Putative replication factor C, subunit 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

replication factor C, subunit 1, putative

Species:

Leishmania mexicana

UniProt:

E9AWU0_LEIMU

TriTrypDb:

LmxM.24.0990

Length:

659

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005663	DNA replication factor C complex	2	11
GO:0032991	protein-containing complex	1	11
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AWU0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWU0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006259	DNA metabolic process	4	11
GO:0006260	DNA replication	5	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0006281	DNA repair	5	5
GO:0006950	response to stress	2	5
GO:0006974	DNA damage response	4	5
GO:0033554	cellular response to stress	3	5
GO:0050896	response to stimulus	1	5
GO:0051716	cellular response to stimulus	2	5

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	11
GO:0003677	DNA binding	4	11
GO:0003689	DNA clamp loader activity	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0008094	ATP-dependent activity, acting on DNA	2	11
GO:0016462	pyrophosphatase activity	5	9
GO:0016787	hydrolase activity	2	9
GO:0016817	hydrolase activity, acting on acid anhydrides	3	9
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	9
GO:0016887	ATP hydrolysis activity	7	9
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	9
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140097	catalytic activity, acting on DNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:0140657	ATP-dependent activity	1	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.292
CLV_C14_Caspase3-7	250	254	PF00656	0.541
CLV_C14_Caspase3-7	324	328	PF00656	0.370
CLV_C14_Caspase3-7	630	634	PF00656	0.557
CLV_C14_Caspase3-7	654	658	PF00656	0.712
CLV_NRD_NRD_1	101	103	PF00675	0.335
CLV_NRD_NRD_1	394	396	PF00675	0.396
CLV_NRD_NRD_1	532	534	PF00675	0.789
CLV_NRD_NRD_1	558	560	PF00675	0.700
CLV_NRD_NRD_1	577	579	PF00675	0.735
CLV_NRD_NRD_1	619	621	PF00675	0.664
CLV_PCSK_KEX2_1	394	396	PF00082	0.306
CLV_PCSK_KEX2_1	511	513	PF00082	0.687
CLV_PCSK_KEX2_1	558	560	PF00082	0.498
CLV_PCSK_KEX2_1	619	621	PF00082	0.641
CLV_PCSK_PC1ET2_1	511	513	PF00082	0.687
CLV_PCSK_PC1ET2_1	558	560	PF00082	0.498
CLV_PCSK_PC1ET2_1	619	621	PF00082	0.660
CLV_PCSK_SKI1_1	103	107	PF00082	0.373
CLV_PCSK_SKI1_1	170	174	PF00082	0.431
CLV_PCSK_SKI1_1	207	211	PF00082	0.404
CLV_PCSK_SKI1_1	222	226	PF00082	0.374
CLV_PCSK_SKI1_1	376	380	PF00082	0.306
CLV_PCSK_SKI1_1	394	398	PF00082	0.306
CLV_PCSK_SKI1_1	429	433	PF00082	0.417
CLV_PCSK_SKI1_1	489	493	PF00082	0.306
