Malic enzyme

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Malic enzyme

Gene product:

malic enzyme

Species:

Leishmania mexicana

UniProt:

E9AWR7_LEIMU

TriTrypDb:

LmxM.24.0761

Length:

571

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

E9AWR7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWR7

Function

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Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006090	pyruvate metabolic process	7	1
GO:0006108	malate metabolic process	7	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0043648	dicarboxylic acid metabolic process	6	1
GO:0044237	cellular metabolic process	2	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	22
GO:0003824	catalytic activity	1	22
GO:0004470	malic enzyme activity	5	22
GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity	5	22
GO:0004473	malate dehydrogenase (decarboxylating) (NADP+) activity	5	1
GO:0005488	binding	1	22
GO:0008948	oxaloacetate decarboxylase activity	5	5
GO:0016491	oxidoreductase activity	2	22
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	22
GO:0016615	malate dehydrogenase activity	4	22

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	360	362	PF00675	0.334
CLV_NRD_NRD_1	38	40	PF00675	0.430
CLV_PCSK_FUR_1	216	220	PF00082	0.292
CLV_PCSK_KEX2_1	218	220	PF00082	0.291
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.291
CLV_PCSK_SKI1_1	131	135	PF00082	0.319
CLV_PCSK_SKI1_1	356	360	PF00082	0.332
CLV_PCSK_SKI1_1	455	459	PF00082	0.347
DEG_APCC_DBOX_1	38	46	PF00400	0.420
DOC_CKS1_1	105	110	PF01111	0.496

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A095AMW7	Leuconostoc mesenteroides	34%	100%
A0A0N0P5V3	Leptomonas seymouri	57%	99%
A0A0N1IKN4	Leptomonas seymouri	81%	100%
A0A0S4J425	Bodo saltans	64%	100%
A0A0S4J4T3	Bodo saltans	55%	95%
A0A1X0NIF9	Trypanosomatidae	55%	100%
A0A1X0NII9	Trypanosomatidae	71%	100%
A0A3R7KLW0	Trypanosoma rangeli	68%	100%
A0A3S7WY68	Leishmania donovani	57%	100%
A0A3S7WYA8	Leishmania donovani	96%	100%

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