DNA replication licensing factor MCM5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

minchromosome maintenance (MCM) complex subunit, putative

Species:

Leishmania mexicana

UniProt:

E9AWT2_LEIMU

TriTrypDb:

LmxM.24.0910

Length:

801

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0032991	protein-containing complex	1	12
GO:0042555	MCM complex	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9AWT2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWT2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006270	DNA replication initiation	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0007049	cell cycle	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0000727	double-strand break repair via break-induced replication	8	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0033554	cellular response to stress	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003678	DNA helicase activity	3	12
GO:0003688	DNA replication origin binding	7	12
GO:0003690	double-stranded DNA binding	5	12
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008094	ATP-dependent activity, acting on DNA	2	12
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0016887	ATP hydrolysis activity	7	11
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0043565	sequence-specific DNA binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:1990837	sequence-specific double-stranded DNA binding	6	12
GO:0003697	single-stranded DNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	315	319	PF00656	0.517
CLV_C14_Caspase3-7	703	707	PF00656	0.493
CLV_NRD_NRD_1	113	115	PF00675	0.252
CLV_NRD_NRD_1	389	391	PF00675	0.253
CLV_NRD_NRD_1	576	578	PF00675	0.718
CLV_NRD_NRD_1	641	643	PF00675	0.253
CLV_NRD_NRD_1	748	750	PF00675	0.424
CLV_NRD_NRD_1	790	792	PF00675	0.437
CLV_PCSK_KEX2_1	282	284	PF00082	0.522
CLV_PCSK_KEX2_1	391	393	PF00082	0.287
CLV_PCSK_KEX2_1	576	578	PF00082	0.730
CLV_PCSK_KEX2_1	641	643	PF00082	0.253
CLV_PCSK_KEX2_1	747	749	PF00082	0.438
CLV_PCSK_KEX2_1	784	786	PF00082	0.446
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.538
CLV_PCSK_PC1ET2_1	391	393	PF00082	0.287
CLV_PCSK_PC1ET2_1	784	786	PF00082	0.461
CLV_PCSK_SKI1_1	114	118	PF00082	0.463
CLV_PCSK_SKI1_1	251	255	PF00082	0.253
CLV_PCSK_SKI1_1	631	635	PF00082	0.339
CLV_PCSK_SKI1_1	712	716	PF00082	0.264
CLV_PCSK_SKI1_1	749	753	PF00082	0.462
CLV_PCSK_SKI1_1	794	798	PF00082	0.525
CLV_Separin_Metazoa	248	252	PF03568	0.453
DEG_APCC_DBOX_1	694	702	PF00400	0.477
DEG_APCC_DBOX_1	793	801	PF00400	0.545
DEG_Nend_UBRbox_3	1	3	PF02207	0.650
DEG_SPOP_SBC_1	158	162	PF00917	0.539
DOC_CYCLIN_RxL_1	111	121	PF00134	0.613
DOC_CYCLIN_RxL_1	628	635	PF00134	0.539
DOC_CYCLIN_RxL_1	94	104	PF00134	0.466
DOC_CYCLIN_yClb5_NLxxxL_5	62	71	PF00134	0.453
DOC_MAPK_DCC_7	419	429	PF00069	0.464
DOC_MAPK_gen_1	214	223	PF00069	0.513
DOC_MAPK_gen_1	378	386	PF00069	0.450
