GOLD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

emp24/gp25L/p24 family/GOLD, putative

Species:

Leishmania mexicana

UniProt:

E9AWS8_LEIMU

TriTrypDb:

LmxM.24.0870

Length:

227

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 7, no: 3
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9AWS8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWS8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.257
CLV_PCSK_SKI1_1	109	113	PF00082	0.408
CLV_PCSK_SKI1_1	40	44	PF00082	0.445
CLV_PCSK_SKI1_1	60	64	PF00082	0.445
DEG_APCC_DBOX_1	183	191	PF00400	0.254
DEG_SCF_FBW7_1	62	67	PF00400	0.257
DOC_MAPK_MEF2A_6	192	200	PF00069	0.343
DOC_MAPK_MEF2A_6	3	11	PF00069	0.481
DOC_MAPK_MEF2A_6	60	68	PF00069	0.257
DOC_MAPK_MEF2A_6	96	104	PF00069	0.279
DOC_PP1_RVXF_1	190	196	PF00149	0.331
DOC_SPAK_OSR1_1	31	35	PF12202	0.343
DOC_USP7_MATH_1	113	117	PF00917	0.265
DOC_USP7_MATH_1	64	68	PF00917	0.286
DOC_USP7_MATH_1	69	73	PF00917	0.286
DOC_USP7_UBL2_3	85	89	PF12436	0.343
DOC_WW_Pin1_4	140	145	PF00397	0.337
DOC_WW_Pin1_4	60	65	PF00397	0.261
LIG_14-3-3_CanoR_1	184	188	PF00244	0.292
LIG_14-3-3_CanoR_1	192	196	PF00244	0.272
LIG_14-3-3_CanoR_1	3	11	PF00244	0.423
LIG_14-3-3_CanoR_1	31	35	PF00244	0.309
LIG_14-3-3_CanoR_1	57	63	PF00244	0.320
LIG_BIR_II_1	1	5	PF00653	0.459
LIG_BRCT_BRCA1_1	100	104	PF00533	0.343
LIG_Clathr_ClatBox_1	187	191	PF01394	0.243
LIG_FHA_1	118	124	PF00498	0.271
LIG_FHA_1	61	67	PF00498	0.253
LIG_FHA_2	175	181	PF00498	0.308
LIG_LIR_Gen_1	164	174	PF02991	0.321
LIG_LIR_Gen_1	182	193	PF02991	0.176
LIG_LIR_Gen_1	212	220	PF02991	0.349
LIG_LIR_Gen_1	63	70	PF02991	0.257
LIG_LIR_Nem_3	194	198	PF02991	0.343
LIG_LIR_Nem_3	212	216	PF02991	0.255
LIG_LIR_Nem_3	53	59	PF02991	0.311
LIG_LIR_Nem_3	63	68	PF02991	0.253
LIG_NRP_CendR_1	224	227	PF00754	0.296
LIG_OCRL_FandH_1	212	224	PF00620	0.268
LIG_Pex14_1	195	199	PF04695	0.304
LIG_SH2_CRK	56	60	PF00017	0.236
LIG_SH2_PTP2	199	202	PF00017	0.311
LIG_SH2_STAP1	163	167	PF00017	0.323
LIG_SH2_STAP1	28	32	PF00017	0.176
LIG_SH2_STAP1	52	56	PF00017	0.271
LIG_SH2_STAT5	161	164	PF00017	0.251
LIG_SH2_STAT5	199	202	PF00017	0.321
LIG_SH3_4	85	92	PF00018	0.343
LIG_SUMO_SIM_anti_2	120	125	PF11976	0.257
LIG_SUMO_SIM_par_1	119	125	PF11976	0.268
LIG_SxIP_EBH_1	192	202	PF03271	0.271
LIG_TYR_ITIM	54	59	PF00017	0.166
LIG_WRC_WIRS_1	163	168	PF05994	0.323
LIG_WRC_WIRS_1	210	215	PF05994	0.379
MOD_CK1_1	138	144	PF00069	0.258
MOD_CK1_1	98	104	PF00069	0.353
MOD_CK2_1	183	189	PF00069	0.289
MOD_DYRK1A_RPxSP_1	60	64	PF00069	0.246
MOD_GlcNHglycan	152	155	PF01048	0.471
MOD_GSK3_1	113	120	PF00069	0.249
MOD_GSK3_1	135	142	PF00069	0.271
MOD_GSK3_1	60	67	PF00069	0.271
MOD_N-GLC_1	117	122	PF02516	0.450
MOD_NEK2_1	1	6	PF00069	0.416
MOD_NEK2_1	30	35	PF00069	0.287
MOD_NEK2_1	58	63	PF00069	0.257
MOD_PKA_1	135	141	PF00069	0.271
MOD_PKA_2	183	189	PF00069	0.266
MOD_PKA_2	191	197	PF00069	0.249
MOD_PKA_2	2	8	PF00069	0.353
MOD_PKA_2	30	36	PF00069	0.268
MOD_Plk_1	117	123	PF00069	0.258
MOD_Plk_1	129	135	PF00069	0.293
MOD_Plk_4	183	189	PF00069	0.366
MOD_Plk_4	191	197	PF00069	0.316
MOD_Plk_4	209	215	PF00069	0.261
MOD_Plk_4	95	101	PF00069	0.323
MOD_ProDKin_1	140	146	PF00069	0.337
MOD_ProDKin_1	60	66	PF00069	0.261
MOD_SUMO_rev_2	82	91	PF00179	0.309
TRG_ENDOCYTIC_2	163	166	PF00928	0.369
TRG_ENDOCYTIC_2	185	188	PF00928	0.314
TRG_ENDOCYTIC_2	199	202	PF00928	0.218
TRG_ENDOCYTIC_2	56	59	PF00928	0.343
TRG_ER_diLys_1	222	227	PF00400	0.609
TRG_Pf-PMV_PEXEL_1	76	80	PF00026	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5X9	Leptomonas seymouri	73%	99%
A0A0S4J7E6	Bodo saltans	31%	100%
A0A1X0NX41	Trypanosomatidae	50%	93%
A0A3S7WY78	Leishmania donovani	95%	100%
A0A422NHH2	Trypanosoma rangeli	50%	100%
A4HDE3	Leishmania braziliensis	81%	100%
D0A756	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
Q4QAP6	Leishmania major	94%	100%
V5DSH1	Trypanosoma cruzi	54%	85%