Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWQ6_LEIMU

TriTrypDb:

LmxM.24.0660

Length:

763

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWQ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.481
CLV_C14_Caspase3-7	649	653	PF00656	0.533
CLV_NRD_NRD_1	137	139	PF00675	0.404
CLV_NRD_NRD_1	395	397	PF00675	0.421
CLV_NRD_NRD_1	712	714	PF00675	0.526
CLV_NRD_NRD_1	719	721	PF00675	0.625
CLV_PCSK_KEX2_1	142	144	PF00082	0.407
CLV_PCSK_KEX2_1	395	397	PF00082	0.400
CLV_PCSK_KEX2_1	405	407	PF00082	0.401
CLV_PCSK_KEX2_1	711	713	PF00082	0.492
CLV_PCSK_KEX2_1	719	721	PF00082	0.621
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.411
CLV_PCSK_PC1ET2_1	405	407	PF00082	0.497
CLV_PCSK_PC1ET2_1	711	713	PF00082	0.584
CLV_PCSK_PC7_1	138	144	PF00082	0.473
CLV_PCSK_SKI1_1	12	16	PF00082	0.562
CLV_PCSK_SKI1_1	139	143	PF00082	0.418
CLV_PCSK_SKI1_1	156	160	PF00082	0.281
CLV_PCSK_SKI1_1	180	184	PF00082	0.517
CLV_PCSK_SKI1_1	354	358	PF00082	0.453
CLV_PCSK_SKI1_1	406	410	PF00082	0.435
CLV_Separin_Metazoa	144	148	PF03568	0.293
DEG_APCC_DBOX_1	142	150	PF00400	0.327
DEG_Nend_Nbox_1	1	3	PF02207	0.547
DEG_SCF_SKP2-CKS1_1	574	581	PF00560	0.460
DOC_CYCLIN_RxL_1	138	150	PF00134	0.391
DOC_CYCLIN_RxL_1	617	627	PF00134	0.391
DOC_MAPK_gen_1	127	136	PF00069	0.609
DOC_MAPK_gen_1	377	386	PF00069	0.566
DOC_MAPK_gen_1	404	412	PF00069	0.264
DOC_MAPK_gen_1	477	485	PF00069	0.427
DOC_MAPK_gen_1	583	593	PF00069	0.365
DOC_MAPK_gen_1	673	681	PF00069	0.531
DOC_MAPK_HePTP_8	402	414	PF00069	0.242
DOC_MAPK_JIP1_4	130	136	PF00069	0.492
DOC_MAPK_MEF2A_6	404	412	PF00069	0.246
DOC_MAPK_MEF2A_6	477	485	PF00069	0.427
DOC_MAPK_MEF2A_6	586	593	PF00069	0.367
DOC_MAPK_MEF2A_6	675	684	PF00069	0.501
DOC_MAPK_NFAT4_5	405	413	PF00069	0.246
DOC_PP1_RVXF_1	457	463	PF00149	0.326
DOC_USP7_MATH_1	178	182	PF00917	0.531
DOC_USP7_MATH_1	244	248	PF00917	0.335
DOC_USP7_MATH_1	517	521	PF00917	0.394
DOC_USP7_MATH_1	616	620	PF00917	0.538
DOC_USP7_MATH_1	650	654	PF00917	0.516
DOC_USP7_MATH_1	661	665	PF00917	0.486
DOC_USP7_MATH_1	692	696	PF00917	0.440
DOC_WW_Pin1_4	412	417	PF00397	0.364
DOC_WW_Pin1_4	575	580	PF00397	0.538
DOC_WW_Pin1_4	76	81	PF00397	0.508
LIG_14-3-3_CanoR_1	121	126	PF00244	0.511
LIG_14-3-3_CanoR_1	147	153	PF00244	0.370
LIG_14-3-3_CanoR_1	340	348	PF00244	0.468
LIG_14-3-3_CanoR_1	516	525	PF00244	0.439
LIG_14-3-3_CanoR_1	570	579	PF00244	0.475
LIG_14-3-3_CanoR_1	83	91	PF00244	0.447
LIG_BRCT_BRCA1_1	551	555	PF00533	0.413
LIG_BRCT_BRCA1_1	694	698	PF00533	0.296
LIG_CaM_IQ_9	113	129	PF13499	0.545
LIG_Clathr_ClatBox_1	237	241	PF01394	0.357
LIG_CSL_BTD_1	658	661	PF09270	0.320
LIG_deltaCOP1_diTrp_1	683	687	PF00928	0.541
LIG_eIF4E_1	200	206	PF01652	0.221
LIG_eIF4E_1	258	264	PF01652	0.415
LIG_eIF4E_1	509	515	PF01652	0.446
LIG_FHA_1	209	215	PF00498	0.363
LIG_FHA_1	251	257	PF00498	0.431
LIG_FHA_1	276	282	PF00498	0.536
LIG_FHA_1	295	301	PF00498	0.464
LIG_FHA_1	417	423	PF00498	0.471
LIG_FHA_1	42	48	PF00498	0.519
LIG_FHA_1	440	446	PF00498	0.348
LIG_FHA_1	702	708	PF00498	0.396
LIG_FHA_1	757	763	PF00498	0.632
LIG_FHA_1	77	83	PF00498	0.624
LIG_FHA_2	149	155	PF00498	0.482
LIG_FHA_2	294	300	PF00498	0.528
LIG_FHA_2	3	9	PF00498	0.356
LIG_FHA_2	625	631	PF00498	0.540
LIG_FHA_2	647	653	PF00498	0.402
LIG_GBD_Chelix_1	589	597	PF00786	0.341
LIG_GBD_Chelix_1	728	736	PF00786	0.455
LIG_IRF3_LxIS_1	29	36	PF10401	0.568
LIG_IRF3_LxIS_1	408	415	PF10401	0.475
LIG_LIR_Apic_2	526	532	PF02991	0.343
LIG_LIR_Apic_2	737	743	PF02991	0.526
LIG_LIR_Gen_1	105	113	PF02991	0.458
LIG_LIR_Gen_1	293	303	PF02991	0.416
LIG_LIR_Gen_1	332	342	PF02991	0.464
LIG_LIR_Gen_1	415	424	PF02991	0.258
LIG_LIR_Gen_1	484	493	PF02991	0.326
LIG_LIR_Gen_1	69	80	PF02991	0.561
LIG_LIR_Gen_1	700	710	PF02991	0.419
LIG_LIR_Nem_3	105	110	PF02991	0.417
LIG_LIR_Nem_3	123	128	PF02991	0.501
LIG_LIR_Nem_3	293	298	PF02991	0.485
LIG_LIR_Nem_3	332	337	PF02991	0.386
LIG_LIR_Nem_3	415	420	PF02991	0.365
LIG_LIR_Nem_3	484	488	PF02991	0.333
LIG_LIR_Nem_3	503	509	PF02991	0.414
LIG_LIR_Nem_3	656	662	PF02991	0.386
LIG_LIR_Nem_3	69	75	PF02991	0.640
LIG_LIR_Nem_3	700	706	PF02991	0.395
LIG_LIR_Nem_3	96	101	PF02991	0.509
LIG_MYND_1	283	287	PF01753	0.429
LIG_NRBOX	201	207	PF00104	0.222
LIG_NRBOX	259	265	PF00104	0.422
LIG_PCNA_yPIPBox_3	634	648	PF02747	0.458
LIG_SH2_CRK	128	132	PF00017	0.496
LIG_SH2_CRK	509	513	PF00017	0.451
LIG_SH2_CRK	529	533	PF00017	0.334
LIG_SH2_CRK	72	76	PF00017	0.555
LIG_SH2_NCK_1	454	458	PF00017	0.335
LIG_SH2_SRC	454	457	PF00017	0.340
LIG_SH2_STAP1	102	106	PF00017	0.430
LIG_SH2_STAP1	454	458	PF00017	0.344
LIG_SH2_STAP1	502	506	PF00017	0.389
LIG_SH2_STAT3	596	599	PF00017	0.528
LIG_SH2_STAT5	295	298	PF00017	0.525
LIG_SH2_STAT5	310	313	PF00017	0.391
LIG_SH2_STAT5	423	426	PF00017	0.390
LIG_SH2_STAT5	529	532	PF00017	0.331
LIG_SH2_STAT5	596	599	PF00017	0.605
LIG_SH2_STAT5	62	65	PF00017	0.523
LIG_SH3_2	283	288	PF14604	0.471
LIG_SH3_3	280	286	PF00018	0.516
LIG_SH3_3	361	367	PF00018	0.530
LIG_SUMO_SIM_anti_2	229	235	PF11976	0.515
LIG_SUMO_SIM_anti_2	296	302	PF11976	0.467
LIG_SUMO_SIM_anti_2	511	516	PF11976	0.306
LIG_SUMO_SIM_par_1	163	169	PF11976	0.392
LIG_SUMO_SIM_par_1	235	241	PF11976	0.360
LIG_SUMO_SIM_par_1	299	304	PF11976	0.452
LIG_SUMO_SIM_par_1	486	491	PF11976	0.444
LIG_SUMO_SIM_par_1	5	10	PF11976	0.420
LIG_TRAF2_1	151	154	PF00917	0.429
LIG_UBA3_1	337	346	PF00899	0.602
LIG_UBA3_1	357	366	PF00899	0.230
LIG_UBA3_1	408	413	PF00899	0.374
LIG_WRC_WIRS_1	122	127	PF05994	0.485
LIG_WRC_WIRS_1	424	429	PF05994	0.382
LIG_WRC_WIRS_1	750	755	PF05994	0.503
MOD_CDK_SPxK_1	575	581	PF00069	0.566
MOD_CDK_SPxxK_3	76	83	PF00069	0.463
MOD_CK1_1	208	214	PF00069	0.522
MOD_CK1_1	247	253	PF00069	0.622
MOD_CK1_1	293	299	PF00069	0.430
MOD_CK1_1	332	338	PF00069	0.594
MOD_CK1_1	344	350	PF00069	0.372
MOD_CK1_1	40	46	PF00069	0.605
MOD_CK1_1	415	421	PF00069	0.486
MOD_CK1_1	426	432	PF00069	0.372
MOD_CK1_1	49	55	PF00069	0.507
MOD_CK1_1	664	670	PF00069	0.617
MOD_CK1_1	722	728	PF00069	0.424
MOD_CK1_1	73	79	PF00069	0.561
MOD_CK1_1	752	758	PF00069	0.682
MOD_CK2_1	147	153	PF00069	0.372
MOD_CK2_1	2	8	PF00069	0.359
MOD_CK2_1	229	235	PF00069	0.389
MOD_CK2_1	301	307	PF00069	0.447
MOD_CK2_1	570	576	PF00069	0.501
MOD_CK2_1	624	630	PF00069	0.509
MOD_CK2_1	650	656	PF00069	0.514
MOD_GlcNHglycan	168	171	PF01048	0.389
MOD_GlcNHglycan	180	183	PF01048	0.596
MOD_GlcNHglycan	303	306	PF01048	0.560
MOD_GlcNHglycan	48	51	PF01048	0.530
MOD_GlcNHglycan	519	522	PF01048	0.421
MOD_GlcNHglycan	721	724	PF01048	0.598
MOD_GlcNHglycan	93	96	PF01048	0.424
MOD_GSK3_1	184	191	PF00069	0.503
MOD_GSK3_1	242	249	PF00069	0.426
MOD_GSK3_1	290	297	PF00069	0.415
MOD_GSK3_1	33	40	PF00069	0.647
MOD_GSK3_1	332	339	PF00069	0.561
MOD_GSK3_1	412	419	PF00069	0.492
MOD_GSK3_1	429	436	PF00069	0.535
MOD_GSK3_1	463	470	PF00069	0.476
MOD_GSK3_1	519	526	PF00069	0.397
MOD_GSK3_1	549	556	PF00069	0.508
MOD_GSK3_1	61	68	PF00069	0.483
MOD_GSK3_1	626	633	PF00069	0.552
MOD_GSK3_1	646	653	PF00069	0.452
MOD_GSK3_1	70	77	PF00069	0.532
MOD_GSK3_1	718	725	PF00069	0.550
MOD_GSK3_1	749	756	PF00069	0.715
MOD_GSK3_1	87	94	PF00069	0.616
MOD_N-GLC_2	192	194	PF02516	0.375
MOD_NEK2_1	120	125	PF00069	0.400
MOD_NEK2_1	145	150	PF00069	0.395
MOD_NEK2_1	188	193	PF00069	0.419
MOD_NEK2_1	205	210	PF00069	0.402
MOD_NEK2_1	25	30	PF00069	0.435
MOD_NEK2_1	263	268	PF00069	0.251
MOD_NEK2_1	301	306	PF00069	0.484
MOD_NEK2_1	33	38	PF00069	0.730
MOD_NEK2_1	341	346	PF00069	0.495
MOD_NEK2_1	55	60	PF00069	0.525
MOD_NEK2_1	624	629	PF00069	0.534
MOD_NEK2_1	646	651	PF00069	0.490
MOD_NEK2_1	66	71	PF00069	0.445
MOD_NEK2_2	423	428	PF00069	0.404
MOD_OFUCOSY	331	336	PF10250	0.460
MOD_PIKK_1	661	667	PF00454	0.651
MOD_PK_1	242	248	PF00069	0.405
MOD_PKA_1	500	506	PF00069	0.500
MOD_PKA_1	713	719	PF00069	0.657
MOD_PKA_2	120	126	PF00069	0.472
MOD_PKA_2	40	46	PF00069	0.678
MOD_PKA_2	55	61	PF00069	0.570
MOD_PKA_2	650	656	PF00069	0.509
MOD_PKA_2	718	724	PF00069	0.594
MOD_PKA_2	82	88	PF00069	0.651
MOD_Plk_1	31	37	PF00069	0.570
MOD_Plk_1	332	338	PF00069	0.309
MOD_Plk_1	467	473	PF00069	0.538
MOD_Plk_1	655	661	PF00069	0.493
MOD_Plk_1	699	705	PF00069	0.480
MOD_Plk_2-3	229	235	PF00069	0.319
MOD_Plk_4	121	127	PF00069	0.489
MOD_Plk_4	2	8	PF00069	0.442
MOD_Plk_4	523	529	PF00069	0.443
MOD_Plk_4	592	598	PF00069	0.540
MOD_Plk_4	650	656	PF00069	0.452
MOD_Plk_4	67	73	PF00069	0.605
MOD_Plk_4	87	93	PF00069	0.288
MOD_ProDKin_1	412	418	PF00069	0.365
MOD_ProDKin_1	575	581	PF00069	0.544
MOD_ProDKin_1	76	82	PF00069	0.508
MOD_SUMO_for_1	141	144	PF00179	0.392
MOD_SUMO_rev_2	150	158	PF00179	0.498
MOD_SUMO_rev_2	270	278	PF00179	0.551
TRG_DiLeu_BaEn_1	352	357	PF01217	0.425
TRG_DiLeu_BaEn_1	87	92	PF01217	0.494
TRG_DiLeu_BaEn_2	95	101	PF01217	0.424
TRG_DiLeu_BaLyEn_6	259	264	PF01217	0.417
TRG_DiLeu_BaLyEn_6	268	273	PF01217	0.377
TRG_DiLeu_BaLyEn_6	337	342	PF01217	0.601
TRG_DiLeu_BaLyEn_6	677	682	PF01217	0.503
TRG_ENDOCYTIC_2	200	203	PF00928	0.405
TRG_ENDOCYTIC_2	261	264	PF00928	0.480
TRG_ENDOCYTIC_2	295	298	PF00928	0.467
TRG_ENDOCYTIC_2	509	512	PF00928	0.454
TRG_ENDOCYTIC_2	72	75	PF00928	0.553
TRG_ENDOCYTIC_2	750	753	PF00928	0.614
TRG_ER_diArg_1	394	396	PF00400	0.361
TRG_ER_diArg_1	718	720	PF00400	0.551
TRG_NES_CRM1_1	229	241	PF08389	0.429
TRG_NLS_MonoCore_2	710	715	PF00514	0.602
TRG_NLS_MonoExtC_3	137	142	PF00514	0.400
TRG_NLS_MonoExtC_3	710	715	PF00514	0.500
TRG_NLS_MonoExtN_4	135	142	PF00514	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5G6	Leptomonas seymouri	47%	100%
A0A1X0NK62	Trypanosomatidae	27%	92%
A0A3S5IQT2	Trypanosoma rangeli	28%	100%
A0A3S7WY64	Leishmania donovani	87%	100%
A4HDC4	Leishmania braziliensis	72%	100%
A4I0Q4	Leishmania infantum	88%	100%
D0A732	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	99%
Q4QAR7	Leishmania major	87%	100%
V5C0M8	Trypanosoma cruzi	27%	100%