Vacuolar protein sorting complex subunit

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWT4_LEIMU

TriTrypDb:

LmxM.24.0930

Length:

929

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AWT4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWT4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	259	263	PF00656	0.454
CLV_C14_Caspase3-7	314	318	PF00656	0.475
CLV_C14_Caspase3-7	870	874	PF00656	0.742
CLV_MEL_PAP_1	898	904	PF00089	0.567
CLV_NRD_NRD_1	487	489	PF00675	0.555
CLV_NRD_NRD_1	495	497	PF00675	0.535
CLV_NRD_NRD_1	65	67	PF00675	0.746
CLV_NRD_NRD_1	750	752	PF00675	0.691
CLV_PCSK_KEX2_1	487	489	PF00082	0.555
CLV_PCSK_KEX2_1	495	497	PF00082	0.535
CLV_PCSK_KEX2_1	64	66	PF00082	0.751
CLV_PCSK_KEX2_1	750	752	PF00082	0.691
CLV_PCSK_SKI1_1	103	107	PF00082	0.496
CLV_PCSK_SKI1_1	141	145	PF00082	0.512
CLV_PCSK_SKI1_1	248	252	PF00082	0.549
CLV_PCSK_SKI1_1	426	430	PF00082	0.548
CLV_PCSK_SKI1_1	495	499	PF00082	0.619
CLV_PCSK_SKI1_1	532	536	PF00082	0.537
CLV_PCSK_SKI1_1	634	638	PF00082	0.784
CLV_PCSK_SKI1_1	80	84	PF00082	0.446
CLV_PCSK_SKI1_1	886	890	PF00082	0.538
DEG_APCC_DBOX_1	885	893	PF00400	0.543
DEG_Nend_UBRbox_1	1	4	PF02207	0.622
DEG_SCF_FBW7_1	105	110	PF00400	0.668
DEG_SPOP_SBC_1	119	123	PF00917	0.553
DOC_CKS1_1	104	109	PF01111	0.600
DOC_CYCLIN_yCln2_LP_2	251	257	PF00134	0.476
DOC_CYCLIN_yCln2_LP_2	399	405	PF00134	0.555
DOC_MAPK_gen_1	392	401	PF00069	0.512
DOC_MAPK_gen_1	906	914	PF00069	0.526
DOC_MAPK_HePTP_8	154	166	PF00069	0.556
DOC_MAPK_MEF2A_6	157	166	PF00069	0.591
DOC_MAPK_MEF2A_6	248	257	PF00069	0.368
DOC_MAPK_MEF2A_6	908	916	PF00069	0.517
DOC_MAPK_NFAT4_5	248	256	PF00069	0.364
DOC_PP2B_LxvP_1	251	254	PF13499	0.539
DOC_PP2B_LxvP_1	358	361	PF13499	0.482
DOC_PP2B_LxvP_1	399	402	PF13499	0.532
DOC_PP2B_LxvP_1	84	87	PF13499	0.556
DOC_PP4_FxxP_1	104	107	PF00568	0.604
DOC_USP7_MATH_1	118	122	PF00917	0.643
DOC_USP7_MATH_1	126	130	PF00917	0.541
DOC_USP7_MATH_1	150	154	PF00917	0.527
DOC_USP7_MATH_1	207	211	PF00917	0.669
DOC_USP7_MATH_1	342	346	PF00917	0.545
DOC_USP7_MATH_1	51	55	PF00917	0.549
DOC_USP7_MATH_1	646	650	PF00917	0.697
DOC_USP7_MATH_1	682	686	PF00917	0.553
DOC_USP7_MATH_1	763	767	PF00917	0.772
DOC_USP7_MATH_1	827	831	PF00917	0.702
DOC_USP7_MATH_1	85	89	PF00917	0.471
DOC_USP7_MATH_1	874	878	PF00917	0.791
DOC_USP7_MATH_1	880	884	PF00917	0.657
DOC_WW_Pin1_4	103	108	PF00397	0.535
DOC_WW_Pin1_4	186	191	PF00397	0.617
DOC_WW_Pin1_4	257	262	PF00397	0.471
DOC_WW_Pin1_4	547	552	PF00397	0.724
DOC_WW_Pin1_4	567	572	PF00397	0.507
DOC_WW_Pin1_4	618	623	PF00397	0.520
DOC_WW_Pin1_4	73	78	PF00397	0.479
DOC_WW_Pin1_4	759	764	PF00397	0.727
LIG_14-3-3_CanoR_1	132	138	PF00244	0.647
