FAD-binding PCMH-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWT8_LEIMU

TriTrypDb:

LmxM.24.0970

Length:

751

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWT8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWT8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	300	304	PF00656	0.531
CLV_C14_Caspase3-7	578	582	PF00656	0.600
CLV_MEL_PAP_1	535	541	PF00089	0.502
CLV_NRD_NRD_1	158	160	PF00675	0.663
CLV_NRD_NRD_1	169	171	PF00675	0.521
CLV_NRD_NRD_1	183	185	PF00675	0.600
CLV_NRD_NRD_1	271	273	PF00675	0.600
CLV_NRD_NRD_1	289	291	PF00675	0.633
CLV_NRD_NRD_1	517	519	PF00675	0.485
CLV_NRD_NRD_1	541	543	PF00675	0.480
CLV_NRD_NRD_1	593	595	PF00675	0.519
CLV_NRD_NRD_1	65	67	PF00675	0.688
CLV_NRD_NRD_1	663	665	PF00675	0.540
CLV_NRD_NRD_1	679	681	PF00675	0.442
CLV_NRD_NRD_1	747	749	PF00675	0.339
CLV_PCSK_KEX2_1	158	160	PF00082	0.663
CLV_PCSK_KEX2_1	169	171	PF00082	0.521
CLV_PCSK_KEX2_1	183	185	PF00082	0.600
CLV_PCSK_KEX2_1	271	273	PF00082	0.600
CLV_PCSK_KEX2_1	289	291	PF00082	0.633
CLV_PCSK_KEX2_1	517	519	PF00082	0.485
CLV_PCSK_KEX2_1	541	543	PF00082	0.480
CLV_PCSK_KEX2_1	593	595	PF00082	0.519
CLV_PCSK_KEX2_1	663	665	PF00082	0.528
CLV_PCSK_KEX2_1	679	681	PF00082	0.430
CLV_PCSK_KEX2_1	69	71	PF00082	0.667
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.611
CLV_PCSK_PC7_1	513	519	PF00082	0.463
CLV_PCSK_SKI1_1	296	300	PF00082	0.585
CLV_PCSK_SKI1_1	322	326	PF00082	0.579
CLV_PCSK_SKI1_1	367	371	PF00082	0.547
CLV_PCSK_SKI1_1	518	522	PF00082	0.552
CLV_PCSK_SKI1_1	556	560	PF00082	0.552
CLV_PCSK_SKI1_1	610	614	PF00082	0.519
CLV_PCSK_SKI1_1	66	70	PF00082	0.742
CLV_PCSK_SKI1_1	691	695	PF00082	0.396
CLV_PCSK_SKI1_1	740	744	PF00082	0.392
CLV_Separin_Metazoa	293	297	PF03568	0.287
CLV_Separin_Metazoa	355	359	PF03568	0.356
DEG_Nend_UBRbox_1	1	4	PF02207	0.400
DEG_SPOP_SBC_1	297	301	PF00917	0.395
DOC_CDC14_PxL_1	23	31	PF14671	0.459
DOC_CDC14_PxL_1	281	289	PF14671	0.323
DOC_CKS1_1	472	477	PF01111	0.600
DOC_CYCLIN_yCln2_LP_2	522	528	PF00134	0.642
DOC_MAPK_gen_1	169	177	PF00069	0.264
DOC_MAPK_gen_1	289	297	PF00069	0.289
DOC_PP2B_LxvP_1	477	480	PF13499	0.608
DOC_PP2B_PxIxI_1	45	51	PF00149	0.402
DOC_USP7_MATH_1	106	110	PF00917	0.501
DOC_USP7_MATH_1	136	140	PF00917	0.390
DOC_USP7_MATH_1	298	302	PF00917	0.400
DOC_USP7_MATH_1	32	36	PF00917	0.349
DOC_USP7_MATH_1	387	391	PF00917	0.431
DOC_USP7_MATH_1	408	412	PF00917	0.510
DOC_USP7_MATH_1	439	443	PF00917	0.565
DOC_USP7_MATH_1	451	455	PF00917	0.277
DOC_USP7_MATH_1	456	460	PF00917	0.301
DOC_USP7_MATH_1	480	484	PF00917	0.695
