Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWU1_LEIMU

TriTrypDb:

LmxM.24.1000

Length:

547

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWU1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.680
CLV_NRD_NRD_1	1	3	PF00675	0.627
CLV_NRD_NRD_1	222	224	PF00675	0.606
CLV_NRD_NRD_1	343	345	PF00675	0.651
CLV_NRD_NRD_1	416	418	PF00675	0.568
CLV_NRD_NRD_1	423	425	PF00675	0.548
CLV_PCSK_KEX2_1	177	179	PF00082	0.731
CLV_PCSK_KEX2_1	19	21	PF00082	0.540
CLV_PCSK_KEX2_1	222	224	PF00082	0.606
CLV_PCSK_KEX2_1	3	5	PF00082	0.673
CLV_PCSK_KEX2_1	342	344	PF00082	0.646
CLV_PCSK_KEX2_1	416	418	PF00082	0.568
CLV_PCSK_KEX2_1	423	425	PF00082	0.548
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.557
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.540
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.673
CLV_PCSK_SKI1_1	40	44	PF00082	0.454
CLV_PCSK_SKI1_1	416	420	PF00082	0.580
CLV_PCSK_SKI1_1	459	463	PF00082	0.510
CLV_Separin_Metazoa	468	472	PF03568	0.601
DEG_APCC_DBOX_1	3	11	PF00400	0.634
DEG_Nend_UBRbox_1	1	4	PF02207	0.691
DEG_SPOP_SBC_1	240	244	PF00917	0.616
DEG_SPOP_SBC_1	302	306	PF00917	0.495
DEG_SPOP_SBC_1	450	454	PF00917	0.634
DOC_CDC14_PxL_1	260	268	PF14671	0.674
DOC_MAPK_gen_1	2	10	PF00069	0.635
DOC_MAPK_gen_1	352	360	PF00069	0.503
DOC_MAPK_RevD_3	209	223	PF00069	0.496
DOC_PP2B_LxvP_1	401	404	PF13499	0.670
DOC_PP4_FxxP_1	542	545	PF00568	0.544
DOC_USP7_MATH_1	140	144	PF00917	0.711
DOC_USP7_MATH_1	153	157	PF00917	0.643
DOC_USP7_MATH_1	169	173	PF00917	0.825
DOC_USP7_MATH_1	218	222	PF00917	0.791
DOC_USP7_MATH_1	255	259	PF00917	0.681
DOC_USP7_MATH_1	280	284	PF00917	0.731
DOC_USP7_MATH_1	288	292	PF00917	0.726
DOC_USP7_MATH_1	302	306	PF00917	0.587
DOC_USP7_MATH_1	310	314	PF00917	0.671
DOC_USP7_MATH_1	450	454	PF00917	0.794
DOC_USP7_MATH_1	492	496	PF00917	0.735
DOC_USP7_MATH_1	527	531	PF00917	0.547
DOC_USP7_MATH_1	535	539	PF00917	0.534
DOC_WW_Pin1_4	114	119	PF00397	0.674
DOC_WW_Pin1_4	146	151	PF00397	0.679
DOC_WW_Pin1_4	266	271	PF00397	0.675
DOC_WW_Pin1_4	282	287	PF00397	0.733
DOC_WW_Pin1_4	358	363	PF00397	0.513
DOC_WW_Pin1_4	515	520	PF00397	0.534
DOC_WW_Pin1_4	87	92	PF00397	0.762
LIG_14-3-3_CanoR_1	499	505	PF00244	0.524
LIG_BRCT_BRCA1_1	451	455	PF00533	0.560
LIG_BRCT_BRCA1_1	517	521	PF00533	0.658
LIG_EVH1_1	401	405	PF00568	0.661
LIG_EVH1_2	126	130	PF00568	0.673
LIG_FHA_1	254	260	PF00498	0.692
LIG_FHA_1	446	452	PF00498	0.646
LIG_FHA_1	460	466	PF00498	0.620
LIG_FHA_1	508	514	PF00498	0.728
LIG_FHA_1	518	524	PF00498	0.665
LIG_FHA_2	100	106	PF00498	0.622
LIG_FHA_2	23	29	PF00498	0.641
LIG_FHA_2	292	298	PF00498	0.655
LIG_FHA_2	407	413	PF00498	0.609
LIG_LIR_Apic_2	540	545	PF02991	0.465
LIG_LIR_Gen_1	258	268	PF02991	0.611
LIG_LIR_Gen_1	324	334	PF02991	0.614
LIG_LIR_Gen_1	452	463	PF02991	0.513
LIG_LIR_Nem_3	128	133	PF02991	0.605
LIG_LIR_Nem_3	258	263	PF02991	0.621
LIG_LIR_Nem_3	28	34	PF02991	0.609
LIG_LIR_Nem_3	452	458	PF02991	0.515
LIG_MYND_1	231	235	PF01753	0.684
LIG_NBox_RRM_1	39	49	PF00076	0.408
LIG_NRBOX	105	111	PF00104	0.555
LIG_PTB_Apo_2	157	164	PF02174	0.684
LIG_PTB_Phospho_1	157	163	PF10480	0.683
LIG_SH2_CRK	260	264	PF00017	0.683
LIG_SH2_PTP2	393	396	PF00017	0.644
LIG_SH2_SRC	393	396	PF00017	0.644
LIG_SH2_STAT3	122	125	PF00017	0.549
LIG_SH2_STAT5	393	396	PF00017	0.693
LIG_SH3_2	466	471	PF14604	0.717
LIG_SH3_3	115	121	PF00018	0.768
LIG_SH3_3	129	135	PF00018	0.604