LIG_14-3-3_CanoR_1	174	182	PF00244	0.495
LIG_14-3-3_CanoR_1	222	227	PF00244	0.579
LIG_14-3-3_CanoR_1	248	254	PF00244	0.458
LIG_14-3-3_CanoR_1	283	288	PF00244	0.534
LIG_14-3-3_CanoR_1	37	42	PF00244	0.526
LIG_14-3-3_CanoR_1	434	444	PF00244	0.520
LIG_14-3-3_CanoR_1	66	72	PF00244	0.653
LIG_14-3-3_CanoR_1	80	85	PF00244	0.343
LIG_14-3-3_CanoR_1	901	905	PF00244	0.554
LIG_14-3-3_CanoR_1	906	911	PF00244	0.560
LIG_Actin_WH2_2	479	497	PF00022	0.539
LIG_Actin_WH2_2	885	903	PF00022	0.568
LIG_APCC_ABBA_1	922	927	PF00400	0.555
LIG_CAP-Gly_1	926	929	PF01302	0.609
LIG_Clathr_ClatBox_1	856	860	PF01394	0.710
LIG_Clathr_ClatBox_1	91	95	PF01394	0.441
LIG_deltaCOP1_diTrp_1	307	311	PF00928	0.701
LIG_eIF4E_1	427	433	PF01652	0.451
LIG_FHA_1	166	172	PF00498	0.545
LIG_FHA_1	176	182	PF00498	0.521
LIG_FHA_1	436	442	PF00498	0.565
LIG_FHA_1	478	484	PF00498	0.586
LIG_FHA_1	732	738	PF00498	0.685
LIG_FHA_1	742	748	PF00498	0.536
LIG_FHA_1	773	779	PF00498	0.642
LIG_FHA_1	782	788	PF00498	0.595
LIG_FHA_1	81	87	PF00498	0.425
LIG_FHA_1	842	848	PF00498	0.552
LIG_FHA_1	915	921	PF00498	0.551
LIG_FHA_2	104	110	PF00498	0.365
LIG_FHA_2	415	421	PF00498	0.690
LIG_FHA_2	533	539	PF00498	0.542
LIG_FHA_2	774	780	PF00498	0.542
LIG_LIR_Gen_1	307	316	PF02991	0.695
LIG_LIR_Gen_1	371	380	PF02991	0.481
LIG_LIR_Gen_1	386	395	PF02991	0.524
LIG_LIR_Gen_1	909	916	PF02991	0.531
LIG_LIR_Gen_1	917	925	PF02991	0.551
LIG_LIR_LC3C_4	744	749	PF02991	0.601
LIG_LIR_Nem_3	307	311	PF02991	0.765
LIG_LIR_Nem_3	371	375	PF02991	0.461
LIG_LIR_Nem_3	378	383	PF02991	0.528
LIG_LIR_Nem_3	386	390	PF02991	0.517
LIG_LIR_Nem_3	744	748	PF02991	0.578
LIG_LIR_Nem_3	806	811	PF02991	0.518
LIG_LIR_Nem_3	909	913	PF02991	0.517
LIG_LIR_Nem_3	917	922	PF02991	0.559
LIG_PCNA_PIPBox_1	584	593	PF02747	0.658
LIG_PCNA_yPIPBox_3	583	591	PF02747	0.660
LIG_Rb_pABgroove_1	919	927	PF01858	0.556
LIG_SH2_CRK	372	376	PF00017	0.438
LIG_SH2_CRK	745	749	PF00017	0.585
LIG_SH2_NCK_1	372	376	PF00017	0.461
LIG_SH2_NCK_1	380	384	PF00017	0.526
LIG_SH2_PTP2	919	922	PF00017	0.546
LIG_SH2_SRC	330	333	PF00017	0.306
LIG_SH2_STAP1	380	384	PF00017	0.540
LIG_SH2_STAP1	469	473	PF00017	0.575
LIG_SH2_STAP1	925	929	PF00017	0.601
LIG_SH2_STAT3	244	247	PF00017	0.458
LIG_SH2_STAT3	427	430	PF00017	0.543
LIG_SH2_STAT5	330	333	PF00017	0.496
LIG_SH2_STAT5	368	371	PF00017	0.427
LIG_SH2_STAT5	372	375	PF00017	0.415
LIG_SH2_STAT5	590	593	PF00017	0.672
LIG_SH2_STAT5	810	813	PF00017	0.641
LIG_SH2_STAT5	919	922	PF00017	0.546
LIG_SH3_3	128	134	PF00018	0.683
LIG_SH3_3	136	142	PF00018	0.474
LIG_SH3_3	255	261	PF00018	0.620
LIG_SH3_3	545	551	PF00018	0.797
LIG_SH3_3	816	822	PF00018	0.530
LIG_SUMO_SIM_anti_2	189	195	PF11976	0.687
LIG_SUMO_SIM_anti_2	223	228	PF11976	0.464
