Non-specific serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWS0_LEIMU

TriTrypDb:

LmxM.24.0790

Length:

572

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9AWS0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWS0

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	7
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	7
GO:0000398	mRNA splicing, via spliceosome	8	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006397	mRNA processing	7	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0008380	RNA splicing	7	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0016071	mRNA metabolic process	6	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.575
CLV_C14_Caspase3-7	21	25	PF00656	0.657
CLV_NRD_NRD_1	188	190	PF00675	0.691
CLV_NRD_NRD_1	258	260	PF00675	0.530
CLV_NRD_NRD_1	326	328	PF00675	0.573
CLV_NRD_NRD_1	374	376	PF00675	0.577
CLV_NRD_NRD_1	528	530	PF00675	0.574
CLV_NRD_NRD_1	87	89	PF00675	0.654
CLV_PCSK_KEX2_1	14	16	PF00082	0.713
CLV_PCSK_KEX2_1	188	190	PF00082	0.691
CLV_PCSK_KEX2_1	22	24	PF00082	0.719
CLV_PCSK_KEX2_1	528	530	PF00082	0.487
CLV_PCSK_KEX2_1	87	89	PF00082	0.654
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.713
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.719
CLV_PCSK_SKI1_1	335	339	PF00082	0.447
CLV_PCSK_SKI1_1	361	365	PF00082	0.294
DEG_APCC_DBOX_1	169	177	PF00400	0.526
DEG_SCF_FBW7_1	212	217	PF00400	0.542
DEG_SCF_FBW7_1	273	280	PF00400	0.616
DEG_SCF_TRCP1_1	158	164	PF00400	0.504
DEG_SPOP_SBC_1	106	110	PF00917	0.610
DEG_SPOP_SBC_1	267	271	PF00917	0.788
DEG_SPOP_SBC_1	281	285	PF00917	0.701
DOC_CDC14_PxL_1	35	43	PF14671	0.584
DOC_CYCLIN_RxL_1	332	341	PF00134	0.469
DOC_MAPK_gen_1	516	525	PF00069	0.510
DOC_MAPK_gen_1	555	562	PF00069	0.496
DOC_PP1_RVXF_1	333	339	PF00149	0.357
DOC_PP1_RVXF_1	359	365	PF00149	0.464
DOC_PP2B_LxvP_1	420	423	PF13499	0.644
DOC_PP4_FxxP_1	139	142	PF00568	0.467
DOC_USP7_MATH_1	100	104	PF00917	0.631
DOC_USP7_MATH_1	106	110	PF00917	0.621
DOC_USP7_MATH_1	166	170	PF00917	0.762
DOC_USP7_MATH_1	2	6	PF00917	0.603
DOC_USP7_MATH_1	208	212	PF00917	0.708
DOC_USP7_MATH_1	214	218	PF00917	0.462
DOC_USP7_MATH_1	268	272	PF00917	0.707
DOC_USP7_MATH_1	281	285	PF00917	0.741
DOC_USP7_MATH_1	286	290	PF00917	0.752
DOC_USP7_MATH_1	400	404	PF00917	0.669
DOC_USP7_MATH_1	92	96	PF00917	0.736
DOC_USP7_UBL2_3	203	207	PF12436	0.507
DOC_USP7_UBL2_3	324	328	PF12436	0.565
DOC_USP7_UBL2_3	454	458	PF12436	0.374
