LeishMANIAdb
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Mnd1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Mnd1 domain-containing protein
Gene product:
Mnd1 family, putative
Species:
Leishmania mexicana
UniProt:
E9AWU2_LEIMU
TriTrypDb:
LmxM.24.1010
Length:
427

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 4
GO:0043226 organelle 2 4
GO:0043227 membrane-bounded organelle 3 4
GO:0043229 intracellular organelle 3 4
GO:0043231 intracellular membrane-bounded organelle 4 4
GO:0110165 cellular anatomical entity 1 4

Expansion

Sequence features

E9AWU2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWU2

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006259 DNA metabolic process 4 1
GO:0006310 DNA recombination 5 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0007131 reciprocal meiotic recombination 3 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0022402 cell cycle process 2 1
GO:0022414 reproductive process 1 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0035825 homologous recombination 6 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0046483 heterocycle metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:0140527 reciprocal homologous recombination 7 1
GO:1901360 organic cyclic compound metabolic process 3 1
GO:1903046 meiotic cell cycle process 2 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 1
GO:0003677 DNA binding 4 1
GO:0003690 double-stranded DNA binding 5 1
GO:0005488 binding 1 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 297 301 PF00656 0.643
CLV_C14_Caspase3-7 392 396 PF00656 0.509
CLV_NRD_NRD_1 126 128 PF00675 0.575
CLV_NRD_NRD_1 279 281 PF00675 0.616
CLV_NRD_NRD_1 311 313 PF00675 0.553
CLV_NRD_NRD_1 8 10 PF00675 0.718
CLV_PCSK_KEX2_1 126 128 PF00082 0.541
CLV_PCSK_KEX2_1 279 281 PF00082 0.554
CLV_PCSK_KEX2_1 311 313 PF00082 0.621
CLV_PCSK_KEX2_1 418 420 PF00082 0.749
CLV_PCSK_KEX2_1 423 425 PF00082 0.720
CLV_PCSK_PC1ET2_1 418 420 PF00082 0.749
CLV_PCSK_PC1ET2_1 423 425 PF00082 0.732
CLV_PCSK_PC7_1 419 425 PF00082 0.741
CLV_PCSK_SKI1_1 126 130 PF00082 0.578
CLV_PCSK_SKI1_1 21 25 PF00082 0.486
CLV_PCSK_SKI1_1 234 238 PF00082 0.593
CLV_PCSK_SKI1_1 283 287 PF00082 0.574
CLV_PCSK_SKI1_1 407 411 PF00082 0.721
CLV_Separin_Metazoa 123 127 PF03568 0.532
DEG_APCC_DBOX_1 180 188 PF00400 0.550
DEG_APCC_DBOX_1 233 241 PF00400 0.544
DEG_SCF_FBW7_1 386 392 PF00400 0.504
DOC_CKS1_1 386 391 PF01111 0.504
DOC_CYCLIN_yCln2_LP_2 286 292 PF00134 0.574
DOC_MAPK_gen_1 279 290 PF00069 0.482
DOC_MAPK_MEF2A_6 283 292 PF00069 0.581
DOC_MAPK_NFAT4_5 283 291 PF00069 0.571
DOC_PP1_RVXF_1 181 187 PF00149 0.608
