DUF523 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF523), putative

Species:

Leishmania mexicana

UniProt:

E9AWR1_LEIMU

TriTrypDb:

LmxM.24.0710

Length:

413

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWR1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	26	30	PF00656	0.466
CLV_C14_Caspase3-7	311	315	PF00656	0.590
CLV_C14_Caspase3-7	391	395	PF00656	0.632
CLV_NRD_NRD_1	298	300	PF00675	0.793
CLV_NRD_NRD_1	308	310	PF00675	0.507
CLV_NRD_NRD_1	366	368	PF00675	0.482
CLV_NRD_NRD_1	377	379	PF00675	0.666
CLV_PCSK_FUR_1	364	368	PF00082	0.482
CLV_PCSK_KEX2_1	298	300	PF00082	0.793
CLV_PCSK_KEX2_1	308	310	PF00082	0.507
CLV_PCSK_KEX2_1	366	368	PF00082	0.482
CLV_PCSK_KEX2_1	376	378	PF00082	0.777
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.777
CLV_PCSK_SKI1_1	322	326	PF00082	0.605
CLV_PCSK_SKI1_1	354	358	PF00082	0.521
DEG_APCC_DBOX_1	144	152	PF00400	0.411
DEG_APCC_DBOX_1	321	329	PF00400	0.611
DEG_SCF_FBW7_1	268	273	PF00400	0.418
DEG_SPOP_SBC_1	301	305	PF00917	0.465
DOC_CKS1_1	36	41	PF01111	0.694
DOC_CYCLIN_yCln2_LP_2	91	97	PF00134	0.411
DOC_MAPK_DCC_7	77	86	PF00069	0.547
DOC_MAPK_gen_1	5	14	PF00069	0.575
DOC_MAPK_MEF2A_6	109	116	PF00069	0.367
DOC_MAPK_MEF2A_6	77	86	PF00069	0.617
DOC_PP2B_LxvP_1	139	142	PF13499	0.411
DOC_USP7_MATH_1	170	174	PF00917	0.389
DOC_USP7_MATH_1	185	189	PF00917	0.388
DOC_USP7_MATH_1	300	304	PF00917	0.605
DOC_WW_Pin1_4	108	113	PF00397	0.411
DOC_WW_Pin1_4	175	180	PF00397	0.276
DOC_WW_Pin1_4	221	226	PF00397	0.377
DOC_WW_Pin1_4	250	255	PF00397	0.411
DOC_WW_Pin1_4	266	271	PF00397	0.587
DOC_WW_Pin1_4	35	40	PF00397	0.689
DOC_WW_Pin1_4	67	72	PF00397	0.632
LIG_14-3-3_CanoR_1	46	54	PF00244	0.597
LIG_14-3-3_CanoR_1	8	13	PF00244	0.727
LIG_14-3-3_CanoR_1	98	108	PF00244	0.347
LIG_BRCT_BRCA1_1	291	295	PF00533	0.644
LIG_FHA_1	109	115	PF00498	0.378
LIG_FHA_1	316	322	PF00498	0.568
LIG_FHA_2	217	223	PF00498	0.436
LIG_FHA_2	389	395	PF00498	0.553
LIG_FHA_2	71	77	PF00498	0.713
LIG_LIR_Nem_3	118	124	PF02991	0.411
LIG_LIR_Nem_3	135	141	PF02991	0.411
LIG_LIR_Nem_3	53	59	PF02991	0.709
LIG_NRBOX	233	239	PF00104	0.416
LIG_SH2_CRK	213	217	PF00017	0.338
LIG_SH2_NCK_1	213	217	PF00017	0.416
LIG_SH2_SRC	264	267	PF00017	0.642
LIG_SH2_STAP1	264	268	PF00017	0.554
LIG_SH2_STAT5	199	202	PF00017	0.513
LIG_SH2_STAT5	360	363	PF00017	0.535
LIG_SH3_2	144	149	PF14604	0.411
LIG_SH3_3	128	134	PF00018	0.411
LIG_SH3_3	141	147	PF00018	0.416
LIG_SH3_3	265	271	PF00018	0.684
LIG_SH3_3	76	82	PF00018	0.692
LIG_SUMO_SIM_anti_2	123	128	PF11976	0.222
LIG_SUMO_SIM_par_1	80	87	PF11976	0.474
