2'-phosphotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphotransferase, putative

Species:

Leishmania mexicana

UniProt:

E9AWS2_LEIMU

TriTrypDb:

LmxM.24.0810

Length:

584

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AWS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWS2

Function

Biological processes
Term	Name	Level	Count
GO:0000459	exonucleolytic trimming involved in rRNA processing	8	1
GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	1
GO:0000469	cleavage involved in rRNA processing	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0031123	RNA 3'-end processing	7	1
GO:0031125	rRNA 3'-end processing	9	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043628	regulatory ncRNA 3'-end processing	8	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	7	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000215	tRNA 2'-phosphotransferase activity	5	12
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140101	catalytic activity, acting on a tRNA	4	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0000175	3'-5'-RNA exonuclease activity	7	1
GO:0004518	nuclease activity	4	1
GO:0004527	exonuclease activity	5	1
GO:0004532	RNA exonuclease activity	5	1
GO:0004540	RNA nuclease activity	4	1
GO:0008408	3'-5' exonuclease activity	6	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.662
CLV_C14_Caspase3-7	308	312	PF00656	0.749
CLV_C14_Caspase3-7	353	357	PF00656	0.571
CLV_C14_Caspase3-7	7	11	PF00656	0.595
CLV_NRD_NRD_1	252	254	PF00675	0.519
CLV_NRD_NRD_1	33	35	PF00675	0.740
CLV_NRD_NRD_1	419	421	PF00675	0.472
CLV_NRD_NRD_1	523	525	PF00675	0.300
CLV_NRD_NRD_1	71	73	PF00675	0.337
CLV_PCSK_KEX2_1	252	254	PF00082	0.496
CLV_PCSK_KEX2_1	33	35	PF00082	0.758
CLV_PCSK_KEX2_1	71	73	PF00082	0.337
CLV_PCSK_SKI1_1	102	106	PF00082	0.243
CLV_PCSK_SKI1_1	166	170	PF00082	0.296
CLV_PCSK_SKI1_1	470	474	PF00082	0.449
CLV_PCSK_SKI1_1	89	93	PF00082	0.320
DOC_CKS1_1	179	184	PF01111	0.563
DOC_CKS1_1	553	558	PF01111	0.348
DOC_CYCLIN_yClb5_NLxxxL_5	241	247	PF00134	0.525
DOC_MAPK_gen_1	192	200	PF00069	0.544
DOC_MAPK_gen_1	252	259	PF00069	0.465
DOC_MAPK_gen_1	30	38	PF00069	0.628
DOC_MAPK_gen_1	335	344	PF00069	0.622
DOC_MAPK_gen_1	381	391	PF00069	0.317
DOC_MAPK_gen_1	420	426	PF00069	0.475
DOC_MAPK_gen_1	524	531	PF00069	0.300
DOC_MAPK_MEF2A_6	252	261	PF00069	0.466
DOC_MAPK_MEF2A_6	382	391	PF00069	0.184
DOC_MAPK_MEF2A_6	524	533	PF00069	0.328
DOC_PP1_RVXF_1	392	399	PF00149	0.475
DOC_PP4_FxxP_1	344	347	PF00568	0.519
DOC_USP7_MATH_1	151	155	PF00917	0.501
DOC_USP7_MATH_1	19	23	PF00917	0.788
DOC_USP7_MATH_1	282	286	PF00917	0.491
