Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Kinesin-13 3, putative

Species:

Leishmania mexicana

UniProt:

E9AWQ4_LEIMU

TriTrypDb:

LmxM.24.0640

Length:

577

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	19
GO:0099080	supramolecular complex	2	19
GO:0099081	supramolecular polymer	3	19
GO:0099512	supramolecular fiber	4	19
GO:0099513	polymeric cytoskeletal fiber	5	19
GO:0110165	cellular anatomical entity	1	19
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0097542	ciliary tip	2	1

Expansion

Sequence features

E9AWQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWQ4

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	20
GO:0007018	microtubule-based movement	3	20
GO:0009987	cellular process	1	20
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007019	microtubule depolymerization	5	1
GO:0016043	cellular component organization	3	1
GO:0022411	cellular component disassembly	4	1
GO:0031109	microtubule polymerization or depolymerization	4	1
GO:0032984	protein-containing complex disassembly	5	1
GO:0043933	protein-containing complex organization	4	1
GO:0051261	protein depolymerization	6	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0097435	supramolecular fiber organization	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	20
GO:0003774	cytoskeletal motor activity	1	20
GO:0003777	microtubule motor activity	2	20
GO:0005488	binding	1	20
GO:0005515	protein binding	2	20
GO:0005524	ATP binding	5	20
GO:0008017	microtubule binding	5	20
GO:0008092	cytoskeletal protein binding	3	20
GO:0015631	tubulin binding	4	20
GO:0017076	purine nucleotide binding	4	20
GO:0030554	adenyl nucleotide binding	5	20
GO:0032553	ribonucleotide binding	3	20
GO:0032555	purine ribonucleotide binding	4	20
GO:0032559	adenyl ribonucleotide binding	5	20
GO:0035639	purine ribonucleoside triphosphate binding	4	20
GO:0036094	small molecule binding	2	20
GO:0043167	ion binding	2	20
GO:0043168	anion binding	3	20
GO:0097159	organic cyclic compound binding	2	20
GO:0097367	carbohydrate derivative binding	2	20
GO:0140657	ATP-dependent activity	1	20
GO:1901265	nucleoside phosphate binding	3	20
GO:1901363	heterocyclic compound binding	2	20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	522	526	PF00656	0.450
CLV_NRD_NRD_1	135	137	PF00675	0.303
CLV_NRD_NRD_1	144	146	PF00675	0.318
CLV_NRD_NRD_1	216	218	PF00675	0.355
CLV_NRD_NRD_1	243	245	PF00675	0.274
CLV_NRD_NRD_1	345	347	PF00675	0.644
CLV_NRD_NRD_1	351	353	PF00675	0.659
CLV_NRD_NRD_1	478	480	PF00675	0.398
CLV_NRD_NRD_1	501	503	PF00675	0.394
CLV_NRD_NRD_1	9	11	PF00675	0.340
CLV_PCSK_KEX2_1	11	13	PF00082	0.369
CLV_PCSK_KEX2_1	146	148	PF00082	0.408
CLV_PCSK_KEX2_1	216	218	PF00082	0.386
CLV_PCSK_KEX2_1	345	347	PF00082	0.645
CLV_PCSK_KEX2_1	351	353	PF00082	0.655
CLV_PCSK_KEX2_1	501	503	PF00082	0.394
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.369
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.238
CLV_PCSK_SKI1_1	113	117	PF00082	0.308
CLV_PCSK_SKI1_1	136	140	PF00082	0.261
CLV_PCSK_SKI1_1	146	150	PF00082	0.292
CLV_PCSK_SKI1_1	255	259	PF00082	0.281
CLV_PCSK_SKI1_1	432	436	PF00082	0.421
CLV_PCSK_SKI1_1	567	571	PF00082	0.485
CLV_Separin_Metazoa	283	287	PF03568	0.290
DEG_APCC_DBOX_1	66	74	PF00400	0.404
DOC_CKS1_1	22	27	PF01111	0.513
DOC_CYCLIN_RxL_1	252	262	PF00134	0.281
DOC_MAPK_gen_1	216	227	PF00069	0.404
DOC_MAPK_HePTP_8	9	21	PF00069	0.347
DOC_MAPK_MEF2A_6	12	21	PF00069	0.478
DOC_MAPK_MEF2A_6	198	207	PF00069	0.333
DOC_MAPK_RevD_3	124	137	PF00069	0.314
DOC_PP1_RVXF_1	222	228	PF00149	0.279
DOC_USP7_MATH_1	194	198	PF00917	0.354
DOC_USP7_MATH_1	443	447	PF00917	0.648
DOC_USP7_MATH_1	517	521	PF00917	0.536
DOC_USP7_UBL2_3	491	495	PF12436	0.531
DOC_WW_Pin1_4	21	26	PF00397	0.398
DOC_WW_Pin1_4	299	304	PF00397	0.290
DOC_WW_Pin1_4	338	343	PF00397	0.642
DOC_WW_Pin1_4	372	377	PF00397	0.673
DOC_WW_Pin1_4	38	43	PF00397	0.104
DOC_WW_Pin1_4	415	420	PF00397	0.688
DOC_WW_Pin1_4	457	462	PF00397	0.471
LIG_14-3-3_CanoR_1	224	228	PF00244	0.265
LIG_14-3-3_CanoR_1	294	298	PF00244	0.295
LIG_14-3-3_CanoR_1	316	324	PF00244	0.295
LIG_14-3-3_CanoR_1	46	52	PF00244	0.285
LIG_Actin_WH2_2	273	288	PF00022	0.279
LIG_APCC_ABBA_1	40	45	PF00400	0.271
LIG_BIR_II_1	1	5	PF00653	0.521
LIG_deltaCOP1_diTrp_1	365	370	PF00928	0.504
LIG_FHA_1	280	286	PF00498	0.281
LIG_FHA_1	293	299	PF00498	0.281
LIG_FHA_1	316	322	PF00498	0.303
LIG_FHA_1	568	574	PF00498	0.539
LIG_FHA_2	244	250	PF00498	0.281
LIG_FHA_2	48	54	PF00498	0.351
LIG_LIR_Gen_1	173	183	PF02991	0.351
LIG_LIR_Gen_1	226	231	PF02991	0.282
LIG_LIR_Gen_1	48	55	PF02991	0.289
LIG_LIR_Nem_3	129	134	PF02991	0.284
LIG_LIR_Nem_3	173	178	PF02991	0.351
LIG_LIR_Nem_3	226	230	PF02991	0.282
LIG_LIR_Nem_3	48	54	PF02991	0.289
LIG_LIR_Nem_3	95	99	PF02991	0.350
LIG_NRP_CendR_1	576	577	PF00754	0.635
LIG_Pex14_1	366	370	PF04695	0.501
LIG_Pex14_2	51	55	PF04695	0.345
LIG_SH2_CRK	96	100	PF00017	0.404
LIG_SH2_NCK_1	108	112	PF00017	0.299
LIG_SH2_SRC	108	111	PF00017	0.295
LIG_SH2_STAP1	108	112	PF00017	0.299
LIG_SH2_STAP1	317	321	PF00017	0.287
LIG_SH2_STAT5	127	130	PF00017	0.286
LIG_SH2_STAT5	317	320	PF00017	0.279
LIG_SH2_STAT5	43	46	PF00017	0.292
LIG_SH2_STAT5	484	487	PF00017	0.521
LIG_SH2_STAT5	530	533	PF00017	0.363
LIG_SH2_STAT5	96	99	PF00017	0.388
LIG_SH3_2	347	352	PF14604	0.609
LIG_SH3_3	19	25	PF00018	0.460
LIG_SH3_3	28	34	PF00018	0.227
LIG_SH3_3	344	350	PF00018	0.740
LIG_SH3_3	425	431	PF00018	0.457
LIG_SUMO_SIM_anti_2	18	24	PF11976	0.550
LIG_SUMO_SIM_par_1	256	262	PF11976	0.281
LIG_TRAF2_1	520	523	PF00917	0.567
LIG_TRFH_1	38	42	PF08558	0.271
LIG_UBA3_1	138	146	PF00899	0.256
LIG_UBA3_1	257	261	PF00899	0.281
LIG_WRC_WIRS_1	127	132	PF05994	0.299
LIG_WRC_WIRS_1	518	523	PF05994	0.440
MOD_CDK_SPK_2	23	28	PF00069	0.396
MOD_CDK_SPK_2	457	462	PF00069	0.558
MOD_CDK_SPxxK_3	21	28	PF00069	0.384
MOD_CDK_SPxxK_3	338	345	PF00069	0.673
MOD_CK1_1	196	202	PF00069	0.316
MOD_CK1_1	279	285	PF00069	0.278
MOD_CK1_1	293	299	PF00069	0.261
MOD_CK1_1	302	308	PF00069	0.209
MOD_CK1_1	372	378	PF00069	0.704
MOD_CK1_1	41	47	PF00069	0.279
MOD_CK1_1	415	421	PF00069	0.702
MOD_CK1_1	506	512	PF00069	0.542
MOD_CK1_1	571	577	PF00069	0.611
MOD_CK1_1	92	98	PF00069	0.281
MOD_CK2_1	126	132	PF00069	0.305
MOD_CK2_1	243	249	PF00069	0.281
MOD_CK2_1	376	382	PF00069	0.748
MOD_CK2_1	443	449	PF00069	0.423
MOD_CK2_1	47	53	PF00069	0.384
MOD_CK2_1	517	523	PF00069	0.496
MOD_CK2_1	98	104	PF00069	0.332
MOD_Cter_Amidation	134	137	PF01082	0.306
MOD_Cter_Amidation	343	346	PF01082	0.606
MOD_GlcNHglycan	181	184	PF01048	0.312
MOD_GlcNHglycan	190	193	PF01048	0.253
MOD_GlcNHglycan	211	214	PF01048	0.323
MOD_GlcNHglycan	325	328	PF01048	0.386
MOD_GlcNHglycan	414	417	PF01048	0.664
MOD_GlcNHglycan	552	555	PF01048	0.370
MOD_GlcNHglycan	573	576	PF01048	0.565
MOD_GlcNHglycan	91	94	PF01048	0.286
MOD_GSK3_1	292	299	PF00069	0.266
MOD_GSK3_1	311	318	PF00069	0.147
MOD_GSK3_1	365	372	PF00069	0.586
MOD_GSK3_1	408	415	PF00069	0.752
MOD_GSK3_1	41	48	PF00069	0.404
MOD_GSK3_1	513	520	PF00069	0.526
MOD_GSK3_1	550	557	PF00069	0.411
MOD_GSK3_1	563	570	PF00069	0.453
MOD_GSK3_1	94	101	PF00069	0.337
MOD_N-GLC_1	253	258	PF02516	0.281
MOD_N-GLC_1	60	65	PF02516	0.391
MOD_N-GLC_1	80	85	PF02516	0.279
MOD_N-GLC_2	159	161	PF02516	0.244
MOD_NEK2_1	269	274	PF00069	0.280
MOD_NEK2_1	276	281	PF00069	0.271
MOD_NEK2_1	285	290	PF00069	0.261
MOD_NEK2_1	297	302	PF00069	0.286
MOD_NEK2_1	315	320	PF00069	0.270
MOD_NEK2_1	55	60	PF00069	0.311
MOD_NEK2_1	565	570	PF00069	0.414
MOD_NEK2_1	72	77	PF00069	0.257
MOD_NEK2_1	98	103	PF00069	0.335
MOD_NEK2_2	80	85	PF00069	0.281
MOD_PIKK_1	302	308	PF00454	0.345
MOD_PIKK_1	315	321	PF00454	0.141
MOD_PIKK_1	98	104	PF00454	0.279
MOD_PK_1	408	414	PF00069	0.759
MOD_PKA_2	207	213	PF00069	0.347
MOD_PKA_2	223	229	PF00069	0.263
MOD_PKA_2	243	249	PF00069	0.278
MOD_PKA_2	276	282	PF00069	0.281
MOD_PKA_2	285	291	PF00069	0.281
MOD_PKA_2	293	299	PF00069	0.281
MOD_PKA_2	315	321	PF00069	0.286
MOD_PKA_2	45	51	PF00069	0.362
MOD_PKB_1	406	414	PF00069	0.717
MOD_Plk_1	253	259	PF00069	0.281
MOD_Plk_1	513	519	PF00069	0.471
MOD_Plk_1	60	66	PF00069	0.245
MOD_Plk_1	80	86	PF00069	0.279
MOD_Plk_2-3	523	529	PF00069	0.446
MOD_Plk_4	126	132	PF00069	0.323
MOD_Plk_4	253	259	PF00069	0.281
MOD_Plk_4	276	282	PF00069	0.292
MOD_Plk_4	293	299	PF00069	0.314
MOD_Plk_4	432	438	PF00069	0.411
MOD_Plk_4	554	560	PF00069	0.454
MOD_Plk_4	60	66	PF00069	0.287
MOD_Plk_4	72	78	PF00069	0.291
MOD_Plk_4	94	100	PF00069	0.290
MOD_ProDKin_1	21	27	PF00069	0.401
MOD_ProDKin_1	299	305	PF00069	0.290
MOD_ProDKin_1	338	344	PF00069	0.646
MOD_ProDKin_1	372	378	PF00069	0.676
MOD_ProDKin_1	38	44	PF00069	0.104
MOD_ProDKin_1	415	421	PF00069	0.685
MOD_ProDKin_1	457	463	PF00069	0.470
MOD_SUMO_for_1	333	336	PF00179	0.622
MOD_SUMO_for_1	490	493	PF00179	0.483
MOD_SUMO_for_1	511	514	PF00179	0.431
MOD_SUMO_rev_2	238	246	PF00179	0.279
MOD_SUMO_rev_2	487	497	PF00179	0.462
TRG_DiLeu_BaLyEn_6	68	73	PF01217	0.337
TRG_ENDOCYTIC_2	127	130	PF00928	0.281
TRG_ENDOCYTIC_2	96	99	PF00928	0.404
TRG_ER_diArg_1	145	148	PF00400	0.414
TRG_ER_diArg_1	345	347	PF00400	0.605
TRG_ER_diArg_1	350	352	PF00400	0.601
TRG_ER_diArg_1	405	408	PF00400	0.685
TRG_ER_diArg_1	9	12	PF00400	0.348
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	136	140	PF00026	0.301

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2G5	Leptomonas seymouri	81%	100%
A0A0N0P6P6	Leptomonas seymouri	42%	87%
A0A0N1PDD6	Leptomonas seymouri	30%	76%
A0A0S4IP49	Bodo saltans	28%	72%
A0A0S4IR67	Bodo saltans	29%	74%
A0A0S4IYW0	Bodo saltans	60%	99%
A0A1X0NIJ1	Trypanosomatidae	63%	98%
A0A1X0NJ40	Trypanosomatidae	45%	68%
A0A1X0NQ03	Trypanosomatidae	26%	70%
A0A1X0NWZ8	Trypanosomatidae	29%	77%
A0A3R7MDH9	Trypanosoma rangeli	27%	81%
A0A3R7NVF2	Trypanosoma rangeli	65%	100%
A0A3S5H4S8	Leishmania donovani	41%	86%
A0A3S7WY84	Leishmania donovani	97%	100%
A0A3S7X9Y1	Leishmania donovani	31%	100%
A0A422MZ05	Trypanosoma rangeli	27%	85%
A0A422NEQ8	Trypanosoma rangeli	30%	76%
A4HAQ7	Leishmania braziliensis	26%	100%
A4HCT2	Leishmania braziliensis	32%	80%
A4HDC2	Leishmania braziliensis	91%	100%
A4HND6	Leishmania braziliensis	30%	100%
A4HRC5	Leishmania infantum	41%	86%
A4I0Q2	Leishmania infantum	97%	100%
A4IC09	Leishmania infantum	31%	100%
B9EY52	Oryza sativa subsp. japonica	38%	82%
C9ZV26	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	77%
C9ZXH0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	84%
D0A729	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9AFU7	Leishmania major	30%	100%
E9AJ89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	86%
E9B6Z9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
Q4QAR9	Leishmania major	97%	100%
Q5R9Y9	Pongo abelii	38%	78%
Q940Y8	Arabidopsis thaliana	38%	84%
V5B8X9	Trypanosoma cruzi	27%	82%
V5BHI2	Trypanosoma cruzi	41%	80%
V5BK25	Trypanosoma cruzi	27%	80%
V5BLH7	Trypanosoma cruzi	30%	67%
V5D311	Trypanosoma cruzi	43%	85%
V5D733	Trypanosoma cruzi	30%	77%
V5DSJ9	Trypanosoma cruzi	67%	100%