DOC_PP2B_LxvP_1 286 289 PF13499 0.488
DOC_USP7_MATH_1 112 116 PF00917 0.699
DOC_USP7_MATH_1 173 177 PF00917 0.517
DOC_USP7_MATH_1 301 305 PF00917 0.572
DOC_USP7_MATH_1 332 336 PF00917 0.743
DOC_USP7_MATH_1 387 391 PF00917 0.683
DOC_USP7_MATH_1 417 421 PF00917 0.692
DOC_USP7_MATH_1 91 95 PF00917 0.687
DOC_USP7_UBL2_3 10 14 PF12436 0.687
DOC_WW_Pin1_4 151 156 PF00397 0.567
DOC_WW_Pin1_4 333 338 PF00397 0.574
DOC_WW_Pin1_4 385 390 PF00397 0.722
DOC_WW_Pin1_4 46 51 PF00397 0.378
LIG_14-3-3_CanoR_1 172 178 PF00244 0.594
LIG_14-3-3_CanoR_1 246 250 PF00244 0.472
LIG_14-3-3_CanoR_1 257 264 PF00244 0.360
LIG_14-3-3_CanoR_1 349 358 PF00244 0.747
LIG_14-3-3_CanoR_1 73 83 PF00244 0.385
LIG_14-3-3_CanoR_1 93 97 PF00244 0.445
LIG_14-3-3_CterR_2 424 427 PF00244 0.806
LIG_BIR_II_1 1 5 PF00653 0.723
LIG_BIR_III_2 329 333 PF00653 0.625
LIG_BIR_III_2 367 371 PF00653 0.685
LIG_BRCT_BRCA1_1 302 306 PF00533 0.459
LIG_CtBP_PxDLS_1 289 293 PF00389 0.646
LIG_FHA_1 120 126 PF00498 0.360
LIG_FHA_1 47 53 PF00498 0.307
LIG_FHA_2 35 41 PF00498 0.307
LIG_FHA_2 370 376 PF00498 0.507
LIG_LIR_Apic_2 78 84 PF02991 0.419
LIG_LIR_Gen_1 119 128 PF02991 0.502
LIG_LIR_Gen_1 148 157 PF02991 0.568
LIG_LIR_Gen_1 161 168 PF02991 0.362
LIG_LIR_Gen_1 247 255 PF02991 0.513
LIG_LIR_Nem_3 119 124 PF02991 0.533
LIG_LIR_Nem_3 148 153 PF02991 0.580
LIG_LIR_Nem_3 161 165 PF02991 0.364
LIG_LIR_Nem_3 247 252 PF02991 0.457
LIG_Pex14_1 258 262 PF04695 0.513
LIG_RPA_C_Fungi 274 286 PF08784 0.525
LIG_SH2_STAP1 121 125 PF00017 0.504
LIG_SH2_STAT5 121 124 PF00017 0.399
LIG_SH2_STAT5 263 266 PF00017 0.473
LIG_SH2_STAT5 294 297 PF00017 0.490
LIG_SH2_STAT5 36 39 PF00017 0.307
LIG_SH3_3 331 337 PF00018 0.709
LIG_SH3_3 383 389 PF00018 0.782
LIG_SUMO_SIM_anti_2 19 26 PF11976 0.351
LIG_SUMO_SIM_par_1 19 26 PF11976 0.351
LIG_SUMO_SIM_par_1 288 293 PF11976 0.572
LIG_TRAF2_1 265 268 PF00917 0.543
LIG_TRAF2_1 55 58 PF00917 0.307
LIG_TYR_ITIM 51 56 PF00017 0.419
MOD_CK1_1 107 113 PF00069 0.686
MOD_CK1_1 143 149 PF00069 0.590
MOD_CK1_1 293 299 PF00069 0.629
MOD_CK1_1 320 326 PF00069 0.682
MOD_CK1_1 352 358 PF00069 0.721
MOD_CK2_1 117 123 PF00069 0.491
MOD_CK2_1 128 134 PF00069 0.633
MOD_CK2_1 14 20 PF00069 0.472
MOD_CK2_1 198 204 PF00069 0.685
MOD_CK2_1 296 302 PF00069 0.636
MOD_CK2_1 34 40 PF00069 0.371
MOD_CK2_1 52 58 PF00069 0.307
MOD_Cter_Amidation 10 13 PF01082 0.690
MOD_Cter_Amidation 421 424 PF01082 0.740
MOD_GlcNHglycan 107 110 PF01048 0.653
MOD_GlcNHglycan 130 133 PF01048 0.637
MOD_GlcNHglycan 142 145 PF01048 0.465
MOD_GlcNHglycan 189 192 PF01048 0.670
MOD_GlcNHglycan 198 203 PF01048 0.682
MOD_GlcNHglycan 2 5 PF01048 0.686
MOD_GlcNHglycan 351 354 PF01048 0.708