CLV_PCSK_SKI1_1	599	603	PF00082	0.739
DEG_APCC_DBOX_1	169	177	PF00400	0.419
DEG_APCC_DBOX_1	221	229	PF00400	0.370
DEG_APCC_DBOX_1	393	401	PF00400	0.450
DEG_APCC_KENBOX_2	105	109	PF00400	0.373
DEG_SPOP_SBC_1	346	350	PF00917	0.417
DEG_SPOP_SBC_1	567	571	PF00917	0.703
DEG_SPOP_SBC_1	600	604	PF00917	0.749
DEG_SPOP_SBC_1	639	643	PF00917	0.755
DOC_CYCLIN_RxL_1	164	177	PF00134	0.426
DOC_CYCLIN_RxL_1	204	212	PF00134	0.415
DOC_MAPK_gen_1	61	68	PF00069	0.541
DOC_PP1_RVXF_1	374	381	PF00149	0.306
DOC_PP2B_LxvP_1	431	434	PF13499	0.417
DOC_PP4_FxxP_1	181	184	PF00568	0.500
DOC_PP4_MxPP_1	478	481	PF00568	0.236
DOC_SPAK_OSR1_1	343	347	PF12202	0.417
DOC_USP7_MATH_1	14	18	PF00917	0.698
DOC_USP7_MATH_1	2	6	PF00917	0.677
DOC_USP7_MATH_1	247	251	PF00917	0.506
DOC_USP7_MATH_1	319	323	PF00917	0.397
DOC_USP7_MATH_1	487	491	PF00917	0.359
DOC_USP7_MATH_1	568	572	PF00917	0.753
DOC_USP7_MATH_1	582	586	PF00917	0.681
DOC_USP7_MATH_1	600	604	PF00917	0.799
DOC_USP7_MATH_1	609	613	PF00917	0.719
DOC_USP7_MATH_1	625	629	PF00917	0.702
DOC_USP7_MATH_1	639	643	PF00917	0.611
DOC_USP7_UBL2_3	507	511	PF12436	0.649
DOC_USP7_UBL2_3	558	562	PF12436	0.761
DOC_USP7_UBL2_3	579	583	PF12436	0.663
DOC_USP7_UBL2_3	615	619	PF12436	0.704
DOC_WW_Pin1_4	471	476	PF00397	0.383
DOC_WW_Pin1_4	48	53	PF00397	0.541
DOC_WW_Pin1_4	635	640	PF00397	0.695
DOC_WW_Pin1_4	68	73	PF00397	0.417
LIG_14-3-3_CanoR_1	100	106	PF00244	0.306
LIG_14-3-3_CanoR_1	116	125	PF00244	0.306
LIG_14-3-3_CanoR_1	180	184	PF00244	0.507
LIG_14-3-3_CanoR_1	235	239	PF00244	0.501
LIG_14-3-3_CanoR_1	429	434	PF00244	0.380
LIG_14-3-3_CanoR_1	581	587	PF00244	0.784
LIG_14-3-3_CanoR_1	606	614	PF00244	0.559
LIG_Actin_WH2_2	136	153	PF00022	0.504
LIG_CtBP_PxDLS_1	202	207	PF00389	0.430
LIG_DLG_GKlike_1	501	509	PF00625	0.575
LIG_eIF4E_1	125	131	PF01652	0.306
LIG_eIF4E_1	285	291	PF01652	0.493
LIG_FHA_1	124	130	PF00498	0.398
LIG_FHA_1	430	436	PF00498	0.302
LIG_FHA_1	630	636	PF00498	0.702
LIG_FHA_1	75	81	PF00498	0.306
LIG_FHA_2	158	164	PF00498	0.362
LIG_FHA_2	234	240	PF00498	0.495
LIG_FHA_2	515	521	PF00498	0.718
LIG_FHA_2	88	94	PF00498	0.417
LIG_Integrin_RGD_1	512	514	PF01839	0.745
LIG_LIR_Apic_2	178	184	PF02991	0.499
LIG_LIR_Gen_1	123	132	PF02991	0.350
LIG_LIR_Gen_1	342	352	PF02991	0.378
LIG_LIR_Gen_1	451	459	PF02991	0.305
LIG_LIR_Gen_1	499	510	PF02991	0.602
LIG_LIR_Nem_3	123	128	PF02991	0.350
LIG_LIR_Nem_3	263	267	PF02991	0.457
LIG_LIR_Nem_3	297	302	PF02991	0.367
LIG_LIR_Nem_3	342	347	PF02991	0.353
LIG_LIR_Nem_3	458	463	PF02991	0.310
LIG_LIR_Nem_3	48	53	PF02991	0.573
LIG_LIR_Nem_3	499	505	PF02991	0.585
LIG_NRBOX	168	174	PF00104	0.448
LIG_Pex14_1	22	26	PF04695	0.400