DOC_USP7_MATH_1	573	577	PF00917	0.683
DOC_USP7_MATH_1	68	72	PF00917	0.420
DOC_USP7_MATH_1	741	745	PF00917	0.625
DOC_USP7_MATH_1	81	85	PF00917	0.550
DOC_WW_Pin1_4	231	236	PF00397	0.472
DOC_WW_Pin1_4	276	281	PF00397	0.429
DOC_WW_Pin1_4	339	344	PF00397	0.544
DOC_WW_Pin1_4	41	46	PF00397	0.559
DOC_WW_Pin1_4	471	476	PF00397	0.589
DOC_WW_Pin1_4	521	526	PF00397	0.651
DOC_WW_Pin1_4	582	587	PF00397	0.718
DOC_WW_Pin1_4	668	673	PF00397	0.674
DOC_WW_Pin1_4	728	733	PF00397	0.747
DOC_WW_Pin1_4	79	84	PF00397	0.560
LIG_14-3-3_CanoR_1	397	404	PF00244	0.501
LIG_14-3-3_CanoR_1	513	517	PF00244	0.653
LIG_14-3-3_CanoR_1	518	523	PF00244	0.746
LIG_14-3-3_CanoR_1	679	685	PF00244	0.674
LIG_14-3-3_CanoR_1	740	746	PF00244	0.608
LIG_14-3-3_CanoR_1	76	80	PF00244	0.607
LIG_APCC_ABBA_1	20	25	PF00400	0.500
LIG_APCC_Cbox_1	265	271	PF00515	0.308
LIG_BRCT_BRCA1_1	453	457	PF00533	0.325
LIG_BRCT_BRCA1_1	481	485	PF00533	0.569
LIG_BRCT_BRCA1_1	497	501	PF00533	0.570
LIG_CaM_IQ_9	648	663	PF13499	0.632
LIG_eIF4E_1	23	29	PF01652	0.474
LIG_FHA_1	139	145	PF00498	0.517
LIG_FHA_1	147	153	PF00498	0.383
LIG_FHA_1	227	233	PF00498	0.468
LIG_FHA_1	311	317	PF00498	0.478
LIG_FHA_1	319	325	PF00498	0.404
LIG_FHA_1	393	399	PF00498	0.420
LIG_FHA_1	445	451	PF00498	0.392
LIG_FHA_1	462	468	PF00498	0.227
LIG_FHA_1	472	478	PF00498	0.612
LIG_FHA_1	5	11	PF00498	0.399
LIG_FHA_1	553	559	PF00498	0.751
LIG_FHA_1	601	607	PF00498	0.769
LIG_FHA_1	692	698	PF00498	0.573
LIG_FHA_1	718	724	PF00498	0.724
LIG_FHA_1	729	735	PF00498	0.591
LIG_FHA_1	741	747	PF00498	0.599
LIG_FHA_2	576	582	PF00498	0.595
LIG_FHA_2	728	734	PF00498	0.600
LIG_HP1_1	451	455	PF01393	0.214
LIG_LIR_Apic_2	515	519	PF02991	0.579
LIG_LIR_Gen_1	498	508	PF02991	0.570
LIG_LIR_Gen_1	5	15	PF02991	0.419
LIG_LIR_Gen_1	720	726	PF02991	0.724
LIG_LIR_Nem_3	482	488	PF02991	0.563
LIG_LIR_Nem_3	498	504	PF02991	0.579
LIG_LIR_Nem_3	5	11	PF02991	0.337
LIG_LIR_Nem_3	720	724	PF02991	0.727
LIG_LIR_Nem_3	737	742	PF02991	0.711
LIG_OCRL_FandH_1	262	274	PF00620	0.312
LIG_PCNA_PIPBox_1	489	498	PF02747	0.634
LIG_PTB_Apo_2	332	339	PF02174	0.438
LIG_PTB_Phospho_1	332	338	PF10480	0.435
LIG_SH2_CRK	644	648	PF00017	0.709
LIG_SH2_CRK	721	725	PF00017	0.649
LIG_SH2_GRB2like	562	565	PF00017	0.672
LIG_SH2_NCK_1	388	392	PF00017	0.510
LIG_SH2_PTP2	162	165	PF00017	0.432
LIG_SH2_SRC	162	165	PF00017	0.421
LIG_SH2_STAP1	171	175	PF00017	0.424
LIG_SH2_STAP1	194	198	PF00017	0.364
LIG_SH2_STAP1	644	648	PF00017	0.709
LIG_SH2_STAP1	717	721	PF00017	0.725
LIG_SH2_STAT5	151	154	PF00017	0.475
LIG_SH2_STAT5	162	165	PF00017	0.432
LIG_SH2_STAT5	323	326	PF00017	0.368