DOC_USP7_MATH_1	401	405	PF00917	0.395
DOC_USP7_MATH_1	42	46	PF00917	0.652
DOC_USP7_MATH_1	471	475	PF00917	0.347
DOC_USP7_UBL2_3	381	385	PF12436	0.447
DOC_USP7_UBL2_3	567	571	PF12436	0.498
DOC_WW_Pin1_4	178	183	PF00397	0.546
DOC_WW_Pin1_4	261	266	PF00397	0.433
DOC_WW_Pin1_4	363	368	PF00397	0.616
DOC_WW_Pin1_4	552	557	PF00397	0.338
DOC_WW_Pin1_4	89	94	PF00397	0.525
LIG_14-3-3_CanoR_1	111	119	PF00244	0.581
LIG_14-3-3_CanoR_1	337	343	PF00244	0.682
LIG_14-3-3_CanoR_1	399	409	PF00244	0.437
LIG_14-3-3_CanoR_1	470	476	PF00244	0.415
LIG_Actin_WH2_2	161	176	PF00022	0.454
LIG_Actin_WH2_2	239	254	PF00022	0.480
LIG_AP2alpha_2	128	130	PF02296	0.581
LIG_APCC_ABBA_1	529	534	PF00400	0.344
LIG_BIR_III_2	148	152	PF00653	0.562
LIG_BIR_III_2	281	285	PF00653	0.646
LIG_BIR_III_2	369	373	PF00653	0.432
LIG_BRCT_BRCA1_1	262	266	PF00533	0.321
LIG_BRCT_BRCA1_1	340	344	PF00533	0.579
LIG_BRCT_BRCA1_1	43	47	PF00533	0.693
LIG_EVH1_2	371	375	PF00568	0.409
LIG_FHA_1	262	268	PF00498	0.330
LIG_FHA_1	547	553	PF00498	0.328
LIG_FHA_1	559	565	PF00498	0.407
LIG_FHA_2	157	163	PF00498	0.475
LIG_FHA_2	284	290	PF00498	0.636
LIG_FHA_2	306	312	PF00498	0.749
LIG_FHA_2	351	357	PF00498	0.512
LIG_FHA_2	364	370	PF00498	0.606
LIG_FHA_2	483	489	PF00498	0.425
LIG_GBD_Chelix_1	243	251	PF00786	0.274
LIG_Integrin_isoDGR_2	577	579	PF01839	0.417
LIG_LIR_Apic_2	341	347	PF02991	0.552
LIG_LIR_Gen_1	154	162	PF02991	0.501
LIG_LIR_Gen_1	384	391	PF02991	0.184
LIG_LIR_Gen_1	404	414	PF02991	0.377
LIG_LIR_Gen_1	56	65	PF02991	0.328
LIG_LIR_Nem_3	128	133	PF02991	0.476
LIG_LIR_Nem_3	154	158	PF02991	0.501
LIG_LIR_Nem_3	384	389	PF02991	0.184
LIG_LIR_Nem_3	404	410	PF02991	0.377
LIG_LIR_Nem_3	44	50	PF02991	0.549
LIG_LIR_Nem_3	488	493	PF02991	0.326
LIG_LIR_Nem_3	56	61	PF02991	0.298
LIG_LIR_Nem_3	80	84	PF02991	0.473
LIG_LIR_Nem_3	96	100	PF02991	0.440
LIG_LYPXL_SIV_4	444	452	PF13949	0.475
LIG_NRBOX	246	252	PF00104	0.536
LIG_PDZ_Class_2	579	584	PF00595	0.588
LIG_RPA_C_Fungi	350	362	PF08784	0.587
LIG_SH2_CRK	155	159	PF00017	0.449
LIG_SH2_PTP2	100	103	PF00017	0.328
LIG_SH2_PTP2	407	410	PF00017	0.385
LIG_SH2_PTP2	58	61	PF00017	0.332
LIG_SH2_SRC	532	535	PF00017	0.344
LIG_SH2_STAT5	100	103	PF00017	0.323
LIG_SH2_STAT5	134	137	PF00017	0.473
LIG_SH2_STAT5	155	158	PF00017	0.360
LIG_SH2_STAT5	407	410	PF00017	0.356
LIG_SH2_STAT5	453	456	PF00017	0.315
LIG_SH2_STAT5	498	501	PF00017	0.355
LIG_SH2_STAT5	532	535	PF00017	0.344
LIG_SH2_STAT5	568	571	PF00017	0.392
LIG_SH2_STAT5	58	61	PF00017	0.332
LIG_SH3_1	23	29	PF00018	0.491
LIG_SH3_2	325	330	PF14604	0.517
LIG_SH3_3	101	107	PF00018	0.362
LIG_SH3_3	206	212	PF00018	0.419
LIG_SH3_3	222	228	PF00018	0.258
