Rab-GAP TBC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rab-GTPase-TBC domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AWT6_LEIMU

TriTrypDb:

LmxM.24.0950

Length:

399

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWT6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWT6

Function

Biological processes
Term	Name	Level	Count
GO:0043085	positive regulation of catalytic activity	4	1
GO:0043087	regulation of GTPase activity	5	1
GO:0043547	positive regulation of GTPase activity	6	1
GO:0044093	positive regulation of molecular function	3	1
GO:0050790	regulation of catalytic activity	3	1
GO:0051336	regulation of hydrolase activity	4	1
GO:0051345	positive regulation of hydrolase activity	5	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1
GO:0090630	activation of GTPase activity	7	1

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	1
GO:0008047	enzyme activator activity	3	1
GO:0030234	enzyme regulator activity	2	1
GO:0030695	GTPase regulator activity	4	1
GO:0060589	nucleoside-triphosphatase regulator activity	3	1
GO:0098772	molecular function regulator activity	1	1
GO:0140677	molecular function activator activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.476
CLV_C14_Caspase3-7	98	102	PF00656	0.455
CLV_NRD_NRD_1	381	383	PF00675	0.542
CLV_PCSK_SKI1_1	110	114	PF00082	0.657
CLV_PCSK_SKI1_1	284	288	PF00082	0.492
CLV_PCSK_SKI1_1	383	387	PF00082	0.532
CLV_PCSK_SKI1_1	394	398	PF00082	0.431
CLV_PCSK_SKI1_1	41	45	PF00082	0.427
DEG_APCC_DBOX_1	283	291	PF00400	0.464
DOC_CDC14_PxL_1	369	377	PF14671	0.543
DOC_MAPK_gen_1	22	31	PF00069	0.589
DOC_MAPK_MEF2A_6	41	48	PF00069	0.406
DOC_USP7_MATH_1	331	335	PF00917	0.492
LIG_14-3-3_CanoR_1	140	147	PF00244	0.504
LIG_14-3-3_CanoR_1	240	250	PF00244	0.492
LIG_Actin_WH2_2	9	26	PF00022	0.463
LIG_BIR_II_1	1	5	PF00653	0.610
LIG_BRCT_BRCA1_1	135	139	PF00533	0.715
LIG_EH1_1	106	114	PF00400	0.659
LIG_FHA_1	352	358	PF00498	0.357
LIG_FHA_1	375	381	PF00498	0.538
LIG_FHA_1	71	77	PF00498	0.563
LIG_FHA_2	106	112	PF00498	0.666
LIG_FHA_2	298	304	PF00498	0.444
LIG_FHA_2	54	60	PF00498	0.606
LIG_LIR_Gen_1	300	309	PF02991	0.492
LIG_LIR_Gen_1	62	72	PF02991	0.457
LIG_LIR_Nem_3	136	142	PF02991	0.717
LIG_LIR_Nem_3	247	252	PF02991	0.378
LIG_LIR_Nem_3	300	305	PF02991	0.436
LIG_LIR_Nem_3	62	68	PF02991	0.459
LIG_NRBOX	229	235	PF00104	0.492
LIG_Pex14_2	279	283	PF04695	0.357
LIG_PTB_Apo_2	66	73	PF02174	0.598
LIG_PTB_Phospho_1	66	72	PF10480	0.591
LIG_Rb_LxCxE_1	364	378	PF01857	0.545
LIG_REV1ctd_RIR_1	310	318	PF16727	0.492
LIG_SH2_CRK	168	172	PF00017	0.618
LIG_SH2_CRK	220	224	PF00017	0.548
LIG_SH2_CRK	344	348	PF00017	0.492
LIG_SH2_CRK	35	39	PF00017	0.414
LIG_SH2_CRK	40	44	PF00017	0.375
LIG_SH2_STAP1	344	348	PF00017	0.492