LIG_SH3_3	147	153	PF00018	0.682
LIG_SH3_3	177	183	PF00018	0.746
LIG_SH3_3	264	270	PF00018	0.562
LIG_SH3_3	399	405	PF00018	0.684
LIG_SH3_3	463	469	PF00018	0.706
LIG_SUMO_SIM_anti_2	102	112	PF11976	0.516
LIG_SUMO_SIM_par_1	207	212	PF11976	0.608
LIG_SUMO_SIM_par_1	6	12	PF11976	0.635
LIG_TRAF2_1	52	55	PF00917	0.419
LIG_TRFH_1	260	264	PF08558	0.683
LIG_WW_3	182	186	PF00397	0.666
LIG_WW_3	405	409	PF00397	0.625
MOD_CDK_SPK_2	358	363	PF00069	0.511
MOD_CK1_1	189	195	PF00069	0.714
MOD_CK1_1	239	245	PF00069	0.725
MOD_CK1_1	258	264	PF00069	0.631
MOD_CK1_1	284	290	PF00069	0.673
MOD_CK1_1	291	297	PF00069	0.657
MOD_CK1_1	368	374	PF00069	0.707
MOD_CK1_1	397	403	PF00069	0.554
MOD_CK1_1	437	443	PF00069	0.595
MOD_CK1_1	495	501	PF00069	0.616
MOD_CK1_1	537	543	PF00069	0.500
MOD_CK2_1	22	28	PF00069	0.672
MOD_CK2_1	291	297	PF00069	0.705
MOD_CK2_1	406	412	PF00069	0.617
MOD_CK2_1	451	457	PF00069	0.646
MOD_CK2_1	79	85	PF00069	0.572
MOD_CK2_1	99	105	PF00069	0.362
MOD_GlcNHglycan	127	130	PF01048	0.771
MOD_GlcNHglycan	138	141	PF01048	0.630
MOD_GlcNHglycan	142	145	PF01048	0.597
MOD_GlcNHglycan	172	175	PF01048	0.551
MOD_GlcNHglycan	191	194	PF01048	0.792
MOD_GlcNHglycan	195	198	PF01048	0.734
MOD_GlcNHglycan	238	241	PF01048	0.673
MOD_GlcNHglycan	244	247	PF01048	0.712
MOD_GlcNHglycan	290	293	PF01048	0.571
MOD_GlcNHglycan	305	308	PF01048	0.514
MOD_GlcNHglycan	367	370	PF01048	0.714
MOD_GlcNHglycan	372	375	PF01048	0.651
MOD_GlcNHglycan	476	480	PF01048	0.610
MOD_GlcNHglycan	500	503	PF01048	0.747
MOD_GlcNHglycan	537	540	PF01048	0.629
MOD_GSK3_1	136	143	PF00069	0.593
MOD_GSK3_1	183	190	PF00069	0.791
MOD_GSK3_1	236	243	PF00069	0.781
MOD_GSK3_1	266	273	PF00069	0.640
MOD_GSK3_1	278	285	PF00069	0.807
MOD_GSK3_1	381	388	PF00069	0.616
MOD_GSK3_1	445	452	PF00069	0.596
MOD_GSK3_1	493	500	PF00069	0.603
MOD_GSK3_1	507	514	PF00069	0.663
MOD_GSK3_1	515	522	PF00069	0.607
MOD_LATS_1	18	24	PF00433	0.658
MOD_N-GLC_1	437	442	PF02516	0.595
MOD_N-GLC_2	337	339	PF02516	0.632
MOD_NEK2_1	236	241	PF00069	0.663
MOD_NEK2_1	347	352	PF00069	0.635
MOD_NEK2_1	451	456	PF00069	0.646
MOD_NEK2_1	475	480	PF00069	0.532
MOD_NEK2_2	255	260	PF00069	0.631
MOD_NEK2_2	519	524	PF00069	0.506
MOD_NEK2_2	527	532	PF00069	0.444
MOD_PIKK_1	183	189	PF00454	0.716
MOD_PIKK_1	394	400	PF00454	0.630
MOD_PIKK_1	511	517	PF00454	0.738
MOD_PIKK_1	71	77	PF00454	0.553
MOD_PIKK_1	79	85	PF00454	0.538
MOD_PKA_2	246	252	PF00069	0.630
MOD_PKA_2	498	504	PF00069	0.512
MOD_Plk_1	437	443	PF00069	0.595
MOD_Plk_4	153	159	PF00069	0.624
MOD_Plk_4	255	261	PF00069	0.669
MOD_Plk_4	273	279	PF00069	0.695
MOD_Plk_4	437	443	PF00069	0.644
MOD_Plk_4	527	533	PF00069	0.455
MOD_ProDKin_1	114	120	PF00069	0.679
MOD_ProDKin_1	146	152	PF00069	0.675
MOD_ProDKin_1	266	272	PF00069	0.677
MOD_ProDKin_1	282	288	PF00069	0.733
MOD_ProDKin_1	358	364	PF00069	0.515
MOD_ProDKin_1	515	521	PF00069	0.534
MOD_ProDKin_1	87	93	PF00069	0.762
TRG_DiLeu_BaEn_1	105	110	PF01217	0.505
TRG_ENDOCYTIC_2	260	263	PF00928	0.686
TRG_ENDOCYTIC_2	393	396	PF00928	0.653
TRG_ER_diArg_1	1	4	PF00400	0.575
TRG_ER_diArg_1	341	344	PF00400	0.648
TRG_ER_diArg_1	416	418	PF00400	0.537
TRG_NLS_MonoExtN_4	423	428	PF00514	0.609
TRG_Pf-PMV_PEXEL_1	416	420	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IEV1	Leishmania donovani	86%	100%
A4HDF6	Leishmania braziliensis	58%	100%
E9AH58	Leishmania infantum	86%	100%
Q4QAN3	Leishmania major	84%	100%