LIG_SUMO_SIM_anti_2	438	445	PF11976	0.609
LIG_SUMO_SIM_anti_2	779	785	PF11976	0.575
LIG_SUMO_SIM_anti_2	88	95	PF11976	0.456
LIG_SUMO_SIM_par_1	82	88	PF11976	0.450
LIG_SUMO_SIM_par_1	855	863	PF11976	0.742
LIG_SUMO_SIM_par_1	89	95	PF11976	0.457
LIG_SUMO_SIM_par_1	920	928	PF11976	0.560
LIG_TRAF2_1	595	598	PF00917	0.790
LIG_TRFH_1	47	51	PF08558	0.608
MOD_CDK_SPxxK_3	73	80	PF00069	0.477
MOD_CK1_1	153	159	PF00069	0.653
MOD_CK1_1	189	195	PF00069	0.723
MOD_CK1_1	260	266	PF00069	0.656
MOD_CK1_1	546	552	PF00069	0.791
MOD_CK1_1	567	573	PF00069	0.545
MOD_CK1_1	589	595	PF00069	0.771
MOD_CK1_1	6	12	PF00069	0.580
MOD_CK1_1	649	655	PF00069	0.692
MOD_CK1_1	773	779	PF00069	0.500
MOD_CK1_1	781	787	PF00069	0.490
MOD_CK1_1	823	829	PF00069	0.649
MOD_CK1_1	830	836	PF00069	0.696
MOD_CK2_1	342	348	PF00069	0.645
MOD_CK2_1	5	11	PF00069	0.593
MOD_CK2_1	532	538	PF00069	0.538
MOD_CK2_1	765	771	PF00069	0.755
MOD_Cter_Amidation	62	65	PF01082	0.486
MOD_GlcNHglycan	113	116	PF01048	0.686
MOD_GlcNHglycan	122	125	PF01048	0.595
MOD_GlcNHglycan	205	208	PF01048	0.611
MOD_GlcNHglycan	209	212	PF01048	0.760
MOD_GlcNHglycan	218	221	PF01048	0.582
MOD_GlcNHglycan	262	265	PF01048	0.675
MOD_GlcNHglycan	288	291	PF01048	0.667
MOD_GlcNHglycan	313	316	PF01048	0.694
MOD_GlcNHglycan	355	358	PF01048	0.595
MOD_GlcNHglycan	409	412	PF01048	0.552
MOD_GlcNHglycan	545	548	PF01048	0.789
MOD_GlcNHglycan	551	554	PF01048	0.810
MOD_GlcNHglycan	579	582	PF01048	0.690
MOD_GlcNHglycan	637	640	PF01048	0.699
MOD_GlcNHglycan	646	649	PF01048	0.713
MOD_GlcNHglycan	677	681	PF01048	0.655
MOD_GlcNHglycan	728	731	PF01048	0.547
MOD_GlcNHglycan	765	768	PF01048	0.748
MOD_GlcNHglycan	77	80	PF01048	0.538
MOD_GlcNHglycan	829	832	PF01048	0.683
MOD_GlcNHglycan	838	841	PF01048	0.655
MOD_GlcNHglycan	851	855	PF01048	0.407
MOD_GlcNHglycan	87	90	PF01048	0.482
MOD_GlcNHglycan	876	880	PF01048	0.702
MOD_GlcNHglycan	883	886	PF01048	0.668
MOD_GSK3_1	103	110	PF00069	0.523
MOD_GSK3_1	203	210	PF00069	0.746
MOD_GSK3_1	216	223	PF00069	0.621
MOD_GSK3_1	256	263	PF00069	0.496
MOD_GSK3_1	35	42	PF00069	0.532
MOD_GSK3_1	543	550	PF00069	0.827
MOD_GSK3_1	563	570	PF00069	0.503
MOD_GSK3_1	586	593	PF00069	0.688
MOD_GSK3_1	623	630	PF00069	0.760
MOD_GSK3_1	640	647	PF00069	0.583
MOD_GSK3_1	678	685	PF00069	0.588
MOD_GSK3_1	759	766	PF00069	0.799
MOD_GSK3_1	778	785	PF00069	0.371
MOD_GSK3_1	823	830	PF00069	0.681
MOD_GSK3_1	846	853	PF00069	0.392
MOD_GSK3_1	902	909	PF00069	0.564
MOD_N-GLC_1	353	358	PF02516	0.610
MOD_N-GLC_1	45	50	PF02516	0.383
MOD_N-GLC_2	686	688	PF02516	0.502
MOD_NEK2_1	14	19	PF00069	0.501
MOD_NEK2_1	202	207	PF00069	0.730
MOD_NEK2_1	249	254	PF00069	0.537
MOD_NEK2_1	3	8	PF00069	0.601
MOD_NEK2_1	311	316	PF00069	0.636
MOD_NEK2_1	407	412	PF00069	0.560
MOD_NEK2_1	432	437	PF00069	0.541
MOD_NEK2_1	45	50	PF00069	0.495
MOD_NEK2_1	489	494	PF00069	0.562
MOD_NEK2_1	512	517	PF00069	0.564
MOD_NEK2_1	579	584	PF00069	0.785
MOD_NEK2_1	627	632	PF00069	0.599
MOD_NEK2_1	678	683	PF00069	0.515
MOD_NEK2_1	770	775	PF00069	0.679
MOD_NEK2_1	782	787	PF00069	0.534
MOD_NEK2_1	900	905	PF00069	0.552
MOD_PIKK_1	26	32	PF00454	0.492
MOD_PIKK_1	477	483	PF00454	0.679
MOD_PIKK_1	593	599	PF00454	0.684
MOD_PIKK_1	649	655	PF00454	0.737
MOD_PKA_1	495	501	PF00069	0.514
MOD_PKA_2	294	300	PF00069	0.765
MOD_PKA_2	36	42	PF00069	0.517
MOD_PKA_2	373	379	PF00069	0.605
MOD_PKA_2	495	501	PF00069	0.514
MOD_PKA_2	519	525	PF00069	0.742
MOD_PKA_2	543	549	PF00069	0.758
MOD_PKA_2	900	906	PF00069	0.555
MOD_Plk_1	353	359	PF00069	0.605
MOD_Plk_1	370	376	PF00069	0.301
MOD_Plk_1	45	51	PF00069	0.390
MOD_Plk_1	453	459	PF00069	0.492
MOD_Plk_1	770	776	PF00069	0.687
MOD_Plk_1	778	784	PF00069	0.580
MOD_Plk_4	189	195	PF00069	0.687
MOD_Plk_4	222	228	PF00069	0.451
MOD_Plk_4	342	348	PF00069	0.627
MOD_Plk_4	386	392	PF00069	0.300
MOD_Plk_4	40	46	PF00069	0.558
MOD_Plk_4	489	495	PF00069	0.594
MOD_Plk_4	51	57	PF00069	0.474
MOD_Plk_4	569	575	PF00069	0.823
MOD_Plk_4	586	592	PF00069	0.505
MOD_Plk_4	623	629	PF00069	0.601
MOD_Plk_4	765	771	PF00069	0.670
MOD_Plk_4	778	784	PF00069	0.439
MOD_Plk_4	803	809	PF00069	0.531
MOD_Plk_4	841	847	PF00069	0.570
MOD_Plk_4	920	926	PF00069	0.542
MOD_ProDKin_1	103	109	PF00069	0.557
MOD_ProDKin_1	186	192	PF00069	0.630
MOD_ProDKin_1	257	263	PF00069	0.471
MOD_ProDKin_1	547	553	PF00069	0.723
MOD_ProDKin_1	567	573	PF00069	0.506
MOD_ProDKin_1	618	624	PF00069	0.518
MOD_ProDKin_1	73	79	PF00069	0.476
MOD_ProDKin_1	759	765	PF00069	0.723
MOD_SUMO_for_1	787	790	PF00179	0.631
MOD_SUMO_rev_2	669	678	PF00179	0.708
TRG_DiLeu_BaEn_1	97	102	PF01217	0.612
TRG_DiLeu_BaLyEn_6	403	408	PF01217	0.597
TRG_DiLeu_BaLyEn_6	852	857	PF01217	0.590
TRG_ENDOCYTIC_2	372	375	PF00928	0.462
TRG_ENDOCYTIC_2	380	383	PF00928	0.531
TRG_ENDOCYTIC_2	745	748	PF00928	0.581
TRG_ENDOCYTIC_2	808	811	PF00928	0.504
TRG_ENDOCYTIC_2	919	922	PF00928	0.546
TRG_ER_diArg_1	391	394	PF00400	0.513
TRG_ER_diArg_1	486	488	PF00400	0.537
TRG_ER_diArg_1	494	496	PF00400	0.488
TRG_ER_diArg_1	64	66	PF00400	0.474
TRG_ER_diArg_1	749	751	PF00400	0.661
TRG_Pf-PMV_PEXEL_1	487	491	PF00026	0.636
TRG_Pf-PMV_PEXEL_1	532	536	PF00026	0.751
TRG_Pf-PMV_PEXEL_1	855	860	PF00026	0.633

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5F2	Leptomonas seymouri	43%	90%
A0A3Q8ICU6	Leishmania donovani	88%	99%
A4HDE9	Leishmania braziliensis	73%	100%
A4I0T2	Leishmania infantum	88%	99%
Q4QAP0	Leishmania major	88%	100%