD_CK1_1	383	389	PF00069	0.614
MOD_CK1_1	401	407	PF00069	0.529
MOD_CK1_1	452	458	PF00069	0.623
MOD_CK1_1	475	481	PF00069	0.709
MOD_CK1_1	61	67	PF00069	0.405
MOD_CK1_1	618	624	PF00069	0.588
MOD_CK1_1	710	716	PF00069	0.760
MOD_CK1_1	855	861	PF00069	0.672
MOD_CK1_1	888	894	PF00069	0.697
MOD_CK1_1	910	916	PF00069	0.641
MOD_CK2_1	2	8	PF00069	0.673
MOD_CK2_1	531	537	PF00069	0.560
MOD_CK2_1	610	616	PF00069	0.737
MOD_CK2_1	642	648	PF00069	0.697
MOD_CK2_1	652	658	PF00069	0.664
MOD_CK2_1	689	695	PF00069	0.802
MOD_CK2_1	738	744	PF00069	0.593
MOD_CK2_1	963	969	PF00069	0.732
MOD_Cter_Amidation	633	636	PF01082	0.676
MOD_Cter_Amidation	716	719	PF01082	0.625
MOD_GlcNHglycan	148	151	PF01048	0.713
MOD_GlcNHglycan	166	169	PF01048	0.756
MOD_GlcNHglycan	179	182	PF01048	0.582
MOD_GlcNHglycan	289	292	PF01048	0.405
MOD_GlcNHglycan	389	392	PF01048	0.639
MOD_GlcNHglycan	400	403	PF01048	0.594
MOD_GlcNHglycan	447	450	PF01048	0.693
MOD_GlcNHglycan	451	454	PF01048	0.652
MOD_GlcNHglycan	475	478	PF01048	0.573
MOD_GlcNHglycan	63	66	PF01048	0.405
MOD_GlcNHglycan	695	699	PF01048	0.570
MOD_GlcNHglycan	763	766	PF01048	0.733
MOD_GlcNHglycan	8	12	PF01048	0.553
MOD_GlcNHglycan	857	860	PF01048	0.678
MOD_GlcNHglycan	950	953	PF01048	0.727
MOD_GSK3_1	120	127	PF00069	0.688
MOD_GSK3_1	131	138	PF00069	0.652
MOD_GSK3_1	142	149	PF00069	0.705
MOD_GSK3_1	160	167	PF00069	0.515
MOD_GSK3_1	184	191	PF00069	0.679
MOD_GSK3_1	236	243	PF00069	0.582
MOD_GSK3_1	3	10	PF00069	0.615
MOD_GSK3_1	376	383	PF00069	0.663
MOD_GSK3_1	397	404	PF00069	0.696
MOD_GSK3_1	445	452	PF00069	0.694
MOD_GSK3_1	468	475	PF00069	0.627
MOD_GSK3_1	478	485	PF00069	0.576
MOD_GSK3_1	588	595	PF00069	0.614
MOD_GSK3_1	59	66	PF00069	0.400
MOD_GSK3_1	624	631	PF00069	0.708
MOD_GSK3_1	648	655	PF00069	0.558
MOD_GSK3_1	727	734	PF00069	0.666
MOD_GSK3_1	817	824	PF00069	0.671
MOD_GSK3_1	851	858	PF00069	0.687
MOD_GSK3_1	884	891	PF00069	0.685
MOD_GSK3_1	906	913	PF00069	0.606
MOD_GSK3_1	982	989	PF00069	0.604
MOD_LATS_1	343	349	PF00433	0.495
MOD_N-GLC_1	747	752	PF02516	0.647
MOD_N-GLC_1	916	921	PF02516	0.482
MOD_N-GLC_1	986	991	PF02516	0.602
MOD_NEK2_1	18	23	PF00069	0.417
MOD_NEK2_1	58	63	PF00069	0.405
MOD_NEK2_1	637	642	PF00069	0.670
MOD_NEK2_1	7	12	PF00069	0.579
MOD_NEK2_1	821	826	PF00069	0.672
MOD_NEK2_1	916	921	PF00069	0.482
MOD_NEK2_1	948	953	PF00069	0.600
MOD_NEK2_1	986	991	PF00069	0.636
MOD_NEK2_1	992	997	PF00069	0.573