LIG_Pex14_1	46	50	PF04695	0.415
LIG_Pex14_2	492	496	PF04695	0.306
LIG_PTB_Apo_2	112	119	PF02174	0.325
LIG_SH2_CRK	125	129	PF00017	0.378
LIG_SH2_GRB2like	125	128	PF00017	0.359
LIG_SH2_GRB2like	285	288	PF00017	0.491
LIG_SH2_SRC	422	425	PF00017	0.373
LIG_SH2_STAP1	125	129	PF00017	0.325
LIG_SH2_STAP1	361	365	PF00017	0.325
LIG_SH2_STAT3	302	305	PF00017	0.524
LIG_SH2_STAT3	334	337	PF00017	0.325
LIG_SH2_STAT5	125	128	PF00017	0.348
LIG_SH2_STAT5	175	178	PF00017	0.402
LIG_SH2_STAT5	192	195	PF00017	0.362
LIG_SH2_STAT5	264	267	PF00017	0.470
LIG_SH2_STAT5	299	302	PF00017	0.371
LIG_SH2_STAT5	356	359	PF00017	0.398
LIG_SH2_STAT5	422	425	PF00017	0.302
LIG_SH2_STAT5	81	84	PF00017	0.306
LIG_SH3_3	375	381	PF00018	0.306
LIG_SH3_3	57	63	PF00018	0.627
LIG_SH3_4	207	214	PF00018	0.518
LIG_SH3_4	579	586	PF00018	0.721
LIG_SUMO_SIM_anti_2	126	134	PF11976	0.382
LIG_SUMO_SIM_par_1	126	134	PF11976	0.351
LIG_SxIP_EBH_1	151	161	PF03271	0.406
LIG_TYR_ITSM	121	128	PF00017	0.450
LIG_UBA3_1	209	216	PF00899	0.529
LIG_WRC_WIRS_1	361	366	PF05994	0.306
LIG_WRC_WIRS_1	502	507	PF05994	0.584
MOD_CK1_1	101	107	PF00069	0.306
MOD_CK1_1	234	240	PF00069	0.597
MOD_CK1_1	474	480	PF00069	0.439
MOD_CK1_1	490	496	PF00069	0.361
MOD_CK1_1	627	633	PF00069	0.661
MOD_CK1_1	634	640	PF00069	0.648
MOD_CK1_1	641	647	PF00069	0.625
MOD_CK1_1	648	654	PF00069	0.669
MOD_CK2_1	101	107	PF00069	0.306
MOD_CK2_1	14	20	PF00069	0.603
MOD_CK2_1	233	239	PF00069	0.509
MOD_CK2_1	268	274	PF00069	0.441
MOD_CK2_1	27	33	PF00069	0.394
MOD_CK2_1	625	631	PF00069	0.628
MOD_CK2_1	653	659	PF00069	0.742
MOD_CK2_1	87	93	PF00069	0.358
MOD_GlcNHglycan	118	121	PF01048	0.464
MOD_GlcNHglycan	216	219	PF01048	0.439
MOD_GlcNHglycan	388	391	PF01048	0.326
MOD_GlcNHglycan	4	7	PF01048	0.657
MOD_GlcNHglycan	411	414	PF01048	0.306
MOD_GlcNHglycan	489	492	PF01048	0.350
MOD_GlcNHglycan	584	587	PF01048	0.721
MOD_GlcNHglycan	644	647	PF01048	0.745
MOD_GlcNHglycan	68	71	PF01048	0.293
MOD_GSK3_1	116	123	PF00069	0.318
MOD_GSK3_1	216	223	PF00069	0.324
MOD_GSK3_1	247	254	PF00069	0.640
MOD_GSK3_1	314	321	PF00069	0.519
MOD_GSK3_1	48	55	PF00069	0.519
MOD_GSK3_1	483	490	PF00069	0.304
MOD_GSK3_1	501	508	PF00069	0.630
MOD_GSK3_1	566	573	PF00069	0.754
MOD_GSK3_1	601	608	PF00069	0.742
MOD_GSK3_1	609	616	PF00069	0.779
MOD_GSK3_1	625	632	PF00069	0.677
MOD_GSK3_1	633	640	PF00069	0.627
MOD_GSK3_1	641	648	PF00069	0.576
MOD_GSK3_1	649	656	PF00069	0.635
MOD_GSK3_1	94	101	PF00069	0.297
MOD_LATS_1	166	172	PF00433	0.427
MOD_N-GLC_1	107	112	PF02516	0.329
MOD_N-GLC_1	337	342	PF02516	0.306
MOD_N-GLC_1	386	391	PF02516	0.306
MOD_N-GLC_1	496	501	PF02516	0.454