DOC_WW_Pin1_4	138	143	PF00397	0.470
DOC_WW_Pin1_4	210	215	PF00397	0.622
DOC_WW_Pin1_4	273	278	PF00397	0.651
DOC_WW_Pin1_4	284	289	PF00397	0.675
DOC_WW_Pin1_4	327	332	PF00397	0.614
DOC_WW_Pin1_4	396	401	PF00397	0.604
DOC_WW_Pin1_4	414	419	PF00397	0.630
LIG_14-3-3_CanoR_1	188	196	PF00244	0.781
LIG_14-3-3_CanoR_1	259	268	PF00244	0.561
LIG_14-3-3_CanoR_1	441	450	PF00244	0.455
LIG_14-3-3_CanoR_1	53	61	PF00244	0.705
LIG_14-3-3_CanoR_1	87	93	PF00244	0.703
LIG_BIR_III_2	9	13	PF00653	0.666
LIG_BIR_III_4	127	131	PF00653	0.537
LIG_BRCT_BRCA1_1	108	112	PF00533	0.608
LIG_BRCT_BRCA1_1	135	139	PF00533	0.503
LIG_BRCT_BRCA1_1	216	220	PF00533	0.656
LIG_Clathr_ClatBox_1	504	508	PF01394	0.494
LIG_deltaCOP1_diTrp_1	131	139	PF00928	0.473
LIG_EVH1_1	420	424	PF00568	0.591
LIG_FHA_1	295	301	PF00498	0.484
LIG_FHA_1	399	405	PF00498	0.588
LIG_FHA_1	43	49	PF00498	0.400
LIG_FHA_1	499	505	PF00498	0.443
LIG_FHA_1	554	560	PF00498	0.497
LIG_FHA_2	182	188	PF00498	0.664
LIG_FHA_2	317	323	PF00498	0.531
LIG_FHA_2	339	345	PF00498	0.477
LIG_FHA_2	545	551	PF00498	0.349
LIG_LIR_Apic_2	136	142	PF02991	0.468
LIG_LIR_Gen_1	217	228	PF02991	0.649
LIG_LIR_Nem_3	217	223	PF02991	0.582
LIG_MLH1_MIPbox_1	109	113	PF16413	0.607
LIG_MYND_1	418	422	PF01753	0.657
LIG_PAM2_1	423	435	PF00658	0.541
LIG_PCNA_yPIPBox_3	249	260	PF02747	0.504
LIG_Pex14_1	135	139	PF04695	0.471
LIG_REV1ctd_RIR_1	362	368	PF16727	0.453
LIG_SH2_PTP2	226	229	PF00017	0.545
LIG_SH2_STAT5	226	229	PF00017	0.547
LIG_SH2_STAT5	372	375	PF00017	0.632
LIG_SH3_3	275	281	PF00018	0.563
LIG_SH3_3	415	421	PF00018	0.709
LIG_SUMO_SIM_par_1	521	527	PF11976	0.514
LIG_TRAF2_1	319	322	PF00917	0.528
MOD_CDK_SPxxK_3	138	145	PF00069	0.473
MOD_CK1_1	107	113	PF00069	0.679
MOD_CK1_1	18	24	PF00069	0.569
MOD_CK1_1	279	285	PF00069	0.700
MOD_CK1_1	293	299	PF00069	0.561
MOD_CK1_1	314	320	PF00069	0.688
MOD_CK1_1	395	401	PF00069	0.600
MOD_CK1_1	414	420	PF00069	0.535
MOD_CK1_1	42	48	PF00069	0.440
MOD_CK2_1	296	302	PF00069	0.496
MOD_CK2_1	316	322	PF00069	0.533
MOD_CK2_1	544	550	PF00069	0.359
MOD_Cter_Amidation	325	328	PF01082	0.548
MOD_Cter_Amidation	451	454	PF01082	0.404
MOD_GlcNHglycan	158	161	PF01048	0.631
MOD_GlcNHglycan	163	166	PF01048	0.604
MOD_GlcNHglycan	184	187	PF01048	0.758
MOD_GlcNHglycan	190	193	PF01048	0.714
MOD_GlcNHglycan	198	201	PF01048	0.693
MOD_GlcNHglycan	216	219	PF01048	0.502
MOD_GlcNHglycan	24	27	PF01048	0.593
MOD_GlcNHglycan	270	273	PF01048	0.777