LIG_SH2_STAT5	424	427	PF00017	0.485
LIG_SH2_STAT5	562	565	PF00017	0.659
LIG_SH3_3	172	178	PF00018	0.352
LIG_SH3_3	422	428	PF00018	0.482
LIG_SUMO_SIM_anti_2	464	469	PF11976	0.335
LIG_SUMO_SIM_par_1	25	31	PF11976	0.473
LIG_SUMO_SIM_par_1	518	524	PF11976	0.745
LIG_SUMO_SIM_par_1	722	728	PF11976	0.632
LIG_SUMO_SIM_par_1	98	104	PF11976	0.470
LIG_TRFH_1	8	12	PF08558	0.488
LIG_TYR_ITIM	719	724	PF00017	0.509
LIG_WW_1	673	676	PF00397	0.477
MOD_CDC14_SPxK_1	279	282	PF00782	0.506
MOD_CDK_SPxK_1	276	282	PF00069	0.526
MOD_CK1_1	109	115	PF00069	0.640
MOD_CK1_1	138	144	PF00069	0.585
MOD_CK1_1	206	212	PF00069	0.626
MOD_CK1_1	318	324	PF00069	0.629
MOD_CK1_1	434	440	PF00069	0.622
MOD_CK1_1	442	448	PF00069	0.705
MOD_CK1_1	461	467	PF00069	0.196
MOD_CK1_1	483	489	PF00069	0.446
MOD_CK1_1	503	509	PF00069	0.545
MOD_CK1_1	580	586	PF00069	0.590
MOD_CK1_1	589	595	PF00069	0.704
MOD_CK1_1	686	692	PF00069	0.742
MOD_CK1_1	75	81	PF00069	0.689
MOD_CK1_1	82	88	PF00069	0.776
MOD_CK2_1	727	733	PF00069	0.489
MOD_Cter_Amidation	539	542	PF01082	0.584
MOD_Cter_Amidation	64	67	PF01082	0.589
MOD_GlcNHglycan	111	114	PF01048	0.567
MOD_GlcNHglycan	138	141	PF01048	0.676
MOD_GlcNHglycan	208	211	PF01048	0.510
MOD_GlcNHglycan	214	217	PF01048	0.510
MOD_GlcNHglycan	32	35	PF01048	0.414
MOD_GlcNHglycan	327	330	PF01048	0.420
MOD_GlcNHglycan	358	361	PF01048	0.438
MOD_GlcNHglycan	362	365	PF01048	0.439
MOD_GlcNHglycan	389	392	PF01048	0.529
MOD_GlcNHglycan	421	424	PF01048	0.611
MOD_GlcNHglycan	425	428	PF01048	0.594
MOD_GlcNHglycan	433	436	PF01048	0.582
MOD_GlcNHglycan	458	461	PF01048	0.346
MOD_GlcNHglycan	485	488	PF01048	0.512
MOD_GlcNHglycan	497	500	PF01048	0.381
MOD_GlcNHglycan	575	578	PF01048	0.510
MOD_GlcNHglycan	603	606	PF01048	0.665
MOD_GlcNHglycan	688	691	PF01048	0.720
MOD_GlcNHglycan	70	73	PF01048	0.619
MOD_GlcNHglycan	706	709	PF01048	0.460
MOD_GlcNHglycan	84	87	PF01048	0.604
MOD_GSK3_1	212	219	PF00069	0.602
MOD_GSK3_1	276	283	PF00069	0.530
MOD_GSK3_1	28	35	PF00069	0.521
MOD_GSK3_1	299	306	PF00069	0.590
MOD_GSK3_1	356	363	PF00069	0.431
MOD_GSK3_1	392	399	PF00069	0.479
MOD_GSK3_1	419	426	PF00069	0.711
MOD_GSK3_1	430	437	PF00069	0.617
MOD_GSK3_1	439	446	PF00069	0.467
MOD_GSK3_1	451	458	PF00069	0.280
MOD_GSK3_1	479	486	PF00069	0.574
MOD_GSK3_1	573	580	PF00069	0.548
MOD_GSK3_1	582	589	PF00069	0.645
MOD_GSK3_1	68	75	PF00069	0.780
MOD_N-GLC_1	338	343	PF02516	0.370
MOD_N-GLC_1	408	413	PF02516	0.595
MOD_NEK2_1	111	116	PF00069	0.423
MOD_NEK2_1	135	140	PF00069	0.632
MOD_NEK2_1	198	203	PF00069	0.418
MOD_NEK2_1	254	259	PF00069	0.560