MOD_N-GLC_1	94	99	PF02516	0.306
MOD_NEK2_1	149	154	PF00069	0.403
MOD_NEK2_1	179	184	PF00069	0.460
MOD_NEK2_1	233	238	PF00069	0.560
MOD_NEK2_1	267	272	PF00069	0.401
MOD_NEK2_1	347	352	PF00069	0.378
MOD_NEK2_1	402	407	PF00069	0.313
MOD_NEK2_1	496	501	PF00069	0.450
MOD_NEK2_1	505	510	PF00069	0.534
MOD_NEK2_1	87	92	PF00069	0.375
MOD_NEK2_2	506	511	PF00069	0.641
MOD_PIKK_1	314	320	PF00454	0.539
MOD_PIKK_1	411	417	PF00454	0.365
MOD_PIKK_1	514	520	PF00454	0.705
MOD_PK_1	151	157	PF00069	0.231
MOD_PK_1	27	33	PF00069	0.506
MOD_PKA_2	101	107	PF00069	0.348
MOD_PKA_2	120	126	PF00069	0.120
MOD_PKA_2	179	185	PF00069	0.410
MOD_PKA_2	234	240	PF00069	0.508
MOD_PKA_2	274	280	PF00069	0.505
MOD_PKA_2	592	598	PF00069	0.737
MOD_PKA_2	605	611	PF00069	0.695
MOD_PKB_1	622	630	PF00069	0.690
MOD_Plk_1	337	343	PF00069	0.306
MOD_Plk_2-3	274	280	PF00069	0.532
MOD_Plk_4	274	280	PF00069	0.411
MOD_Plk_4	360	366	PF00069	0.320
MOD_Plk_4	379	385	PF00069	0.325
MOD_Plk_4	76	82	PF00069	0.306
MOD_Plk_4	87	93	PF00069	0.302
MOD_ProDKin_1	471	477	PF00069	0.383
MOD_ProDKin_1	48	54	PF00069	0.551
MOD_ProDKin_1	635	641	PF00069	0.694
MOD_ProDKin_1	68	74	PF00069	0.417
MOD_SUMO_rev_2	55	63	PF00179	0.598
TRG_DiLeu_BaLyEn_6	205	210	PF01217	0.514
TRG_DiLeu_BaLyEn_6	392	397	PF01217	0.348
TRG_ENDOCYTIC_2	125	128	PF00928	0.348
TRG_ENDOCYTIC_2	264	267	PF00928	0.470
TRG_ENDOCYTIC_2	361	364	PF00928	0.323
TRG_ENDOCYTIC_2	453	456	PF00928	0.306
TRG_ENDOCYTIC_2	469	472	PF00928	0.450
TRG_ER_diArg_1	394	396	PF00400	0.417
TRG_ER_diArg_1	99	102	PF00400	0.327
TRG_NLS_Bipartite_1	583	601	PF00514	0.783
TRG_NLS_MonoCore_2	577	582	PF00514	0.756
TRG_NLS_MonoCore_2	618	623	PF00514	0.689
TRG_NLS_MonoExtC_3	557	562	PF00514	0.687
TRG_NLS_MonoExtC_3	619	624	PF00514	0.673
TRG_NLS_MonoExtN_4	558	563	PF00514	0.688
TRG_NLS_MonoExtN_4	594	601	PF00514	0.739
TRG_NLS_MonoExtN_4	619	625	PF00514	0.697
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.306
TRG_Pf-PMV_PEXEL_1	196	201	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	241	245	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5X2	Leptomonas seymouri	77%	100%
A0A1X0NVJ4	Trypanosomatidae	68%	100%
A0A3R7KMZ0	Trypanosoma rangeli	65%	100%
A0A3S7WYE5	Leishmania donovani	94%	100%
A4HDF5	Leishmania braziliensis	89%	100%
A4I0T7	Leishmania infantum	94%	100%
D0A768	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
O60182	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	71%
P35600	Drosophila melanogaster	31%	67%
P38630	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	77%
Q4QAN4	Leishmania major	92%	100%
Q9C587	Arabidopsis thaliana	32%	69%
V5BAM4	Trypanosoma cruzi	65%	100%