MOD_GlcNHglycan	292	295	PF01048	0.776
MOD_GlcNHglycan	313	316	PF01048	0.552
MOD_GlcNHglycan	41	44	PF01048	0.508
MOD_GlcNHglycan	413	416	PF01048	0.650
MOD_GlcNHglycan	477	480	PF01048	0.672
MOD_GlcNHglycan	482	485	PF01048	0.660
MOD_GlcNHglycan	94	97	PF01048	0.774
MOD_GSK3_1	100	107	PF00069	0.650
MOD_GSK3_1	134	141	PF00069	0.588
MOD_GSK3_1	150	157	PF00069	0.693
MOD_GSK3_1	18	25	PF00069	0.797
MOD_GSK3_1	203	210	PF00069	0.758
MOD_GSK3_1	268	275	PF00069	0.702
MOD_GSK3_1	276	283	PF00069	0.615
MOD_GSK3_1	286	293	PF00069	0.637
MOD_GSK3_1	392	399	PF00069	0.561
MOD_GSK3_1	410	417	PF00069	0.600
MOD_GSK3_1	456	463	PF00069	0.413
MOD_GSK3_1	480	487	PF00069	0.748
MOD_GSK3_1	492	499	PF00069	0.568
MOD_GSK3_1	71	78	PF00069	0.555
MOD_LATS_1	13	19	PF00433	0.697
MOD_N-GLC_1	182	187	PF02516	0.725
MOD_N-GLC_1	395	400	PF02516	0.634
MOD_N-GLC_1	553	558	PF02516	0.371
MOD_NEK2_1	134	139	PF00069	0.604
MOD_NEK2_1	143	148	PF00069	0.703
MOD_NEK2_1	234	239	PF00069	0.555
MOD_NEK2_1	338	343	PF00069	0.395
MOD_NEK2_1	355	360	PF00069	0.382
MOD_NEK2_1	377	382	PF00069	0.432
MOD_NEK2_1	75	80	PF00069	0.774
MOD_NEK2_2	484	489	PF00069	0.725
MOD_NEK2_2	71	76	PF00069	0.511
MOD_PKA_1	188	194	PF00069	0.643
MOD_PKA_1	22	28	PF00069	0.648
MOD_PKA_2	187	193	PF00069	0.713
MOD_PKA_2	22	28	PF00069	0.796
MOD_PKA_2	440	446	PF00069	0.447
MOD_PKA_2	75	81	PF00069	0.579
MOD_PKA_2	86	92	PF00069	0.622
MOD_Plk_1	338	344	PF00069	0.409
MOD_Plk_1	544	550	PF00069	0.463
MOD_Plk_4	296	302	PF00069	0.556
MOD_Plk_4	509	515	PF00069	0.376
MOD_ProDKin_1	138	144	PF00069	0.471
MOD_ProDKin_1	210	216	PF00069	0.617
MOD_ProDKin_1	273	279	PF00069	0.651
MOD_ProDKin_1	284	290	PF00069	0.677
MOD_ProDKin_1	327	333	PF00069	0.600
MOD_ProDKin_1	396	402	PF00069	0.607
MOD_ProDKin_1	414	420	PF00069	0.629
TRG_DiLeu_BaEn_1	500	505	PF01217	0.462
TRG_DiLeu_BaLyEn_6	332	337	PF01217	0.387
TRG_DiLeu_BaLyEn_6	434	439	PF01217	0.369
TRG_ENDOCYTIC_2	226	229	PF00928	0.547
TRG_ER_diArg_1	44	47	PF00400	0.566
TRG_ER_diArg_1	466	469	PF00400	0.528
TRG_ER_diArg_1	535	538	PF00400	0.506
TRG_Pf-PMV_PEXEL_1	327	332	PF00026	0.595
TRG_Pf-PMV_PEXEL_1	335	339	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD00	Leptomonas seymouri	46%	100%
A0A3S7WYC4	Leishmania donovani	83%	98%
A4HDD7	Leishmania braziliensis	69%	98%
A4I0R8	Leishmania infantum	82%	98%
D0A749	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4QAQ4	Leishmania major	81%	100%
V5BR63	Trypanosoma cruzi	32%	100%