MOD_NEK2_1	28	33	PF00069	0.526
MOD_NEK2_1	325	330	PF00069	0.490
MOD_NEK2_1	337	342	PF00069	0.392
MOD_NEK2_1	356	361	PF00069	0.572
MOD_NEK2_1	429	434	PF00069	0.646
MOD_NEK2_1	455	460	PF00069	0.346
MOD_NEK2_1	512	517	PF00069	0.655
MOD_NEK2_1	56	61	PF00069	0.658
MOD_NEK2_1	621	626	PF00069	0.488
MOD_NEK2_2	106	111	PF00069	0.629
MOD_NEK2_2	32	37	PF00069	0.354
MOD_NEK2_2	480	485	PF00069	0.560
MOD_NEK2_2	623	628	PF00069	0.661
MOD_PIKK_1	124	130	PF00454	0.372
MOD_PIKK_1	621	627	PF00454	0.735
MOD_PKA_2	1	7	PF00069	0.433
MOD_PKA_2	136	142	PF00069	0.519
MOD_PKA_2	203	209	PF00069	0.660
MOD_PKA_2	396	402	PF00069	0.634
MOD_PKA_2	419	425	PF00069	0.712
MOD_PKA_2	429	435	PF00069	0.610
MOD_PKA_2	512	518	PF00069	0.537
MOD_PKA_2	573	579	PF00069	0.521
MOD_PKA_2	75	81	PF00069	0.724
MOD_Plk_1	18	24	PF00069	0.550
MOD_Plk_1	4	10	PF00069	0.400
MOD_Plk_1	691	697	PF00069	0.414
MOD_Plk_2-3	575	581	PF00069	0.476
MOD_Plk_4	18	24	PF00069	0.648
MOD_Plk_4	203	209	PF00069	0.501
MOD_Plk_4	480	486	PF00069	0.450
MOD_Plk_4	500	506	PF00069	0.320
MOD_Plk_4	518	524	PF00069	0.689
MOD_Plk_4	586	592	PF00069	0.728
MOD_Plk_4	683	689	PF00069	0.596
MOD_Plk_4	741	747	PF00069	0.496
MOD_ProDKin_1	231	237	PF00069	0.587
MOD_ProDKin_1	276	282	PF00069	0.526
MOD_ProDKin_1	339	345	PF00069	0.688
MOD_ProDKin_1	41	47	PF00069	0.713
MOD_ProDKin_1	471	477	PF00069	0.473
MOD_ProDKin_1	521	527	PF00069	0.554
MOD_ProDKin_1	582	588	PF00069	0.646
MOD_ProDKin_1	668	674	PF00069	0.590
MOD_ProDKin_1	728	734	PF00069	0.697
MOD_ProDKin_1	79	85	PF00069	0.710
MOD_SUMO_rev_2	363	372	PF00179	0.445
TRG_DiLeu_BaEn_1	25	30	PF01217	0.488
TRG_DiLeu_BaEn_2	496	502	PF01217	0.456
TRG_DiLeu_BaLyEn_6	227	232	PF01217	0.599
TRG_DiLeu_BaLyEn_6	24	29	PF01217	0.598
TRG_DiLeu_BaLyEn_6	244	249	PF01217	0.567
TRG_ENDOCYTIC_2	644	647	PF00928	0.527
TRG_ENDOCYTIC_2	721	724	PF00928	0.509
TRG_ENDOCYTIC_2	739	742	PF00928	0.627
TRG_ER_diArg_1	169	171	PF00400	0.405
TRG_ER_diArg_1	182	184	PF00400	0.545
TRG_ER_diArg_1	270	272	PF00400	0.481
TRG_ER_diArg_1	288	290	PF00400	0.475
TRG_ER_diArg_1	516	518	PF00400	0.593
TRG_ER_diArg_1	593	596	PF00400	0.694
TRG_ER_diArg_1	607	610	PF00400	0.476
TRG_ER_diArg_1	663	665	PF00400	0.677
TRG_NLS_MonoExtC_3	65	70	PF00514	0.497
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.352
TRG_Pf-PMV_PEXEL_1	289	293	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKM5	Leptomonas seymouri	39%	98%
A0A3Q8IG41	Leishmania donovani	87%	98%
A4HDF3	Leishmania braziliensis	71%	100%
A4I0T6	Leishmania infantum	87%	98%
Q4QAN6	Leishmania major	85%	99%