LIG_UBA3_1	237	242	PF00899	0.338
LIG_WRC_WIRS_1	28	33	PF05994	0.410
LIG_WRC_WIRS_1	393	398	PF05994	0.499
MOD_CDK_SPK_2	35	40	PF00069	0.597
MOD_CK1_1	154	160	PF00069	0.471
MOD_CK1_1	175	181	PF00069	0.494
MOD_CK1_1	392	398	PF00069	0.520
MOD_CK1_1	60	66	PF00069	0.536
MOD_CK1_1	69	75	PF00069	0.650
MOD_CK2_1	200	206	PF00069	0.499
MOD_CK2_1	392	398	PF00069	0.527
MOD_Cter_Amidation	296	299	PF01082	0.793
MOD_GlcNHglycan	174	177	PF01048	0.342
MOD_GlcNHglycan	202	206	PF01048	0.513
MOD_GlcNHglycan	230	233	PF01048	0.411
MOD_GlcNHglycan	291	294	PF01048	0.633
MOD_GlcNHglycan	304	307	PF01048	0.689
MOD_GlcNHglycan	86	89	PF01048	0.353
MOD_GSK3_1	171	178	PF00069	0.494
MOD_GSK3_1	179	186	PF00069	0.411
MOD_GSK3_1	248	255	PF00069	0.375
MOD_GSK3_1	266	273	PF00069	0.460
MOD_GSK3_1	284	291	PF00069	0.481
MOD_GSK3_1	354	361	PF00069	0.602
MOD_GSK3_1	388	395	PF00069	0.562
MOD_GSK3_1	63	70	PF00069	0.701
MOD_GSK3_1	89	96	PF00069	0.462
MOD_N-GLC_1	216	221	PF02516	0.443
MOD_N-GLC_1	381	386	PF02516	0.716
MOD_N-GLC_2	282	284	PF02516	0.731
MOD_NEK2_1	200	205	PF00069	0.478
MOD_NEK2_1	324	329	PF00069	0.530
MOD_NEK2_1	396	401	PF00069	0.456
MOD_PIKK_1	315	321	PF00454	0.562
MOD_PIKK_1	406	412	PF00454	0.563
MOD_PKA_2	151	157	PF00069	0.384
MOD_PKA_2	406	412	PF00069	0.641
MOD_PKA_2	45	51	PF00069	0.573
MOD_PKA_2	7	13	PF00069	0.730
MOD_PKA_2	97	103	PF00069	0.513
MOD_Plk_1	216	222	PF00069	0.436
MOD_Plk_2-3	358	364	PF00069	0.529
MOD_Plk_4	392	398	PF00069	0.472
MOD_ProDKin_1	108	114	PF00069	0.411
MOD_ProDKin_1	175	181	PF00069	0.276
MOD_ProDKin_1	221	227	PF00069	0.377
MOD_ProDKin_1	250	256	PF00069	0.411
MOD_ProDKin_1	266	272	PF00069	0.590
MOD_ProDKin_1	35	41	PF00069	0.689
MOD_ProDKin_1	67	73	PF00069	0.629
MOD_SUMO_for_1	191	194	PF00179	0.319
TRG_DiLeu_BaEn_1	196	201	PF01217	0.513
TRG_DiLeu_BaEn_1	206	211	PF01217	0.265
TRG_DiLeu_BaLyEn_6	109	114	PF01217	0.411
TRG_DiLeu_BaLyEn_6	351	356	PF01217	0.433
TRG_ER_diArg_1	298	300	PF00400	0.752
TRG_ER_diArg_1	308	310	PF00400	0.507
TRG_ER_diArg_1	364	367	PF00400	0.483
TRG_ER_diArg_1	377	379	PF00400	0.612
TRG_NES_CRM1_1	123	135	PF08389	0.411
TRG_NLS_Bipartite_1	366	380	PF00514	0.447
TRG_NLS_MonoCore_2	374	379	PF00514	0.591
TRG_NLS_MonoExtN_4	373	380	PF00514	0.752
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	354	358	PF00026	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3F4	Leptomonas seymouri	42%	100%
A0A3S7WY61	Leishmania donovani	87%	94%
A4HDC8	Leishmania braziliensis	75%	100%
A4I0Q9	Leishmania infantum	87%	94%
Q4QAR2	Leishmania major	89%	100%