LIG_SH2_STAP1	392	396	PF00017	0.596
LIG_SH2_STAP1	72	76	PF00017	0.642
LIG_SH2_STAT5	195	198	PF00017	0.477
LIG_SH2_STAT5	220	223	PF00017	0.499
LIG_SH2_STAT5	329	332	PF00017	0.357
LIG_SH2_STAT5	367	370	PF00017	0.539
LIG_SH2_STAT5	42	45	PF00017	0.398
LIG_SH2_STAT5	72	75	PF00017	0.633
LIG_SH3_3	159	165	PF00018	0.767
LIG_SH3_3	283	289	PF00018	0.492
LIG_TRAF2_1	185	188	PF00917	0.563
LIG_TRAF2_1	56	59	PF00917	0.630
LIG_TYR_ITIM	218	223	PF00017	0.340
LIG_TYR_ITIM	38	43	PF00017	0.525
LIG_WRC_WIRS_1	112	117	PF05994	0.581
LIG_WW_1	32	35	PF00397	0.464
MOD_CK1_1	116	122	PF00069	0.536
MOD_CK1_1	153	159	PF00069	0.584
MOD_CK1_1	307	313	PF00069	0.486
MOD_CK1_1	351	357	PF00069	0.492
MOD_CK1_1	390	396	PF00069	0.443
MOD_CK1_1	53	59	PF00069	0.552
MOD_CK1_1	96	102	PF00069	0.760
MOD_CK2_1	122	128	PF00069	0.497
MOD_CK2_1	297	303	PF00069	0.379
MOD_CK2_1	349	355	PF00069	0.492
MOD_CK2_1	53	59	PF00069	0.630
MOD_GlcNHglycan	118	121	PF01048	0.678
MOD_GlcNHglycan	124	127	PF01048	0.669
MOD_GlcNHglycan	128	132	PF01048	0.623
MOD_GlcNHglycan	143	146	PF01048	0.503
MOD_GlcNHglycan	152	155	PF01048	0.567
MOD_GlcNHglycan	156	159	PF01048	0.474
MOD_GlcNHglycan	171	174	PF01048	0.609
MOD_GlcNHglycan	179	182	PF01048	0.542
MOD_GlcNHglycan	210	213	PF01048	0.451
MOD_GlcNHglycan	243	246	PF01048	0.492
MOD_GlcNHglycan	93	96	PF01048	0.797
MOD_GSK3_1	111	118	PF00069	0.406
MOD_GSK3_1	150	157	PF00069	0.780
MOD_GSK3_1	241	248	PF00069	0.408
MOD_GSK3_1	46	53	PF00069	0.483
MOD_GSK3_1	91	98	PF00069	0.724
MOD_N-GLC_1	221	226	PF02516	0.547
MOD_NEK2_1	113	118	PF00069	0.663
MOD_NEK2_1	133	138	PF00069	0.458
MOD_NEK2_1	282	287	PF00069	0.351
MOD_NEK2_1	349	354	PF00069	0.492
MOD_NEK2_1	375	380	PF00069	0.314
MOD_NEK2_1	67	72	PF00069	0.489
MOD_NEK2_2	105	110	PF00069	0.621
MOD_NEK2_2	135	140	PF00069	0.502
MOD_NEK2_2	245	250	PF00069	0.492
MOD_PIKK_1	257	263	PF00454	0.415
MOD_PKA_2	245	251	PF00069	0.492
MOD_PKA_2	387	393	PF00069	0.554
MOD_Plk_1	221	227	PF00069	0.546
MOD_Plk_1	24	30	PF00069	0.515
MOD_Plk_1	375	381	PF00069	0.246
MOD_Plk_1	53	59	PF00069	0.490
MOD_Plk_2-3	292	298	PF00069	0.412
MOD_Plk_4	245	251	PF00069	0.412
MOD_Plk_4	304	310	PF00069	0.383
MOD_Plk_4	387	393	PF00069	0.437
TRG_ENDOCYTIC_2	220	223	PF00928	0.544
TRG_ENDOCYTIC_2	291	294	PF00928	0.339
TRG_ENDOCYTIC_2	344	347	PF00928	0.369
TRG_ENDOCYTIC_2	35	38	PF00928	0.430
TRG_ENDOCYTIC_2	40	43	PF00928	0.364
TRG_ENDOCYTIC_2	72	75	PF00928	0.633

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WY95	Leishmania donovani	94%	100%
A0A422NHQ9	Trypanosoma rangeli	38%	100%
A4HDF1	Leishmania braziliensis	85%	100%
A4I0T4	Leishmania infantum	94%	100%
D0A763	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4QAN8	Leishmania major	94%	100%
V5BAM9	Trypanosoma cruzi	37%	92%