MOD_PIKK_1	193	199	PF00454	0.670
MOD_PIKK_1	236	242	PF00454	0.574
MOD_PIKK_1	323	329	PF00454	0.405
MOD_PIKK_1	34	40	PF00454	0.543
MOD_PIKK_1	347	353	PF00454	0.569
MOD_PIKK_1	405	411	PF00454	0.697
MOD_PIKK_1	516	522	PF00454	0.558
MOD_PIKK_1	600	606	PF00454	0.559
MOD_PIKK_1	652	658	PF00454	0.555
MOD_PIKK_1	886	892	PF00454	0.554
MOD_PK_1	491	497	PF00069	0.645
MOD_PKA_2	142	148	PF00069	0.589
MOD_PKA_2	164	170	PF00069	0.801
MOD_PKA_2	376	382	PF00069	0.703
MOD_PKA_2	637	643	PF00069	0.717
MOD_PKA_2	717	723	PF00069	0.761
MOD_PKA_2	738	744	PF00069	0.571
MOD_PKA_2	859	865	PF00069	0.567
MOD_PKA_2	992	998	PF00069	0.622
MOD_Plk_1	440	446	PF00069	0.686
MOD_Plk_1	58	64	PF00069	0.405
MOD_Plk_1	916	922	PF00069	0.517
MOD_Plk_4	185	191	PF00069	0.680
MOD_Plk_4	19	25	PF00069	0.555
MOD_Plk_4	502	508	PF00069	0.719
MOD_Plk_4	531	537	PF00069	0.560
MOD_Plk_4	768	774	PF00069	0.589
MOD_Plk_4	806	812	PF00069	0.670
MOD_Plk_4	987	993	PF00069	0.647
MOD_ProDKin_1	121	127	PF00069	0.694
MOD_ProDKin_1	224	230	PF00069	0.687
MOD_ProDKin_1	24	30	PF00069	0.544
MOD_ProDKin_1	453	459	PF00069	0.625
MOD_ProDKin_1	482	488	PF00069	0.715
MOD_ProDKin_1	523	529	PF00069	0.664
MOD_ProDKin_1	553	559	PF00069	0.661
MOD_ProDKin_1	588	594	PF00069	0.705
MOD_ProDKin_1	725	731	PF00069	0.752
MOD_ProDKin_1	852	858	PF00069	0.689
MOD_ProDKin_1	879	885	PF00069	0.711
MOD_ProDKin_1	894	900	PF00069	0.592
MOD_SUMO_rev_2	969	974	PF00179	0.704
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.508
TRG_DiLeu_BaLyEn_6	845	850	PF01217	0.588
TRG_ENDOCYTIC_2	222	225	PF00928	0.687
TRG_ENDOCYTIC_2	258	261	PF00928	0.405
TRG_ENDOCYTIC_2	269	272	PF00928	0.292
TRG_ENDOCYTIC_2	314	317	PF00928	0.363
TRG_ENDOCYTIC_2	40	43	PF00928	0.571
TRG_ENDOCYTIC_2	447	450	PF00928	0.693
TRG_ENDOCYTIC_2	563	566	PF00928	0.671
TRG_ENDOCYTIC_2	60	63	PF00928	0.320
TRG_ENDOCYTIC_2	798	801	PF00928	0.680
TRG_ENDOCYTIC_2	834	837	PF00928	0.610
TRG_ER_diArg_1	248	250	PF00400	0.405
TRG_ER_diArg_1	635	638	PF00400	0.714
TRG_ER_diArg_1	666	668	PF00400	0.550
TRG_ER_diArg_1	738	740	PF00400	0.570
TRG_ER_diArg_1	876	879	PF00400	0.559
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.540
TRG_Pf-PMV_PEXEL_1	573	577	PF00026	0.687

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WYA7	Leishmania donovani	86%	100%
A4HDF8	Leishmania braziliensis	73%	100%
A4I0T9	Leishmania infantum	86%	100%
Q4QAN1	Leishmania major	88%	100%