LIG_SH3_3	23	29	PF00018	0.693
LIG_SH3_3	295	301	PF00018	0.760
LIG_SH3_3	322	328	PF00018	0.799
LIG_SUMO_SIM_par_1	255	260	PF11976	0.457
LIG_SUMO_SIM_par_1	82	87	PF11976	0.330
LIG_TRAF2_1	357	360	PF00917	0.591
LIG_WW_3	300	304	PF00397	0.774
LIG_WW_3	370	374	PF00397	0.429
MOD_CDK_SPxxK_3	261	268	PF00069	0.321
MOD_CK1_1	41	47	PF00069	0.701
MOD_CK1_1	500	506	PF00069	0.333
MOD_CK2_1	471	477	PF00069	0.378
MOD_CK2_1	482	488	PF00069	0.336
MOD_CMANNOS	487	490	PF00535	0.449
MOD_GlcNHglycan	175	178	PF01048	0.449
MOD_GlcNHglycan	203	206	PF01048	0.398
MOD_GlcNHglycan	234	237	PF01048	0.243
MOD_GlcNHglycan	26	29	PF01048	0.726
MOD_GlcNHglycan	40	43	PF01048	0.725
MOD_GlcNHglycan	520	523	PF01048	0.334
MOD_GSK3_1	107	114	PF00069	0.328
MOD_GSK3_1	13	20	PF00069	0.709
MOD_GSK3_1	257	264	PF00069	0.349
MOD_GSK3_1	301	308	PF00069	0.801
MOD_GSK3_1	38	45	PF00069	0.740
MOD_GSK3_1	381	388	PF00069	0.361
MOD_GSK3_1	573	580	PF00069	0.493
MOD_N-GLC_1	201	206	PF02516	0.398
MOD_NEK2_1	13	18	PF00069	0.696
MOD_NEK2_1	173	178	PF00069	0.417
MOD_NEK2_1	213	218	PF00069	0.329
MOD_NEK2_1	545	550	PF00069	0.338
MOD_PIKK_1	117	123	PF00454	0.355
MOD_PIKK_1	193	199	PF00454	0.398
MOD_PK_1	385	391	PF00069	0.184
MOD_PKA_1	381	387	PF00069	0.255
MOD_PKA_2	173	179	PF00069	0.449
MOD_PKA_2	433	439	PF00069	0.440
MOD_PKB_1	335	343	PF00069	0.572
MOD_Plk_1	257	263	PF00069	0.506
MOD_Plk_4	164	170	PF00069	0.338
MOD_Plk_4	213	219	PF00069	0.267
MOD_Plk_4	385	391	PF00069	0.394
MOD_Plk_4	482	488	PF00069	0.332
MOD_ProDKin_1	178	184	PF00069	0.427
MOD_ProDKin_1	261	267	PF00069	0.441
MOD_ProDKin_1	363	369	PF00069	0.617
MOD_ProDKin_1	552	558	PF00069	0.338
MOD_ProDKin_1	89	95	PF00069	0.398
MOD_SUMO_rev_2	162	168	PF00179	0.344
MOD_SUMO_rev_2	376	383	PF00179	0.607
TRG_DiLeu_BaEn_2	135	141	PF01217	0.449
TRG_ENDOCYTIC_2	155	158	PF00928	0.363
TRG_ENDOCYTIC_2	407	410	PF00928	0.385
TRG_ENDOCYTIC_2	532	535	PF00928	0.342
TRG_ENDOCYTIC_2	58	61	PF00928	0.321
TRG_ER_diArg_1	124	127	PF00400	0.184
TRG_ER_diArg_1	251	253	PF00400	0.500
TRG_ER_diArg_1	334	337	PF00400	0.745
TRG_ER_diArg_1	71	73	PF00400	0.420
TRG_NES_CRM1_1	220	230	PF08389	0.454
TRG_NLS_MonoExtN_4	328	334	PF00514	0.505
TRG_Pf-PMV_PEXEL_1	253	258	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWH5	Leptomonas seymouri	56%	94%
A0A0S4J7G0	Bodo saltans	40%	90%
A0A1X0NVN6	Trypanosomatidae	42%	100%
A0A3Q8IBU9	Leishmania donovani	89%	100%
A0A422MZ86	Trypanosoma rangeli	46%	100%
A4HDD9	Leishmania braziliensis	77%	99%
A4I0S0	Leishmania infantum	89%	100%
D0A750	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
Q4QAQ2	Leishmania major	87%	99%
V5C0L6	Trypanosoma cruzi	46%	92%