DOC_MAPK_gen_1	475	484	PF00069	0.453
DOC_MAPK_MEF2A_6	122	130	PF00069	0.402
DOC_MAPK_MEF2A_6	214	223	PF00069	0.513
DOC_MAPK_MEF2A_6	378	386	PF00069	0.453
DOC_MAPK_MEF2A_6	399	406	PF00069	0.464
DOC_PP2B_PxIxI_1	673	679	PF00149	0.453
DOC_USP7_MATH_1	26	30	PF00917	0.657
DOC_USP7_MATH_1	322	326	PF00917	0.553
DOC_USP7_MATH_1	523	527	PF00917	0.464
DOC_USP7_MATH_1	570	574	PF00917	0.589
DOC_USP7_MATH_1	582	586	PF00917	0.620
DOC_USP7_MATH_1	592	596	PF00917	0.670
DOC_USP7_MATH_1	702	706	PF00917	0.532
DOC_USP7_MATH_1	721	725	PF00917	0.272
DOC_USP7_MATH_2	344	350	PF00917	0.425
DOC_USP7_UBL2_3	351	355	PF12436	0.513
DOC_USP7_UBL2_3	419	423	PF12436	0.464
DOC_WW_Pin1_4	263	268	PF00397	0.453
DOC_WW_Pin1_4	670	675	PF00397	0.464
LIG_14-3-3_CanoR_1	251	256	PF00244	0.453
LIG_14-3-3_CanoR_1	335	341	PF00244	0.581
LIG_14-3-3_CanoR_1	507	511	PF00244	0.453
LIG_14-3-3_CanoR_1	618	625	PF00244	0.466
LIG_14-3-3_CanoR_1	64	74	PF00244	0.518
LIG_14-3-3_CanoR_1	688	696	PF00244	0.443
LIG_14-3-3_CanoR_1	760	768	PF00244	0.430
LIG_14-3-3_CanoR_1	791	797	PF00244	0.461
LIG_APCC_ABBA_1	51	56	PF00400	0.481
LIG_Clathr_ClatBox_1	222	226	PF01394	0.464
LIG_FHA_1	123	129	PF00498	0.428
LIG_FHA_1	244	250	PF00498	0.450
LIG_FHA_1	252	258	PF00498	0.436
LIG_FHA_1	440	446	PF00498	0.453
LIG_FHA_1	490	496	PF00498	0.453
LIG_FHA_1	499	505	PF00498	0.453
LIG_FHA_1	5	11	PF00498	0.701
LIG_FHA_1	506	512	PF00498	0.453
LIG_FHA_1	609	615	PF00498	0.305
LIG_FHA_1	671	677	PF00498	0.464
LIG_FHA_1	95	101	PF00498	0.459
LIG_FHA_2	313	319	PF00498	0.518
LIG_HP1_1	219	223	PF01393	0.513
LIG_IBAR_NPY_1	218	220	PF08397	0.453
LIG_Integrin_RGD_1	399	401	PF01839	0.264
LIG_LIR_Gen_1	358	367	PF02991	0.496
LIG_LIR_Gen_1	471	480	PF02991	0.453
LIG_LIR_Gen_1	539	548	PF02991	0.452
LIG_LIR_Gen_1	56	67	PF02991	0.460
LIG_LIR_Gen_1	635	644	PF02991	0.453
LIG_LIR_Gen_1	75	84	PF02991	0.386
LIG_LIR_Nem_3	347	353	PF02991	0.453
LIG_LIR_Nem_3	358	363	PF02991	0.453
LIG_LIR_Nem_3	520	524	PF02991	0.463
LIG_LIR_Nem_3	539	544	PF02991	0.356
LIG_LIR_Nem_3	611	616	PF02991	0.459
LIG_LIR_Nem_3	635	640	PF02991	0.453
LIG_LIR_Nem_3	75	79	PF02991	0.490
LIG_NRP_CendR_1	799	801	PF00754	0.448
LIG_PCNA_PIPBox_1	630	639	PF02747	0.453
LIG_PCNA_yPIPBox_3	140	151	PF02747	0.453
LIG_Pex14_2	47	51	PF04695	0.453
LIG_Pex14_2	541	545	PF04695	0.453
LIG_RPA_C_Fungi	502	514	PF08784	0.305
LIG_RPA_C_Fungi	699	711	PF08784	0.321
LIG_RPA_C_Fungi	755	767	PF08784	0.446
LIG_SH2_CRK	521	525	PF00017	0.321
LIG_SH2_CRK	780	784	PF00017	0.441
LIG_SH2_GRB2like	182	185	PF00017	0.340
LIG_SH2_NCK_1	616	620	PF00017	0.297
LIG_SH2_PTP2	220	223	PF00017	0.390
LIG_SH2_PTP2	637	640	PF00017	0.321
LIG_SH2_SRC	182	185	PF00017	0.340
LIG_SH2_STAT3	229	232	PF00017	0.305
LIG_SH2_STAT5	182	185	PF00017	0.321
LIG_SH2_STAT5	220	223	PF00017	0.305
LIG_SH2_STAT5	260	263	PF00017	0.305
LIG_SH2_STAT5	305	308	PF00017	0.364
LIG_SH2_STAT5	430	433	PF00017	0.305
LIG_SH2_STAT5	613	616	PF00017	0.305