MOD_GlcNHglycan 389 392 PF01048 0.557
MOD_GlcNHglycan 415 418 PF01048 0.744
MOD_GSK3_1 103 110 PF00069 0.742
MOD_GSK3_1 112 119 PF00069 0.622
MOD_GSK3_1 126 133 PF00069 0.475
MOD_GSK3_1 194 201 PF00069 0.657
MOD_GSK3_1 296 303 PF00069 0.646
MOD_GSK3_1 316 323 PF00069 0.562
MOD_GSK3_1 348 355 PF00069 0.779
MOD_GSK3_1 385 392 PF00069 0.685
MOD_GSK3_1 413 420 PF00069 0.714
MOD_N-GLC_1 229 234 PF02516 0.424
MOD_N-GLC_1 244 249 PF02516 0.301
MOD_N-GLC_1 317 322 PF02516 0.484
MOD_N-GLC_1 91 96 PF02516 0.614
MOD_N-GLC_2 343 345 PF02516 0.753
MOD_NEK2_1 104 109 PF00069 0.657
MOD_NEK2_1 128 133 PF00069 0.691
MOD_NEK2_1 186 191 PF00069 0.593
MOD_NEK2_1 244 249 PF00069 0.301
MOD_NEK2_1 275 280 PF00069 0.576
MOD_NEK2_1 290 295 PF00069 0.600
MOD_NEK2_2 301 306 PF00069 0.610
MOD_OFUCOSY 317 324 PF10250 0.720
MOD_PIKK_1 85 91 PF00454 0.495
MOD_PKA_1 126 132 PF00069 0.596
MOD_PKA_1 418 424 PF00069 0.738
MOD_PKA_2 126 132 PF00069 0.596
MOD_PKA_2 245 251 PF00069 0.469
MOD_PKA_2 256 262 PF00069 0.349
MOD_PKA_2 348 354 PF00069 0.695
MOD_PKA_2 376 382 PF00069 0.678
MOD_PKA_2 418 424 PF00069 0.694
MOD_PKA_2 92 98 PF00069 0.633
MOD_Plk_1 203 209 PF00069 0.425
MOD_Plk_1 244 250 PF00069 0.326
MOD_Plk_1 290 296 PF00069 0.611
MOD_Plk_1 301 307 PF00069 0.642
MOD_Plk_1 317 323 PF00069 0.659
MOD_Plk_1 91 97 PF00069 0.449
MOD_Plk_2-3 194 200 PF00069 0.620
MOD_Plk_4 203 209 PF00069 0.391
MOD_Plk_4 245 251 PF00069 0.514
MOD_Plk_4 290 296 PF00069 0.581
MOD_Plk_4 301 307 PF00069 0.745
MOD_Plk_4 75 81 PF00069 0.432
MOD_ProDKin_1 151 157 PF00069 0.565
MOD_ProDKin_1 333 339 PF00069 0.576
MOD_ProDKin_1 385 391 PF00069 0.721
MOD_ProDKin_1 46 52 PF00069 0.378
MOD_SUMO_rev_2 17 23 PF00179 0.428
TRG_DiLeu_BaEn_1 161 166 PF01217 0.313
TRG_DiLeu_BaEn_1 20 25 PF01217 0.492
TRG_DiLeu_BaEn_1 40 45 PF01217 0.419
TRG_DiLeu_BaEn_1 58 63 PF01217 0.368
TRG_DiLeu_BaEn_2 181 187 PF01217 0.611
TRG_ENDOCYTIC_2 121 124 PF00928 0.464
TRG_ENDOCYTIC_2 53 56 PF00928 0.419
TRG_ER_diArg_1 125 127 PF00400 0.560
TRG_NES_CRM1_1 210 223 PF08389 0.456
TRG_NLS_Bipartite_1 407 427 PF00514 0.659
TRG_NLS_MonoExtC_3 8 13 PF00514 0.703
TRG_NLS_MonoExtN_4 405 411 PF00514 0.686
TRG_NLS_MonoExtN_4 9 16 PF00514 0.584

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBI5 Leptomonas seymouri 50% 100%
A0A1X0NVH3 Trypanosomatidae 33% 100%
A0A3S7WY90 Leishmania donovani 86% 100%
A0A422N8J6 Trypanosoma rangeli 32% 100%
A4HDF7 Leishmania braziliensis 74% 100%
A4I0T8 Leishmania infantum 85% 100%
D0A770 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
Q4QAN2 Leishmania major 86% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS