Methyltransf_25 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWT3_LEIMU

TriTrypDb:

LmxM.24.0920

Length:

454

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWT3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	232	236	PF00656	0.616
CLV_C14_Caspase3-7	332	336	PF00656	0.520
CLV_C14_Caspase3-7	380	384	PF00656	0.501
CLV_NRD_NRD_1	107	109	PF00675	0.406
CLV_NRD_NRD_1	199	201	PF00675	0.508
CLV_PCSK_KEX2_1	107	109	PF00082	0.378
CLV_PCSK_KEX2_1	199	201	PF00082	0.508
CLV_PCSK_KEX2_1	229	231	PF00082	0.709
CLV_PCSK_KEX2_1	368	370	PF00082	0.279
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.571
CLV_PCSK_PC1ET2_1	368	370	PF00082	0.257
CLV_PCSK_SKI1_1	131	135	PF00082	0.453
CLV_PCSK_SKI1_1	389	393	PF00082	0.353
CLV_Separin_Metazoa	443	447	PF03568	0.446
DEG_SPOP_SBC_1	258	262	PF00917	0.504
DOC_ANK_TNKS_1	410	417	PF00023	0.642
DOC_MAPK_gen_1	288	296	PF00069	0.355
DOC_MAPK_MEF2A_6	158	165	PF00069	0.554
DOC_PP1_RVXF_1	384	391	PF00149	0.469
DOC_USP7_MATH_1	18	22	PF00917	0.699
DOC_USP7_MATH_1	190	194	PF00917	0.510
DOC_USP7_MATH_1	209	213	PF00917	0.264
DOC_USP7_MATH_1	25	29	PF00917	0.671
DOC_USP7_MATH_1	258	262	PF00917	0.661
DOC_USP7_MATH_1	290	294	PF00917	0.438
DOC_USP7_MATH_1	64	68	PF00917	0.641
DOC_USP7_MATH_1	70	74	PF00917	0.644
DOC_USP7_UBL2_3	395	399	PF12436	0.348
DOC_WW_Pin1_4	242	247	PF00397	0.615
DOC_WW_Pin1_4	437	442	PF00397	0.482
LIG_14-3-3_CanoR_1	136	146	PF00244	0.469
LIG_14-3-3_CanoR_1	216	221	PF00244	0.316
LIG_14-3-3_CanoR_1	291	295	PF00244	0.447
LIG_14-3-3_CanoR_1	353	358	PF00244	0.421
LIG_APCC_ABBAyCdc20_2	13	19	PF00400	0.495
LIG_BIR_II_1	1	5	PF00653	0.811
LIG_BIR_III_2	41	45	PF00653	0.434
LIG_BIR_III_4	153	157	PF00653	0.586
LIG_deltaCOP1_diTrp_1	308	314	PF00928	0.318
LIG_eIF4E_1	215	221	PF01652	0.436
LIG_EVH1_1	243	247	PF00568	0.554
LIG_FHA_1	138	144	PF00498	0.577
LIG_FHA_1	170	176	PF00498	0.340
LIG_FHA_1	356	362	PF00498	0.505
LIG_FHA_1	440	446	PF00498	0.413
LIG_FHA_2	330	336	PF00498	0.532
LIG_FHA_2	372	378	PF00498	0.474
LIG_GBD_Chelix_1	321	329	PF00786	0.421
LIG_LIR_Gen_1	111	117	PF02991	0.488
LIG_LIR_Gen_1	159	168	PF02991	0.545
LIG_LIR_Gen_1	39	44	PF02991	0.429
LIG_LIR_LC3C_4	293	296	PF02991	0.426
LIG_LIR_Nem_3	104	109	PF02991	0.365
LIG_LIR_Nem_3	111	116	PF02991	0.347
LIG_LIR_Nem_3	159	165	PF02991	0.572
LIG_LIR_Nem_3	212	218	PF02991	0.503
LIG_LIR_Nem_3	362	367	PF02991	0.495
LIG_LIR_Nem_3	39	43	PF02991	0.431
LIG_NRBOX	324	330	PF00104	0.391
LIG_PCNA_PIPBox_1	55	64	PF02747	0.434
LIG_PCNA_yPIPBox_3	53	62	PF02747	0.425
LIG_Pex14_1	299	303	PF04695	0.344
LIG_Pex14_2	367	371	PF04695	0.353
LIG_REV1ctd_RIR_1	389	399	PF16727	0.499
LIG_SH2_CRK	113	117	PF00017	0.354
LIG_SH2_CRK	215	219	PF00017	0.490
LIG_SH2_STAP1	113	117	PF00017	0.338
LIG_SH2_STAP1	191	195	PF00017	0.392
LIG_SH2_STAP1	357	361	PF00017	0.494
LIG_SH2_STAT5	303	306	PF00017	0.337
LIG_SH2_STAT5	357	360	PF00017	0.503
LIG_SH2_STAT5	364	367	PF00017	0.467
LIG_SH3_1	438	444	PF00018	0.514
LIG_SH3_2	441	446	PF14604	0.572
LIG_SH3_3	241	247	PF00018	0.696
LIG_SH3_3	438	444	PF00018	0.514
LIG_SH3_3	82	88	PF00018	0.593
LIG_SUMO_SIM_anti_2	217	222	PF11976	0.429
LIG_SUMO_SIM_par_1	337	343	PF11976	0.334
LIG_WRC_WIRS_1	95	100	PF05994	0.427
MOD_CK1_1	193	199	PF00069	0.452
MOD_CK1_1	237	243	PF00069	0.731
MOD_CK1_1	256	262	PF00069	0.610
MOD_CK1_1	355	361	PF00069	0.459
MOD_CK1_1	60	66	PF00069	0.592
MOD_CK1_1	73	79	PF00069	0.681
MOD_CK2_1	371	377	PF00069	0.444
MOD_CK2_1	404	410	PF00069	0.708
MOD_CK2_1	437	443	PF00069	0.495
MOD_CMANNOS	432	435	PF00535	0.359
MOD_GlcNHglycan	19	23	PF01048	0.749
MOD_GlcNHglycan	207	210	PF01048	0.462
MOD_GlcNHglycan	211	214	PF01048	0.495
MOD_GlcNHglycan	225	228	PF01048	0.402
MOD_GlcNHglycan	3	6	PF01048	0.717
MOD_GlcNHglycan	347	350	PF01048	0.577
MOD_GlcNHglycan	406	409	PF01048	0.746
MOD_GlcNHglycan	50	53	PF01048	0.568
MOD_GlcNHglycan	62	65	PF01048	0.594
MOD_GlcNHglycan	66	69	PF01048	0.725
MOD_GlcNHglycan	72	75	PF01048	0.645
MOD_GSK3_1	205	212	PF00069	0.379
MOD_GSK3_1	25	32	PF00069	0.723
MOD_GSK3_1	253	260	PF00069	0.528
MOD_GSK3_1	317	324	PF00069	0.514
MOD_GSK3_1	345	352	PF00069	0.494
MOD_GSK3_1	367	374	PF00069	0.437
MOD_GSK3_1	426	433	PF00069	0.335
MOD_GSK3_1	445	452	PF00069	0.610
MOD_GSK3_1	60	67	PF00069	0.524
MOD_GSK3_1	72	79	PF00069	0.616
MOD_GSK3_1	90	97	PF00069	0.617
MOD_LATS_1	214	220	PF00433	0.321
MOD_N-GLC_1	120	125	PF02516	0.484
MOD_N-GLC_1	345	350	PF02516	0.438
MOD_NEK2_1	1	6	PF00069	0.736
MOD_NEK2_1	115	120	PF00069	0.471
MOD_NEK2_1	202	207	PF00069	0.464
MOD_NEK2_1	284	289	PF00069	0.427
MOD_NEK2_1	329	334	PF00069	0.384
MOD_NEK2_1	367	372	PF00069	0.438
MOD_NEK2_1	426	431	PF00069	0.428
MOD_PIKK_1	156	162	PF00454	0.554
MOD_PIKK_1	282	288	PF00454	0.448
MOD_PIKK_1	355	361	PF00454	0.509
MOD_PKA_2	125	131	PF00069	0.441
MOD_PKA_2	290	296	PF00069	0.432
MOD_PKA_2	352	358	PF00069	0.497
MOD_PKA_2	445	451	PF00069	0.610
MOD_Plk_1	120	126	PF00069	0.409
MOD_Plk_1	193	199	PF00069	0.467
MOD_Plk_1	234	240	PF00069	0.595
MOD_Plk_4	125	131	PF00069	0.432
MOD_Plk_4	174	180	PF00069	0.374
MOD_Plk_4	193	199	PF00069	0.532
MOD_Plk_4	216	222	PF00069	0.438
MOD_Plk_4	290	296	PF00069	0.347
MOD_Plk_4	299	305	PF00069	0.310
MOD_Plk_4	317	323	PF00069	0.427
MOD_Plk_4	45	51	PF00069	0.492
MOD_Plk_4	90	96	PF00069	0.615
MOD_ProDKin_1	242	248	PF00069	0.608
MOD_ProDKin_1	437	443	PF00069	0.495
MOD_SUMO_for_1	5	8	PF00179	0.702
MOD_SUMO_rev_2	375	380	PF00179	0.496
TRG_DiLeu_BaEn_1	111	116	PF01217	0.416
TRG_ENDOCYTIC_2	106	109	PF00928	0.371
TRG_ENDOCYTIC_2	113	116	PF00928	0.340
TRG_ENDOCYTIC_2	215	218	PF00928	0.493
TRG_ENDOCYTIC_2	364	367	PF00928	0.228
TRG_ER_diArg_1	106	108	PF00400	0.410
TRG_ER_diArg_1	198	200	PF00400	0.426
TRG_NLS_MonoCore_2	11	16	PF00514	0.695
TRG_NLS_MonoExtN_4	9	16	PF00514	0.733

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYW2	Leptomonas seymouri	57%	100%
A0A0S4IXA1	Bodo saltans	34%	100%
A0A1X0NVG3	Trypanosomatidae	30%	89%
A0A3Q8ICU5	Leishmania donovani	89%	97%
A0A3R7KEJ9	Trypanosoma rangeli	44%	100%
A4HDE8	Leishmania braziliensis	74%	100%
A4I0T1	Leishmania infantum	89%	97%
D0A760	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
Q4QAP1	Leishmania major	89%	100%
V5BVT1	Trypanosoma cruzi	44%	100%