LIG_SH2_STAT5	637	640	PF00017	0.321
LIG_SH2_STAT5	73	76	PF00017	0.425
LIG_SH3_3	218	224	PF00018	0.390
LIG_SH3_3	544	550	PF00018	0.305
LIG_SUMO_SIM_par_1	149	154	PF11976	0.374
LIG_SUMO_SIM_par_1	253	258	PF11976	0.305
LIG_SUMO_SIM_par_1	275	281	PF11976	0.305
LIG_TRAF2_1	278	281	PF00917	0.432
LIG_TRAF2_1	344	347	PF00917	0.544
LIG_TRFH_1	220	224	PF08558	0.321
LIG_UBA3_1	371	379	PF00899	0.305
MOD_CDK_SPxxK_3	263	270	PF00069	0.305
MOD_CK1_1	121	127	PF00069	0.476
MOD_CK1_1	160	166	PF00069	0.373
MOD_CK1_1	176	182	PF00069	0.187
MOD_CK1_1	266	272	PF00069	0.305
MOD_CK1_1	336	342	PF00069	0.600
MOD_CK1_1	444	450	PF00069	0.306
MOD_CK1_1	506	512	PF00069	0.305
MOD_CK1_1	536	542	PF00069	0.305
MOD_CK1_1	587	593	PF00069	0.721
MOD_CK1_1	65	71	PF00069	0.452
MOD_CK1_1	670	676	PF00069	0.380
MOD_CK2_1	275	281	PF00069	0.305
MOD_CK2_1	702	708	PF00069	0.425
MOD_Cter_Amidation	574	577	PF01082	0.746
MOD_GlcNHglycan	15	18	PF01048	0.686
MOD_GlcNHglycan	153	156	PF01048	0.308
MOD_GlcNHglycan	19	22	PF01048	0.699
MOD_GlcNHglycan	197	201	PF01048	0.452
MOD_GlcNHglycan	211	214	PF01048	0.335
MOD_GlcNHglycan	26	29	PF01048	0.719
MOD_GlcNHglycan	363	366	PF01048	0.403
MOD_GlcNHglycan	431	434	PF01048	0.305
MOD_GlcNHglycan	436	439	PF01048	0.305
MOD_GlcNHglycan	568	571	PF01048	0.535
MOD_GlcNHglycan	572	575	PF01048	0.589
MOD_GlcNHglycan	584	587	PF01048	0.565
MOD_GlcNHglycan	589	592	PF01048	0.614
MOD_GlcNHglycan	594	597	PF01048	0.679
MOD_GlcNHglycan	656	659	PF01048	0.314
MOD_GlcNHglycan	660	663	PF01048	0.295
MOD_GlcNHglycan	67	70	PF01048	0.384
MOD_GlcNHglycan	723	726	PF01048	0.468
MOD_GlcNHglycan	84	87	PF01048	0.227
MOD_GSK3_1	118	125	PF00069	0.529
MOD_GSK3_1	13	20	PF00069	0.716
MOD_GSK3_1	172	179	PF00069	0.305
MOD_GSK3_1	31	38	PF00069	0.596
MOD_GSK3_1	313	320	PF00069	0.481
MOD_GSK3_1	329	336	PF00069	0.534
MOD_GSK3_1	4	11	PF00069	0.704
MOD_GSK3_1	408	415	PF00069	0.305
MOD_GSK3_1	429	436	PF00069	0.300
MOD_GSK3_1	499	506	PF00069	0.305
MOD_GSK3_1	532	539	PF00069	0.321
MOD_GSK3_1	562	569	PF00069	0.365
MOD_GSK3_1	592	599	PF00069	0.639
MOD_GSK3_1	608	615	PF00069	0.308
MOD_GSK3_1	654	661	PF00069	0.340
MOD_GSK3_1	666	673	PF00069	0.265
MOD_GSK3_1	729	736	PF00069	0.497
MOD_LATS_1	758	764	PF00433	0.493
MOD_N-GLC_1	24	29	PF02516	0.661
MOD_N-GLC_1	328	333	PF02516	0.518
MOD_N-GLC_1	498	503	PF02516	0.305
MOD_N-GLC_1	570	575	PF02516	0.675
MOD_N-GLC_1	65	70	PF02516	0.423
MOD_N-GLC_1	658	663	PF02516	0.451
MOD_N-GLC_1	670	675	PF02516	0.375
MOD_NEK2_1	13	18	PF00069	0.641
MOD_NEK2_1	196	201	PF00069	0.438
MOD_NEK2_1	312	317	PF00069	0.414
MOD_NEK2_1	386	391	PF00069	0.321
MOD_NEK2_1	441	446	PF00069	0.305
MOD_NEK2_1	503	508	PF00069	0.305
MOD_NEK2_1	533	538	PF00069	0.293
MOD_NEK2_1	566	571	PF00069	0.607
MOD_NEK2_1	62	67	PF00069	0.361
MOD_NEK2_2	617	622	PF00069	0.390
MOD_PIKK_1	313	319	PF00454	0.581
MOD_PIKK_1	412	418	PF00454	0.321
MOD_PIKK_1	46	52	PF00454	0.413
MOD_PKA_2	121	127	PF00069	0.444
MOD_PKA_2	313	319	PF00069	0.581
MOD_PKA_2	336	342	PF00069	0.658
MOD_PKA_2	506	512	PF00069	0.305
MOD_PKA_2	617	623	PF00069	0.305
MOD_PKA_2	687	693	PF00069	0.305
MOD_PKB_1	333	341	PF00069	0.561
MOD_PKB_1	390	398	PF00069	0.362
MOD_Plk_1	346	352	PF00069	0.390
MOD_Plk_1	498	504	PF00069	0.305
MOD_Plk_4	251	257	PF00069	0.317
MOD_Plk_4	441	447	PF00069	0.305
MOD_Plk_4	456	462	PF00069	0.305
MOD_Plk_4	499	505	PF00069	0.305
MOD_Plk_4	506	512	PF00069	0.305
MOD_Plk_4	533	539	PF00069	0.295
MOD_Plk_4	682	688	PF00069	0.301
MOD_ProDKin_1	263	269	PF00069	0.305
MOD_ProDKin_1	670	676	PF00069	0.321
MOD_SUMO_for_1	783	786	PF00179	0.448
MOD_SUMO_rev_2	109	117	PF00179	0.321
MOD_SUMO_rev_2	375	380	PF00179	0.340
TRG_DiLeu_BaEn_1	757	762	PF01217	0.407
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.544
TRG_DiLeu_LyEn_5	757	762	PF01217	0.423
TRG_ENDOCYTIC_2	220	223	PF00928	0.305
TRG_ENDOCYTIC_2	521	524	PF00928	0.305
TRG_ENDOCYTIC_2	59	62	PF00928	0.305
TRG_ENDOCYTIC_2	637	640	PF00928	0.321
TRG_ENDOCYTIC_2	73	76	PF00928	0.296
TRG_ENDOCYTIC_2	780	783	PF00928	0.411
TRG_ER_diArg_1	334	337	PF00400	0.669
TRG_ER_diArg_1	390	393	PF00400	0.374
TRG_ER_diArg_1	640	642	PF00400	0.305
TRG_ER_diArg_1	695	698	PF00400	0.321
TRG_ER_diArg_1	746	749	PF00400	0.418
TRG_NES_CRM1_1	628	643	PF08389	0.321
TRG_NLS_Bipartite_1	378	394	PF00514	0.321
TRG_Pf-PMV_PEXEL_1	140	144	PF00026	0.305
TRG_Pf-PMV_PEXEL_1	259	263	PF00026	0.305
TRG_Pf-PMV_PEXEL_1	41	46	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	760	764	PF00026	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P686	Leptomonas seymouri	34%	93%
A0A0N0P860	Leptomonas seymouri	30%	81%
A0A0N0P9H0	Leptomonas seymouri	28%	87%
A0A0N1I2J6	Leptomonas seymouri	28%	90%
A0A0N1I371	Leptomonas seymouri	31%	100%
A0A0N1I383	Leptomonas seymouri	31%	78%
A0A0N1PC47	Leptomonas seymouri	88%	100%
A0A0S4IVB8	Bodo saltans	30%	92%
A0A0S4IW18	Bodo saltans	31%	99%
A0A0S4IYQ3	Bodo saltans	60%	100%
A0A0S4J5X8	Bodo saltans	29%	100%
A0A1X0NNF6	Trypanosomatidae	31%	88%
A0A1X0NQM5	Trypanosomatidae	30%	90%
A0A1X0NT66	Trypanosomatidae	30%	100%
A0A1X0NVE7	Trypanosomatidae	72%	100%
A0A1X0NZT6	Trypanosomatidae	31%	85%
A0A1X0P1Q1	Trypanosomatidae	27%	100%
A0A1X0P4W1	Trypanosomatidae	27%	100%
A0A3Q8IAX4	Leishmania donovani	30%	82%
A0A3R7MUG3	Trypanosoma rangeli	28%	100%
A0A3R7NBN0	Trypanosoma rangeli	31%	84%
A0A3S5H7J9	Leishmania donovani	30%	91%
A0A3S5H7S8	Leishmania donovani	31%	100%
A0A3S7WQI8	Leishmania donovani	30%	89%
A0A3S7WY81	Leishmania donovani	98%	100%
A0A3S7X726	Leishmania donovani	33%	91%
A0A422N694	Trypanosoma rangeli	30%	100%
A0A422NDD9	Trypanosoma rangeli	31%	92%
A0A422NDR0	Trypanosoma rangeli	26%	100%
A0A422NHH5	Trypanosoma rangeli	70%	100%
A0A422NZW3	Trypanosoma rangeli	30%	100%
A4FUD9	Bos taurus	33%	99%
A4H5K0	Leishmania braziliensis	30%	87%
A4HDE7	Leishmania braziliensis	93%	100%
A4HGC9	Leishmania braziliensis	30%	82%
A4HGU2	Leishmania braziliensis	29%	100%
A4HKT9	Leishmania braziliensis	30%	100%
A4HNF5	Leishmania braziliensis	26%	87%
A4HTX2	Leishmania infantum	30%	89%
A4I0T0	Leishmania infantum	98%	100%
A4I3G2	Leishmania infantum	30%	82%
A4I3W9	Leishmania infantum	30%	91%
A4I8B8	Leishmania infantum	31%	100%
A4I9B0	Leishmania infantum	33%	91%
B8AEH3	Oryza sativa subsp. indica	40%	100%
B8AZ14	Oryza sativa subsp. indica	31%	100%
B8AZ99	Oryza sativa subsp. indica	33%	100%
B8AZX3	Oryza sativa subsp. indica	31%	97%
B8B406	Oryza sativa subsp. indica	29%	100%
B8BKI8	Oryza sativa subsp. indica	32%	83%
B8BMI1	Oryza sativa subsp. indica	31%	100%
B9FKM7	Oryza sativa subsp. japonica	32%	100%
C9ZYH2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
D0A4I0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A759	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
D0A7X6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	84%
D0A936	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	92%
D0A999	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	96%
D0AAI9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
D3ZVK1	Rattus norvegicus	31%	97%
E1BPX4	Bos taurus	31%	98%
E9AFW6	Leishmania major	27%	88%
E9AMM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	89%
E9AZQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	82%
E9B059	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	91%
E9B377	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9B4B0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	92%
E9B719	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	88%
F1M5F3	Rattus norvegicus	29%	71%
F1N2W9	Bos taurus	28%	70%
F1QDI9	Danio rerio	29%	71%
F4IFF3	Arabidopsis thaliana	28%	100%
F4KAB8	Arabidopsis thaliana	32%	96%
F6RIX4	Xenopus tropicalis	29%	72%
I0IUP3	Gallus gallus	31%	97%
I0IUP4	Gallus gallus	27%	69%
O75001	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
O80786	Arabidopsis thaliana	40%	100%
P24279	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	82%
P25205	Homo sapiens	33%	99%
P25206	Mus musculus	33%	99%
P29458	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	86%
P29469	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	92%
P29496	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	100%
P30664	Xenopus laevis	31%	93%
P30665	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	86%
P30666	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	91%
P33991	Homo sapiens	31%	93%
P33992	Homo sapiens	39%	100%
P33993	Homo sapiens	32%	100%
P34647	Caenorhabditis elegans	30%	99%
P38132	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	95%
P40377	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	97%
P41389	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	100%
P43299	Arabidopsis thaliana	32%	100%
P49717	Mus musculus	31%	93%
P49718	Mus musculus	39%	100%
P49731	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	90%
P49735	Drosophila melanogaster	30%	90%
P49736	Homo sapiens	30%	89%
P49739	Xenopus laevis	34%	99%
P53091	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	79%
P55861	Xenopus laevis	31%	90%
P55862	Xenopus laevis	38%	100%
P97310	Mus musculus	30%	89%
P97311	Mus musculus	31%	98%
Q0DHC4	Oryza sativa subsp. japonica	33%	100%
Q0V8B7	Bos taurus	39%	100%
Q0V9Q6	Xenopus tropicalis	31%	95%
Q0WVF5	Arabidopsis thaliana	31%	95%
Q14566	Homo sapiens	30%	98%
Q21902	Caenorhabditis elegans	39%	100%
Q24849	Entamoeba histolytica	30%	100%
Q26454	Drosophila melanogaster	30%	92%
Q28BS0	Xenopus tropicalis	34%	99%
Q28CM3	Xenopus tropicalis	31%	98%
Q29JI9	Drosophila pseudoobscura pseudoobscura	32%	98%
Q2KHI9	Mus musculus	27%	71%
Q2KIZ8	Bos taurus	30%	98%
Q2QNM1	Oryza sativa subsp. japonica	31%	100%
Q2R482	Oryza sativa subsp. japonica	31%	83%
Q3ZBH9	Bos taurus	31%	100%
Q43704	Zea mays	33%	100%
Q498J7	Xenopus laevis	31%	97%
Q4Q3R6	Leishmania major	34%	91%
Q4Q826	Leishmania major	29%	100%
Q4Q8I2	Leishmania major	30%	83%
Q4QAP2	Leishmania major	98%	100%
Q4QI01	Leishmania major	30%	89%
Q54CP4	Dictyostelium discoideum	40%	100%
Q561P5	Xenopus tropicalis	38%	100%
Q58884	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	25%	100%
Q5F310	Xenopus laevis	29%	96%
Q5FWY4	Xenopus laevis	31%	98%
Q5JKB0	Oryza sativa subsp. japonica	32%	93%
Q5R8G6	Pongo abelii	33%	99%
Q5XK83	Xenopus laevis	31%	93%
Q5ZMN2	Gallus gallus	32%	99%
Q61881	Mus musculus	32%	100%
Q61J08	Caenorhabditis briggsae	29%	99%
Q69QA6	Oryza sativa subsp. japonica	29%	100%
Q6DIH3	Xenopus tropicalis	30%	91%
Q6F353	Oryza sativa subsp. japonica	32%	97%
Q6GL41	Xenopus tropicalis	31%	93%
Q6KAJ4	Oryza sativa subsp. japonica	40%	100%
Q6NRM6	Xenopus laevis	29%	70%
Q6NX31	Xenopus tropicalis	29%	100%
Q6P1V8	Xenopus tropicalis	30%	97%
Q6PCI7	Xenopus laevis	38%	100%
Q7Q0Q1	Anopheles gambiae	30%	98%
Q7ZXB1	Xenopus laevis	30%	100%
Q7ZXZ0	Xenopus laevis	33%	99%
Q7ZY18	Xenopus laevis	30%	97%
Q86B14	Dictyostelium discoideum	31%	92%
Q91876	Xenopus laevis	30%	100%
Q95XQ8	Caenorhabditis elegans	31%	97%
Q9CWV1	Mus musculus	30%	96%
Q9FL33	Arabidopsis thaliana	31%	100%
Q9LPD9	Arabidopsis thaliana	31%	86%
Q9NXL9	Homo sapiens	28%	70%
Q9SF37	Arabidopsis thaliana	30%	100%
Q9SX03	Zea mays	33%	100%
Q9SX04	Zea mays	33%	100%
Q9U1E0	Leishmania major	30%	100%
Q9UJA3	Homo sapiens	31%	95%
Q9UXG1	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	30%	100%
Q9V461	Drosophila melanogaster	30%	98%
Q9VF30	Drosophila melanogaster	23%	91%
Q9VGW6	Drosophila melanogaster	40%	100%
Q9XYU0	Drosophila melanogaster	31%	100%
Q9XYU1	Drosophila melanogaster	34%	98%
V5B8T3	Trypanosoma cruzi	27%	100%
V5BGQ5	Trypanosoma cruzi	29%	94%
V5BQA9	Trypanosoma cruzi	31%	100%
V5BSG2	Trypanosoma cruzi	33%	92%
V5C0K6	Trypanosoma cruzi	71%	100%